ʻIke wau he paʻakikī ke hoʻopuka i nā huaʻōlelo i kou manaʻo ke haʻi aku kāu kauka iā ʻoe he maʻi ʻaʻai umauma kou. He mea maʻamau ka nui o nā nīnau a me nā makaʻu e hiki mai ana i kou noʻonoʻo. Akā ʻo kekahi o nā mea nui e hiki ke kōkua iā ʻoe ma o kēia huakaʻi paʻakikī, ʻo ia ka hoʻomaopopo ʻana i ke ʻano pololei o kou maʻi ʻaʻai. ʻO ka ʻike ʻana i ke kahua o ke maʻi ʻaʻai, kona ʻano, kona nui, a me kekahi o nā protein i loko o kāu mau hunaola maʻi ʻaʻai he mea nui loa ia i ka hoʻoholo ʻana i ka lāʻau lapaʻau.
I ka ʻōlelo maʻalahi, he aha ka HER2-Negative?
E hoʻomaopopo kākou i kēia ma kēia ʻano. Ua like nā pūnaewele i loko o ko kākou kino me nā hale liʻiliʻi. Loaʻa i kēia mau hale nā 'antennas' kūikawā e loaʻa ai nā leka mai waho. I ka lāʻau lapaʻau, kapa mākou i kēia mau mea loaʻa. Mai kēia mau antennas e loaʻa ai i kahi pūnaewele nā leka e like me 'e ulu' a me 'e māhele'.
ʻO HER2 (Human Epidermal Growth Factor Receptor 2) kekahi o ia mau antenna kūikawā. Kōkua ʻo HER2 i ka hoʻomalu ʻana i ka ulu ʻana o nā cell olakino. Eia nō naʻe, hana nui nā cell kanesa i kēia antenna HER2 i kekahi manawa, ʻoi aku ka nui ma mua o ka maʻamau. A laila loaʻa i ka maʻi kanesa kahi leka mau e haʻi ana iā ia e 'ulu', a hoʻomaka ka maʻi kanesa e pālahalaha koke. Kāhea mākou i kēia kūlana he HER2-Positive .
No laila, inā ʻōlelo kāu kauka he HER2-negative kou maʻi ʻaʻai umauma , ʻo ia hoʻi, ʻaʻole i loaʻa i kāu mau hunaola maʻi kēia antenna HER2 keu. I ka ʻōlelo maʻalahi, ʻaʻohe kumu nui o kāu maʻi ʻaʻai e hoʻonui wikiwiki ai i kona ulu ʻana.
He nūhou maikaʻi kēia ma kekahi ʻano, no ka mea, ʻoi aku ka liʻiliʻi o ka ikaika o nā maʻi kanesa HER2-negative ma mua o nā maʻi kanesa HER2-positive. ʻO ka hapa nui o nā maʻi kanesa umauma ma ka honua ua hoʻokaʻawale ʻia he HER2-negative.
Pehea ʻoe e ʻike pono ai i ke kūlana HER2 o kou maʻi kanesa?
Ua like nā hōʻailona o nā maʻi kanesa HER2-negative a me HER2-positive. ʻAʻole hiki i kāu kauka ke haʻi iā ʻoe i ke ʻano āu i loaʻa ai ma ka nānā wale ʻana iā ʻoe. Pono ʻo ia e lawe i kahi laʻana liʻiliʻi o kāu puʻupuʻu (biopsy) a hoʻāʻo ʻia. E hoʻoholo pono kēia hoʻāʻo i ka nui o ka protein HER2 i loko o nā hunaola kanesa.
Pono kākou e nānā aku ma mua o HER2 wale nō!
ʻAʻole ʻo HER2 wale nō ke kumu e hoʻopilikia ai i ka ulu ʻana o ka maʻi kanesa. Aia ʻelua ʻano ʻē aʻe o nā mea loaʻa (nā mea loaʻa hormone - HR) i loko o ko kākou kino i maʻalahi i nā hormones.
- Nā Mea Loaʻa Estrogen (ER)
- Nā Mea Loaʻa Progesterone (PR)
Inā loaʻa kēia mau mea loaʻa ma nā hunaola kanesa, hiki i nā hormones estrogen a me progesterone ke kōkua i ka ulu ʻana o ke kanesa. Kamaʻilio pū nā kauka e pili ana i kēia mau mea loaʻa āpau. ʻO ia hoʻi, hiki ke hoʻokaʻawale hou ʻia kāu kanesa HER2-negative i ʻelua ʻano:
1. HR-Positive / HER2-Negative: ʻO ke ʻano kēia, ʻaʻole pili ka maʻi kanesa i ka HER2, akā pili i nā hormones. ʻO kēia ke ʻano maʻamau o ka maʻi kanesa o ka umauma.
2. HR-Negative / HER2-Negative: ʻO ke ʻano kēia, ʻaʻole i pili ka maʻi kanesa i ka HER2 a i ʻole nā hormones. No ka mea, ua nalowale kēia mau mea loaʻa ʻekolu (HER2, ER, PR), ua kapa ʻia kēia ʻano he Triple Negative .
ʻO ka ʻike ʻana i kēia mau mea āpau e kōkua iā ʻoe a me kāu kauka e loaʻa i kahi kiʻi maopopo o ke ʻano olaola o kou maʻi ʻaʻai, nāna e kōkua iā ʻoe e koho i ke koho lapaʻau kūpono a maikaʻi loa nāu.
He aha nā lāʻau lapaʻau no ka maʻi kanesa HER2-maikaʻi ʻole?
No ka mea he HER2-negative kou maʻi kanesa, ʻaʻole e hāʻawi ʻia iā ʻoe ka lāʻau lapaʻau i kuhikuhi ʻia, kahi e kuhikuhi ana i ka protein HER2. ʻO ia no ka mea pono i nā lāʻau lapaʻau ke loaʻa ka antenna HER2 ma nā hunaola kanesa e hana. Akā, e koho ʻia nā lāʻau lapaʻau ʻē aʻe ma muli o ke kahua o kou maʻi kanesa a inā he maʻalahi ia i nā hormones.
- ʻO ke ʻoki kino a me ka radiation: Inā ʻike mua ʻia ke kanesa, hiki i ke ʻoki kino ke hoʻopau loa iā ia. Hiki ke ʻōlelo ʻia ka radiation therapy ma mua a ma hope paha o ke ʻoki kino.
- Lapaʻau Endocrine/ Hormone : He mea nui loa kēia lāʻau lapaʻau inā he HR-Positive/HER2-Negative kou maʻi ʻaʻai. Hana ia ma ka hoʻemi ʻana i nā pae o nā hormones e like me ka estrogen i loko o ke kino. Ke pau nā hormones, nalowale nā pūnaewele kanesa i ka leka e ulu, a hiki i ke kanesa ke emi a oki paha i ka ulu ʻana.
- Kemoterapia: Hiki ke hāʻawi ʻia ke kemoterapia i kekahi manawa me ka hoʻōla hormone no nā maʻi ʻaʻai HR-positive / HER2-negative. Aia kēia i nā mea e like me ke kahua a me ke ʻano o ke kanesa, kou makahiki, a me kou olakino holoʻokoʻa. I kekahi manawa hiki i nā hopena ʻaoʻao o ka kemoterapia ke ʻoi aku ma mua o nā pono, no laila he mea nui e kamaʻilio me kāu kauka e pili ana i ka mea maikaʻi loa iā ʻoe.
- Immunotherapy: Inā he triple negative kou maʻi ʻaʻai a holomua, a he protein ʻē aʻe i kapa ʻia ʻo PD-L1, he koho paha kēia lāʻau lapaʻau. Hana ia ma ka hoʻoulu ʻana i kāu ʻōnaehana pale ponoʻī e hakakā i ke kanesa.
Nānā a me ka Wānana
ʻO ka mea nui e pili ana i ka maʻi ʻaʻai umauma, ʻo ia ka ʻike ʻana iā ia ma mua o ka laha ʻana i nā wahi ʻē aʻe o ke kino. Inā pili kou maʻi ʻaʻai HER2-negative i ka umauma, kiʻekiʻe loa ka nui o ke ola ʻana no 5 makahiki. He ʻoiaʻiʻo kēia inā he HR-positive kou maʻi ʻaʻai.
ʻOi aku ka paʻakikī o ka mālama ʻana i nā maʻi kanesa triple-negative no ka mea ʻaʻole lākou e pane i ka lāʻau hormonal a i ʻole nā lāʻau lapaʻau i kuhikuhi ʻia e HER2. Hiki iā lākou ke ʻoi aku ka ikaika.
Aia ma lalo iho nā helu ola pili 5 makahiki e pili ana i ke kahua o ke kanesa. He awelika wale nō kēia, e hoʻomanaʻo he ʻokoʻa paha kou kūlana pilikino.
| ʻAno maʻi kanesa | Pehea i laha ai | Ola ola 5 makahiki |
|---|---|---|
| HR-Maikaʻi / HER2-Maikaʻi ʻole (ʻAno maʻamau loa) | Kaupalena ʻia i ka umauma (Kūloko) | 100% |
| Hohola i nā lymph nodes kokoke (ʻāpana) | 90% | |
| Mamao | 31% | |
| ʻEkolu-ʻAʻole (HR-Maiʻole / HER2-Maiʻole) | Kaupalena ʻia i ka umauma (Kūloko) | 91% |
| Hohola i nā lymph nodes kokoke (ʻāpana) | 65% | |
| Mamao | 12% |
Mai hopohopo i kēia mau helu. He mau awelika wale nō kēia mai nā tausani o ka poʻe. E hilinaʻi kou manaʻo pilikino i nā kumu he nui, me ke ʻano o ka pane ʻana o kou kino i ka lāʻau lapaʻau a me kou olakino holoʻokoʻa. No laila, e kamaʻilio me kāu kauka e pili ana i kou kūlana a me nā hoʻokolohua hou āu e pono ai.
Leka Lawe-Home
- ʻO ke ʻano o ka HER2-Negative , ʻaʻohe protein koʻikoʻi o kāu mau hunaola kanesa e hoʻonui wikiwiki ai i ko lākou ulu ʻana. Hoʻemi pinepine kēia i ka ikaika o kēia mau kanesa.
- ʻOiai inā he HER2-negative kou maʻi kanesa, he mea nui ka ʻike inā he pilikino ia i nā hormones (HR-positive) a i ʻole (HR-negative) i ka hoʻoholo ʻana i ka lāʻau lapaʻau.
- Aia nā koho lapaʻau i ke ʻano a me ke kahua o ke kanesa, a me kou olakino pilikino. ʻO ke ʻoki kino, ka radiation therapy, ka hormone therapy, a me ka chemotherapy nā lāʻau lapaʻau nui.
- ʻAʻole kēia kaua me ka maʻi kanesa he mea pono ʻoe e hana hoʻokahi. E kamaʻilio me kāu kauka e pili ana i kāu mau nīnau a me nā makaʻu āpau. ʻO ka loaʻa ʻana o ka ʻike kūpono kou ikaika nui loa ma kēia huakaʻi.
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