Yu tink se dɛn kin pɔyzin wi nerv dɛn? Lɛ wi tɔk bɔt nyurotoksisiti!

Sɔntɛnde, yu kin fil lɛk se yu ed de tɔn fɔ natin? Yu an ɛn fut dɛn kin swɛt? Ɔ yu kin fil lɛk se yu de mɛmba mɔ ɛn mɔ, ɔ i nɔ kin izi fɔ mek yu tink na wan ples? Sɔntɛm di rizin fɔ dis na sɔntin we wi nɔ kin ivin tink bɔt. Dat na nyurotoksisiti, ɔ as wi kin kɔl am pan mɛrɛsin, wan sik we dɛn kɔl nyurotoksisiti . Mek wi tok abaut dis fo likl mo ditel tide, okay?

Fɔ tɔk am simpul wan, wetin na nyurotoksisiti?

Nyurotoksisiti na we pɔyzin we de na di wɔl ɔ we mɔtalman mek (we dɛn kɔl nyurotoksik) na di briz we wi de blo, di wata we wi de drink, di it we wi de it, ɛn sɔm pan di tin dɛn we wi de yuz de pwɛl wi nervɔs sistɛm. Yu no se wi nervous system na wan netwok we rili kɔmpleks? I inklud wi bren, spɛshal kɔd, ɛn di nɛf dɛn we de ɔlsay na wi bɔdi . Na dɛn wan ya de kɔntrol ɔltin we wi de tink, du, tɔk, ɛn fil.

So, dεn tכxin dεm ya kin mek chenj dεm na di fכnshכn na di nεv sεstem. Sɔntɛnde, dɛn chenj ya kin bi smɔl smɔl, ɛn sɔntɛnde dɛn kin rili bad . Pan ɔl we sɔm chenj dɛn kin trit ɛn mɛn, sɔm kin de fɔ ɔl in layf. If i bad bad wan, dis nyurotoksisiti kin ivin mek pɔsin day . Imajin aw dat denja!

Sɔntɛnde, ivin tin dɛm wae nɔrmal nɔr pɔyzin to wi, fɔ ɛgzampul, sɔm mɛrɛsin dɛm, kin mek wi gɛt nyurotoksisiti if dɛn tek am pasmak. Ɔ, sɔm tin dɛn de, lɛk lid, we kin gɛt pɔyzin ivin if dɛn smɔl.

dis nyurotoksisiti kin apin di tεm we di pikin de divεlכp , di pikin de divεl כp כ di tεm we i big . כltu, di damej we dεn kin gεt we dεn de εkspos to dεn tכxin dεm we di pikin in bεlε εn we i smɔl, kin bכku bכku wan. Dɔn bak, pipul dɛn we gɛt sɔm sik dɛn, fɔ ɛgzampul, di wan dɛn we gɛt janda (hyperbilirubinemia) ɔ di wan dɛn we gɛt sik lɛk Charcot-Marie-Tooth Disease (CMT), kin gɛt dis nyurotoksisiti.

Wetin na dɛn nyurotoxicant ya?

Infakt, bɔku bɔku kayn tin dɛn de we de mek pɔsin in nerv. Dɛn kin bi gas, wata, ɔ sɔlid fɔm. Sɔm pɔyzin kin mek yu gɛt di sik ivin if yu smɔl, ɔ afta yu dɔn gɛt am wan tɛm. Wae ɔda wan dɛn nid fɔ it bɔku bɔku tin ɛn fɔ de wit dɛn fɔ lɔng tɛm fɔ mek dɛn gɛt di sik.

Na sɔm ɛgzampul dɛn ya:

• Ebi ebi mɛtal dɛn: Fɔ ɛgzampul, lid, mɛkuri.
• Ɔda tin dɛn we de na di wɔl: Fɔ ɛgzampul, di kabɔn monoksayd, asɛnik, ɛn trikotɛsin maykotoksin dɛn we kɔmɔt frɔm sɔm mol dɛn.
• Insektisayd: .Fɔ ɛgzampul, `(ɔrganofosfɛt)` ɛn `(klɔpirifɔs)`. Dɛn kin yuz dɛn tin ya we wi de du fam wok, nɔto so?
• Sɔlvɛnt dɛn we dɛn kin fɛn na faktri ɛn klin prɔdak dɛm: Fɔ ɛgzampul, `(tetrachloroethylene)`.
• Di tin dɛn we dɛn kin yuz fɔ mek tin: Fɔ ɛgzampul `(vaynil klorayd)`, `(toluɛn)`, `(fɔmaldayd)` ɛn `(pɔlibrominɛt difɛnil ɛtɛr) (PBDE)`.
• Drug ɛn Alkol: Alkol, Amfetamin, Opioid, Inhalant, ɛn Kɔkɛyn.

Kεmεkal dεm de bak we de afekt wi כmon sistεm dεm we dεn kכl Endocrine-disrupting chemicals (EDCs). εgzampl dεm na Bisphenol A (BPA) (we dεn kin fכnshכn insay sכm plastic dεm), phthalates, εn polychlorinated biphenyl compounds (PCBs). dis kin mek nyurotoksisiti indaykt wan.

Di rilayshɔn bitwin mɛrɛsin ɛn nyurotoksisiti

Yu no se sɔm mɛrɛsin, fɔ ɛgzampul, sɔm antibayɔtik ɛn ivin sɔm antisaykotik, kin mek yu gɛt nyurotoksisiti fɔ difrɛn rizin dɛn? Bɔt bɔku tɛm, di bɛnifit dɛn we dɛn mɛrɛsin ya kin gi kin pas di prɔblɛm dɛn we kin mek pɔsin gɛt nyurotoksisiti . Na dat mek dɔktɔ dɛn kin tek tɛm gi dɛn mɛrɛsin.

Sɔm mɛrɛsin dɛn, mɔ di wan dɛn we dɛn kin yuz fɔ mɛn kansa, kin mek pɔsin gɛt nyurotoksisiti bak.

• Drug dεm we gεt platin: `(oksaliplatin)`, `(sisplatin)`, `(kaboplatin)`
• Taksan drɔgs: `(paklitaksɛl)`, `(dɔsɛtaksɛl)`
• Vinka alkaloyd dɛn: `(vinkristin)`, `(vinblastin)`
• Proteasome inhibitor dɛn we de mek pɔsin nɔ ebul fɔ du sɔntin
• Thalidomide analɔg dɛn

Nɔto jɔs kemotɛrapi, bɔt redyushɔn tɛrapi kin pwɛl di sɛntral nervɔs sistɛm ɛn mek nyurotoksisiti.

Aw dis sik kin kɔmɔn?

Infakt, i nɔ kin izi fɔ mek di wan dɛn we de stɔdi bɔt dis sik tɔk klia wan aw dis sik kin bɔku, we dɛn tink bɔt di bɔku bɔku kayn tin dɛn we kin mek pɔsin gɛt nerv ɛn di difrɛn difrɛn sayn dɛn we de sho se i sik. Bɔt sɔm pipul dɛn we de stɔdi bɔt dis tɔk se di we aw wi kin gɛt dɛn nerve agents ya kin bɔku .

Mek a gi yu tu ɛgzampul dɛn fɔ ɛp yu fɔ ɔndastand aw dis big:

• Wan stɔdi sho se ɛvri ia na lɛk 385 milyɔn pipul dɛn kin gɛt pɔyzin we dɛn kin yuz fɔ kil animal dɛn bay aksidɛnt , ɛn dis kin mek lɛk 11,000 pipul dɛn kin day ɛvri ia.
• Dɛn tɔk bak se na lɛk wan milyɔn pipul dɛn kin day ɛvri ia bikɔs dɛn gɛt pɔyzin we dɛn kɔl lid . Wan pan tri pikin dɛm ɔlsay na di wɔl – dat na lɛk 800 milyɔn pikin dɛm – gɛt bɔku bɔku lid na dɛn blɔd . Imajin aw dis na siriɔs tin! Yu kin fɛn lid insay pent na ol os dɛn ɛn insay sɔm tɔys dɛn.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

Di sayn dɛm fɔ pɔyzin na di nerve agent kin difrɛn bad bad wan. I dipen pan di kayn pɔyzin we yu bin gɛt. Di sayn dɛm kin kɔmɔt frɔm smɔl to siriɔs . Sɔntɛnde, di sayn dɛn kin sho wantɛm wantɛm afta dɛn dɔn gɛt di pɔyzin, ɔ i kin tek sɔm wik, mɔnt, ɔ ivin ia fɔ sho.

Na sɔm sayn dɛm wae de sho se yu gɛt dis sik:

• Prɔblɛm wit balans ɛn kɔdineshɔn (nɔ ebul fɔ waka fayn, gɛt prɔblɛm fɔ ol tin) .
• Dayarɛa (bɛlɛ de at) .
• Taya, taya
• Ed de at
• Fil fɔ it
• Pen kכndishכn lεk nyuropatik pen
• Prɔblɛm dɛn na di mɔsul dɛn: wik, kramp, twitch
• Nɔs ɛn/ɔ vɔmit
• Di limb dɛn we de na di an ɛn fut dɛn kin swɛla
• Slip chenj: lεk wae yu nɔr de slip
• I nɔ izi fɔ tɔk, fɔ tɔk fayn (dysarthria) .
• Prɔblɛm fɔ si ɔ yu nɔ de si fayn

Naw lɛ wi si wetin na di mental ɛn kɔgnitiv simptom dɛm:

• Di chenj we pɔsin de biev ɔ prɔblɛm dɛn
• Di intellectual abiliti dεm we de dכn, fכ egzampl, mild cognitive impairment
• Diziz ɔ disorienteshɔn
• Executive dysfunction: Dis min se i nɔ kin izi fɔ kɔntrol di filin ɛn nɔ kin ebul fɔ pe atɛnshɔn.
• Fɔ vɛks kwik pas aw i kin vɛks, fɔ vɛks kwik
• Di mɛmori we yu nɔ ebul fɔ mɛmba
• Di we aw pɔsin de fil kin chenj

Di tin we impɔtant pas ɔl na fɔ go to dɔktɔ if yu ɔ yu pikin notis ɛni chenj ɔ prɔblɛm na in tink, bihayvya, mud, ɔ bɔdi wɛlbɔdi . Dis kin bi bikɔs ɔf di nyurotoxicants, bɔt ɔda tin dɛn kin de we kin mek i apin.

Simptom dɛm wae de sho se yu gɛt imejensi

sכmtεm nyurotoksisiti kin bi rili sכdεn εn siriכs (akyu nyurotoksisiti). Dɛn sayn ya kin apin wantɛm wantɛm. If yu gɛt ɛni wan pan di sayn dɛm we de dɔŋ ya, yu fɔ go na ɔspitul wantɛm wantɛm. Kɔl 911 (1990 na Sri Lanka) ɔ go na di ɔspitul we de nia yu.

Di sayn dɛm fɔ akyu nɛv pɔyzin kin bi:

• Di chenj dɛn we de apin na di at rit
• Kɔnfyushɔn ɔ delirium
• Lɔs fɔ no bɔt sɔntin
• Saykosis, inklud di hallucinations
• Di sik dɛn we kin mek pɔsin sik
• Big chenj dεm na di bכdi tεmprachכ (vεri hεvi fiva (hyperthermia) כ rili lכw bכdi tεmprachכ (hypothermia)) .
• Wantɛm wantɛm, di mɔsul dɛn kin wik bad bad wan
• Prɔblɛm fɔ si wantɛm wantɛm ɔ yu nɔ de si fayn igen
• I nɔ kin izi fɔ yu fɔ blo

Wetin na di tin dɛn we kin mek pɔsin gɛt pɔyzin na di nerve?

Fɔ tɔk am simpul wan, nyurotoksisiti kin apin we di nyurotoksik dɛn we wi bin dɔn tɔk bɔt kin pwɛl, chenj, ɔ kil di sɛl dɛn na wi periferik ɔ sɛntral nɛvɔ sistɛm. Bɔku tɛm, dis kin afɛkt di nɛv sɛl dɛn, ɔ di nyuron dɛn . yu no se na dεn nyuron dεm ya na di men wan dεm we de transmit εn proכses signal dεm na wi bren, spεnal kכd, εn pεrifεral nεv dεm. Nɔto di nyuron dɛn nɔmɔ, bɔt ɔda pat dɛn na di nervɔs sistɛm kin pwɛl bak, fɔ ɛgzampul , di maylin we de kɔba di nɛv dɛn.

Bikɔs wi nervɔs sistɛm na so kɔmpleks sistɛm, di damej we nyurotoksisiti kin mek kin sho difrɛn we dɛn. Na sɔm ɛgzampul dɛn ya:

• di chenj dεm we de apin na di lεvεl dεm fכ di nyurotransmit dεm (fכ egzampl, dopamin), we na wan imכtant kεmikכl na wi bren, εn di signal we dεn de gi.
• Inflameshɔn, ɔ swel, na di bren ɔ spɛshal kɔd (nyuroinflammation).
• di strכkchכ chenj dεm na di bren, fכ egzampl, di chenj dεm na di vכlyum fכ grey εn wayt tin dεm na di bren.
• di damej pan di maylin sεt we de rawnd di pεrifεral nεv dεm.

Eksposhɔn to di nerve agents

Difrɛn we dɛn de we dɛn nerve agent ya kin go insay wi bɔdi:

• Na bay we yu de blo
• Tru it ɔ drink (frɔm tin dɛn we yu de it ɔ drink) .
• Na bay we i de absɔb tru di skin

Dɛn pɔyzin ya kin afɛkt pikin bak. if dεn tכxin dεm ya go insay di mama in bכdi we i bεlε, dεn kin pas tru di bכdi to di pikin tru di כmbilikal kכd . na dat mek dεn nכ kin rεkomεnd sכm mεdikeshכn dεm we uman bεlε, biכs dεn kin gεt nyurotoxik ifekt pan di pikin.

We dɛn pɔyzin ya go insay wi blɔd, dɛn kin krɔs di blɔd-bren barɛri (BBB) ​​we de protɛkt wi bren ɛn afɛkt sɔm pat dɛn na di sɛntral nervɔs sistɛm dairekt wan. כ, lεk di EDC dεm we wi bin dכn tכk bכt, dεn kin afekt di bren indaykt wan bay we dεn de chenj כda bכdi sistεm dεm.

Bɔrku ples de wae yu kin gɛt dɛn nerve ejen ya, bikɔs di say dɛm wae dɛn pɔyzin ya kin kɔmɔt de skata ɔlsay.

• Envayrɔmɛnt pɔyushɔn: di ɛkzoz we motoka dɛn de pul, di gas dɛn we de kɔmɔt na agrikalchɔral wok, di gas dɛn we de kɔmɔt na faktri dɛn.
• Di dɔti we de na di say we dɛn de: Na ples dɛn lɛk pak, skul, ɔ frɔm kemikal aksidɛnt dɛn na di eria.
• Pɔlyushɔn na os: Frɔm sɔm tin dɛn we de na os, it ɛn drink. Fɔ ɛgzampul, sɔm wata fɔ klin, insɛkt sprɛy, ɛn pent.

Wetin na di prɔblɛm dɛn we kin apin?

Wi dɔn tɔk bɔt se sɔm nyurotɔksik dɛn kin mek pɔsin gɛt nyurolɔjik kɔndishɔn we nɔ de dɔn . If tin tranga, ivin day kin apin.

fכ εkspos to sכm nyurotoxicant dεm, spεshal wan we di pikin de divεlכp εn we i sכm pikin, i kin gεt sεvεra pan dεn kכndyushכn dεm ya:

• Atɛnshɔn-dɛfisit/haypa aktiviti disɔda (ADHD) .
• Disabiliti fɔ lan
• Pwɛl at
• Wɔri
Skizofrenia-imɔshɔnal `(Skizofrenia)`
• Ɔtizm spɛktrum disɔda (ASD) .

bכt i imכtant fכ mεmba se dis de כnli sho se wan link de bitwin di εksposhכn to nyurotoksin dεm εn dεn kכndyushכn dεm ya. Risach pipul dɛm stil nɔr no fɔ tru if dɛn pɔyzin ya kin mek dɛn kayn tin ya kin apin dairekt wan. Dɛn de kɔntinyu fɔ stɔdi ɔl di pɔsibul ifɛkt ɛn kɔmplikeshɔn dɛn we dɛn nyurotoksin ya kin gɛt.

Aw yu kin fɛn dis? (Diagnosis) .

Bikɔs bɔku bɔku kayn nerve agent dɛn de ɛn di sayn dɛm fɔ nerve agents kin difrɛn bad bad wan, fɔ no if pɔsin gɛt di sik kin nid fɔ du bɔku tɛst ɛn ɛgzam. Yu dɔktɔ go aks yu fɔs bɔt yu sik dɛn ɛn yu mɛrɛsin istri . Dɔn dɛn go du ɛgzam fɔ dɛn bɔdi ɛn nyurolɔjik.

Apat frɔm dat, dɛn kin advays fɔ du dɛn tɛst ya:

• Asɛsmɛnt fɔ di we aw pɔsin de biev
• Blɔd tɛst dɛn
• Test dɛn we pɔsin kin gɛt we i de ɔndastand
• Ilɛktroɛnsɛfalɔgram (EEG) .
• Wan ɛgzam fɔ di yay
• Imej tɛst dɛn lɛk bren MRI skan
• Nεv kכndukshכn stכdi εn εlektromayografi (EMG) .
• Nyurosaykolojik tɛst ɛn asɛsmɛnt
• Sεribral spεnal fכluid (CSF) analisis (Spinal tap / Lumbar pankshכn) .

Sɔntɛnde, dɔktɔ dɛn nɔ kin ebul fɔ fɛn di rayt tin we kin mek pɔsin gɛt di sik we de mek pɔsin gɛt nyurotoksisiti.

Wetin na di tritmɛnt dɛn?

Di tritmɛnt we dɛn kin pik kin dipen mɔ pan di sik dɛn we yu gɛt ɛn di kayn nyurotoksin we de mek yu gɛt dɛn. Bɔku tɛm, di tritmɛnt kin min fɔ pul ɔ ridyus di pɔyzin, dɔn dɛn fɔ trit ɔ kɔntrol di sayn dɛm .

Wetin na di tin dɛn we wi go si? (Prɔgnosis) .

De luk fɔ pɔrsin wae gɛt nyurotoksikosis kin dipen pan bɔku tin dɛm, lɛk:

• Us kayn nerve agent bin de pan am?
• Aw bɔku ɛksplɔshɔn bin de?
• Aw lɔng di ɛksplɔshɔn bin tek?
• Aw bɔku damej dɔn apin to di nervɔs sistɛm?
• Yu ej ɛn ɔl yu wɛlbɔdi

If yu gɛt sɔm tin dɛn we de mek yu gɛt nerve, dat kin mek yu day. Sɔntɛnde, ivin if di tin we dɛn dɔn put pan am kin mek pɔsin in layf de pan denja, di nervɔs sistɛm nɔ kin wɛl. Ɔda tɛm dɛn, i pɔsibul fɔ mek pɔsin wɛl ful wan afta dɛn dɔn trit am.

Aw yu go avɔyd dis? (Prɛvenshɔn) .

Fɔ tɔk tru, we yu tink bɔt aw dɛn nerve agent ya de ɔlsay na ɛvride, i nɔ kin izi fɔ avɔyd dɛn ɔl kpatakpata . Bɔt sɔm tin dɛn de we yu kin du fɔ mek yu nɔ gɛt bɔku prɔblɛm wit di sik:

• Instɔl wan tin we de no bɔt kabon monoksayd na yu os, ɛn chenj in batri wan tɛm insay di ia.
• Nɔ ɛva miks tin dɛn we yu kin yuz fɔ klin ɔ di kemikal dɛn we yu kin yuz na os togɛda. If yu du dat, dat kin mek yu denja, ivin kil.
• Mek dɛn tɛst yu os fɔ ɔda pɔyzin dɛn we de ambɔg yu, lɛk lid.
• Kip yu winda dɛn lɔk pan de dɛn we di briz nɔ fayn (we di briz nɔ fayn).
• Nɔ yuz drɔgs ɛn rɔm.
• if yu bεlε, tכk to yu dכkta bכt aw yu de εkspos to nerve ejen dεm εn aw i kin afekt di pikin in divεlכpmεnt.

Di tin we impɔtant pas ɔl na dat, fɔ protɛkt yusɛf ɛn yu famili frɔm dɛn nerve agent ya nɔto yu wan wok. Na di kɔlektif rispɔnsibiliti fɔ di stet ɛn lokal gɔvmɛnt, kɔmni dɛn, ɛn sitizin dɛn ɔl tu. Institiushɔn dɛn lɛk di Nashɔnal Instityut fɔ Envayrɔmɛnt Ɛlth Sɛvis (NIEHS) de kɔntinyu fɔ du risach bɔt aw di envayrɔmɛnt ɛn di tin dɛn we de mek di nerv de afɛkt mɔtalman wɛlbɔdi.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Nyurotoksisiti kin kam wit difrɛn tin dɛm ɛn kin mek yu gɛt difrɛn kayn sayn dɛm. Pan ɔl we i nɔ kin izi fɔ avɔyd ɔl di nyurotoxicant dɛn, tin dɛn de we yu kin du fɔ protɛkt yusɛf ɛn yu famili. If yu ɔ yu pikin gɛt ɛni nyurolɔjik simptom, ɔ if yu gɛt wɔri bɔt aw yu go gɛt nyurotoxicant, mek shɔ se yu go to dɔktɔ. Dɛn de ya fɔ ɛp.

` Nyurotoksisiti, Nyurolɔjik sistɛm, Tɔksin, Simptom, Bren wɛlbɔdi, Prɛvenshɔn