Wake waba nobuhlungu emhlane kusukela usemusha, noma wazizwa uqinile emhlane lapho uvuka ekuseni? Ingabe ubuhlungu bubonakala buphela ngemva kokuhamba ibanga elifushane noma lapho uqala umsebenzi wakho wosuku? Ungase ucabange ukuthi lokhu kumane kuyibuhlungu emhlane. Kodwa ngezinye izikhathi lezi zimpawu zingaba izimpawu zokuqala zesimo esibizwa ngokuthi i-Ankylosing Spondylitis, esikhuluma ngaso namuhla. Ungakhathazeki, sizokhuluma ngalokhu ngokucacile nangokulula.
Iyini ngempela i-Ankylosing Spondylitis (AS)?
Kalula nje, i-Ankylosing Spondylitis (AS) uhlobo lwe-arthritis. Kodwa ithinta ngqo amalunga emgogodleni wethu . Umgogodla wethu wakhiwe ngamathambo amaningi amancane ahlangana, futhi amalunga aphakathi kwala mathambo ayavuvukala, avuvuke, futhi abe buhlungu. Ngokuhamba kwesikhathi, lokhu kuvuvukala kungabangela amalunga emgogodleni ukuthi ahlangane, kunciphise ukuguquguquka komgogodla.
Izimpawu ezivamile zalesi sifo yilezi:
- Ubuhlungu nokuqina komhlane: Lokhu kuzwakala ikakhulukazi uma uvuka ekuseni noma ngemva kokuma isikhathi eside.
- Ubuhlungu obunciphile ngesikhathi sokuzivocavoca: Ngokumangalisayo, ubuhlungu buyanda lapho uphumula futhi buyancipha lapho usebenza, njengokuhamba, ukugijima, noma ukugxuma.
- Ubuhlungu kwamanye amalunga: Abanye abantu bangase babe nobuhlungu emalungeni njengezinqe, amadolo, kanye nezithende.
- Ukuzizwa ukhathele kakhulu.
Lesi sifo sivame ukuqala kubantu abasha abaneminyaka ephakathi kwengu-15 no-30. Yingakho abantu abaningi bengase basiphathe kabi njengobuhlungu bomhlane obuvamile.
Ngakho-ke ingabe kukhona ukuxhumana kwezakhi zofuzo kulokhu?
Yebo. Leli yiphuzu elibaluleke kakhulu kulesi sihloko. I-Ankylosing Spondylitis yisifo esidluliselwa ngofuzo kakhulu, okungukuthi, sinethonya lezakhi zofuzo . Uma othile emndenini wakho, okungukuthi, abazali, izingane zakini, enalesi sifo, khona-ke nawe usengozini enkulu yokuthola lesi sifo kunabanye.
Njengoba ososayensi becwaninga ngalokhu, bagxile kakhulu ku-gene eyodwa ethile: i-HLA-B27 gene.
Cabanga nje, iziguli ezingaphezu kuka-85% ezitholakale zine-Ankylosing Spondylitis zitholakale zinalesi sakhi sofuzo esibizwa ngokuthi i-HLA-B27. Ingabe lokho akubonisi yini ukuxhumana okuqinile phakathi kwalesi sakhi sofuzo nesifo?
Le gene ye-HLA-B27 isiza amasosha omzimba wethu. Kalula nje, iyaqaphela futhi ilwe nabahlaseli bakwamanye amazwe njengama-virus namabhaktheriya. Kodwa ngezinye izikhathi, ngenxa yezinguquko kule gene, amasosha omzimba ayaphazamiseka futhi aqale ukuhlasela izingxenye zomzimba wethu ezinempilo, kulokhu, amalunga emgogodleni wethu. Ososayensi bakholelwa ukuthi lokhu kuvuvukala kubangelwa yilokhu.
Ingabe i-HLA-B27 iyona yodwa ebangela lokhu?
Cha. Lowo ngumbuzo obaluleke kakhulu. Nakuba i-HLA-B27 ingumlingisi oyinhloko kule ndaba, bakhona nabanye abasekeli abambalwa. Ososayensi bathi cishe u-30% wengozi iyonke yezakhi zofuzo yokuthuthukisa lesi sifo ivela ku-HLA-B27 gene. Okunye kuthonywa ezinye izakhi zofuzo ezincane eziningana.
Ngenxa yokuthi imiphumela yalezi zakhi zofuzo mincane, kunzima ukuzibona ngayinye ngayinye. Kodwa-ke, ezinye izakhi zofuzo eziningana zitholakale ngocwaningo olwenziwe ososayensi emhlabeni wonke abaye babambisana futhi babelane ngolwazi.
| I-Gene | Incazelo elula |
|---|---|
| I-HLA-B27 | Lesi yi-gene eyinhloko. Sihlobene nesistimu yomzimba yokuzivikela. Iningi leziguli ze-AS linalesi gene. |
| I-ERAP1 | Lokhu futhi kuyi-gene ehilelekile ekusebenzeni kwesimiso somzimba sokuzivikela. Kukhulisa ingozi yesifo uma kuhlanganiswa ne-HLA-B27. |
| I-IL23R kanye ne -IL1A | Lezi futhi ziyizakhi zofuzo ezihilelekile ekuthuthukisweni nasekulawulweni kokuvuvukala emzimbeni. Ukwehluka kwalezi zakhi zofuzo kungandisa nengozi ye-AS. |
Abacwaningi basafuna ezinye izakhi zofuzo ezingakahlonzwa ezingase zithinte lokhu.
Ingabe wonke umuntu uthola lesi sifo ngoba nje enesakhi sofuzo?
Cha. Akunjalo neze.Lokhu kuyinto okudingeka uyikhumbule. Ukuba ne-HLA-B27 gene emzimbeni wakho akusho ukuthi uzoba ne-Ankylosing Spondylitis. Kusho ukuthi usengozini enkulu yokuthuthukisa lesi sifo kunezinye.
Cabanga ngalokhu. Ucwaningo olulodwa luthole ukuthi ama-75% ezingane athola ifa le-HLA-B27 gene kubazali abane-Ankylosing Spondylitis, noma amathathu kwamane, ngeke aphinde abe nesifo.
Lokhu kusho ukuthi izakhi zofuzo zodwa azanele ukubangela lesi sifo. Ngaphezu kwamathonya ezakhi zofuzo , izici zemvelo nazo kumele zibe khona. Nakuba kungakaziwa kahle ukuthi ziyini lezi zici, kukholelwa ukuthi izici ezithile, njengokutheleleka okuthile, zingadlala indima. Kalula nje, izakhi zofuzo zifana nesibhamu esilungele ukuvutha, futhi sidinga inhlansi ukuze sivuthe.
Ngakho-ke kufanele ngenzeni?
Uma unezimpawu ezifana nalezo okukhulunywe ngazo kulesi sihloko (ubuhlungu bomhlane obuqala usemncane, bube bubi kakhulu ekuseni, futhi budambiswa ukuzivocavoca), noma uma othile emndenini wakho ene-Ankylosing Spondylitis, akudingeki ukhathazeke.
Into engcono kakhulu ongayenza ukubona udokotela ofanelekayo, udokotela wakho, ngokushesha . Uzolalela izimpawu zakho, akuhlole, futhi uma kudingeka, acele ukuhlolwa kwegazi kanye ne-X-ray. Bangase futhi batuse ukuhlolwa ukuze babone ukuthi une-HLA-B27 gene.
Khumbula, into ebaluleke kakhulu ukuhlonza nokuphatha lezi zimo kusenesikhathi . Uma wenza kanjalo, ungalawula ubuhlungu, uvimbele ubuhlungu bomhlane, futhi uphile impilo evamile nejabulisayo.
Umlayezo Wokuya Nawe Ekhaya
- I-Ankylosing Spondylitis (AS) uhlobo lwe-arthritis oluthinta kakhulu umgogodla. Luvame kakhulu kubantu abasha.
- Lesi sifo sinobudlelwano obuqinile kakhulu ngezakhi zofuzo, ikakhulukazi i-gene HLA-B27 iyimbangela enkulu.
- Kodwa-ke, ukuba nesakhi sofuzo se-HLA-B27 emzimbeni wakho akusho ukuthi uzoba nalesi sifo. Kumane kuyisici esiyingozi.
- Ngaphezu kwezakhi zofuzo, izici zemvelo nazo zithonya ukuvela kwalesi sifo.
- Uma unezinhlungu zomhlane isikhathi eside, ukuqina kwasekuseni, noma umlando womndeni wokugula, ungesabi futhi uxhumane nodokotela wakho ukuze uthole iseluleko esifanele.
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