Uke waphawula muva nje ukuthi umuntu osekhulile emndenini wakho, mhlawumbe umama wakho, ubaba, ugogo noma u-anti wakho, ukhohlwa izinto ezincane? Izinto ezifana nokuthi izikhiye zakho zikuphi, igama lomuntu, umsebenzi okwakufanele uwenze... Empeleni kuyinto evamile ukuthi lezi zinhlobo zokukhohlwa zenzeke njengoba siguga. Kodwa uma lesi simo siba sibi kancane kancane futhi inkumbulo yakho iba buthaka kangangokuthi awukwazi ngisho nokwenza imisebenzi yansuku zonke, kungaba uphawu lokuqala lwesifo esifana ne-Alzheimer's. Ngakho-ke kungaba usizo kangakanani ukube bekukhona indlela yokuthola ngalokhu kusenesikhathi, kalula? Yilokho esikhuluma ngakho kulesi sihloko namuhla, futhi kusinika ithemba elikhulu.
Kuyini lokhu kuhlolwa kwegazi okusha?
Ucwaningo lwamuva nje luthole ukuhlolwa kwegazi okusha okungathola izimpawu zesifo i-Alzheimer's. Okukhethekile ngalokhu ukuthi lokhu kuhlolwa kwegazi okulula kunembile njengokuhlolwa okusetshenziswayo njengamanje, okubuhlungu nokuyinkimbinkimbi, umpompi womgogodla.
Kalula nje, lokhu kuhlolwa kwegazi kulinganisa amazinga eprotheni ethile egazini lethu ebizwa ngokuthi i-p-tau217 . Abacwaningi bathole ukuthi uma umuntu enamazinga aphezulu kakhulu ale phrotheni ye-p-tau217 egazini lakhe, kuyisibonakaliso esinamandla sezinguquko kwamanye amaprotheni amabili ahlobene ngqo nesifo se-Alzheimer: i-amyloid beta kanye ne-tau . Lawa amaprotheni ayinhloko aqongelela ebuchosheni lapho kuvela isifo se-Alzheimer.
Lokhu kuhlolwa kwegazi okusha kubonise ukunemba okufika ku-97% , okuthembekile kakhulu. Futhi, ama-20% kuphela abantu abahlanganyele kulolu cwaningo abadinga ukuhlolwa okwengeziwe ukuqinisekisa lesi sifo.
Lokhu kuhluke kanjani ezivivinyweni ezisetshenziswayo njengamanje?
Izindlela zamanje ezingcono kakhulu zokuxilonga ngokunembile isifo i-Alzheimer's ziyinkimbinkimbi kancane. Ake sibheke ukuthi ziyini nokuthi zihluke kanjani kulokhu kuhlolwa kwegazi okusha.
| Indlela yokuhlola | Incazelo | Ububi kanye nokuphazamiseka |
|---|---|---|
| Ukuthepha Komgogodla | Ukufaka inalithi ekhethekile ngentambo yomgogodla bese kususwa inani elincane loketshezi lwe-cerebrospinal, uketshezi oluzungeze ubuchopho kanye nentambo yomgogodla. | Kungaba buhlungu, kunengozi ethile, futhi kudingeka ukulaliswa esibhedlela, futhi abantu abaningi bayakwesaba lokhu. |
| Ukuskena kwezilwane ezifuywayo | Isithwebuli esikhethekile nesizwela kakhulu sithatha izithombe zama-amyloid kanye nama-tau protein deposits ebuchosheni. | Kubiza kakhulu. Lezi zikhungo azitholakali kuzo zonke izibhedlela. Kunzima kulabo abahlala kude ukuzithola. |
| Ukuhlolwa kwegazi okusha kwe-p-tau217 | Ukuhlola izinga leprotheni ye-p-tau217 ngesampula yegazi elijwayelekile elithathwe emthanjeni osengalweni. | Kulula kakhulu, akunangozi ephansi, akubizi kakhulu uma kuqhathaniswa nezinye izindlela, futhi kungenziwa kalula noma kuphi. |
Kuthiwa ukuhlolwa kwegazi okusetshenziswe kulolu cwaningo kungatholakala emazweni angaphandle ngentengo ephakathi kuka-$200 no-$500. Nakuba lokhu kuyimali eningi eSri Lanka, le ntengo iphansi kakhulu uma iqhathaniswa nokuhlolwa okufana ne-PET scan, okubiza amakhulu ezinkulungwane zamaRandi.
Yimuphi umyalezo esiwutholayo ngempela kulolu cwaningo?
Lolu cwaningo, olushicilelwe ephephabhukwini lezokwelapha elidumile emhlabeni wonke i-JAMA Neurology, lusikisela ukuthi ukuhlolwa kwegazi kwe-p-tau217 kungasebenza njengethuluzi lokuqala lokuhlola izinkinga zenkumbulo .
Cabanga ngalokhu. Uma umuntu esola ukuthi kungenzeka ukuthi unezinkinga zokukhumbula, angaqala ngalokhu kuhlolwa kwegazi okulula. Kuphela uma kunikeza inkomba yokuthi unezimpawu lapho angaqhubeka khona nokuhlolwa okubizayo nokuyinkimbinkimbi. Lokhu kungasindisa iziguli nodokotela isikhathi esiningi nemali.
Into ebalulekile ukuthi uma lesi sifo sitholakala kusenesikhathi ngale ndlela, ukwelashwa okusha okuhlose iphrotheni ye-amyloid ebuchosheni kungaqalwa kusenesikhathi. Uma ukwelashwa kuqalwa ngokushesha kwanoma yisiphi isifo, imiphumela iba ngcono.
Ukukhohlwa okuvamile kanye nesifo i-Alzheimer's
Isifo i-Alzheimer's uhlobo oluvame kakhulu lwe-dementia, noma ukwehla kwengqondo. Kuvamile ukuzwa izinguquko ezincane enkumbulo nasekucabangeni njengoba siguga. Kodwa-ke, uma lezi zinguquko ziba zimbi ngokwanele ukwenza kube nzima ukwenza imisebenzi yansuku zonke, kungaba uphawu lwe-dementia.
Isibonelo, kuyinto eyodwa ukukhohlwa ukuthi ubekephi okhiye bakho bese ubakhumbula futhi ngemva kwesikhashana. Kodwa-ke, uma ukhohlwa ngokuphelele ukuthi ukhiye uyini nokuthi usetshenziselwani, leso yisimo esibucayi. Yilapho-ke kufanele sifune iseluleko sezokwelapha.
Ngakho-ke singakwenza lokhu kuhlolwa kwegazi njengamanje?
Lona ngumbuzo obaluleke kakhulu. Nakuba lokhu kuhlolwa sekuvele kutholakala kwezentengiselwano kwamanye amazwe, kusesesigabeni sokuqala. Abacwaningi ngokwabo bathi kudingeka ucwaningo olwengeziwe ukuqinisekisa ukuthi le miphumela isebenza kanjani kubantu abavamile, okungukuthi, abantu abangenazo izimpawu.
Lokhu kuhlolwa akukavamile kakhulu eSri Lanka. Kodwa kuphakamise amathemba amakhulu emkhakheni wezokwelapha emhlabeni wonke. Esikhathini esizayo, kuzofika usuku lapho nathi sizokwazi ukwenza kalula ukuhlolwa okulula nokungabizi kangaka.
Into ebaluleke kakhulu ukuthi, uma wena noma othile emndenini wakho enokungabaza noma izinkinga mayelana nenkumbulo, ungazenzeli izinqumo zakho ngokusekelwe kulokho okufundayo ku-inthanethi. Qiniseka ukuthi ubona udokotela womndeni wakho (udokotela) bese uxoxa ngalokhu. Uzokunikeza isiqondiso esiqondile sokuthi yiziphi izivivinyo ozidingayo nokuthi yiziphi izinyathelo okufanele uzithathe, kuye ngezimpawu zakho.
Umlayezo Wokuya Nawe Ekhaya
- Ucwaningo oluphumelelayo luyaqhubeka ngokuhlolwa kwegazi okusha okulula okungaba nethemba lokutholakala kwesifo i-Alzheimer's kusenesikhathi.
- Lokhu kuhlolwa kulinganisa iphrotheni ebizwa ngokuthi i-p-tau217 egazini, futhi kutholakale ukuthi kunembile njengezivivinyo ezibizayo neziyinkimbinkimbi ezisetshenziswayo njengamanje.
- Lokhu kungaba yinto ebaluleke kakhulu esikhathini esizayo njengokuhlolwa kokuhlolwa kokuthola lesi sifo kusenesikhathi.
- Uma wena noma othile oseduze nawe enenkinga enkulu yokukhumbula, into engcono kakhulu futhi okuwukuphela kwayo okufanele uyenze ukufuna iseluleko kudokotela ofanelekayo ngokushesha.
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