Ingabe une-asthma enzima? Ingabe usahlaselwa njalo naphezu kokusebenzisa i-inhaler yakho neminye imithi? Ukhathele ukungalali kahle ebusuku futhi ungakwazi ukwenza ngisho nemisebenzi emincane? Yilabo kuphela abahlushwa yiyo abaziyo ukuthi kunzima kangakanani ukuphila ne-asthma enzima kangaka ukuyilawula. Kodwa ungesabi, ngokuthuthuka kwesayensi yezokwelapha, izindlela ezintsha zokwelapha sezifikile ukukusiza. Namuhla, sizokhuluma ngenye yezindlela ezintsha nezithuthukisiwe zokwelapha. Leyo yi-Tezspire.
Lo muthi obizwa ngokuthi iTezspire usebenza kanjani ngempela?
Kulungile, ake siqale siqonde kalula ukuthi kwenzekani emizimbeni yethu uma sine-asthma. I-asthma yisimo lapho imigudu yethu yomoya, noma amapayipi omoya, evuvukala, evuvukala, futhi ezwela khona. Uma into ethile engezwani nomzimba (isibonelo, uthuli, intuthu) ingena emzimbeni, le migudu yomoya iba mincane futhi kuba nzima ukuphefumula.
Ngokuvamile, sisebenzisa izinhlobo ezimbili eziyinhloko zemithi yokwelapha i-asthma. Eyokuqala imithi yokulawula . Le isetshenziswa nsuku zonke ukulawula i-asthma nokuvimbela ukuhlaselwa. Olunye uhlobo imithi yokusindisa . Le isetshenziselwa ukunciphisa ngokushesha izimpawu lapho kuvela ukuhlaselwa yi-asthma.
I -Tezspire iyimithi eyengeziwe emuthini wokulawula osuvele uwuthatha. Iyasiza ekuvimbeleni ukuhlaselwa yi-asthma, hhayi umuthi 'wokusindisa' okufanele uwuthathe uma unawo.
Kalula nje, i-Tezspire umuthi owenziwe ngohlobo oluthile lweprotheni. Ukuze kube sobala, lokhu kubizwa ngokuthi (i-monoclonal antibody) . Umzimba wethu unekhemikhali ebizwa ngokuthi (i-Thymic Stromal Lymphopoietin - TSLP) . Le TSLP iyona ebangela ukuvuvukala (ukuvuvukala) kanye nokuzwela okungadingekile emigudwini yomoya. Umuthi we-Tezspire uvimba isenzo saleyo khemikhali ebizwa ngokuthi i-TSLP. Uma i-TSLP ivinjiwe, ukuvuvukala nokuncipha kwemigudu yomoya kuyancishiswa futhi izimpawu ze-asthma zilawulwa kangcono.
Uthole kanjani ukuthi lo muthi usebenza kahle kangakanani?
Ngaphambi kokuba noma yimuphi umuthi omusha ufike emakethe, kwenziwa izifundo ezinkulu zezokwelapha ukuze kutholakale ukuthi uphephile yini ukusetshenziswa kubantu nokuthi uyasebenza ngempela yini. Izifundo ezimbili ezinkulu zenziwe ngeTezspire.
Abahlanganyeli kulolu cwaningo kwakungabantu abaneminyaka engu-12 nangaphezulu abane -asthma enzima . Okusho ukuthi, labo ababehlaselwa njalo yi-asthma okwakudingeka amaphilisi e-steroid noma ukulaliswa esibhedlela.
Ucwaningo luhlolisise izici eziningana:
- Ukwanda Kwesifo Sofuba: Sibheke ukuthi ukuhlaselwa yisifo sofuba kwehle kangakanani ngemva kokuthatha umuthi.
- Umsebenzi wamaphaphu : Ukuhlolwa okukhethekile kulinganisa inani lomoya ongakhishwa ngamandla ngomzuzwana owodwa. Lokhu kubizwa ngokuthi i-Forced Expiratory Volume ngomzuzwana owodwa - FEV1 .
- Ukulawulwa kwezimpawu: Kusetshenziswa uhlu lwemibuzo olukhethekile (`Umbuzo Wokulawulwa Kwesifuba 6` noma i-ACQ-6 ), iziguli nazo zahlolwa ukuze kubonwe ukuthi izimpawu zazo zilawulwa kahle kangakanani.
Lezi zifundo zazihlanganisa abantu abavela ezizweni nasezizindeni ezahlukene, kodwa abantu ababhemayo kanye nalabo abanezinye izifo zokuphefumula bakhishwe kulezi zifundo.
Iyini imiphumela yalolu cwaningo?
Abahlanganyeli ocwaningweni baqhubeka nokuphuza imithi yabo evamile yokulawula i-asthma (isib. ama-corticosteroids aphefumulayo ). Iqembu elilodwa lanikezwa umuthi wokugomela i-Tezspire, kanti elinye lanikwa i-placebo . I-placebo yinto ebukeka njengomuthi kodwa empeleni ayinawo umuthi osebenzayo. Isetshenziselwa ukukala ngokunembile imiphumela yomuthi wangempela.
Imiphumela ekupheleni kwamasonto angu-52, okungukuthi, unyaka, iyakhuthaza ngempela.
- Uma kuqhathaniswa neqembu le-placebo, labo abathola i-Tezspire babe nokwehla okungu-56% kuya ku-72% ekukhuphukeni kwe-asthma (ukuhlaselwa).
- Futhi, ukusebenza kwamaphaphu , okungukuthi, i-FEV1, kwanda ngamalitha angaba ngu-0.13 kulabo abathatha i-Tezspire.
- Ngokusho kwemibuzo ye-ACQ-6, ama-86% alabo abathatha i-Tezspire abike ukuthuthuka kwezimpawu zabo, uma kuqhathaniswa nama-77% eqenjini le-placebo.
Le miphumela ikhombisa ngokusobala ukuthi i-Tezspire iyindlela yokwelapha ephumelela kakhulu yokulawula i-asthma enzima. Kodwa khumbula ukuthi imiphumela yocwaningo ayifani kuwo wonke umuntu. Imiphumela yakho ingase ihluke.
Ungayithola kanjani i-Tezspire? Ungayisebenzisa kanjani?
Uma i-asthma yakho kunzima ukuyilawula futhi unesithakazelo ku-Tezspire, ungakhuluma nodokotela womndeni wakho noma udokotela wamaphaphu ngakho. Uma udokotela wakho enquma ukuthi lo muthi uyafaneleka esimweni sakho, uzokwenza amalungiselelo adingekayo ukuze uwuthole.
I-Tezspire iwumjovo ongaphansi kwesikhumba onikezwa njalo emavikini ama-4.Lokhu kuvame ukunikezwa ehhovisi likadokotela, emtholampilo, noma esibhedlela. Ngezinye izikhathi, udokotela wakho angase anqume ukuthi kuphephile futhi kufanelekile ukuthi uzinike umuthi wokugoma ekhaya. Uma kunjalo, udokotela wakho noma umhlengikazi oqeqeshiwe uzokufundisa ukuthi uwunikeza kanjani umuthi wokugoma ngendlela efanele.
Okubalulekile: Ungalokothi uyeke ukuthatha noma yimiphi imithi ye-asthma oyithathayo njengamanje, ikakhulukazi ama-steroid, ngaphandle kweseluleko sikadokotela wakho. I-Tezspire iwumuthi owengeziwe kuphela.
Imiphumela emibi nezinto okufanele uziqaphele
Njenganoma yimuphi umuthi, i-Tezspire ingabangela imiphumela emibi emincane futhi ngezinye izikhathi emibi kakhulu. Kubalulekile ukuqaphela lokhu.
| Umphumela/ingozi | Incazelo nezinyathelo okufanele zithathwe |
|---|---|
| Imiphumela emibi evamile | Umphimbo obuhlungu, ubuhlungu bamalunga, kanye nobuhlungu bomhlane. Lokhu ngokuvamile akukubi kangako. Kodwa uma ukhathazekile, tshela udokotela wakho. |
| Ukusabela kwendawo yomjovo | Ububomvu, ukuvuvukala, noma ubuhlungu bungase buvele endaweni yomjovo. Lokhu kungancishiswa ngokukhipha umjovo esiqandisini ihora ngaphambi komjovo bese uwufaka endaweni ehlukile isikhathi ngasinye. |
| Ukusabela Okubi Kakhulu Kokungezwani Nomzimba | Izimpawu ezinjengobunzima bokuphefumula, ukuvuvukala kobuso/izindebe, ukushaya kwenhliziyo okusheshayo, kanye nokuqubuka kungase kube khona. Lesi yisimo esiphuthumayo! Yeka ukuthatha umuthi ngokushesha bese uya eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela esiseduze. |
| Amathuba okutheleleka | Lokhu kungathinta amasosha omzimba, okwenza kube nzima ukulwa nezifo ezithile, ikakhulukazi izifo ze-helminth ezibangelwa amagciwane . Uma unegciwane elinjalo, kufanele lilashwe ngaphambi kokuqala i-Tezspire. |
| Imigomo | Ungatholi imijovo ephilayo enciphile ngenkathi uthatha lo muthi. Buza udokotela wakho ukuthi yimiphi imijovo okufanele uyithole ngaphambi kokuqala i-Tezspire. |
| Ingozi yesifo senhliziyo | Kokunye ukuhlola, abantu abasebenzisa i-Tezspire babenengozi ephezulu kancane yezehlakalo zenhliziyo, njengokuhlaselwa yinhliziyo kanye nohlangothi, uma kuqhathaniswa nalabo abasebenzisa i-placebo. Khuluma nodokotela wakho ngalokhu uma usengozini yesifo senhliziyo. |
| Ukukhulelwa nokuncelisa | Akukho datha eyanele okwamanje mayelana nokuphepha kokusebenzisa i-Tezspire ngesikhathi sokukhulelwa noma ukuncelisa. Uma uhlela ukukhulelwa, ukhulelwe, noma uncelisa, tshela udokotela wakho ngokushesha. |
Khumbula, i-Tezspire akuyona imithi 'yokuhlangula' ongayisebenzisa uma uhlaselwa yi-asthma. Ingumuthi osiza ukulawula i-asthma yakho isikhathi eside.
Ingabe kungaba nezinkinga ngeminye imithi?
Ngokusho kolwazi lwamanje, i-Tezspire ayibikwanga ukuthi ibangela ukuhlangana okukhulu neminye imithi. Kodwa-ke, kungcono ukutshela udokotela wakho ngayo yonke imithi, amavithamini, kanye nezithasiselo ozithathayo. Buza udokotela wakho njalo ngaphambi kokuqala noma yimuphi umuthi omusha.
Uma usola ukuthi uke waba nomphumela omubi ngalo muthi, noma ngabe awuqiniseki ngokuphelele ukuthi ubangelwa yiTezspire, ungawubika eNational Poisons Information Centre eColombo National Hospital . Lolu lwazi luzoba lubaluleke kakhulu ekuqoqeni ulwazi olwengeziwe ngalo muthi esikhathini esizayo.
Umlayezo Wokuya Nawe Ekhaya
- I-Tezspire iyindlela yokwelapha eyengeziwe ye -asthma enzima kubantu abadala abaneminyaka engaphezu kwengu-12 ubudala abangalawulwa yimithi yokwelapha yamanje.
- Lona umuthi wokugomela onikezwa njalo emavikini ama-4 futhi usiza ekuvimbeleni ukuhlaselwa yi-asthma, hhayi umuthi 'wokuhlenga' osetshenziswa ezimweni eziphuthumayo.
- Ngaphambi kokuqala lokhu kwelashwa, xoxa ngokucophelela ngezinzuzo nezinkinga zako nodokotela wakho.
- Gwema ukuyeka noma yimiphi imithi ye-asthma oyithathayo njengamanje ngaphandle kweseluleko sikadokotela.
- Uma uhlangabezana nezimpawu ezinkulu zokungezwani komzimba njengobunzima bokuphefumula kanye nokuvuvukala kobuso, hamba ngokushesha eMnyangweni Wezimo Eziphuthumayo (ETU) .
- Yazisa udokotela wakho nganoma yimiphi imiphumela emibi noma izinkinga ohlangabezana nazo.
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