Ke ʻeha pinepine nei ʻoe i ka ʻeha hui , ka ʻeha kua , a i ʻole ka ʻeha nui e hele mai me ka menstruation? A laila lawe koke mākou i kahi lāʻau ʻeha . Akā ua ʻike anei ʻoe he ʻano like ʻole o kēia mau ʻeha ʻeha? I kēia lā e kamaʻilio mākou e pili ana i kahi ʻano lāʻau ʻeha e lawe ana i kahi kūikawā i waena o lākou, a hana ma ke ʻano ʻokoʻa iki. ʻO ia nā mea hoʻopaʻa COX-2 .
I ka ʻōlelo maʻalahi, he aha kēia mau mea hoʻopale COX-2?
ʻO nā mea hoʻopaʻa COX-2 he hui maoli ia o nā lāʻau lapaʻau e hōʻoluʻolu i ka ʻeha a hoʻēmi i ka mumū (anti-inflammatory). ʻO ka inoa lapaʻau no kēia hui ʻo NSAIDs, ʻo ia hoʻi nā lāʻau lapaʻau Nonsteroidal Anti-inflammatory. ʻO nā lāʻau lapaʻau e like me Ibuprofen , Naproxen , a me Diclofenac āu e lohe pinepine ai no kēia hui i kapa ʻia ʻo NSAIDs .
Eia nō naʻe, ʻo kēia ʻano kikoʻī, i kapa ʻia ʻo COX-2 inhibitors, hana i loko o ke kino ma ke ʻano ʻokoʻa iki ma mua o nā NSAID kuʻuna a mākou i kamaʻāina ai. E nānā kākou i kēlā ʻokoʻa.
Pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino? He ʻano hana kupaianaha loa ia!
No ka hoʻomaopopo ʻana i kēia, pono mua mākou e hoʻomaopopo i ʻelua ʻano enzymes i loko o ko mākou kino. ʻO kēia nā enzymes COX-1 a me COX-2 . Hoʻopuka kēia mau enzymes ʻelua i nā kemika i loko o ko mākou kino i kapa ʻia ʻo prostaglandins . ʻO kēia mau prostaglandins ke kumu nui e loaʻa ai iā mākou ka ʻeha, ka pehu (ka mumū), a me ke kuni.
E noʻonoʻo i kēia: Aia ʻelua mau limahana i loko o ka hale hana i kapa ʻia ʻo ko mākou kino.
- COX-1 (mea hana mua): He mea hana maikaʻi kēia. Hana ia i nā prostaglandins e hoʻoulu ai i ka ʻeha a me ka pehu. Akā ma waho aʻe o kēlā, hana ia i ʻelua mau mea nui loa . ʻO kekahi, ʻo ia ka pale ʻana i ka uhi o ko kākou ʻōpū a me nā naʻau mai ka waikawa o ka ʻōpū. ʻO kekahi, ʻo ia ke kōkua i ke kaʻina hana koko.
- COX-2 (Luna Hana 2): ʻO kēia ka pilikia maoli. ʻO kāna hana nui ka hana ʻana i nā prostaglandins e hoʻoulu ai i ka ʻeha a me ka mumū.
I kēia manawa, e nānā, ke lawe mākou i nā lāʻau ʻeha (Non-selective NSAIDs) e like me Ibuprofen lāua ʻo Diclofenac, hoʻōki ka lāʻau i kēlā mau hana ʻelua . A laila, no ka mea ua hoʻōki ʻia ʻo COX-2, ua emi ka ʻeha a me ka pehu. Akā no ka mea ua hoʻōki ʻia ka mea hana maikaʻi, ʻo ia hoʻi ʻo COX-1, ua nalowale nā pale o ka ʻōpū , a piʻi aʻe ka manawa kūpono o ka gastritis, ka mumū o ka ʻōpū, a me nā ʻōpū paha.
Akā, he akamai loa kēia papa o nā lāʻau i kapa ʻia ʻo COX-2 inhibitors. Hele pololei lākou i ka mea hana pilikia, ʻo ia hoʻi, ka enzyme COX-2 . Hoʻokuʻu lākou i ka mea hana maikaʻi (COX-1) e hana i kāna hana. No laila, he liʻiliʻi ka pōʻino i ka ʻōpū. ʻO kēia ka pōmaikaʻi nui loa o kēia papa o nā lāʻau.
He aha nā kūlana e hoʻohana ʻia ai nā mea hoʻopaʻa COX-2?
Paipai nā kauka i kēia ʻano lāʻau lapaʻau e kāohi i ka ʻeha a me ka pehu iki a kaulike i hoʻokumu ʻia e nā ʻano maʻi like ʻole.
| Kūlana olakino | He wehewehe maʻalahi |
|---|---|
| ʻO ka ʻeha puʻuwai | ʻEha a me ka ʻoʻoleʻa ma muli o ke komo ʻana a me ka haehae ʻana o nā hono i ko kākou wā ʻelemakule. |
| ʻO ka ʻāʻī rheumatoid | He maʻi e hoʻoulu ai i ka pehu a me ka ʻeha ma nā hono ma muli o ka hoʻāla ʻia ʻana o ka ʻōnaehana pale ponoʻī o ke kino. |
| ʻO ka ʻāʻī ʻōpiopio | ʻO ka rumatika i nā keiki ʻōpio. |
| ʻO ka Spondylitis Ankylosing | He maʻi kahi e pehu ai nā hono, ʻo ia hoʻi ma ka iwi kuamoʻo, a hiki ke hui pū i ka hala ʻana o ka manawa. |
| ʻEha i ka wā o ka menstruation (Dysmenorrhea) | ʻEha nui o ka ʻōpū i ka wā o ka menstruation. |
| Nā ʻeha pōkole, e like me nā ʻeha haʻuki | I nā hihia o nā sprains, nā ʻeha o nā uaua, a pēlā aku. |
Eia kekahi, hiki i kāu kauka ke kuhikuhi i kēia lāʻau lapaʻau no nā kūlana e like me ka gout a me ka migraine.
He aha nā pilikia a me nā hopena ʻaoʻao o ka hoʻohana ʻana i nā mea hoʻopale COX-2?
ʻOiai ua emi ko lākou hopena ʻaoʻao gastrointestinal, ʻaʻole nā lāʻau lapaʻau COX-2 inhibitors he mau lāʻau palekana ʻole. Aia paha kekahi mau pilikia , ʻoiai ke hoʻohana ʻia ma nā dosis kiʻekiʻe a no ka manawa lōʻihi .
Nā pilikia nui
- Nā hōʻeha puʻuwai a me ka hahau ʻana: Ua ʻike ʻia ua pili nā mea hoʻopaʻa COX-2 me kahi piʻi iki o ka pilikia o nā hōʻeha puʻuwai a me nā hahau ʻana. ʻOi aku ka nui o kēia pilikia i ka poʻe i loaʻa mua i ka maʻi puʻuwai a i ʻole nā kumu pilikia no ia mea. No kēia kumu, ua wehe ʻia kekahi mau mea hoʻopaʻa COX-2, e like me `Rofecoxib (Vioxx®)` a me `Valdecoxib (Bextra®)`, mai ka mākeke.
- Nā pilikia o ka ʻōpū a me ka naʻau: ʻOiai ua emi ka pōʻino o ka ʻōpū, ʻaʻole ia e nalo loa. Hiki i kekahi poʻe ke ʻike i ke kahe koko a me nā ʻōpū .
Nā hopena ʻaoʻao maʻamau
| ʻAno o ka hopena ʻaoʻao | Nā hōʻailona hiki ke loaʻa |
|---|---|
| ʻŌnaehana hoʻoheheʻe | Pehu, maʻi pākī, paʻa paʻa, nausea, ʻeha ʻōpū, ʻeha umauma. |
| Puʻuwai a me nā kīʻaha koko | Ke koko kiʻekiʻe, ʻeha umauma, hōʻeha puʻuwai, hahau. |
| nā puʻupaʻa | Hoʻemi ʻia ka hana o nā puʻupaʻa, hōʻiliʻili ʻana o ka wai i loko o ke kino a me ka pehu ʻana (edema). |
| ʻŌnaehana nerve | ʻEha poʻo, poniuniu. |
ʻO wai ka mea pono ʻole e lawe i nā mea hoʻopale COX-2?
E nānā hou kāu kauka i kāu mōʻaukala olakino piha e hoʻoholo ai inā kūpono kēia lāʻau lapaʻau iā ʻoe. Pono ʻoe e pale i ka lawe ʻana i kēia lāʻau lapaʻau inā loaʻa iā ʻoe kekahi o kēia mau kūlana:
- Inā ua loaʻa iā ʻoe kahi hahau ma mua.
- Inā ua loaʻa iā ʻoe i kēia manawa a i ʻole e kokoke ana e hana i ke ʻoki ʻoki coronary artery bypass .
- Inā loaʻa iā ʻoe ka maʻi puʻupaʻa koʻikoʻi a i ʻole ka maʻi akepaʻa .
- Inā ua loaʻa iā ʻoe kahi hōʻeha hānō ma mua a i ʻole kahi hopena maʻi koʻikoʻi i kahi NSAID ʻē aʻe, aspirin, a i ʻole kahi antibiotic sulfa.
- Inā ʻoe i nā mahina ʻekolu hope loa o ka hāpai ʻana .
- Inā he makuahine hānai ʻoe (e kamaʻilio me kāu kauka e pili ana i kēia).
Āhea ʻoe e ʻike koke ai i ke kauka?
Inā ʻike ʻoe i kekahi o kēia mau hōʻailona i ka wā e lawe ana i kēia lāʻau lapaʻau, mai hoʻokaʻulua a e ʻike koke i kāu kauka a i ʻole e hele i ka haukapila kokoke loa i ka Emergency Department (ETU) .
- Nā hōʻailona o ka pilikia o ke akepaʻa: mimi ʻeleʻele, luhi loa, melemele o ka ʻili a i ʻole nā maka, nā ʻōpala kala māmā, ʻeha ka ʻōpū.
- Nā hōʻailona o ke kahe ʻana o ke koko: ka luaʻi ʻana i ke koko a i ʻole ka luaʻi e like me ke ʻano o ka lepo kofe, ke kahe ʻana o ke koko i loko o ka ʻōpala (nā ʻōpala ʻeleʻele a ʻulaʻula paha), ke kahe ʻana o ke koko i loko o ka mimi, nā ʻāʻī koko, nā palapū ʻē o ka ʻili.
- Nā hōʻailona o ka pilikia o ka puʻupaʻa: hiki ʻole ke mimi, loli o ka nui o ka mimi i hana ʻia, piʻi koke ke kaumaha.
- Nā hōʻailona o kahi maʻi ʻaleka koʻikoʻi: ʻulaʻula a hives paha ka ʻili, ka maneʻo, ka paʻakikī o ka hanu ʻana, ka pehu ʻana o ka maka, nā lehelehe, a i ʻole ke alelo.
- Nā hōʻailona o ka hāʻule puʻuwai: ʻeha o ka umauma, ka hanu pōkole, ka ʻeha e pālahalaha ana i ka ʻāwae a i ʻole ka poʻohiwi.
- Nā hōʻailona o ka hahau ʻana: ka mae ʻana o kekahi ʻaoʻao o ke kino, ka paʻakikī o ka ʻōlelo ʻana, ke kūlou ʻana o ka maka.
Leka Lawe-Home
- He papa kūikawā nā lāʻau lapaʻau COX-2 inhibitors i emi iki ka ʻino i ka ʻōpū ma mua o nā lāʻau ʻeha maʻamau (NSAID). ʻO nā ʻano i hoʻohana pinepine ʻia ma Sri Lanka ʻo Celecoxib lāua ʻo Etoricoxib.
- ʻAʻole kēia mau mea i palekana loa, ʻoiai no ka mea hiki iā lākou ke hoʻonui i ka pilikia o ka hōʻeha puʻuwai a me ka hahau.
- Mai hoʻohana i kēia lāʻau lapaʻau mai kahi hale kūʻai lāʻau me ke kauoha ʻole a ke kauka.
- E hoʻohana mau i ka mahele haʻahaʻa loa i ʻōlelo ʻia e kāu kauka, no ka manawa pōkole loa .
- Inā loaʻa iā ʻoe nā maʻi e like me ka maʻi puʻuwai, ka maʻi puʻupaʻa, ka maʻi akepaʻa, a i ʻole ka gastritis, he mea nui e haʻi i kāu kauka ma mua o ka lawe ʻana i kēia lāʻau.
- E makaʻala mau i nā hōʻailona hōʻike i ʻōlelo ʻia ma luna. Inā kū mai kekahi pilikia, e ʻimi koke i ke kōkua lapaʻau.
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