Umuthi omusha wokucindezeleka: Okudingeka ukwazi nge-Auvelity

Ukucindezeleka yisimo esenza impilo ibe mnyama kakhulu futhi ibe nzima. Uma ulwa nalokhu, kungenzeka ukuthi awutholi impumuzo enkulu njengoba ucabanga ngemithi oyisebenzisayo njengamanje. Ngakho-ke, manje, izinhlobo ezintsha zemithi sezivele zelapha ukucindezeleka. Namuhla sikhuluma ngomuthi obizwa ngokuthi 'i-Auvelity' olethe ithemba elisha kangaka. Lo muthi owavunyelwa e-United States ngo-2022 futhi usetshenziselwa i-Major Depression Disorder.

Kuyini i-Auvelity? Isebenza kanjani?

Kalula nje, i-'Auvelity' iyinhlanganisela yemithi emibili. Lokho kusho ukuthi kunezinhlobo ezimbili zemithi ephilisini elilodwa. Ziyi-'dextromethorphan' kanye ne-'bupropion'. Cabanga ngakho njengokusebenza njengeqembu. Abantu ababili abasebenza ndawonye benza imithi engaphezu kweyodwa bebodwa.

• I-Bupropion : Lesi kakade siwumuthi osetshenziswa ukwelapha ukucindezeleka . Sisebenza ngokwandisa amazinga amakhemikhali ebuchosheni bethu abizwa ngokuthi i-'dopamine' kanye ne-'norepinephrine', athinta isimo sethu sengqondo.
• I-Dextromethorphan : Ungase ujwayelene nalokhu. Amanye ama-syrup okukhwehlela aqukethe lo muthi. Kodwa-ke, lo muthi utholakale uthinta namakhemikhali asebuchosheni ahlobene nesimo sengqondo.

Ngakho-ke, uma le mithi emibili ihlanganiswa , inikeza usizo olukhulu ekunciphiseni izimpawu zokucindezeleka kune-bupropion yodwa.

Impumelelo yalo muthi yahlolwa kanjani?

Ngaphambi kokunikeza abantu noma yimuphi umuthi, bahlola ukuthi uphephile futhi usebenza kahle kangakanani. Kwenziwe izifundo ezimbili ezifanayo zezokwelapha ku-'Auvelity'. Kulokhu, kwasetshenziswa indlela ekhethekile ukukala ubukhulu bokucindezeleka. Ibizwa ngokuthi 'i-Montgomery-Asberg Depression Rating Scale (MADRS).' Kufana nohlu lwemibuzo. Ubuzwa imibuzo eyi-10 mayelana nezinto ezifana nokudabuka, izinkinga zokulala, kanye nemizwa yecala bese unikezwa amaphuzu. Unganikeza amaphuzu kusukela ku-0 kuya ku-60. Uma amaphuzu ephezulu, kulapho ucindezeleka khona kakhulu. Ukwehla kwamaphuzu ngemva kokuthatha umuthi kusho ukuthi lesi sifo siya ngokuba ngcono. Lezi zifundo zazihlanganisa abantu abaneminyaka engu-18-65 abanokucindezeleka okukhulu. Kodwa-ke, abantu abanezinye izifo zengqondo (njenge-'bipolar disorder', 'psychotic disorder'), abantu abasengozini enkulu yokuzibulala, kanye nabantu abanesifo sokuwa abafakwanga.

Iyini imiphumela yalezi zifundo?

Imiphumela iyakhuthaza ngempela. Umuthi i-'Auvelity' wawusebenza kahle kakhulu ekunciphiseni izimpawu zokucindezeleka kune-placebo kanye ne-'bupropion' kuphela. Lokhu kusho ukuthi amaphuzu e-'MADRS' ayephansi kulabo abathatha i-'Auvelity' kunalabo abathatha eminye imithi.

Ingabe i-Auvelity ingasebenzisana neminye imithi? (Ukusebenzisana kwezidakamizwa)

Lena yingxenye ebaluleke kakhulu . Yebo, i-Auvelity ingasebenzisana neminye imithi oyithathayo. Ngakho-ke, kufanele utshele udokotela wakho ngayo yonke imithi oyithathayo, okuhlanganisa imithi ethengiswa ngaphandle kwemithi kadokotela, amavithamini, ngisho nemithi ye-Ayurvedic.

Isimo esiyingozi esibizwa ngokuthi i-Serotonin Syndrome

Uma i-Auvelity ithathwa kanye neminye imithi yokucindezeleka ekhulisa amazinga e-serotonin, ingabangela ukwanda okungafunwa kwe-serotonin yamakhemikhali obuchopho. Lokhu kubizwa ngokuthi i-Serotonin Syndrome. Lesi yisimo esiphuthumayo esisongela ukuphila. Uma uhlangabezana nalezi zimpawu, hamba ngokushesha esibhedlela esiseduze noMnyango Wezimo Eziphuthumayo (ETU). Kufanele kube negebe lezinsuku ezingu-14 phakathi kokuthatha imithi yokucindezeleka ye-MAOI nokuthatha i-Auvelity.

Eminye imiphumela

• Ngemithi ekhulisa i-dopamine: 'i-Auvelity' ikhulisa i-dopamine ebuchosheni. Ngakho-ke uma ithathwa neminye imithi ekhulisa i-dopamine (njengeminye imithi yesifo sikaParkinson), amazinga e-dopamine angakhuphuka kakhulu, okubangela ukungaphumuli, ukuthuthumela,Ukuhamba kungaba nzima.
• Ngotshwala: Ukuphuza utshwala kufanele kugwenywe noma kuncishiswe kakhulu lapho uphuza i-'Auvelity'. Ukuthatha kokubili ndawonye kwandisa ingozi yokuxhuzula .
• Imithi yenhliziyo: Ukusebenza kahle kwemithi yenhliziyo efana ne-digoxin kungashintshwa yi-Auvelity. Kubalulekile ukwazisa udokotela wakho ngalokhu.
• Eminye imithi ephulwa yisibindi: Isibindi sethu sifana nefektri ephula imithi. Ukuqina komzimba kuthinta uhlelo lwe-enzyme olubizwa ngokuthi i-`cytochrome P450 (CYP450)` kulesi simiso. Lokhu kungashintsha indlela eminye imithi oyithathayo esebenza ngayo.

Usetshenziswa kanjani lo muthi futhi yimiphi imiphumela emibi?

I-'Auvelity' umuthi onikezwa ngodokotela kuphela. Umthamo ojwayelekile yithebhulethi elilodwa ngosuku ezinsukwini ezintathu zokuqala, bese kuba yithebhulethi elilodwa kabili ngosuku (ukushiyana ngamahora ayi-8).

Imiphumela emibi engaba khona nezinto okufanele uziqaphele

• Umfutho wegazi ophakeme: Udokotela wakho angakutshela ukuthi uhlole umfutho wegazi lakho njalo.
• Isiyezi: Lo muthi ungabangela isiyezi. Ngakho-ke, qaphela lapho ushayela, usebenzisa imishini, futhi wenza imisebenzi engase ihilele ukuwa.
• Imiphumela emehlweni: Tshela udokotela wakho uma uzwa ubuhlungu bamehlo, ukubomvu, noma izinguquko embonweni.
• Izinguquko zokuziphatha: Abanye abantu bangase babe nokudideka kwengqondo, ukubona noma ukuzwa izinto ezingekho (ukungaboni kahle), kanye nobunzima bokubona iqiniso.
• Ukuquleka: Le ngozi iyanda uma iphuzwa notshwala. Uma uhlangabezana nokuquleka ngenkathi uthatha umuthi, yeka ukuthatha umuthi ngokushesha bese utshela udokotela wakho.
• Omama abakhulelwe nabancelisayo: Lo muthi awuphephile ngesikhathi sokukhulelwa noma sokuncelisa. Uma uhlela ukukhulelwa, ukhulelwe, noma uncelisa, yazisa udokotela wakho ngokushesha.

Ukwazi okukhethekile ngemicabango yokuzibulala

Njengeminye imithi yokucindezeleka, i-Auvelity ingandisa kancane ingozi yemicabango noma izenzo zokuzibulala kwabanye abantu, ikakhulukazi ekuqaleni kokwelashwa.Lokhu kuvame kakhulu entsheni. Uma wena noma othile emndenini wakho enale micabango, ungabi wedwa.

• Shayela u-1926 (uNombolo Kazwelonke Wosizo Lwezempilo Yengqondo) ngokushesha.
• Uma kungenjalo, iya e-Emergency Treatment Unit (ETU) yesibhedlela esiseduze.
• Yazisa udokotela wakho ngalokhu ngokushesha.

Lokhu akuyona into yokufihla. Kubaluleke kakhulu ukuthola usizo ngokushesha. Ukuqina, ukucindezeleka, impilo yengqondo, ukucindezeleka, i-dextromethorphan, i-bupropion, i-serotonin syndrome, imithi yokucindezeleka, imiphumela emibi