Siyazi ukuba kunzima kangakanani ukulwa nomhlaza. Kuqhelekile ukuziva uxinezelekile xa oogqirha bethetha amagama amatsha nantsonkothileyo afana nelithi "unyango lwezakhi zofuzo." Kodwa ungakhathazeki. Namhlanje siza kuthetha ngolunye unyango olunjalo. Khawuthelekelele usebenzisa iiseli zomzimba wakho, uziqeqesha, kwaye uzithumela ukuba zitshabalalise iiseli zomhlaza. Yiloo nto olu nyango lubizwa ngokuba yiTisagenlecleucel luyenzayo. Masithethe ngayo ngokulula nangokucacileyo.
Yintoni iTisagenlecleucel (KYMRIAH)?
Ngamafutshane, le ayisiyopilisi oyithathayo okanye iyeza eliqhelekileyo olifaka emthanjeni. I-Tisagenlecleucel lunyango lwezakhi zofuzo . Ibandakanya ukuthatha uhlobo lweseli kwinkqubo yakho yokuzikhusela komzimba, uyitshintshe kwilebhu, kwaye uyiqeqeshe ukuba ibone kwaye ihlasele iiseli zomhlaza.
Ukuchaneka, imizimba yethu inohlobo lweeseli zokulwa ezibizwa ngokuba zii-T-cells. Ezi seli zezona zilwa nezifo. Kolu nyango, oogqirha bathatha ezinye zezi T-cells emzimbeni wakho. Emva koko, kwilebhu, basebenzisa ubuchwepheshe bemfuza ukubeka "iiglasi ezikhethekileyo" ezimbini kwezi T-cells. Oko kukuthi, batshintsha ezi seli ukuze bakwazi ukubona iimpawu ezithile kumphezulu weeseli zomhlaza. Emva koko, izigidi zezi T-cells "ezinamandla amakhulu" ziyakhuliswa kwaye zifakwe emzimbeni wakho ngemithambo. Ngoku ezi seli ziqeqeshweyo ziya ngqo kwiiseli zomhlaza kwaye zizitshabalalise.
Olu nyango lusetyenziswa kakhulu ukunyanga iintlobo ezahlukeneyo zomhlaza, kuquka i-acute lymphoblastic leukemia (ALL) , uhlobo lwe-leukemia, kunye ne -non-Hodgkin lymphoma .
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale unyango
Nangona olu nyango lusebenzisa iiseli zakho, kubalulekile ukuba nencoko evulekileyo neqela lakho lokhathalelo ngaphambi kokuba uqale. Bafanele baziswe ngezi zinto zilandelayo:
- Usulelo lwangoku: Sixelele ukuba ngaba okwangoku unayo nayiphi na intsholongwane, efana nomkhuhlane, ukukhwehlela, umkhuhlane, okanye usulelo lomchamo.
- Iimeko zokudumba: Xelela ugqirha wakho ngazo naziphi na iingxaki zokudumba naphi na emzimbeni.
- Ii-Allergy: Qiniseka ukuba ukhankanya naziphi na ii-allergies onazo, kungekuphela nje kweli yeza, kodwa nakweminye imithi, ukutya, okanye idayi.
- Ukukhulelwa: Ukuba ukhulelwe, uzama ukukhulelwa, okanye unesikrokro sokuba ukhulelwe, xelela ugqirha wakho ngoko nangoko. Oku kubaluleke kakhulu.
- Ukuncancisa: Ukuba uncancisa, yazisa ugqirha.
Ulunika njani olu nyango?
Olu nyango lubandakanya amanyathelo aliqela kwaye lwenziwa phantsi kweliso elibukhali leqela lezonyango esibhedlele okanye kwikliniki ekhethekileyo.
1. Ukuqokelelwa kweeseli: Malunga neeveki ezi-3-4 ngaphambi konyango, ii-T-cells ziqokelelwa emzimbeni wakho. Oku kwenziwa ngenkqubo ebizwa ngokuba yi-leukapheresis . Kufana nokunikela ngegazi. Igazi lithathwa emthanjeni, lidluliselwe kumatshini okhethekileyo, owahlula iiseli zegazi ezimhlophe, kuquka ii-T-cells, kwaye emva koko igazi eliseleyo libuyiselwa emzimbeni wakho.
2. Uqeqesho lweeseli: Ezi seli ziqokelelweyo emva koko zithunyelwa kwilebhu kwaye ziqeqeshwe ukulwa nomhlaza.
3. Ukufakwa kwe-Infusion: Nje ukuba iiseli ziqeqeshwe kwaye zikhule, zifakwa emzimbeni wakho ngemithambo yegazi, njengesisombululo se-saline. Le nkqubo yonke yenzeka esibhedlele.
Eyona nto ibalulekileyo kukuba ngenxa yokuba eli yeza lenziwe ngeeseli zakho, linyango olulungiselelwe wena . Ke ngoko, eli yeza alinakwabelwana ngalo nabanye abantu.
Izinto ekufuneka ziqwalaselwe xa usenza unyango
Imeko yakho iya kuhlolwa ngononophelo ngoogqirha bakho ngeli xesha lonyango. Kufuneka uzazi ezi zinto.
- Ukozela nokuqhuba: Usenokuziva ulele kwaye unesiyezi . Ngoko ke , musa ukwenza nantoni na efuna ukuphaphama kwengqondo, njengokuqhuba okanye ukusebenzisa oomatshini abanzima, ude wazi kakuhle ukuba eli yeza likuchaphazela njani.
- Umngcipheko wokosuleleka: Olu nyango lunokunciphisa okwethutyana amandla omzimba wakho okulwa nokugula. Ngoko zama ukuhlala kude nabantu abagulayo. Ukuba ubonakalisa iimpawu ezifana nomkhuhlane, iintlungu zomzimba, okanye umphimbo obuhlungu , tsalela umnxeba ugqirha wakho ngoko nangoko endaweni yokuzinyanga.
- Ukunikela ngegazi okanye amalungu omzimba: Kuphephe ukunikela ngegazi, amalungu omzimba, izicubu zomzimba, isidoda, okanye amaqanda (ii-oocytes) ngelixa uthatha olu nyango kwaye emva kwexesha elithile.
- Ukukhulelwa (Kubaluleke Kakhulu): Musa ukukhulelwa nangasiphi na isizathu ngelixa usebenzisa eli yeza. Kwakhona, ukuba uceba ukuba nomntwana okanye ukrokrela ukuba ukhulelwe, kufuneka uxelele ugqirha wakho ngoko nangoko. Eli yeza linokulimaza kakhulu usana olungakazalwa.
- Amanye amayeza: Xelela ugqirha wakho ngamanye amayeza owasebenzisayo (kuquka iivithamini kunye namayeza esintu). Amayeza okugonya aphilayo awafumaneki kakhulu ngeli xesha.
- Ingxamiseko:Oku kunikwa esibhedlele, ngoko ke akuyi kuthatha amayeza amaninzi. Nangona kunjalo, ukuba kukho imeko engxamisekileyo, yazisa iqela lezonyango ngoko nangoko. Ukuba kuyimfuneko, baya kukuthumela kwiCandelo loNyango oluNgxamisekileyo (ETU) . Ukuba ukrokrela ukuba kukho nayiphi na ityhefu, ungatsalela umnxeba iZiko loLwazi lweePoisons kwiSibhedlele sikaZwelonke saseColombo .
Iziphumo ebezingalindelekanga ezinokubakho zale yeza
Njengazo zonke amayeza, le inokuba nemiphumo emibi. Ezinye zezi zinto kufuneka zixelwe ngoko nangoko, ngelixa ezinye zingabi yingozi kangako. Jonga itheyibhile engasezantsi.
| Uhlu lweziphumo ebezingalindelekanga | |
|---|---|
| Izinto ekufuneka uzixelele ugqirha wakho okanye iqela lezonyango ngoko nangoko | |
| Ii-aleji | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe okanye ulwimi. |
| Ubunzima bokuphefumla | Ubunzima bokuphefumla. |
| Utshintsho lwengqondo | Ukudideka, ubunzima bokuthetha okanye ukuqonda. |
| Iimpawu zokubala iiseli zegazi eziphantsi | Iimpawu zosulelo: umkhuhlane, ukubanda, umphimbo obuhlungu. Iimpawu zokopha: ukudumba, amabala abomvu eluswini, indle emnyama, igazi emchameni. Inani eliphantsi leeseli ezibomvu zegazi: ukudinwa kakhulu, ukuquleka, ukuphaphatheka. |
| Ezinye iimpawu ezinzulu | Urhudo, ukulahlekelwa kukulinganisela, iintlungu zezihlunu okanye amalungu, isicaphucaphu, ukuhlanza, ukuxhuzula, iimpawu zoxinzelelo lwegazi oluphantsi (isiyezi, ukuquleka). |
| Ukuba iyaqhubeka okanye iyakhathaza, xelela ugqirha wakho. | |
| Iziphumo ebezingalindelekanga eziqhelekileyo | Ukuqhinwa, ukungabi namdla wokutya, intloko ebuhlungu, iintlungu zesisu, ukudumba kwemilenze neenyawo. |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana into engaqhelekanga, thetha nogqirha wakho ngayo.
Umyalezo Wokuya Ekhaya
- I-Tisagenlecleucel lunyango lwezakhi zofuzo olulungiselelwe wena olusebenzisa iiseli zakho zomzimba ukunyanga umhlaza.
- Olu lunyango olukhethekileyo olunikwa esibhedlele, olusetyenziselwa iimeko ezinzima ze-leukemia kunye ne-lymphoma.
- Kubalulekile ukuba uxelele ugqirha wakho lonke ulwazi lwakho lwezempilo (usulelo, ii-allergies, ukukhulelwa) ngaphambi kokuba uqalise unyango.
- Ngexesha lonyango, qaphela ngakumbi iimpawu zosulelo (umkhuhlane, ukukhwehlela). Ukuba ezi mpawu ziyabonakala, funa ingcebiso kagqirha ngokukhawuleza.
- Njengoko usenokuziva ulele, kuphephe ukuqhuba nokwenza imisebenzi efuna ingqalelo ude uphile ngokupheleleyo.
- Kuphephe ukukhulelwa ngokupheleleyo ngexesha lonyango. Oku kubaluleke kakhulu.
- Musa ukoyika ukuthetha neqela lakho lezonyango malunga nazo naziphi na iingxaki okanye amathandabuzo onokuba nawo. Bakho ukuze bakuncede.
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