Ingabe wena noma othile omaziyo unikezwe imithi ngudokotela ngenxa yesimo esifana nokucindezeleka? Uma kunjalo, kungenzeka ukuthi uke wezwa igama elithi SNRI. Kuvamile ukuthi kuvele imibuzo eminingi engqondweni uma uzwa leli gama. "Ayini ama-SNRI? Asebenza kanjani ngempela? Ingabe ikhona imiphumela emibi?" Mhlawumbe unemibuzo efana nale. Ungakhathazeki, kulungile-ke, ake sixoxe ngakho konke lokhu ngendlela elula kakhulu nenobungane namuhla.
Ake siqale sibone, ziyini lezi SNRI?
Kalula nje, ama-SNRI (i-Serotonin kanye ne-Norepinephrine Reuptake Inhibitors) ayizinhlobo zemithi esetshenziswa ukulawula izimpawu zezimo zempilo yengqondo njengokucindezeleka. Kodwa-ke, odokotela banikeza lo muthi kwezinye izimo eziningi, hhayi ukucindezeleka kuphela.
ESri Lanka, imithi eminingana engaphansi kwalesi sigaba inqunywa odokotela. Isibonelo, imithi efana neVenlafaxine, iDuloxetine, neDesvenlafaxine iwela kulesi sigaba. Kodwa-ke , udokotela wakho kuphela onganquma ukuthi yimuphi umuthi ofanele wena nokuthi ungakanani umthamo.
Lo muthi usebenza kanjani emzimbeni?
Ukuze siqonde lokhu, sidinga ukwazi okuncane ngobuchopho bethu. Ubuchopho bethu bunezithunywa zamakhemikhali ezikhethekile ezibizwa ngokuthi ama-neurotransmitters , njengabathumeli abathwala imiyalezo phakathi kwezingxenye ezahlukene zomzimba wethu.
Phakathi kwalezi , i-Serotonin ne -Norepinephrine ziyizithunywa ezimbili eziyinhloko ezilawula izinto eziningi ezibalulekile, njengemizwa yethu, ukulala, inkumbulo, kanye nokunaka.
Ezimweni ezifana nokucindezeleka, umsebenzi walaba bantu uyancipha. Okusho ukuthi, basheshe bamuncwe babuyele emangqamuzaneni ezinzwa ngemva kokuba sebedlulise umyalezo (lokhu kubizwa ngokuthi i-reuptake). Bese umphumela wabo ebuchosheni uyancipha.
Ama-SNRI asebenza ngokuvimbela ukuthathwa kabusha kwe-serotonin kanye ne-norepinephrine. Lokhu kusho ukuthi lezi zithunywa ezimbili zihlala zisebenza ebuchosheni isikhathi eside. Ngenxa yalokho, isimo sethu sengqondo siyathuthuka futhi izimpawu zokucindezeleka ziqala ukwehla kancane kancane.
Ngakho-ke uyini umehluko phakathi kwe-SSRI ne-SNRI?
Kungenzeka ukuthi uke wezwa ngama-SSRI. Ama-SSRI (Selective Serotonin Reuptake Inhibitors) ahlasela kuphela i-neurotransmitter serotonin, kuyilapho ama-SNRI ethinta kokubili i-serotonin kanye ne-norepinephrine.
Lokhu akusho ukuthi ama-SNRI "angcono" kune-SSRI. Abanye abantu bangase bathole ama-SSRI esebenza kangcono, kanti abanye bangase bathole ama-SNRI esebenza kangcono. Udokotela wakho uzonquma ukuthi yikuphi okungcono kakhulu kuwe ngokusekelwe esimweni sakho, izimpawu, kanye nendlela umzimba wakho osabela ngayo kuzo.
Yiziphi izifo ezisetshenziswa imithi ye-SNRI?
Lolu hlobo lomuthi lusetshenziselwa ukwelapha izimo ezahlukene zezokwelapha. Ake sibheke ukuthi ziyini.
| Isimo sezokwelapha | Incazelo elula |
|---|---|
| Isifo Sokucindezeleka Esiyinhloko | Ukudabuka isikhathi eside kanye nokulahlekelwa yisithakazelo okuthinta imisebenzi yansuku zonke. |
| Isifo Sokukhathazeka Okujwayelekile (i-GAD) | Ukuzizwa ukhathazekile ngezinto zansuku zonke ngaphandle kwesizathu esithile. |
| I-Fibromyalgia | Ubuhlungu obungapheli emzimbeni wonke, ukukhathala nezinkinga zokulala. |
| I-Diabetic Neuropathy | Ubuhlungu, njengokuvuvukala kanye nokungazweli, okubangelwa ukulimala kwemizwa ngenxa yesifo sikashukela. |
| Ubuhlungu Bemisipha Engapheli | Ubuhlungu obuhlala isikhathi eside, njengobuhlungu bomhlane. |
| Isifo Sokukhathazeka Komphakathi | Ukwesaba nokukhathazeka ngokweqile ezimweni zomphakathi. |
Ngaphezu kwalokho, kuye ngokuthi udokotela unolwazi olunjani kanye nokwahlulela kwakhe kwezokwelapha, lo muthi ungase unconywe futhi ekujulukeni ebusuku okuhlobene nokunqamuka kokuya esikhathini, ukuvimbela i-migraine, kanye nezinye izimo zokukhathazeka.
Yimiphi imiphumela emibi evamile yale mithi?
Njenganoma yimuphi umuthi, ama-SNRI angabangela abanye abantu ukuthi babe nemiphumela emibi emincane. Kodwa-ke, lokhu kuvame ukuba okwesikhashana . Iningi lalokhu lizophela phakathi namasonto ambalwa okuqala njengoba umzimba wakho ujwayela umuthi.
- Isicanucanu nokuhlanza
- Umlomo owomile
- Ukuqunjelwa
- Ukukhathala kanye nokozela
- Isiyezi
- Ukujuluka ngokweqile
- Izinkinga ngomsebenzi wocansi (isb., ukwehla kwesifiso)
Into ebaluleke kakhulu ukuthi uma ukhathazwa yile miphumela emibi, ungayinaki bese ukhuluma nodokotela wakho. Angase akwazi ukulungisa umthamo wakho noma akunikeze omunye umuthi.
Izimo eziyingozi ezidinga ukunakwa okukhethekile
Nakuba ama-SNRI ewumuthi osebenza kahle kakhulu, kunezimo ezithile ezingavamile kodwa ezingaba yingozi okufanele siziqaphele.
1. Ingozi eyengeziwe yemicabango yokuzibulala
Ucwaningo luye lwabonisa ukuthi kungase kube nokwanda kwemicabango yokuzibulala, ikakhulukazi entsheni engaphansi kweminyaka engu-25, lapho lo muthi uqala ukusetshenziswa noma lapho umthamo ushintshwa. Uma wena noma ingane yakho ninemicabango enjalo ngenkathi nithatha lo muthi, ningangabazi ukuxhumana nodokotela wakho ngokushesha.
2. Isifo se-Serotonin
Lesi yisimo esingavamile kakhulu, kodwa esingasongela impilo. Senzeka lapho amazinga e-serotonin emzimbeni eba phezulu kakhulu. Le ngozi iphezulu kakhulu uma ama-SNRI ethathwa neminye imithi ekhulisa amazinga e-serotonin (njenge-MAOIs). Ngakho-ke, kubaluleke kakhulu ukwazisa udokotela wakho ngayo yonke imithi oyithathayo, ngisho namavithamini.
| Izimpawu ze-Serotonin Syndrome | |
|---|---|
| Izici ezijwayelekile | Ukungaphumuli, isicanucanu, isifo sohudo, amehlo avuleke kakhulu , ukuthuthumela kwemisipha, ukujuluka, kanye nokubanda. |
| Izici eziyingozi | Ukudideka, i-tachycardia, umfutho wegazi ophakeme, umkhuhlane ophakeme, ukuxhuzula, ukungazi lutho. |
| Uma unezinye zalezi zimpawu eziyingozi, hamba uye eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela esiseduze ngokushesha! | |
3. Ukuyeka umuthi ngokuzumayo
Uma uyeka ukuthatha i-SNRI amasonto angaphezu kwayisithupha, ungase ube nezimpawu ezithile ezingathandeki. Lokhu kubizwa ngokuthi i-Antidepressant Discontinuation Syndrome. Lokhu akuyona "ukulutheka kwezidakamizwa." Lokhu kumane kuyimizamo yomzimba yokujwayela imithi lapho iyeka ngokuzumayo. Izimpawu zingase zihlanganise ubuhlungu bomzimba obufana nomkhuhlane, ikhanda elibuhlungu, isicanucanu, isiyezi, kanye nomuzwa wokububula.
Ngakho-ke , ungalokothi, nganoma yisiphi isizathu, uyeke ukuthatha lo muthi ngokuzumayo ngaphandle kokubonisana nodokotela wakho. Uma udinga ukuyeka ukuthatha umuthi, yenza lokho ngokwemiyalelo kadokotela wakho, wehlise kancane kancane umthamo.
Kuthatha isikhathi esingakanani ukubona imiphumela yomuthi?
Lona umbuzo abantu abaningi abawubuzayo. Ngokuvamile kungathatha amasonto ayisithupha kuya kwayisishiyagalombili ukuthi imiphumela ephelele yemithi ye-SNRI izwakale. Uzoqala ukuzizwa ungcono ngemva kwamasonto amabili kuya kwamathathu okuqala. Ngakho-ke, kubalulekile ukubekezela nokusebenzisa imithi ngendlela efanele. Uma ungazizwa umehluko ngemva kwalesi sikhathi, khuluma nodokotela wakho ngakho.
Umlayezo Wokuya Nawe Ekhaya
- Ama-SNRI ayiqembu lemithi elisebenza kahle kakhulu elapha izimo ezinjengokucindezeleka, ukukhathazeka kanye nobuhlungu obungapheli.
- Lo muthi usebenza ngokulinganisela amazinga ezithunywa zamakhemikhali ezibizwa ngokuthi i-serotonin ne-norepinephrine ebuchosheni.
- Imiphumela emibi yokuqala ivame ukuba yesikhashana, kodwa uma ikhathaza, qiniseka ukuthi uyatshela udokotela wakho.
- Ungalokothi uyeke ukuthatha lo muthi ngokuzumayo ngaphandle kweseluleko sikadokotela wakho.
- Qaphela izimpawu eziyingozi ze-serotonin syndrome (umkhuhlane ophakeme, ukudideka, ukuxhuzula). Uma lokhu kwenzeka, iya ekamelweni eliphuthumayo (ETU) ngokushesha.
- Kungathatha isikhathi ukuthola imithi efanele wena. Ngakho-ke yiba nesineke futhi uhlale uxhumana nodokotela wakho njalo. Udokotela wakho uhlala ekulungele ukukusiza.
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