Ne ame aɖe le wò ƒomea me si Alzheimer Dɔléle le fu ɖem na, eɖanye dawò, fofowò, mamawò, alo nyruiwò o, ɖewohĩ ènya be vivivi la , woŋlɔa nuwo be. Emae nye dɔléle sia ƒe dzesi vevitɔ. Gake, tsɔ kpe ɖe woƒe ŋkuɖoɖonudzi ƒe bublu ŋu la, ɖewohĩ ède dzesi tɔtrɔ gãwo le woƒe nuwɔna me. Ɣeaɖewoɣi la, wotsia dzimaɖi, wodoa dziku, léa blanui, alo ɖeko wonɔa tsatsam le zã me alɔ̃ manɔmee. Ne èkpɔ nusiawo la, ele be nàlé blanui ŋutɔ hã. Egbea míele nu ƒom tso atikewɔwɔ bubuwo, alo ``Adjunct Treatments``, siwo wonana na nuwɔna kple susu me kuxi siwo dzɔna tsɔ kpe ɖe ŋkuɖoɖonudzi ƒe bublu le Alzheimer dɔlélea me ŋu.
Kpuie ko la, ne Alzheimer ƒe dɔlélea gblẽ nu le ahɔhɔ̃meka siwo le ahɔhɔ̃a me ŋu la, menye ŋkuɖoɖonudzi koe wògblẽa nu le o, ke egblẽa nu le akpa siwo kpɔa ŋusẽ ɖe míaƒe nuwɔna dzi hã dzi. Esia tae kuxi siawo doa mo ɖa ɖo.
- Zitɔtɔ
- Aglãdzedze
- Dzimaɖitsitsi
- Delusions (nu siwo meli o dzi xɔxɔ se) .
- Teteɖeanyi
- Nusiwo womekpɔna o kpɔkpɔ alo nusiwo womekpɔna o sese (Hallucinations) .
- Alɔ̃ madɔmadɔ
- Dzimaɖitsitsi
Dzesi siawo ate ŋu anye nuteɖeamedzi na dɔnɔa kple wò, dɔnɔdzikpɔla la ŋutɔ. Zi geɖe la, ɖɔktawo ɖoa aɖaŋu be nàdze agbagba gbã atsɔ agbenɔnɔ ƒe tɔtrɔ kple nuwɔna ƒe atikewɔwɔ akpɔ dzesi siawo gbɔ hafi nàzã atikewo. Ele be nànya hã gbã nenye be nu bubu aɖe li si gbɔ nuwɔna ƒe tɔtrɔwo tso (le kpɔɖeŋu me, dɔlékui aɖe, ŋku alo tosese ƒe kuxi, alo atike bubu ƒe nugbegblẽ le ame ŋu).
Gake ɣeaɖewoɣi la, atikewo zazãe nyea tiatia nyuitɔ kekeake. Atike geɖe siwo ŋu míele nu ƒom tsoe le afisia la, womeda asi ɖe wo dzi koŋ na Alzheimer ƒe dɔlélea o. Ðɔktawo ŋlɔa esiawo na "off-label." Eyae nye be wonaa atike si dzi woda asi ɖo na dɔléle bubu (abe blanuiléle ene) elabena ɖɔktaa ƒe nuteƒekpɔkpɔ ɖee fia be ate ŋu asɔ na Alzheimer-dɔléla ƒe nuwɔna me kuxiwo hã.
Dɔwɔnu siwo kpena ɖe ame ŋu le alɔ̃dɔdɔ me
Alɔ̃dɔdɔ ƒe kuxiwo nɔa ame geɖe ŋu ne wole tsitsim.Edzɔna. Gake ebɔ wu le Alzheimer-dɔlélawo dome. Le ahɔhɔ̃ ƒe tɔtrɔ ta la, wofɔna enuenu le zã me eye ɖeɖi tea wo ŋu le ŋkeke me.
Nu vevitɔe nye be nàdze agbagba adɔ alɔ̃ atike manɔmee, tsɔ wu be nàzã alɔ̃dɔdɔtikewo. Elabena alɔ̃dɔtike siwo wonana Alzheimer-dɔlélawo ate ŋu anye afɔku ɣeaɖewoɣi.
Ne agbenɔnɔ ƒe tɔtrɔ mekpena ɖe ŋuwò be nàdɔ alɔ̃ o, eye ŋudzɔnɔnɔ le zã me ɖea fu na wò ŋutɔ ko hafi wò ɖɔkta neŋlɔ atike aɖe abe esia ene na wò:
- Suvorexant (Belsomra): Esia koe nye atike si dzi United States ƒe FDA da asi ɖo na alɔ̃dɔdɔ ƒe kuxi siwo do ƒome kple Alzheimer ƒe dɔlélea. Enɔ atikewo ƒe hatsotso aɖe si woyɔna be ``Orexin inhibitors.'' Kpuie ko la, ewɔa dɔ to mɔxexe ɖe atike aɖe si le míaƒe ahɔhɔ̃ me si fia be "ɣeyiɣia de be míanyɔ." Gake atike sia ate ŋu ahe nugbegblẽ le ame ŋu abe alɔ̃dɔdɔ, blanuiléle, kple alɔ̃dɔdɔ le ŋkeke me ene vɛ.
- Atike Bubu siwo naa ame ƒe dzi dzea eme: Wò ɖɔkta ate ŋu aŋlɔ alɔ̃dɔdɔ ƒe atike bubuwo na wò, abe `Eszopiclone (Lunesta)` alo `Zolpidem (Ambien).` Gake esiawo nono ate ŋu ana nàwɔ nu siwo mebɔ o ne èle alɔ̃ dɔm (abe nuɖuɖu alo ʋukuku le alɔ̃ me ene). Woate ŋu ana ŋkeke me tɔtɔ, ŋkuɖoɖonudzi ƒe kuxi, kple afɔku si le eme be màda asɔ o eye nàdze anyi hã nadzi ɖe edzi.
Vevietɔ ŋutɔ: Ɣeyiɣi kpuitɔ kekeake si woate ŋu azã koe wòle be woazã alɔ̃dɔdɔtikewo . Woate ŋu ana nàtɔtɔ eye nàdɔ alɔ̃ bɔbɔe. Ne wò alɔ̃dɔdɔ gaɖo nɔnɔme si sɔ me ko la, ele be nàƒo nu kple wò ɖɔkta eye nàdze agbagba adzudzɔ wo nono.
Azɔ hã, alɔ̃dɔdɔtike aɖewo (siwo me atike siwo wua alɔ̃madɔmadɔ le, e.g. diphenhydramine) siwo nàte ŋu aƒle le atikedzraƒewo le atikedzraƒewo mesɔ na Alzheimer-dɔlélawo kura o . Woate ŋu ado kplamatse kadodo si le ahɔhɔ̃meka siwo le ahɔhɔ̃a me dome, si ana ŋkuɖoɖonudzi kple tamebubu ƒe ŋutetewo nagblẽ ɖe edzi.
Blanuilélenutsitikewo & Atike siwo tsia dzimaɖitsitsi nu
Blanuiléle bɔ ɖe Alzheimer-dɔlélea hã me ŋutɔ. Be dɔnɔa ƒe seselelãme nanyo ɖe edzi la, ɖɔkta ate ŋu aŋlɔ blanuilélenutsitikewo nɛ. Menye blanuiléle koe atike siawo ate ŋu akpe ɖe ame ŋu o, ke woate ŋu akpe ɖe ame ŋu le dzimaɖitsitsi, alɔ̃dɔdɔ ƒe kuxiwo, dzitsitsi, kple susumenuwo hã me.
| Atike ƒomevi aɖe | Kpɔɖeŋuwo |
|---|---|
| SSRI (Serotonin Gbugbɔgaxɔ Mɔxenu Tiatia) . (Atike siwo wozãna zi geɖe, siwo me afɔku mele o) . | Dɔlékuiwutike (Celexa), Sertraline (Zoloft), Dɔlékuiwutike (Lexapro) . |
| SNRI (Serotonin-Noradrenaline ƒe Gbugbɔgaxɔ Mɔxenu) . | Venlafaxine (Effexor), Duloxetine (Cymbalta) ƒe atike . |
| Blanuilélenutsitike Siwo Mebɔ O | Mirtazapine (Remeron), Trazodone (Desyrel) ƒe atike . |
Nuxlɔ̃ame: Womekafu blanuilélenutsitike xoxowo, abe blanuilélenutsitike siwo wozãna zi etɔ̃ (e.g., amitriptyline) kple SSRIwo abe paroxetine (Paxil) ene na amesiwo ŋu Alzheimer ƒe dɔlélea le o. Woate ŋu agblẽ nu le ŋkuɖoɖonudzi kple tamebubu ŋutete ŋu geɖe wu.
Ɣeaɖewoɣi la, ɖɔktawo ŋlɔa atike siwo wozãna ɣeyiɣi kpui aɖe si woyɔna be benzodiazepines (e.g., Lorazepam (Ativan), Diazepam (Valium)) tsɔ daa dzimaɖitsitsi, dzimaɖitsitsi, kple adãwɔwɔ. Gake esiawo hã ate ŋu ana ame nadɔ alɔ̃, atɔtɔ, ame natɔtɔ, eye wòate ŋu adze anyi.
Tagbɔdɔlékuiwutikewo (atike siwo wozãna na dzimaɖitsitsi sesẽwo kple susu me kuxiwo) .
Nuwɔna me kuxi aɖewo siwo doa mo ɖa le Alzheimer ƒe dɔlélea ŋu ate ŋu anye afɔku na dɔnɔa alo wo dzikpɔlawo. Le kpɔɖeŋu me, adãwɔwɔ si gbɔ eme, agbagbadzedze be yeawɔ nuvevi yewo ɖokui alo ame bubuwo, kple nusiwo mele afima o kpɔkpɔ alo sese. Le nɔnɔme mawo me la, woate ŋu azã tagbɔdɔlékuiwutikewo abe mɔnu mamlɛtɔ ene, ne mɔnu bubu aɖeke meli o .
Ele be woazã atike siawo kple ŋuɖɔɖɔɖo vevie, le ɖɔkta ƒe dzikpɔkpɔ te. Esi wònye be afɔkuawo ate ŋu asɔ gbɔ wu viɖe siwo le eme ta la, eŋutinunyalawo kafui be ne tiatia bubu aɖeke mewɔ dɔ o ko hafi nàzã wo.
Hafi woadze atike sia zazã gɔme la, .
- Nɔnɔme si me tomefafa le wɔwɔ
- Nuwɔna aɖe si wowɔna edziedzi ƒe numame
- Kamedede ƒe gomekpɔkpɔ le eme
Ele be nàte nu mawo tɔgbe kpɔ godoo.
Wozãa tagbɔdɔlékuiwutikewo (e.g., `Risperidone (Risperdal)`, `Quetiapine (Seroquel)`, `Olanzapine (Zyprexa)`) tsɔ:
- Ne dɔnɔa le nɔnɔme si me wòate ŋu ade eɖokui alo ame bubuwo afɔku me.
- Ne nuwɔna ƒe kuxia na be womate ŋu ana atikewɔwɔ si hiã o.
- Ne tagbɔdɔ bubu aɖe le ŋuwò (e.g. tagbɔdɔléle ) tsɔ kpe ɖe Alzheimer ƒe dɔlélea ŋu.
Le atike siawo meAfɔku gã aɖe le eme. Eyae nye be enaa ʋusɔgbɔdɔ kple ku ƒe afɔkua dzina ɖe edzi le dɔnɔ tsitsi siwo ŋu Alzheimer-dɔlélea le me. Tsɔ kpe ɖe eŋu la, wonaa alɔ̃dɔdɔ sesẽe eye wodzia anyidzedze ƒe afɔkua ɖe edzi. Tsɔ kpe ɖe eŋu la, wo dometɔ aɖewo ate ŋu atsi atike siwo nana ŋkuɖoɖonudzi kple tamebubu nyona ɖe edzi le Alzheimer-dɔlélea me ƒe dɔwɔwɔ nu, si ana atike mawo ƒe viɖe dzi naɖe akpɔtɔ.
Atikewɔwɔ bubu siwo woatsɔ akpe ɖe eŋu
Tsɔ kpe ɖe atike siwo míeyɔ ɖe etame ŋu la, wozãa atike bubuwo ɣeaɖewoɣi "off-label".
- Atike siwo tsia ʋuʋudedi nu: Wozãa atike siwo wua asrãdɔ abe Carbamazepine kple Gabapentin ene ɣeaɖewoɣi tsɔ léa tɔtɔ nu le Alzheimer dɔnɔwo ŋu.
- Atike siwo tsia Parkinson ƒe dɔléle nu: Wole nu srɔ̃m tso atike aɖewo siwo wozãna tsɔ daa Parkinson ƒe dɔlélea ŋu be woakpɔe ɖa be woate ŋu akpe ɖe Alzheimer ƒe dzesiwo hã ŋu hã.
Gbedasi si Wotsɔ Yi Aƒeme
- Menye ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie koe Alzheimer dɔlélea ku ɖo o. Nuwɔna kple susu me kuxi siwo dona tso eme hã nye dɔlélea ƒe akpa aɖe.
- Hafi nàzã atikewo atsɔ akpɔ kuxi siawo gbɔ la, kpɔ egbɔ be yete mɔnu siwo menye atike muamewo zazã o abe nɔnɔme si me tomefafa le, gbesiagbenuwɔna me léle ɖe asi, kple nuƒoƒo lɔlɔ̃tɔe kple dɔmenyonyo ene kpɔ .
- Atike siwo katã kloe míeyɔ le nyati sia me la ƒe nugbegblẽ le ame ŋu vevie eye afɔku le wo me. Mele be woadze wo gɔme alo adzudzɔ wo gbeɖe ɖɔkta ƒe aɖaŋuɖoɖo manɔmee o.
- Ne ède dzesii be dɔnɔa ƒe nuwɔna trɔ kpata la, ŋutilã me nu bubu aɖe ate ŋu anɔ anyi (e.g., aɖuɖɔtoedɔléle). Eyata, kpɔ wò ɖɔkta gbã eye nàdzro eme.
- Wò lɔlɔ̃tɔa dzi kpɔkpɔ nye dɔ si bia nu geɖe le susu me. Eyata, lé be na wò susu ƒe lãmesẽ hã. Mègahe ɖe megbe le kpekpeɖeŋu biabia me ne èhiãe o.
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