Mí katã míese nya "mRNA" geɖe kple COVID-19 dɔvɔ̃a, alo? Gake le ɣeyiɣi ma ke me la, nyabiasewo le ame geɖe si ku ɖe esia ŋu, eye vɔvɔ̃ vi aɖe gɔ̃ hã. "Nu yeye aɖee esia nyea?", "Nukae esia awɔ na míaƒe ŋutilã?" Ðewohĩ èbia ɖokuiwò be. Eyata egbea, mina míaƒo nu tso nusi mRNA ƒe atike sia nye kple alesi wòwɔa dɔ ŋutɔŋutɔ le míaƒe ŋutilã me ŋu le mɔ bɔbɔe ŋutɔ nu.
Mina míakpɔe ɖa gbã be, nukae nye mRNA sia?
mRNA ƒe ŋkɔ bliboae nye dɔla Ribonucleic Acid. Togbɔ be ŋkɔa sesẽ vie hã la, dɔa le bɔbɔe ŋutɔ. Bu DNA si le míaƒe ŋutilã me be enye nuɖaɖa ŋuti mɔfiamegbalẽ gã aɖe. Mɔfiame siwo ku ɖe protein siwo katã míaƒe ŋutilã hiã la wɔwɔ ŋu le agbalẽ sia me. Gake màte ŋu atsɔ agbalẽ gã blibo sia ayi nuɖaƒe o (si fia be nàtsɔ ayi ribosome siwo le míaƒe lãmenugbagbeviwo me siwo wɔa proteinwo gbɔ).
Afi siae ‘dɔla’ si woyɔna be mRNA la va le.Nusi wòwɔna enye be eŋlɔa protein si wòle be wòawɔ tso DNA gbalẽ gã ma me ƒe nuɖaɖa ɖe pepa dzi, eye wòtsɔa gbedasi ma yia nuɖaƒe. Kpuie ko la, mRNA le abe gbedasi kpui aɖe si wɔa mɔfiame siwo le DNA me ƒe kɔpi heɖoa wo ɖe teƒe si wowɔa protein la le ene. Esia nye nusi dzɔna le dzɔdzɔme nu le míaƒe ŋutilã me ɣesiaɣi.
Eyata nukae dzɔna ɖe mRNA ƒe atikewɔmɔnu dzi?
Abe atikewɔmɔnuwo katã ene la, mRNA-tike naa hehe míaƒe ŋutilã ƒe dɔlélenutsiŋutete be wòawɔ avu kple dɔléle aɖe. Gake ale si wòwɔnɛ la to vovo vie.
Tsɔ mRNA ƒe atike na COVID-19 abe kpɔɖeŋu ene. Nusi atike sia wɔna enye be mɔfiame (mRNA gbedasi) siwo hiã be woatsɔ awɔ ‘Spike Protein’, si nye SARS-CoV-2 dɔlékui si hea COVID-19 vɛ ƒe akpa aɖe la ko naa míaƒe lãmenugbagbeviwo.
Vevietɔ wu la, dɔlékui bliboa mele atike sia me o, eye dɔlékuia ƒe akpa gbagbe alo kuku aɖeke hã mele eme o . ‘Nuɖaɖa’ si woatsɔ awɔ dɔlékuia ƒe akpa ɖeka koe le eme.
Ne míaƒe lãmenugbagbeviwo xɔ mɔfiame sia la, wowɔa ‘ŋù protein’ sia ƒe ɖe. Ne míaƒe dɔlélenutsiŋutete kpɔ protein yeye sia si wowɔ la, egblɔna be, "Oo... esia nye amedzidzela si menye míaƒe ŋutilã tɔ o." Emegbe, edzrana ɖo be yeawɔ aʋawɔnuwo, abe dɔlékuiwutikewo ene, atsɔ awɔ avu kplii.
Esi wona hehe mí le mɔ sia nu do ŋgɔ ta la, ne COVID-19 dɔlékui ŋutɔŋutɔ ge ɖe ŋutilã me emegbe la, míaƒe dɔlélenutsiŋutete akpɔe adze sii ne ekpɔe ko, adze edzi kaba ŋutɔ eye wòawɔ dɔ nyuie, eye wòakpɔ mía ta be míagadze dɔ sesẽ o.
mRNA gbedasi si tso atikewɔmɔnua me gblẽna, gblẽna, eye wòbuna le ŋkeke ʋɛ aɖewo megbe le ŋutilãa me. Abe nuɖaɖagbalẽ si míetsɔna yia nuɖaƒe eye míegblẽnɛ ne míewu enu ene. Mewɔa ɖeka kple míaƒe DNA alo trɔa míaƒe domenyiŋusẽfianu gbeɖe o.
Vovototo kae le mRNA ƒe atikewo kple atikewɔmɔnu xoxowo dome?
Vovototo vevitɔe nye alesi dɔlékuia tsɔna yia dɔlélenutsiŋutete gbɔe. Kpɔ kplɔ̃ si le ete hena nyatakaka bubuwo.
| mRNA ƒe Atikewɔmɔnuwo | Atikewɔmɔnu siwo wozãna le kɔnu nu |
|---|---|
| Wotsɔa mɔfiame (mRNA) siwo hiã be wòawɔ dɔlékuia ƒe akpa aɖe la naa ŋutilãa. | Wotsɔa dɔlékui siwo mewɔa dɔ o ("wowu") , dɔlékui siwo gbɔdzɔ , alo dɔlékui la ŋutɔ ƒe protein kakɛwo naa ŋutilãa. |
| Dɔlékuia ƒe akpa aɖeke mele atike si wotsɔna tsia dɔlékuiwutikea me la me o. | Dɔlékui la ƒe akpa aɖe ƒomevi le atikewɔmɔnua me. |
| Kpɔɖeŋuwo: Pfizer-BioNTech (Comirnaty®), Moderna (Spikevax®) COVID-19 ƒe atikewo. | Kpɔɖeŋuwo: Novavax® COVID-19 ƒe atike (si nye protein subunit vaccine), aɖitsi ƒe atike (attenuated virus). |
Nukae dzɔna ne wodo atike na wò?
Ðɔkta alo dɔnɔdzikpɔla atsɔ aha akɔ wò abɔ tame eye wòana atike si wodo na wò. Emegbe, woabia tso asiwò be nàlala abe miniti 15 ene. Esia nye be woatsɔ akpɔe ɖa be nulɔdɔ le atike si wodo nɛ ŋu enumake hã. Ame aɖewo sena le wo ɖokui me be yewogbɔdzɔ le atikeawo dodo me, eyata anyo wu be woanɔ anyi.
Viɖe kple afɔku kawoe le mRNA ƒe atikewɔmɔnuwo ŋu?
Viɖe siwo le eŋu
Viɖe gãtɔ kekeake siwo le mRNA mɔ̃ɖaŋununya ŋu dometɔ ɖekae nye duƒuƒu . Atikewɔmɔnu siwo wozãna tsã bia be woade dɔlékuia le nudokpɔƒe. Ema ate ŋu axɔ ɣleti geɖe, ƒe geɖe gɔ̃ hã. Gake mRNA-tikewo mehiã nenema o, eyata woate ŋu awɔ wo kaba ŋutɔ, ne dɔvɔ̃ yeye aɖe do mo ɖa gɔ̃ hã.
Ne míeƒo nu tso COVID-19 ƒe atikewɔmɔnuwo ŋu la, atikewɔmɔnu xɔxɔ, .
- Eɖea COVID-19 dɔlékuiwo xɔxɔ ƒe afɔkua dzi kpɔtɔna.
- Ne exɔ dɔa gɔ̃ hã la, afɔku si le dɔléle sesẽwo, kɔdziyiyi, kple ku me dzi ɖena kpɔtɔna ŋutɔ.
- Eɖea afɔku si ate ŋu agblẽ nu le ame ŋu ɣeyiɣi didi (Long COVID) le COVID-19 xɔxɔ vɔ megbe dzi kpɔtɔna.
Afɔkuwo Kple Eƒe Nugbegblẽ le ame ŋu
Abe atike ɖesiaɖe ene la, mRNA ƒe atikewo ate ŋu agblẽ nu suesuesuewo. Le nyateƒe me la, esiawo nye dzesi be wò dɔlélenutsiŋutete le dɔ wɔm.
Nusiwo dona tso eme zi geɖe:
- Vevesese alo vuvu le afisi wodoe ɖo
- Ɖeɖiteameŋu
- Taɖuame
- Lãmetsiwo ƒe vevesese
- Asrã si nu mesẽ o
Zi geɖe la, dzesi siawo nu yina keŋkeŋ le ŋkeke ɖeka alo eve me.
Nulɔdɔ siwo mebɔ o gake wosẽa ŋu:
Ƒã ŋutɔ la, ame aɖe ate ŋu awɔ nulɔdɔ le nane si le atike si wozãna tsɔ doa atike me ŋu. Dzesiawo dometɔ aɖewoe nye:
- Ŋutilã ƒe ʋuʋudedi alo ʋuʋudedi
- Ʋuʋudedi
- Mo, nuyi, aɖe, alo ŋɔti ƒe vuvu (Anaphylaxis) .
Ne èkpɔ nulɔdɔ ƒe dzesi sesẽwo abe gbɔgbɔ sesẽ, mo alo ŋɔti ƒe vuvu ene la, yi kɔdzi si te ɖe ŋuwò ƒe Dɔwɔƒe si Kpɔa Nudzɔdzɔ Kpatawo Gbɔ (ETU) enumake.
Ðe mɔ̃ɖaŋununya sia nye nu yeye ŋutɔŋutɔa?
Ao, wole numekuku wɔm tso mRNA mɔ̃ɖaŋununya ŋu tso ƒe 1970-awo me ke. Ƒe 1990-awo me hafi wodze numekuku gɔme tso mɔ̃ɖaŋununya sia zazã atsɔ awɔ atikewɔmɔnuwo ŋu. Exɔ ƒe 20 kple edzivɔ hafi dzɔdzɔmeŋutinunyalawo va kpɔ alesi woawɔ ana mRNA sia nage ɖe lãmenugbagbeviwo me evɔ míaƒe dɔlélenutsiŋutete magblẽe o.
Wonɔ mɔ̃ɖaŋununya sia zãm dzidzedzetɔe na atike (Patisiran) si daa ahɔhɔ̃medɔléle si mebɔ o do ŋgɔ na COVID-19 dɔvɔ̃a gɔ̃ hã. Esi COVID-19 dɔvɔ̃a dze edzi la, dzɔdzɔmeŋutinunyalawo te ŋu zã sidzedze si wokpɔ tso numekuku ƒe bla nanewo me tsɔ to atikewɔmɔnu siwo le dedie, siwo wɔa dɔ nyuie vɛ kabakaba wu tsã.
Enye nusi sɔ be nàvɔ̃ vie ahake ɖi le nu yeyewo ŋu. Gake mRNA nye ŋgɔyiyi gã aɖe le atikewɔwɔ ŋuti dzɔdzɔmeŋutinunya me, si ŋu wowɔ numekuku le heto vɛ le ƒe bla nanewo me. Dɔla molecule sue sia ate ŋu akpe ɖe mía ŋu míada dɔléle bubu geɖewo, abe kansa ene, le etsɔme.
Gbedasi si Wotsɔ Yi Aƒeme
- Dɔlékuia mele mRNA-dɔlékuiwutikewo me o , eɖanye agbagbee alo kuku o. Mɔfiame siwo nye be woawɔ dɔlékuia ƒe akpa ɖeka koe le wo me.
- Atike siawo metrɔa wò DNA o . Woɖea mRNA gbedasi si le atikewɔmɔnua me ɖa le ŋutilãa me le ŋkeke ʋɛ aɖewo megbe.
- Esia nye be nàna hehe wò dɔlélenutsiŋutete do ŋgɔ be wòawɔ avu kple dɔléle aɖe.
- Zi geɖe la, eƒe nugbegblẽ le ame ŋu nu mesẽna o eye wòdzona le ŋkeke ʋɛ aɖewo megbe, si fia be wò dɔlélenutsiŋutete le dɔ wɔm.
- Esia nye mɔ̃ɖaŋununya si le dedie eye wòwɔa dɔ nyuie si ŋu wowɔ numekuku le ƒe bla nanewoe nye sia.
- Ne nya aɖe le ŋuwò alo nya aɖe le ŋuwò la, ƒo nu tso eŋu na wò ɖɔkta .
💬 Comments (0)
Womeɖo nya aɖeke ɖe amewo haɖe o. Tsɔ wò nyaŋuɖoɖo kpe ɖe afisia zi gbãtɔ.
Tsɔ wò nyaŋuɖoɖo kpee