Uma wena noma othile omaziyo ethola
ukwelashwa komdlavuza , okungukuthi,
i-chemotherapy , njengoba sonke sazi, odokotela bavame ukuthi, "Kudingeka uqaphele, ngoba amangqamuzana alwa nezifo angase anciphe." Isizathu salokhu ukuthi lapho amangqamuzana omdlavuza ebhujiswa, amangqamuzana anempilo abalulekile emizimbeni yethu nawo angabhujiswa ngezinga elithile. Ngakho-ke, kukhona uhlobo olukhethekile lomuthi olusiza ukuzivikela komzimba ngalesi sikhathi. Yilokho esikhuluma ngakho namuhla.
Kalula nje, iyini i-G-CSF?
I-G-CSF umuthi osiza imizimba yethu ukuthi yenze
ama-neutrophil engeziwe, uhlobo lweseli elimhlophe legazi elisiza imizimba yethu ukuthi ilwe nezifo. Lawa ma-neutrophil afana namasosha okuzivikela ayinhloko emizimbeni yethu. Lapho izinto ezifana
namagciwane , amagciwane, namabhaktheriya zingena emzimbeni, lawa maseli ayalwa nawo futhi asisindise ekuguleni. Uma sibheka incazelo yegama elithi G-CSF, singakuqonda kangcono lokhu:
- I-Granulocyte: Leli igama elinikezwa uhlobo lweseli elimhlophe legazi . Ama-neutrophil nawo awuhlobo lwe-granulocyte. I-G-CSF ikhuthaza kakhulu ukukhiqizwa kwala ma-neutrophil.
- Isici Esikhuthaza Ikholoni: Lokhu kufana nephrotheni etshela amangqamuzana ukuthi "akwenzeni." I-G-CSF ingatshela iseli le-stem elisemongweni wethu wethambo ukuthi, "Uzoba yi-neutrophil manje." Ingatshela futhi i-neutrophil ekhona ukuthi "ihlukane futhi yande."
Kalula nje, i-G-CSF iyisidakamizwa esiya emnkantsheni wethu bese sithumela umlayezo othi, "Isimo esiphuthumayo! Sidinga amasosha okuzivikela engeziwe (ama-neutrophil), zenze ngokushesha bese uzidedela egazini."
Yiziphi izimo ezisetshenziswa yi-G-CSF?
I-G-CSF isetshenziswa kakhulu ukwelapha nokuvimbela
i-neutropenia . I-Neutropenia yilapho inani lama-neutrophil egazini liphansi kunokujwayelekile. Uma lokhu kwenzeka, ikhono lomzimba lokulwa nokutheleleka liyancipha kakhulu. Kunezizathu eziningana eziyinhloko zokuthi kungani udokotela wakho engase akunike lo muthi.
Ngesikhathi sokwelashwa komdlavuza (i-Chemotherapy)
Uma imithi ye-chemotherapy ibulala amangqamuzana omdlavuza, ingabulala nama-neutrophil anempilo. Yingakho i-neutropenia ivame kakhulu ngemva kwe-chemotherapy. Ngezinye izikhathi lokhu kungaba yingozi empilweni. I-G-CSF inciphisa le ngozi ngokuvuselela umongo wamathambo ukuthi ukhiqize ama-neutrophil amasha ngokushesha.
Ngesikhathi sokufakelwa i-stem cell
Abantu abanomdlavuza noma izifo ezithile zegazi bangadinga ukufakelwa amaseli okuqala. I-G-CSF iyasiza kule nqubo ngaphambi nangemva kwayo.
- Ngaphambi kokufakelwa: Uma kunikezwa i-G-CSF, inani elikhulu lamaseli okuqala avela emnkantsheni wethambo likhishwa liye egazini. Odokotela babe sebeqoqa lawo maseli okuqala anempilo.
- Ngemva kokufakelwa: Ngemva kokuba amangqamuzana angavamile emzimbeni wesiguli ebhujisiwe, amangqamuzana okuqala aphilile aqoqwe ngaphambilini ayabuyiselwa emzimbeni. I-G-CSF isiza lawo maseli ukuba akhule kahle futhi abe amangqamuzana egazi ajwayelekile.
Ezinye izimo ze-neutropenia
Abanye abantu bazalwa bene-neutropenia enzima. Abanye bangase babe nalesi simo ngaphandle kwesizathu esibonakalayo. Kulezi zimo, i-G-CSF isetshenziselwa futhi ukwandisa amazinga e-neutrophil.
Izinhlobo ze-G-CSF nokuthi zinikezwa kanjani
Umuthi i-G-CSF uyatholakala emakethe ngamagama ahlukahlukene. Lokhu kuyahlukahluka kancane ngokwesikhathi sokusebenza kwawo kanye nenqubo yokukhiqiza.
| Uhlobo lwesidakamizwa | Incazelo nezibonelo |
|---|
| I-G-CSF esebenza isikhathi esifushane | Lezi zivame ukudinga ukuthathwa nsuku zonke. Umuthi oyinhloko yiFilgrastim (igama lomkhiqizo: Neupogen®). Kunemithi eminingana efanayo, ephephile futhi esebenza kahle (i-biosimilars). |
| I-G-CSF esebenza isikhathi eside | Lokhu kuhlala isikhathi eside emzimbeni, ngakho-ke awudingi ukuthola imijovo kaningi. Umuthi oyinhloko yiPegfilgrastim (igama lomkhiqizo: Neulasta®). Kungase kwanele ukuthola umjovo owodwa phakathi kwemijikelezo emibili ye-chemotherapy. |
Into ebaluleke kakhulu ukuthi udokotela wakho anqume uhlobo kanye nomthamo wemithi ofanele wena.
I-G-CSF ivame ukunikezwa njengomjovo ongaphansi kwesikhumba. Ngezinye izikhathi inikezwa njengomjovo we-IV. Uma ukwazi ukuzijova ekhaya, udokotela wakho noma umhlengikazi uzochaza ukuthi ungakwenza kanjani.
Yiziphi imiphumela emibi ye-G-CSF?
Njenganoma yimuphi umuthi, i-G-CSF inezinzuzo nemiphumela emibi. Kodwa khumbula, udokotela ukubhalela lo muthi ngoba izinzuzo zidlula kakhulu izingozi. Imiphumela eminingi emibi iyanyamalala uma ukwelashwa kuyekwa.
| Imiphumela emibi evamile | Izimo ezingavamile ukuba zimbi kakhulu |
|---|
| - Ukusabela okukhulu kwe-allergy (i-Anaphylaxis)
- Ukuqhekeka kwe-spleen
- I-Acute respiratory distress syndrome (ARDS)
- Ukuvuvukala komzimba
|
Kungani i-G-CSF ibangela ubuhlungu emathanjeni?
Lona umphumela ovamile obhekene nabantu abaningi. Nakuba imbangela eqondile ingaziwa, ososayensi bacabanga ukuthi kungenxa yokuthi i-G-CSF ibangela ukuthi umongo wethambo uqale ngokuzumayo ukukhiqiza amangqamuzana amasha ngesivinini esikhulu kakhulu. Ingcindezi ebangelwa yilokhu kukhula okusheshayo yilokho esikuzwayo njengobuhlungu. Lobuhlungu buvame ukubekezeleleka. Ungakhuluma nodokotela wakho ngakho bese uthola umuthi wokuqeda izinhlungu ofanele.
Kufanele ubonane nini nodokotela?
Kubaluleke kakhulu ukutshela udokotela wakho nganoma yimiphi imiphumela emibi oyitholayo ngenkathi uthatha i-G-CSF. Ikakhulukazi, uma uhlangabezana nanoma yiziphi izimpawu ezilandelayo, kufanele
ufune iseluleko sezokwelapha ngokushesha . Ngezinye izikhathi kungadingeka uye eMnyangweni Wezimo Eziphuthumayo wesibhedlela (i-ETU).
- Izimpawu zokutheleleka: umkhuhlane, ukubanda, umphimbo obuhlungu, ukukhwehlela.
- Izimpawu zokungezwani komzimba:Ukuqubuka kwesikhumba, ukuvuvukala, ubunzima bokuphefumula .
- Ukuphelelwa umoya ngokuzumayo.
- Ukushaya kwenhliziyo okusheshayo.
- Ukuvuvukala okungazelelwe kwezandla noma izinyawo.
Ungakhohlwa, ukuphepha kwakho kuza kuqala. Uma unokungabaza, noma ngabe kuyinto encane nje, ungesabi ukushayela udokotela wakho ucingo ubuze.
Umlayezo Wokuya Nawe Ekhaya
- I-G-CSF umuthi onikezwa ukwandisa inani lamaseli amhlophe egazi alwa nezifo abizwa ngokuthi ama-neutrophils, ancishiswa yizinto ezifana nokwelashwa komdlavuza (i-chemotherapy).
- Lokhu kuzonciphisa ingozi yakho yokuthola izifo futhi kukusize uqhubeke nokwelashwa kwakho komdlavuza ngesikhathi esibekiwe.
- Ubuhlungu bamathambo nemisipha buyimiphumela emibi evamile yalo muthi, kodwa ngokuvamile bubekezeleleka.
- Uma uba nezimpawu ezifana nobunzima bokuphefumula, ukungezwani komzimba okukhulu, noma umkhuhlane , yazisa udokotela wakho ngokushesha.
- Udokotela wakho kuphela onganquma ukuthi uyawudinga lo muthi noma cha, nokuthi yiluphi uhlobo olukufanele. Ngakho xoxa naye ngakho konke.
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