Yu gɛt nos we stɔf bak? Yu nɔ de smɛl ɛn nɔ de te? Yu kin gɛt wata we de rɔn ɔltɛm? Dɛn tin ya nɔto jɔs kol, bɔt na wan sik we dɛn kɔl Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) . Pan ɔl we bɔku pipul dɛn kin gɛt fridɔm frɔm sprɛy na dɛn nos ɔ mɛrɛsin we dɛn kin tek bay mɔt, sɔm pipul dɛn kin rili at fɔ kɔntrol dɛn sik wit dɛn tritmɛnt ya. Bɔt nɔ wɔri, wit di advans we di mɛdikal sayɛns dɔn go bifo, naw nyu ɛn fayn we dɛn de fɔ trit dɛn kayn sik ya. Tide wi go tɔk bɔt wan pan dɛn kayn spɛshal tritmɛnt ya, we na Dupixent.
Aw di drɔg Dupixent de wok fɔ CRSwNP?
Fɔ tɔk am simpul wan, di nos polip na smɔl smɔl tin dɛn we de gro we de fɔm pan di mכkus mεmbran dεm na di ay sak dεm (saynus) insay כ rawnd wi nos. Di men tin we kin mek dis apin na di sayn we nɔ de mɛn . dis na we di nos εn di sayn kכva dεm de swεla εn inflam fכ pas 3 mכnt. dis swel we de go bifo na in de mek di polip dεm fכm.
Bɔrku tɛm, dɛn polyp ya nɔr kin kɔz ɛni sayn. bכt as dεn de gro, dεn kin bigin fכ blok di nכmal fכnshכn fכ di nos εn di sayn kכva dεm. Tink bɔt am lɛk wata paip we kin stɔp fɔ flɔ we sɔntin stɔp insay.
Dis kin mek yu gɛt sɔm sayn dɛn lɛk we yu nos kin rɔtin, yu nɔs kin rɔn ɔltɛm , yu kin sniz, ɛn mɔ we yu nɔ kin smɛl ɛn te . כlso, we mכkus (flegm) nכ kin kכmכt fayn fayn wan frכm di sayn kכva dεm, i kin bכku, we kin mek yu fil pen εn infεkshכn.
di men gol fכ tritmεnt ya na fכ ridyus di inflameshn na di nos εn di sayn kכva, we go shrink di mכkus εn gi bכku rilif frכm di simptom dεm.
Di aktif ingridiɛnt we de insay Dupixent na dupilumab . i de wok bay we i de blok tu protin dεm (`interleukin-4` εn `interleukin-13`) we de sεnd signal dεm we de trigεr wi bכdi in imyun sistεm fכ riak pasmak εn mek inflameshn. we dεn blכk dεn protin dεm ya, di swεla εn di diskכmfכt na di nos εn di sayn dεm de rεdכks bכku bכku wan.
Enibodi wae get dis kondishon kin yuse Dupixent?
Mɔs pipul dɛn we gɛt CRSwNP kin trit dɛn fɔs wit nos sprɛy. Dɛn tin ya na wan kayn mɛrɛsin we dɛn kɔl kɔtikosterɔyd. If yu dɔn de yuz dis sprɛy fɔ sɔm mɔnt ɛn dɛn nɔ ebul fɔ kɔntrol yu sik dɛn, i kin bi se na tɛm fɔ tink bɔt yu dɔktɔ.Di dɔktɔ kin gi yu wan kɔtikosterɔyd pil fɔ shɔt tɛm. Sɔm pipul dɛn kin nid ɔpreshɔn bak fɔ pul di lump.
Dupixent na fayn tin fɔ pipul dɛn we dɔn tray ɔl dɛn tin ya, lɛk fɔ sprɛy na dɛn nos, pils, ɛn sɔntɛm ɔpreshɔn, bɔt stil gɛt siriɔs sik dɛn. Dis min se dɛn kin yuse am as sɛkɔn ɔ tɔd layn tritmɛnt.
Stɔdi dɛn bɔt di ɛfɛktiv we Dupixent de du (LIBERTY Studies) .
Dɛn bin du tu big klinik trial dɛn, we dɛn kɔl LIBERTY, fɔ no aw dis mɛrɛsin sef ɛn i wok. Ɔl di wan dɛn we tek pat pan dɛn trayal ya bin yuz sprɛy na dɛn nos ɛvride bɔt dɛn bin stil sɔfa wit di sayn dɛn. Apat frɔm dat, 76% pan dɛn bin dɔn lɔs dɛn sɛns fɔ smɛl ɔl ɔ sɔm pat pan dɛn.
Insay dɛn stɔdi ya, dɛn kɔmpia Dupixent wit wan plasɛbo, wan drɔg we tan lɛk drɔg bɔt nɔ rili gɛt ɛni aktif ingridiɛnt. Dɛn bin mɛzhɔ di rizɔlt afta 6 mɔnt.
| Di bɛnifit dɛn we dɛn dɔn sho bay we dɛn du risach | Tɔk bɔt |
|---|---|
| di sayz fכ di nos septum | Di wan dɛn we tek Dupixent fɔ 6 mɔnt bin gɛt signifyant smɔl mol ɛn smɔl mol pas di wan dɛn we tek plasɛbo. Di tin dɛn we bin apin na di sem tin bin apin wan ia afta dat. |
| Di sayn dɛn we de sho se yu nos de rɔtin | Di wan dɛn we tek Dupixent bin gɛt signifyant smɔl simptom dɛn fɔ nos kɔnjɛshɔn ɛn nɔs we de rɔn pas di wan dɛn we tek plasɛbo. Dis bin las bak fɔ wan ia. |
| Sɛns fɔ smɛl | Pan di wan dɛn we nɔ bin ebul fɔ smɛl fayn, di wan dɛn we bin tek Dupixent bin rili impɔtant fɔ smɛl we dɛn kɔmpia dɛn wit di wan dɛn we bin tek plesibo. |
Aw dɛn de yuz Dupixent?
Dupixent na wata we dɛn kin injɛkt ɔnda di skin ɛvri tu wik , bɔku tɛm na di shɔl, bɛlɛ, ɔ ɔp an.
Dis kin kam insay wan tin we tan lɛk pen we yu dɔn ful-ɔp ɛn yu kin injɛkt yusɛf na os. So nid nɔ de fɔ wɔri bɔt nidul ɔ sirinj. Bɔt mɛmba se yu dɔktɔ ɔ nɔs go sho yu di rayt we fɔ injekt am fɔs. I rili impɔtant fɔ fala dɛn instrɔkshɔn dɛn de kɔrɛkt wan.
Aw lɔng i tek fɔ si di rizɔlt frɔm Dupixent?
If dis mɛrɛsin woke fɔ yu, yu kin notis smɔl impɔtant pan yu sɛns fɔ smɛl insay di fɔs wik. I kin tek sɔm wik ɔ wan ɔ tu mɔnt fɔ mek ɔda sayn dɛn lɛk we yu nos kin rɔtin, nɔ de igen.
I rili impɔtant: Nɔ ɛva stɔp fɔ tek Dupixent ɔ ɛni ɔda mɛrɛsin fɔ dis sik we yu nɔ tɔk to yu dɔktɔ, ivin if yu sik dɔn rili bɛtɛ. If yu du dat, dat kin mek yu sik kam bak.
Sayd ɛfɛkt ɛn prɔblɛm wit ɔda mɛrɛsin dɛn
di sayd ifekt we Dupixent kin du pas ɔl na we di skin kin riak na di say we dɛn injεkt am . Dis kin inklud fɔ rɛd, pen, swel, ɔ brus usay dɛn gi di injɛkshɔn. di bεst we fכ avכyd dis na fכ rotate di injεkshכn sayt dεm. Dɔn bak, nɔ fɔ injekt am na di skin we brok, we dɔn brus, ɔ we wund.
Dis nɔto ɔl di sayd ɛfɛkt dɛn we pɔsin kin gɛt. If yu gɛt ɛni sayn we de mɔna yu, mek shɔ se yu tɔk to yu dɔktɔ bɔt am.
Ɔda mɛrɛsin ɛn vaysin dɛn
- Ɔda mɛrɛsin dɛm: Bifo yu bigin fɔ tek Dupixent, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛm we yu de tek (especially asma mɛrɛsin dɛm), vaytamɛn dɛm, ɛn ivin ɛbul mɛrɛsin dɛm.
- Vaksin: Sɔm "layv vaysin" nɔ fɔ gi we yu de tek Dupixent. So if yu fɔ gɛt ɛni vaysin jisnɔ, tɛl yu dɔktɔ bifo yu bigin tritmɛnt.
Ɛni spɛshal tin de we yu fɔ tink bɔt we yu de tek Dupixent?
Dupixent nɔto drɔg we yu kin gɛt izi wan na rɛgyula famasi. Dɛn kin klas am as "spɛshal mɛrɛsin." Dis min se na sɔm big ɔspitul ɔ spɛshal famasi dɛn nɔmɔ dɛn kin gɛt am.
Dis tritmɛnt kin rili dia. So, e fayn fɔ tɔk to yu dɔktɔ bɔt dis bifo yu bigin fɔ trit yu ɛn tɛl yu klia wan bɔt di kɔst ɛn di we aw yu go gɛt am na wi kɔntri.
Mɛsej we dɛn kin kɛr go na os
- Dupixent na nyu tritmɛnt fɔ kronik raynosinusitis ɛn saynɔsaytis (CRSwNP). Dɛn kin gi am fɔ pipul dɛm wae gɛt siriɔs sik wae nɔr dɔn kɔntrol wit ɔda tritmɛnt dɛm (nasal spray, pils, ɔpreshɔn).
- dis de wok bay we i de blok di imyun sistεm signal dεm we de mek inflameshn, i de ridyus di swεla na di nos εn di sayn dεm.
- Dis na injεkshכn we dεn kin injεkt כnda di skin εvri tu wik. I impɔtant fɔ lan fɔs aw fɔ injɛkt am kɔrɛkt wan frɔm dɔktɔ ɔ nɔs.
- Nɔ stɔp fɔ trit yu fɔ ɛni rizin we yu nɔ gɛt yu dɔktɔ in advays. If yu du dat, i kin mek yu gɛt di sik bak.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn, vaytamɛn dɛn, ɛn vaysin dɛn we yu de tek.
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