Kunzima ukusho ngamazwi ukwesaba, ukukhathazeka, kanye nokungaqiniseki okuhambisana nokuxilongwa ukuthi unomdlavuza webele. Kodwa into ebaluleke kakhulu okudingeka uyazi ukuthi ukwelashwa komdlavuza sekuthuthuke kakhulu namuhla. Namuhla, sizokhuluma ngenye yokwelapha okusha, okuthuthukile. Ibizwa ngokuthi iDatroway. Ake sibone ukuthi iDatroway iyini nokuthi ingakusiza yini.
Uhlobo luni lomuthi iDatroway? Isebenza kanjani?
Kalula nje, i-Datroway iyindlela yokwelapha eqondiwe eyathuthukiswa kusetshenziswa ubuchwepheshe obusezingeni eliphezulu. Kwezokwelapha, lokhu sikubiza ngokuthi i -Antibody Drug Conjugate (ADC) . Cabanga ngakho njengesevisi ekhethekile yokuthumela. Le molekyuli yemithi yakhiwe izingxenye ezintathu eziyinhloko.
1. I-Antibody: Lena "i-address finder" ye-courier yethu. Ithola iphrotheni ethile (iphrotheni ebizwa ngokuthi i-Trop-2) ebusweni bamangqamuzana omdlavuza bese inamathela kuyo. Umsebenzi wayo ukubulala nokubamba amangqamuzana omdlavuza ngokukhetha kuphela, ngaphandle kokulimaza amangqamuzana anempilo.
2. Umuthi wokulwa nomdlavuza ( i-chemotherapy ): Lona "iphakethe" elise-courier. Lona umuthi obhubhisa amangqamuzana omdlavuza.
3. Isixhumanisi: Le ngxenye ixhumanisa i-antibody kanye nomuthi wokulwa nomdlavuza. Lokhu kokubili kuhlanganiswa ndawonye ngenkathi kuhamba egazini, bese kuhlukaniswa ngemva kokungena engqamuzaneni lomdlavuza.
Ngakho-ke, lapho umuthi we-Datroway ungena emzimbeni, i-antibody ekuwo ithola ngqo amangqamuzana omdlavuza bese izinamathisela. Ngemuva kwalokho, leyo linker iyaphuka, ikhiphe umuthi wokulwa nomdlavuza ngqo engqamuzaneni lomdlavuza. Ngale ndlela, ingqamuzana lomdlavuza liyabhujiswa ngaphakathi. Inzuzo enkulu yale ndlela ukuthi umonakalo kumaseli anempilo uncishiswa kakhulu.
Ukwelashwa kweDatroway kunikezwa kanjani?
I-Datroway iwukwelashwa okunikezwa esibhedlela, emtholampilo, noma esikhungweni sokwelashwa ngaphansi kokuqondisa kukadokotela wakho. Inikezwa njengesixazululo sikasawoti ngemithambo yegazi (i-intravenous - IV infusion ) .
- Isilinganiso: Isilinganiso somuthi owunikezwayo sinqunywa isisindo somzimba wakho.
- Isimiso: Lokhu kwelashwa kuvame ukunikezwa njalo emavikini amathathu . Udokotela wakho uzonquma ukuthi udinga izikhathi ezingaki.
- Ukulungiselela Ngaphambi Kokuthi Uphuze Usawoti: Ngaphambi kokuthi uphuze usawoti, uzonikezwa eminye imithi yokuvimbela isicanucanu, ukuhlanza, nanoma yikuphi ukusabela kokungezwani komzimba okungase kwenzeke ngenxa yosawoti.
- Isikhathi sokwelashwa:Isikhathi sokuqala sokwelashwa sithatha cishe imizuzu engama-90. Uma ungaboni imiphumela emibi ebalulekile okokuqala, ukwelashwa okulandelayo kunganikezwa ngemizuzu engama-30 kuphela.
- Ukuqaphela: Ngemva kokwelashwa kokuqala okubili, uzobhekwa ngabasebenzi bezokwelapha okungenani ihora elilodwa. Uma kungekho zinkinga, uzobhekwa cishe imizuzu engama-30 ezifundweni ezilandelayo bese uvunyelwa ukuya ekhaya.
Ngingazi kanjani ukuthi lokhu kwelashwa kulungile kimi?
I-Datroway akuyona indlela yokwelapha zonke izinhlobo zomdlavuza webele . Udokotela wakho uzoncoma lokhu kwelashwa kuphela uma umdlavuza wakho uhlangabezana nalezi zidingo ezilandelayo:
- Umdlavuza kumele ube ne-hormone receptor-positive kanye ne-HER2-negative .
- Uma umdlavuza ungeke ususwe ngokuphelele ngokuhlinzwa (`ongasuswa`) noma ususakazekele kwezinye izingxenye zomzimba (`ongasasebenzi`).
Into ebaluleke kakhulu ukuthi ukuze ufanelekele lokhu kwelashwa, kumele ukuthi uke wathola ukwelashwa okusekelwe ku-endocrine kanye nokunye ukwelashwa ngamakhemikhali.
Ngakho-ke, isinqumo esingcono kakhulu mayelana nokuthi lokhu kwelashwa kulungile yini kuwe senziwa udokotela wakho womdlavuza . Uzobuyekeza wonke amarekhodi akho ezokwelapha bese enza lesi sinqumo.
Imiphumela emibi nokuthi ungayilawula kanjani?
Njenganoma yikuphi ukwelashwa komdlavuza, i-Datroway ingabangela eminye imiphumela emibi. Kodwa izindaba ezinhle ukuthi kunezindlela zokuphatha iningi lale miphumela emibi. Ake sibheke imiphumela emibi eyinhloko engaba khona nokuthi yini ongayenza ngayo.
| Umphumela ongemuhle | Indlela yokuphatha |
|---|---|
| Izinkinga zamehlo (Amehlo omile, ukubomvu, ubuhlungu, ukubona okufiphele) | Sebenzisa amaconsi amehlo agcobayo anconywe udokotela wakho okungenani izikhathi ezine ngosuku. Gwema ukugqoka ama-contact lens ngesikhathi sokwelashwa. Tshela udokotela wakho ngokushesha uma ubona noma yiziphi izinguquko noma ukungakhululeki emehlweni akho. Cishe uzothunyelwa kudokotela wamehlo. |
| Izilonda zomlomo | Gcina i-ice cube noma amanzi eqhwa amancane emlonyeni wakho ngenkathi unikeza isisombululo se-saline. Sebenzisa i-mouthwash ekhethekile enqunywe udokotela wakho njengoba kuyalelwe. Uma kukhona izilonda emlonyeni ezikhula noma eziba zimbi, yazisa udokotela wakho ngokushesha. |
| Isicanucanu nokuhlanza | Thatha umuthi wokulwa nesicanucanu onikezwe udokotela wakho ngesikhathi esifanele, ngaphambi nangemva kokwelashwa. |
Lena yimiphumela emibi evame kakhulu. Uma uhlangabezana nanoma yikuphi ukungakhululeki ngaphezu kwalokhu, ungesabi ukukhuluma nodokotela wakho ngakho.
Yiziphi izinto okufanele uzinake kakhulu?
Uma uthatha ukwelashwa kwe-Datroway, kunezinto ezimbalwa okufanele uzinake ngokukhethekile.
Izinkinga ezihlobene namaphaphu
Akuvamile kakhulu, abanye abantu bangase babe nokuvuvukala kwamaphaphu (`Interstitial Lung Disease` noma `Pneumonitis`) ngenxa yalolu hlobo lokwelashwa. Ngakho-ke, uma uba nezimpawu ezifana nokukhwehlela, ubunzima bokuphefumula, ukuphefumula kanzima, umkhuhlane, noma ukuqina kwesifuba , ungakushayi indiva futhi wazise udokotela wakho ngokushesha . Uma kudingeka, udokotela uzoqala ukwelashwa ngakho.
Ukukhulelwa kanye nokulawula ukubeletha
Lolu udaba olubaluleke kakhulu.
- Ukwelashwa kwe-Datroway kungaba yingozi enganeni engakazalwa. Ngakho-ke, uzohlolwa ukuze kubonakale ukuthi ukhulelwe yini ngaphambi kokuqala ukwelashwa.
- Uma ungowesifazane onethuba lokuzala, kufanele usebenzise uhlobo lokuvimbela inzalo olusebenza kahle kakhulu ngesikhathi sokwelashwa kanye nezinyanga eziyi-7 ngemuva komthamo wokugcina .
- Uma uyindoda futhi umlingani wakho ekwazi ukukhulelwa, kufanele usebenzise izindlela zokuvimbela inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nezinyanga ezine ngemuva komthamo wokugcina .
Uma unemibuzo ngalokhu, ungangabazi ukukhuluma nodokotela wakho.
Umlayezo Wokuya Nawe Ekhaya
- I-Datroway iyindlela yokwelapha eqondiwe futhi ethuthukisiwe yezinhlobo ezithile zomdlavuza webele. Ifana "nesibhamu esiqondiswayo" esifuna futhi sibhubhise amangqamuzana omdlavuza.
- Lokhu kwelashwa akufanele wonke umuntu. Udokotela wakho wezifo zomdlavuza uzonquma ukuthi kulungile yini kuwe.
- Ukwelashwa kunikezwa njengesixazululo sikasawoti ngomthambo, kanye njalo emavikini amathathu.
- Imiphumela emibi efana nezinkinga zamehlo, izilonda emlonyeni, kanye nesicanucanu ingase ivele. Kodwa lokhu kungalawulwa. Tshela udokotela wakho ngokushesha nganoma yikuphi ukungakhululeki.
- Uma ubona izimpawu ezifana nobunzima bokuphefumula, ungazinaki. Funa iseluleko sezokwelapha ngokushesha.
- Kubalulekile ukugwema ukukhulelwa ngesikhathi sokwelashwa kanye nesikhathi esithile ngemva kwalokho.
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