Ingabe umzimba wakho uqinile ngaphandle kwesizathu? Ake sixoxe nge-Stiff Person Syndrome!

Ingabe ngezinye izikhathi uzizwa imisipha yakho iqina ngendlela engaqondakali, noma imisipha yakho idikiza kabuhlungu? Ngezinye izikhathi kungenzeka uma uzwa umsindo omkhulu noma othile ekushayisa. Uma lezi zinto zenzeka njalo, kuwumqondo omuhle ukuzihlola. Namuhla sizokhuluma ngesimo esingavamile kakhulu esingabangela izimpawu ezifanayo. Lokho kubizwa ngokuthi i-Stiff Person Syndrome (SPS) .

Iyini i-Stiff Person Syndrome?

Kalula nje, i-Stiff Person Syndrome (SPS) iyisifo sezinzwa esingavamile . Kwenzeka lapho amasosha omzimba wethu, asivikela ezifweni, ehlasela ngephutha amangqamuzana ethu ezinzwa aphilile. Kuyisimo sokuzivikela komzimba. Lokhu kubangela ukuthi imisipha esemzimbeni wakho, ikakhulukazi isisu sakho, isifuba, nomhlane , iqine noma iqine . Ngokuhamba kwesikhathi, lokhu kuqina kanye nokuqaqamba kungasakazekela kweminye imisipha emilenzeni nasezingalweni zakho. Lokhu kungenza kube nzima ukuhamba, kukwenze uwe kaningi, futhi kukwenze ube sengozini yokulimala.

Lokhu kwakubizwa ngokuthi "i-stiff man syndrome," kodwa lelo gama selishintshiwe manje ngoba lesi sifo singathinta noma ubani, kungakhathaliseki ubudala noma ubulili.

Ukutholwa unalesi simo kungaba nzima kakhulu. Kodwa ithimba lakho lezokwelapha lizokwakha uhlelo lokwelapha oluzokusebenzela wena kanye nezimpawu zakho. Lokhu kungahluka kumuntu nomuntu. Into ebaluleke kakhulu ukubona odokotela bakho njalo, uthole ukwesekwa okudingayo, futhi uzame ukuhlala uphilile.

Ziyini izimpawu ze-Stiff Person Syndrome (SPS)?

Kunezimpawu ezimbili eziyinhloko zalesi sifo:

• Ukuqina kwemisipha noma ukuqina kwayo.
• Ubuhlungu bemisipha.

Nakuba lezi zimpawu zingaqala kunoma yimuphi ubudala, zivame kakhulu phakathi kweminyaka engama-30 nengama-40 .

Izimpawu ze-Stiff Person Syndrome zingasakazekela kwezinye izingxenye zomzimba futhi zibe zimbi kakhulu ngokuhamba kwesikhathi. Kwabanye abantu, kungathatha izinyanga kuya eminyakeni ukuthi izimpawu zivele. Kwabanye, izimpawu zingase zihlale zifana iminyaka. Kwabanye abantu, izimpawu zingase zibe zimbi kancane kancane futhi zenze kube nzima ukwenza imisebenzi yansuku zonke.

Ukuqina kwemisipha

Ngokuvamile, uphawu lokuqala olubonayo nge-Stiff Person Syndrome ukuqina kwemisipha esiqwini . Lokhu kusho ukuthi ezindaweni ezifana nesisu, isifuba, nomhlane. Lokhu kuqina kungabangela ubuhlungu nokungakhululeki. Lezi zimpawu zingafika zidlule ngaphandle kwesizathu esibonakalayo. Lesi simo singathinta nezingalo nemilenze. Njengoba ukuqina kwanda, abanye abantu bangase babe nokuma okungavamile okwenza kube nzima ukuhamba noma ukunyakaza.

Ukuqaqamba kwemisipha

Ubuhlungu bemisipha bungenye impawu enkulu yalesi simo. Lokhu kungathinta umzimba wonke, noma kungatholakala endaweni ethile. Lokhu kuqina kungahlala imizuzwana, imizuzu, noma ngisho namahora. Cabanga nje, lapho umi nje, ngokuzumayo umlenze noma umhlane wakho uzizwa uqinile futhi uthambile. Kuyinto ebuhlungu kakhulu.

Yiziphi izimbangela ze-Stiff Person Syndrome (SPS)?

Kunezizathu eziningana zokuthi kungani izimpawu ezifana nokudikiza kwemisipha zingavela ngokuzumayo:

• Umsindo ongazelelwe noma omkhulu. Cabanga nje uma uhamba emgwaqweni bese imoto ishaya uphondo lwayo ngokuzumayo, noma uma into ethile ekhaya iwela phansi ngomsindo omkhulu.
• Ukuthintwa ngokomzimba noma ukukhuthazwa. Uma othile ekuthinta ngokuzumayo, uyakumbambatha.
• Izinguquko ekushiseni, ikakhulukazi ezindaweni ezibandayo. Uma ngokuzumayo uya endaweni ebandayo, noma uma amanzi abandayo ewela emzimbeni wakho.
• Izehlakalo ezicindezelayo. Izikhathi ezicasulayo nezesabekayo.

Ngenxa yokuthi lokhu kuphazamiseka kwemisipha kungenzeka ngezikhathi ezingalindelekile, abanye abantu abane-Stiff Person Syndrome babhekana nokukhathazeka kanye ne -agoraphobia . I-Agoraphobia ukwesaba okukhulu ukuya ezindaweni ezinabantu abaningi, ukuphuma ngaphandle, noma ukuphuma ekhaya. Ngoba uma usuphumile, kunzima ukubalekela lezi zinto ezikubangelayo.

Yini ebangela i-Stiff Person Syndrome (SPS)?

Abacwaningi abakaqiniseki ukuthi yini ebangela lesi sifo, kodwa bakholelwa ukuthi kuyisimo sokuzivikela komzimba, okusho ukuthi amasosha omzimba wethu ahlasela amangqamuzana anempilo.

Ucwaningo lukhombisile ukuthi ama-antibodies ahilelekile. Abantu abaningi abane-Stiff Person Syndrome banama-antibodies amelene ne-enzyme ebizwa ngokuthi i-Glutamic Acid Decarboxylase (GAD) . Le enzyme (GAD) isiza ekwenzeni i-neurotransmitter i-gamma-aminobutyric acid (GABA) . Le neurotransmitter (GABA) isiza ukulawula ukusebenza kwemisipha.

Kodwa abacwaningi abakaqondi ngokugcwele ukuthi i-enzyme `(GAD)` ithinta kanjani ukuthuthukiswa kanye nokuqhubeka kwe-Stiff Person Syndrome. Into eyodwa okufanele uyikhumbule ukuthi ukuba nama-antibodies `(GAD)` emzimbeni wakho akusho ukuthi une-Stiff Person Syndrome. Iphesenti elincane labantu abavamile lingase libe nala ma-antibodies `(GAD)` emizimbeni yalo ngaphandle kwemiphumela emibi.

Ngaphezu kwe-GAD, amanye ama-antibodies afana ne-glycine receptor, i-amphiphysin, kanye ne-DPPX (iphrotheni efana ne-dipeptidyl peptidase 6) atholakale ehlotshaniswa nalesi sifo. Futhi, ezinye iziguli kungenzeka zingenawo lawa ma-antibodies. Ucwaningo olwengeziwe luyaqhubeka ukuze kutholakale ukuthi yimaphi amanye ama-antibodies angase ahileleke.

Yiziphi izici eziyingozi ze-Stiff Person Syndrome (SPS)?

I-Stiff person syndrome ivame kabili kwabesifazane . Ingavela nakwezinye izimo zokuzivikela komzimba. Isibonelo:

• Isifo sikashukela sohlobo 1
• Isifo se-thyroid esizivikela ngokuzenzakalelayo
• I-Vitiligo
• I-anemia eyingozi
• Isifo se-Celiac

Ivame kangakanani i-Stiff Person Syndrome (SPS)?

Lesi yisimo esingavamile kakhulu . Kuthiwa umuntu oyedwa kuphela kwabayisigidi onalesi sifo. Lokho kusho ukuthi yisifo esingavamile kakhulu.

I-Stiff Person Syndrome (SPS) ihlolwa kanjani?

Udokotela uhlonza lesi sifo ngezimpawu ezithile, ukuhlolwa, kanye nokuhlolwa. Bazokubuza ngezimpawu zakho, benze ukuhlolwa ngokomzimba, futhi benze ukuhlolwa kwezinzwa.

Uma udokotela esola ukuthi une-Stiff Person Syndrome, angenza izivivinyo ezifana nalezi:

• Ukuhlolwa kwegazi le-antibody: Lokhu kusiza ukuhlola ukuba khona kwama-antibodies ku-(GAD) (noma amanye ama-antibodies ahlobene) nokususa ezinye izimo zezokwelapha.
• I-Electromyography (EMG): Lokhu kulinganisa ukusebenza kukagesi kwemisipha yakho. Lokhu kungasiza ekususeni ezinye izimbangela zezimpawu zakho.
• Ukubhoboza i-Lumbar (umpompi womgogodla): Kulesi sivivinyo, udokotela usebenzisa inaliti ukuthatha isampula yoketshezi oluvela emgogodleni wakho bese eluhlola ukuze athole ama-antibodies ku-GAD. Lokhu kubalulekile futhi ukuze kunqunywe ezinye izimo.

I-Stiff Person Syndrome ingaba nzima ukuyixilonga ngoba ayivamile futhi izimpawu zayo zingafana nezinye izifo ezizimele, njenge-ankylosing spondylitis kanye ne-multiple sclerosis.

Ingabe zikhona izinhlobo ze-Stiff Person Syndrome (SPS)?

Kunezinhlobo eziningana ezahlukene zalesi sifo:

• I-Classic stiff person syndrome: Lolu uhlobo oluvame kakhulu. Luvame ukuhlotshaniswa nama-antibodies e-GAD, kodwa ucwaningo luthole ukuthi namanye ama-antibodies nawo ahilelekile.
• Izinhlobo ze-Stiff person syndrome:Ngaphansi kwalokhu, kunezinhlobo ezithinta izingxenye ezithile zomzimba kuphela, noma ezibonisa izimpawu ezengeziwe njengokulahlekelwa ukuzithiba ngenkathi uhamba (`ataxia`).
• I-progressive encephalomyelitis enokuqina kanye ne-myoclonus (PERM): I-PERM iwuhlobo olubi kakhulu lwe-stiff person syndrome. Ingabangela ukulahlekelwa ukwazi, izinkinga zokunyakaza kwamehlo, i-ataxia, kanye nokungasebenzi kahle kwe-autonomic. Ukungasebenzi kahle kwe-autonomic kudinga ukulaliswa esibhedlela kubantu abane-PERM.

Iphathwa kanjani i-Stiff Person Syndrome (SPS)?

Kunezindlela ezimbili eziyinhloko zokwelapha lokhu:

• Imithi kanye nokwelashwa ukulawula izimpawu.
• Ukwelashwa nge-immunotherapy, noma ukwelashwa okuguqula izifo.

Izinketho zokwelapha ziyahlukahluka kuye ngezimpawu zakho. Umgomo oyinhloko wokwelashwa ukulawula indlela izimpawu zakho ezikuthinta ngayo nokuthuthukisa ukuhamba kwakho kanye nenduduzo.

Ithimba lakho lezokwelapha lingafaka ochwepheshe abaningana, njengalaba:

• Odokotela bezinzwa, ikakhulukazi odokotela bezifo zezinzwa.
• Abelaphi bezokwelapha emsebenzini kanye nabelaphi bezokwelapha ngokomzimba.
• Ochwepheshe bezokwelapha ngokomzimba kanye nokuvuselelwa.
• Abelaphi benkulumo.
• Ochwepheshe bezempilo yengqondo, isibonelo izazi zengqondo.

Imithi kanye nokwelashwa

Imithi efana nale ingasiza ekunciphiseni ukuqina kwemisipha, ukuqina, kanye nobuhlungu bemisipha:

• Ama-Benzodiazepine: Lawa ayizinhlobo zemithi esetshenziselwa ukwelapha izimo ezahlukahlukene, okuhlanganisa ukukhathazeka, isifo sokuwa, kanye nokungalali. Athinta isignali ye-neurotransmitter (GABA). Odokotela bavame ukunquma i-diazepam njengokwelashwa kokuqala kwe-Stiff Person Syndrome.
• Iziphumuli zemisipha: Imithi efana neBaclofen ingasiza ekuqineni kwemisipha. Iphumuza imisipha futhi inciphise ukuqina.
• Imithi yobuhlungu ye-neuropathic: Imithi efana ne -gabapentin ne -pregabalin nayo ithinta izimpawu ze-GABA futhi iyasiza ngezimpawu.

Ezinye izindlela zokwelapha ezingasiza ukulawula izimpawu zifaka:

• Ukwelashwa ngokomzimba noma ukwelashwa ngokomsebenzi.
• Ukuhlikihla.
• Ukwelashwa ngamanzi (i-hydrotherapy).
• Ukwelashwa ngokushisa.
• Ukwelashwa nge-acupuncture.

Ukwelashwa nge-immunotherapy

Kunobufakazi obuthile bokuthi ukwelashwa nge-intravenous immunoglobulin (IVIg) (futhi uhlobo lokwelashwa nge-immunotherapy) kungasiza ekunciphiseni izimpawu ze-Stiff Person Syndrome. I-IVIg iqukethe ama-immunoglobulin (ama-antibodies emvelo) anikelwa izinkulungwane zabantu abanezinhlelo zomzimba eziphilile.

Ingabe i-Stiff Person Syndrome (SPS) ingelapheka?

Okwamanje, ayikho ikhambi le- Stiff Person Syndrome. Ukwelashwa kungasiza kuphela ekulawuleni izimpawu.

Iyini inhloso ye-Stiff Person Syndrome (SPS)?

Lesi yisimo esihlala isikhathi eside (esingamahlalakhona) . Umbono uyahlukahluka kumuntu nomuntu kuye ngezici eziningana:

• Ubunzima bezimpawu.
• Isivinini salesi sifo sasakazeka.
• Iphumelela kangakanani le ndlela yokwelapha?

Kubalulekile ukuqala ukwelashwa ngokushesha nje lapho izimpawu ziqala. Lokhu kungasiza ekuvimbeleni noma ekunciphiseni ukusabalala kwalesi sifo futhi kusize ekuvimbeleni izinkinga zesikhathi eside. Nakuba abantu abaningi bethola impumuzo ngemithi, ngezinye izikhathi kungaba nzima ukulawula izinto ezibangela ukuqaqamba kwemisipha.

Ukuhamba kungaba nzima ngokuhamba kwesikhathi. Ikhono lokwenza imisebenzi yansuku zonke nalo lingancipha kancane kancane. Njengoba lesi sifo siqhubeka, ingozi yokuwa iyanda. Kungase kudingeke usebenzise udondolo, i-walker, noma ngisho nesihlalo sabakhubazekile.

Ingabe i-Stiff Person Syndrome (SPS) ingavinjelwa?

Ngenxa yokuthi lesi yisifo sokuzivikela komzimba, akukho ongakwenza ukusivimbela .

Ngingazinakekela kanjani uma ngine-Stiff Person Syndrome (SPS)?

Uma kungenzeka, zama ukuthola udokotela ogxile ekucwaningeni nasekuphatheni i-Stiff Person Syndrome. Lesi simo asivamile, ngakho-ke singaba nzima kancane. Uma ufuna ukuthola ukunakekelwa kwezokwelapha okungcono kakhulu futhi ube nempilo engcono kakhulu, kuzodingeka ukhulume futhi ube nentshisekelo ngaso.

Kuvamile ukuthi abantu abanalesi sifo babe nezinkinga zempilo yengqondo, njengokukhathazeka noma ukucindezeleka . Uma ubhekene nalezi zimpawu, kubalulekile ukukhuluma nodokotela wakho noma uchwepheshe wezempilo yengqondo, njengososayensi wengqondo.

Uma wena nomndeni wakho nikwazi, ningajoyina iqembu lokusekelana lapho ningahlangana khona nabanye abaqonda okuhlangenwe nakho kwenu.

Kufanele ngimbone nini udokotela?

Uma une-Stiff Person Syndrome, kufanele uhlangane nethimba lakho lezokwelapha njalo ukuze ubone ukuthi ukwelashwa kwakho kuphumelele yini futhi kuqaphe ukuthuthukiswa kwezimpawu zakho.

Uma ubona izimpawu ezintsha noma unemiphumela emibi evela emithini, tshela udokotela wakho.

Yimiphi imibuzo okufanele ngiyibuze udokotela wami?

Uma une-Stiff Person Syndrome, kungaba usizo ukubuza udokotela wakho le mibuzo:

• Yikuphi ukwelashwa okuncomayo ngezimpawu zami?
• Yini engingayenza ekhaya ukuze ngisize ngezimpawu zami?
• Yiziphi izimpawu zezinkinga okufanele ngiziqaphele?
• Ngingalindela ukuthi impilo yami ibe njani esikhathini esizayo?
• Ingabe kukhona ukuhlolwa kwemitholampilo kwe-Stiff Person Syndrome?

Okokugcina, izinto okufanele uzikhumbule (Umyalezo Wokuya Ekhaya)

Ukuthola ukuthi unesifo esingavamile njenge-Stiff Person Syndrome akulula. Ungase uzizwe ukhungathekile, ukhathazekile, futhi ungaqiniseki ngekusasa. Kodwa akudingeki ubhekane nalokhu wedwa. Ithimba lakho lezokwelapha lilapha ukuze liphendule noma yimiphi imibuzo ongase ube nayo futhi likusize ulawule izimpawu zakho.

Nakuba ukwelashwa kwakho kugxile empilweni yakho yomzimba, qaphela nempilo yakho yengqondo . Izimpawu ziyahlukahluka kumuntu nomuntu. Kodwa ukuphila nobuhlungu, ukungakhululeki, kanye nokuqina kwemisipha okungalindelekile kungayilimaza inhlalakahle yakho yengqondo. Lesi simo singenza kube nzima ukuphuma uyokwenza imisebenzi yansuku zonke. Ngakho-ke, uma udinga ukwesekwa, ungangabazi ukuxhumana nodokotela ngaphezu kwabathandekayo bakho. Khumbula, awuwedwa.

I- Stiff Person Syndrome, ukuqina kwemisipha, izifo zemizwa, i-autoimmune, ama-antibodies e-GAD, i-GABA, ukudikiza kwemisipha, izimpawu ze-SPS