Ngaba unesifo seswekile sohlobo lwesibini? Ugqirha wakho usenokuba ukunike ipilisi ebizwa ngokuba yiJardiance. Usenokuba nomdla wokwazi okungakumbi ngale mithi. Luhlobo luni lweyeza, kwenzeka ntoni emzimbeni wakho, kwaye zeziphi izilumkiso ekufuneka uzithathe. Ke namhlanje, masithethe ngokufutshane ngeJardiance, indlela esebenza ngayo, iingenelo zayo, kunye noko kufuneka ukuqaphele.
Yintoni iJardiance? Isebenza njani emzimbeni?
I-Jardiance liyeza elisetyenziselwa ukunyanga abantu abadala nabantwana abanesifo seswekile sohlobo lwesibini. Lisebenza ngokulawula amanqanaba eswekile egazini. Likwanceda ekunciphiseni umngcipheko wokuhlaselwa yintliziyo kunye nesifo sohlangothi kubantu abadala abanesifo seswekile. Nangona kunjalo, alivumelekanga kwisifo seswekile sohlobo loku-1. Ngamanye amaxesha lisetyenziswa nakubantu abangenaso isifo seswekile kodwa abanesifo sentliziyo okanye izintso.
Kulungile, ngoku masibone ukuba oku kusebenza njani. Ngamafutshane, into eyenziwa zizintso zethu kukucoca iswekile (iglucose) egazini ize iyibuyisele emzimbeni. Aziyikhuphi emchameni.
Kukho iproteni ekhethekileyo enceda izintso kulo msebenzi, ebizwa ngokuba yi -SGLT2 (Sodium-glucose cotransporter-2) .
Ipilisi yeJardiance ithintela okwethutyana ukusebenza kweproteni ye-SGLT2. Oku kuvumela iswekile engaphezulu engenakukwazi ukuyifunxa emzimbeni ukuba idlule kumchamo. Oku kunciphisa amanqanaba eswekile egazini. Le nkqubo inokukunceda unciphise ubunzima kwaye ulawule uxinzelelo lwakho lwegazi .
Zingakanani iingenelo zale mithi eziye zabonakaliswa?
Izifundo ezininzi ezinkulu zeklinikhi zenziwe ukufumanisa ukuba iJardiance ikhuselekile kwaye isebenza kangakanani na. Ezi zifundo zijonge ikakhulu ukuba eli yeza lisebenza kangakanani ekunciphiseni i-HbA1c (uvavanyo olubonisa amanqanaba aphakathi eswekile egazini kwiinyanga ezi-3 ezidlulileyo).
Ezi zifundo zaziquka abantu abadala abanesifo seswekile sohlobo lwesibini, abantwana abaneminyaka eli-10-17 ubudala, abantu abanesifo sezintso, kunye nabantu abanesifo sentliziyo. Iziphumo zeli yeza zithelekiswa nezinye iziyobisi zeswekile (umz., i-insulin, i-metformin, i-glimepiride).
Kulungile, ngoku masibone ukuba iziphumo zezi zifundo zifumene ntoni. Khumbula, ezi ziziphumo eziqhelekileyo. Iziphumo zakho zinokwahluka ngokuxhomekeke emzimbeni wakho.
| Iziphumo zabantu abadala (Abantu abadala abanesifo seswekile sohlobo lwesibini) | ||
|---|---|---|
| Umlinganiselo wamayeza | Ukuncipha kweswekile yegazi yokuzila ukutya (mg/dL) | Ukwehla kwe-HbA1c |
| I-Jardiance 10 mg (ngaphandle kwamanye amayeza) | Malunga ne-19 mg/dL | Malunga ne-0.7% |
| I-Jardiance 25 mg (ngaphandle kwamanye amayeza) | Malunga ne-25 mg/dL | Malunga ne-0.8% |
| I-Jardiance (kunye namanye amayeza) | Malunga ne-10 - 22 mg/dL | Phakathi kwe-0.2% - 2.1% |
| Iziphumo kubantu abadala abaneSifo seNtliziyo | |
|---|---|
| Unyango | Ipesenti yokufa ngenxa yokuhlaselwa sisifo sentliziyo, isifo sohlangothi, okanye isifo sentliziyo |
| I-Jardiance 10 mg okanye 25 mg | 10.5% |
| I-Placebo | 12.1% |
Iziphumo zabantwana kunye nezigulana zezintso
I-Jardiance ibonakalisiwe ukuba iyawanciphisa kakhulu amanqanaba e-HbA1c kunye namanqanaba eswekile egazini ngokuzila ukutya kubantwana abaneminyaka eli-10-17 ubudala. Ikwancede ekunciphiseni amanqanaba e-HbA1c kubantu abadala abanesifo seswekile kunye nesifo sezintso.
Ngaba amanye amayeza anokusebenzisana neJardiance?
Ewe, kubaluleke kakhulu ukunyamekela oku.
- Iswekile ephantsi egazini: Ukuba uthatha amanye amayeza esifo seswekile, ingakumbi i-insulin okanye i-sulfonylureas (efana ne-glimepiride), unokufumana iswekile ephantsi egazini (hypoglycemia) xa uqala i-Jardiance. Ke ngoko, ugqirha wakho unokunciphisa umthamo wezinye iziyobisi zakho.
- Ukuphelelwa ngamanzi emzimbeni: Ukuba usebenzisa amayeza okukhupha umchamo, ukuwasebenzisa kunye neJardiance kunokubangela ukuphelelwa ngamanzi emzimbeni. Ngoko ke, kubalulekile ukusela ulwelo oluninzi.
- I-Lithium: Ukuba uthatha i-lithium ngenxa yengxaki yengqondo, iziphumo zayo zingatshintsha xa uqala i-Jardiance. Thetha nogqirha wakho ngale nto kwaye ufumane uvavanyo lwegazi ukuba kuyimfuneko.
Ungaziphepha njani iziphumo ebezingalindelekanga eziyingozi?
Le nxalenye ibaluleke kakhulu. Nangona iJardiance iyiyeza eliluncedo kakhulu, kukho iziphumo ebezingalindelekanga ezinzulu ekufuneka siziqaphele.
1. I-Diabetic Ketoacidosis (DKA):
- Le yimeko eyingozi kancinci. Xa umzimba ungakwazi ukusebenzisa iswekile, usebenzisa enye indlela yokufumana amandla. Oku kudala iikhemikhali ezibizwa ngokuba ziiketones . Xa ezi ziqokelelana egazini, zinokuba yingozi kakhulu.
- Iimpawu: isicaphucaphu, ukuhlanza, isisu esibuhlungu, ukudinwa kakhulu, ubunzima bokuphefumla.
- > Ukuba ufumana ezi mpawu, yeka ukuthatha iJardiance ngoko nangoko uze ubonane nogqirha okanye uye kwigumbi likaxakeka esibhedlele (ETU). Le yingxamiseko.
2. Iintsholongwane:
- Eli yeza lonyusa inani leswekile kumchamo, nto leyo enyusa umngcipheko wosulelo lweentsholongwane kunye nemvubelo. Usulelo lunokwenzeka kwindlela yomchamo, isinyi, kunye neendawo zangasese.
- I-Fournier's Gangrene: Usulelo olungaqhelekanga, kodwa oluyingozi kakhulu olunokwenzeka kwindawo yangasese. Funa uncedo lwezonyango ngokukhawuleza ukuba unentlungu, ububomvu, okanye ukudumba kwindawo leyo kunye nomkhuhlane kunye nobuthathaka.
3. Iingxaki zemilenze neenyawo:
- Ezinye izifundo zibonise ukwanda okuncinci kokunqunyulwa kwamalungu omzimba, ingakumbi kubantu abanesifo semithambo yegazi engaphandle.
- Ngoko ke jonga iinyawo zakho ngononophelo yonke imihla.Ukuba unezilonda, izilonda, imifantu, okanye iimpawu zosulelo, xelela ugqirha wakho ngoko nangoko.
4. Iziphumo kwizintso:
- Ukuphelelwa ngamanzi emzimbeni kunokuchaphazela ukusebenza kwezintso. Kungoko ke, kubalulekile ukusela amanzi amaninzi. Ugqirha wakho angayalela uvavanyo lwegazi ukujonga ukusebenza kwezintso zakho.
5. Iimpendulo ze-Allergic:
- Ukuba ufumana iimpembelelo ezinkulu ze-allergy ezifana nokudumba kwemilebe, ubuso, okanye ulwimi, ubunzima bokuphefumla, okanye amaqhakuva eluswini, yeka ukuthatha iyeza ngoko nangoko kwaye ufune iingcebiso zonyango.
Indlela yokusebenzisa amayeza ngokuchanekileyo?
I-Jardiance yipilisi oyithatha kube kanye ngemini. Thatha idosi (10mg okanye 25mg) echazwe ngugqirha wakho.
- Kungcono ukuyithatha kusasa: Uninzi loogqirha bacebisa ukuba uyithathe kusasa. Isizathu kukuba inyusa amaxesha okuchama, ukuze ivele emini ngaphandle kokuphazamisa ubuthongo ebusuku.
- Uyazi njani ukuba iyeza liyasebenza?: Ungabona ngokuncipha kwenqanaba leswekile egazini lakho kunye ne-HbA1c. Kodwa kuthatha malunga neenyanga ezi-3 ukuba i-HbA1c yakho itshintshe. Ukuba wenza uvavanyo lomchamo ngelixa uthatha iJardiance, kuya kubonisa ukuba kukho iswekile kumchamo wakho. Oku kuqhelekile, ungakhathazeki ngako. Kuthetha ukuba iyeza liyasebenza.
Umyalezo Wokuya Ekhaya
- I-Jardiance liyeza lesifo seswekile sohlobo lwesibini elinciphisa iswekile egazini ngokukhupha iswekile emchameni.
- Soloko uthatha kuphela idosi echazwe ngugqirha wakho, ngexesha elimiselweyo (kungcono kusasa).
- Sela amanzi amaninzi imini yonke ukuze uthintele ukuphelelwa ngamanzi emzimbeni.
- Qaphela iimpawu zeswekile ephantsi egazini (hypoglycemia) kunye neempawu eziyingozi ze-diabetes ketoacidosis (DKA) (ukugabha, iintlungu zesisu, ubunzima bokuphefumla). Funa uncedo lwezonyango ngokukhawuleza ukuba uneempawu ze-DKA.
- Hlola iinyawo zakho yonke imihla ukuze ubone amanxeba, izilonda, okanye iimpawu zosulelo.
- Thetha nogqirha wakho malunga nazo naziphi na iziphumo ebezingalindelekanga okanye iingxaki ozifumanayo. Ungaze uyeke ukuthatha amayeza akho okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha.
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