Ziyini lezi prostaglandin? Kungani zibaluleke kangaka emizimbeni yethu?

Namuhla sizokhuluma ngento encane yamakhemikhali ekhiqizwa ngaphakathi emzimbeni wethu futhi esebenza ngendlela exakile. Lokhu kubizwa ngokuthi ama-prostaglandins . Kungenzeka ukuthi awukaze uzwe leli gama ngaphambili. Kodwa, uyazi ukuthi lezi zinto ezincane zithinta kangakanani impilo yomzimba wethu kanye nezinqubo zansuku zonke! Ngakho-ke, namuhla sizokhuluma ngala ma-prostaglandins ngendlela elula neqondakala kalula.

Ayini ngempela ama-prostaglandin?

Kalula nje, ama-prostaglandin ayiqembu lama-lipid akhiqizwa emizimbeni yethu lapho kunomonakalo wezicubu noma ukutheleleka, futhi asebenza njengama-hormone. Kunezinhlobo eziningi ezahlukene zawo, futhi asiza ukulawula izinqubo eziningi ezibalulekile emizimbeni yethu.

Cabanga ngabo njengezithunywa ezincane ngaphakathi emizimbeni yethu. Uma kunenkinga endaweni ethile, lezi zithunywa zakhiwa khona lapho futhi zithumele izimpawu kwamanye amaseli ukuthi enze okudingekayo.

Ingabe lokhu kuyi-hormone efanayo?

Ungase ucabange, "Ngakho-ke lolu uhlobo lwe-hormone?" Empeleni, ama-prostaglandin uhlobo lwe-lipid olunezakhiwo ezifana nama-hormone. Ama-lipids angama-fatty acid noma ama-derivatives awo. Imizimba yethu yenza la ma-prostaglandin nge-fatty acid ebizwa ngokuthi i-arachidonic acid.

Lawa abizwa ngokuthi ama-hormone ngoba ahlanganisa imisebenzi eyahlukahlukene emzimbeni wethu futhi atshela umzimba ukuthi wenzeni nokuthi ukwenze nini.

Kodwa, lawa ahlukile kuma-hormone angempela. Wazi kanjani? Ama-Prostaglandin awasebenzi njengama-hormone akhiqizwa yizindlala ohlelweni lwethu lwe-endocrine futhi akhishwe egazini. Kunalokho, akhiqizwa yizicubu zethu endaweni yomonakalo noma ukutheleleka, lapho kwenzeka khona isenzo. Yilokho okuwenza abe akhethekile.

Iyiphi insizakalo enikezwa yi-prostaglandins emizimbeni yethu?

Eqinisweni, kunezinhlobo eziningana zama-prostaglandin, futhi kukhona nama-receptor ahlukene asabela kuwo. Lokhu kusho ukuthi imiphumela yawo ingabonakala cishe kuzo zonke izingxenye zomzimba wethu. Umphumela we-prostaglandin uncike ezintweni eziningana:

• Isitho noma izicubu esixhumene nazo.
• I-receptor ebopha kuyo.
• Inqubo noma isimo somzimba esenzeka emzimbeni.

Ake sibheke eminye yemisebenzi eyinhloko yala ma-prostaglandin:

• Kuyasiza ukuqala ukwakheka kwamahlule egazini endaweni yokulimala, noma kungakuvimba.
• Imithambo yegazi iyanda (i-vasodilation) noma inciphe (i-vasoconstriction), okuthinta ukugeleza kwegazi .
• Kusiza inqubo yokuphulukiswa .
• Ukuvuvukala (Yilokhu okubangela ukuvuvukala nokubomvu uma unenxeba .
• Kuyasiza ukuqala ukubeletha ngesikhathi sokukhulelwa (ukuqaliswa kokubeletha) .
• Ngesikhathi sokuya esikhathini, kubangela ukuthi isibeletho sinciphe futhi kusize ekukhipheni ulwelwesi lwesibeletho (i-endometrium).
• Okuhlobene nokuvuthwa kwamaqanda .
• Kungabangela umkhuhlane .
• Ukulawula indlela ozizwa ngayo ubuhlungu .
• Kusiza ukunciphisa ukucindezeleka ngaphakathi kweso.
• Kunciphisa ukukhiqizwa kwe-asidi esiswini.
• Imisipha ebushelelezi emgudwini wethu wokugaya ukudla iyafinyela noma iphumule.
• Ilawula umsebenzi wezinye ama-hormone amaningana.

Into ebaluleke kakhulu ukuthi ama-prostaglandin aphila isikhathi esifushane kakhulu. Lokho kusho ukuthi asebenza isikhathi esifushane kakhulu. Ngakho-ke, angathinta kuphela amaseli aseduze. Angenziwa yizicubu ezahlukahlukene emzimbeni wethu.

Ake sithathe isibonelo empilweni yansuku zonke?

Ake sithi usika umunwe wakho. Ngisho nesilonda esincane singenza umsebenzi omningi. Nansi indlela ama-prostaglandin asiza ngayo:

1. Kumisa ukopha: Okokuqala, ama-prostaglandin akhishwa ezicutshini zesilonda. Lawa atshela ama-platelet egazini ukuthi "ahlangane ngokushesha futhi avale inxeba, amise ukopha." Bese kwakheka ihlule legazi lapho.

2. Ilawula imithambo yegazi: Okulandelayo, olunye uhlobo lwe-prostaglandin luvela ezicutshini ezisendaweni yokulimala futhi lubangela ukuthi imithambo yegazi inciphe kancane. Lokhu kubizwa ngokuthi i-vasoconstriction . Lokhu kunciphisa ukopha kakhulu.

3. Ukuvuvukala (ukuvuvukala): Ngemuva kwalokho, ama-prostaglandin ayakhishwa, abangela ukuvuvukala. Lawa abangela ukuvuza koketshezi oluvela emithanjeni yegazi luye ezicutshini, okwenza inxeba livuvuke, libe bomvu, futhi lizizwe lishisa. Ungakhathazeki, lokhu kuvuvukala kuhle. Lokhu kungenxa yokuthi kuvimbela izinto ezifana namagciwane ayengangena enxebeni ukuthi ziye kwezinye izingxenye zomzimba. Lawa ma-prostaglandin avuvukalayo nawo enza okunye. Okusho ukuthi, aletha amangqamuzana amhlophe egazi abizwa ngokuthi ama-phagocytes enxebeni. Lawa maseli yiwo 'adla' amagciwane namaseli afile futhi ahlanze inxeba.

4. Ihlule legazi liyasuswa uma selipholile: Ekugcineni, lapho inxeba selipholile ngokuphelele, ama-prostaglandin ayabuya ancibilikise ihlule legazi bese elisusa. Ngoba akusadingeki ukuthi libe lapho.

Uke wabona ukuthi ama-prostaglandin asebenza kangakanani ngisho nasenxebeni elincane?

Ngakho-ke, ingabe ama-prostaglandin amahle noma amabi?

Lona umbuzo obaluleke kakhulu. Ngaphansi kwezimo ezivamile, ama-prostaglandinKubalulekile futhi kungokwemvelo emizimbeni yethu. Badlala indima enkulu ekulawuleni izinqubo zemvelo zomzimba njengobuhlungu nokuvuvukala. Inqubo evamile yokuvuvukala empeleni iyindlela imizimba yethu eyisebenzisayo ukuzivikela ekulimaleni okuqhubekayo.

Kodwa-ke, ngezinye izikhathi inani lama-prostaglandin emzimbeni wethu linganda ngokungadingekile. Yilapho-ke izinkinga ziqala khona. Uma lokho kwenzeka, ukuvuvukala okuqhubekayo kanye nobuhlungu obungabekezeleleki kungavela. Ezimweni ezinjalo, ama-prostaglandin amaningi angaholela ezifweni ezingamahlalakhona kanye nezimpawu ezingakhululekile.

Isibonelo, nakuba ama-prostaglandin ebalulekile esikhathini, uma ekhula kakhulu, ukuphuma kwegazi okubuhlungu nokukhulu esikhathini (i-menorrhagia) kungenzeka.

Indima yama-prostaglandin ngesikhathi sokukhulelwa

Ngesikhathi sokukhulelwa nokubeletha, amaseli esibelethweni akhiqiza ama-prostaglandin. Lawa asiza ukwandisa umlomo wesibeletho futhi abangele ukufinyela kwesibeletho. Lawa mafinyela asiza ekusunduzeni umntwana phansi emgudwini wokubeletha.

Futhi, odokotela ngezinye izikhathi basebenzisa ama-prostaglandin okwenziwa ukuze babangele ukubeletha uma bencoma ukuthi ukubeletha kuqale ngaphambi kokuba kuqale ngokwemvelo.

Ama-prostaglandin asetshenziswa kanjani kwezokwelapha?

Odokotela basebenzisa izinhlobo eziningana zama-prostaglandin okwenziwa ukwelapha izimo nezimo ezahlukahlukene. Ake sibheke izibonelo ezimbalwa.

• I-Travoprost: Isetshenziselwa ukwelapha i-glaucoma kanye nomfutho wegazi ophakeme emehlweni.
• I-Dinoprostone: Isiza ukwandisa umlomo wesibeletho komama abasondela ekupheleni kokukhulelwa kwabo futhi baqale ukubeletha.
• I-Alprostadil: Lokhu kungokwesigaba semithi ebizwa ngokuthi ama-vasodilator. Yandisa ukugeleza kwegazi. Isiza ekwelapheni ezinye izimo zenhliziyo ezinganeni (isib. isifo senhliziyo esibangelwa yi-cyanotic) kanye nokungasebenzi kahle kwe-erectile (ED) kwabesilisa.
• I-Misoprostol: Kwezinye izimo, lo muthi unikezwa nge-rectally ukuze kumiswe ukopha ngokweqile ngemva kokubeletha (ukuphuma kwegazi ngemva kokubeletha).
• I-Iloprost: Isetshenziselwa ukwelapha umfutho wegazi ophezulu emaphashini kanye nesimo esibizwa ngokuthi i-CREST syndrome.

Ngenxa yokuthi i-prostaglandin eningi kakhulu ingabangela ubuhlungu nokuvuvukala okungadingekile, odokotela basebenzisa nemithi enciphisa imiphumela ye-prostaglandin, noma eyivimbela. Imithi evame ukusetshenziswa kakhulu evimba i-prostaglandin yile:Izidakamizwa Ezingavimbeli Ukuvuvukala (ama-NSAID). Lezi zivame ukubizwa ngokuthi ama-painkiller. Izibonelo zifaka phakathi i-aspirin (isib. i-Excedrin®), i-ibuprofen (isib. i-Advil®, i-Motrin®), kanye ne-naproxen sodium (isib. i-Aleve®).

Yiziphi izinkinga ezingabangelwa ama-prostaglandin?

Ngezinye izikhathi imizimba yethu ikhiqiza ama-prostaglandin amaningi kakhulu, noma anganele. Lokhu kungaholela ezinkingeni ezithile zempilo kanye nezimpawu.

Ama-prostaglandin amaningi

Uma inani lama-prostaglandin emzimbeni wethu landa ngokungadingekile, lingabangela ukuvuvukala okungadingekile nokungasizi emzimbeni. Nazi ezinye zezimo zempilo ezingaba khona:

• Ubuhlungu obungapheli.
• Ukuzwela okukhulu ebuhlungwini.
• Ubuhlungu bokuya esikhathini noma ubuhlungu bokuya esikhathini (i-dysmenorrhea).
• Ukopha okukhulu kokuya esikhathini.
• Ezinye izinhlobo zomdlavuza.

Ukuntuleka kwama-prostaglandin

Ngezinye izikhathi, umzimba ungase ungakhiqizi ama-prostaglandin anele ukwelapha isilonda noma ukuqala ukubeletha ngemva kokukhulelwa okuphelele. Ngisho noma lezi zimo zingahlobene nezimo ezingamahlalakhona, ama-prostaglandin okwenziwa angasiza. Odokotela basebenzisa ama-prostaglandin okwenziwa ukwelapha izilonda zesisu kanye ne-glaucoma. Angasiza futhi ekuqaleni kokubeletha.

Kufanele ubonane nini nodokotela mayelana nezinkinga ezihlobene nama-prostaglandin?

Uma unobuhlungu obungapheli kanye/noma ukuvuvukala okungapheli , qiniseka ukuthi ubona udokotela. Nakuba kungaba nezimbangela eziningi zalezi zimo, imbangela eyodwa engaba khona ukusebenza kwama-prostaglandin emzimbeni wakho.

I-Dysmenorrhea yisimo esivamile esihlotshaniswa nama-prostaglandin futhi yisimo sezokwelapha esidinga ukunakekelwa kwezokwelapha. Uma unezikhathi zokuya esikhathini ezibuhlungu ezinganciphisi ngokuthatha imithi yobuhlungu (ama-NSAID), khuluma nodokotela wakho. Ngezinye izikhathi, izikhathi zokuya esikhathini ezibuhlungu zingabangelwa yisimo sezokwelapha esicashile, njenge -endometriosis noma i-uterine fibroids .

Ama-prostaglandin atholakala ngokwemvelo, izinto ezinamandla ezithinta izici eziningi zemizimba yethu. Nakuba zibalulekile ezinqubweni zomzimba ezifana nokuphulukiswa, i-prostaglandin eningi kakhulu ingabangela ubuhlungu obungapheli, ukuvuvukala, kanye nekhwalithi yokuphila ephansi. Uma unobuhlungu obuqhubekayo noma ukuvuvukala, bheka udokotela ukuze uthole imbangela bese uthola uhlelo lokwelashwa olufanele.

Umlayezo Wokuya Nawe Ekhaya

Kulungile, ngakho-ke sesikhulume kakhulu ngama-prostaglandin namuhla, akunjalo? Into ebaluleke kakhulu okufanele uyikhumbule ukuthi lawa afana nezithunywa ezincane zamakhemikhali ezikhiqizwa emizimbeni yethu futhi ezenza umsebenzi obaluleke kakhulu.

• Lokhu kusiza ngezinto eziningi, njengokwelapha amanxeba, ukuvimba ukopha, ukulawula ukuvuvukala, ukusiza ekubelethweni, kanye nokulawula ukuya esikhathini.
• Futhi, uma lokhu kwanda kakhulu, izinkinga ezifana nobuhlungu nokuvuvukala okuqhubekayo zingavela.
• Uma unezinhlungu ezingapheli, ukuvuvukala, noma ubuhlungu obukhulu bokuya esikhathini, kubalulekile ukufuna iseluleko sezokwelapha ngaphandle kokuzishaya indiva, njengoba zingase zibangelwe ukungalingani kwala ma-prostaglandin.

Ngakho-ke, ukuqaphela lezi zinto ezimangalisayo ezenzeka emizimbeni yethu kuzosiza kakhulu ekugcineni impilo yethu.

Ama - prostaglandin, ama-hormone, ubuhlungu, ukuvuvukala, ukuvuvukala, ukuya esikhathini, ukukhulelwa