Na nɔmal tin fɔ fil big big lod we dɔktɔ tɛl yu, ɔ pɔsin we yu sabi, se yu gɛt prɔblɛm wit yu kidni , mɔ wan sik we dɛn kɔl IgA Nephropathy (IgAN). Dis na sik we de pwɛl di kidni dɛm bikɔs ɔf wan smɔl mistek na wi bɔdi in yon imyun sistɛm. So tide wi go tɔk bɔt dis sik ɛn di nyu mɛrɛsin we dɛn dɔn kam wit we dɛn kɔl Vanrafia, rili simpul.
Wetin na di ɛksaktɔli IgA nɛfrɔpati (IgAN)?
Fɔ tɔk am simpul wan, IgA nɛfrɔpati (IgAN) na wan sik we pɔsin kin gɛt we i de fɛt insɛf . Sɔntɛnde dɛn kin kɔl am di sik we dɛn kɔl Berger’s disease , i kin apin we di antibodi dɛn , we na wan kayn prɔtin we dɛn kɔl Immunoglobulin A (IgA), kin gɛda na di kidni dɛn ɛn mek smɔl smɔl grup dɛn.
Imajin se di wan dɛn we de gayd wi bɔdi dɔn go na di rɔng rod ɛn mek kamp insay wi yon kidni. dis antibodi dεm kin mek di kidni dεm in dilik filta sistεm inflameshn , εn as tεm de go, di kidni dεm kin bigin fכ pwεl sכmtεm (nεfrכpati). Dis damej de mek di kidni dɛn nɔ ebul fɔ filta di dɔti we de kɔmɔt na di bɔdi fayn fayn wan.
Vanrafia na nyu drɔg we dɛn dɔn gri fɔ trit pipul dɛn we gɛt IgAN we de pan risk fɔ gɛt siriɔs sik. i de pan wan klas dεm we dεn kכl εndotelin rεsεptכr antagonist. dis dכg dεm de wok bay we dεn de blכk di rεsεpכta dεm we de pik mεsej dεm we de mek di kidni dεm inflameshn εn damej. I tan lɛk se yu stɔp mɛsej we de ambɔg yu fɔ mek i nɔ rich di rayt ples.
Aw dɛn kin ɔltɛm de manej IgAN?
Di Kidney Disease Initiative Group (KDIGO) de mek kɔmɛnt bɔt di bɛst we fɔ trit sik dɛn lɛk IgAN. Na sɔm pan di men tin dɛn we dɛn kin tɔk bɔt.
Di tin we impɔtant pas ɔl na dat na di dɔktɔ we de chɛk yu sik de disayd ɔl dɛn tritmɛnt ya. So , nɔ ɛva bigin ɔ stɔp fɔ tek ɛni mɛrɛsin if yu nɔ gɛt dɔktɔ advays.
Dis dɔŋ ya na di men tritmɛnt we dɛn de yuz naw ɛn di gol dɛm we dɛn gɛt.
| Di rizin fɔ di we aw dɛn de trit am | Diskripshɔn ɛn ɛgzampul dɛn |
|---|---|
| Fɔ kɔntrol blɔd prɛshɔn | i impɔtant fɔ kip blɔd prɛshɔn dɔŋ 130 mm Hg (ɔpa limit) pan IgAN pasɛnt dɛn. Dɛn kin yuz difrɛn mɛrɛsin dɛn fɔ dis. Ɛgzampul dɛn: - ACE inhibito dεm (e.g. Kaptopril, Lisinopril) . - ARB dɛn (ɛgz. Lɔsartan, Valsartan) - Kכlsyכm chεnal blכk dεm (e.g. Amlodipine, Nifedipine) . |
| di protin we de dכn na di urine (Proteinuria) . | If yu gɛt bɔku prɔtin na yu urine (proteinuria), dɛn kin gi yu wan ACE inhibitor ɔ ARB, ivin if yu nɔ gɛt ay blɔd prɛshɔn. Sɔntɛnde, dɛn kin yuz mɛrɛsin dɛn bak we dɛn kɔl SGLT2 inhibito (e.g., Dapagliflozin, Empagliflozin). |
| Di we aw pipul dɛn de liv dɛn layf kin chenj | Fɔ ridyus sɔl na di it, fɔ du ɛksɛsayz, fɔ lɛf fɔ smok, ɛn fɔ kɔntrol yu wet, ɔl impɔtant fɔ kɔntrol blɔd prɛshɔn ɛn ɔl wɛlbɔdi. |
| Fɔ ridyus di risk fɔ gɛt at sik | Apat frɔm we yu de liv fayn layf, i fayn bak fɔ ridyus di risk fɔ gɛt at sik bay we yu de yuz mɛrɛsin dɛn we de mek yu nɔ gɛt bɔku kɔlɔstrel if nid de. |
Dɛn dɔn gri fɔ di drɔg Vanrafia fɔ "high-risk" pasɛnt dɛn we gɛt ay lɛvɛl prɔtin na dɛn urine (mɔ pas 0.75 - 1 gram fɔ wan de) pan ɔl we dɛn dɔn fala di tritmɛnt dɛn we wi dɔn tɔk bɔt fɔ at le tri mɔnt.
Aw dɛn bin tɛst di sakrifays we di Vanrafia drɔg bin gɛt?
Di ALIGN klinik trayal bin stɔdi di ɛfifikɛshɔn ɛn sef fɔ Vanrafia pan pasɛnt dɛn we gɛt ay risk fɔ divɛlɔp siriɔs IgAN.
- Udat dɛn tek pat?:Na lɛk 270 pasɛnt dɛn. Dɛn bin gi af pan dɛn di drɔg we nem Vanrafia, ɛn di ɔda af dɛn bin gi wan plesibo pil we nɔ gɛt ɛni drɔg.
- Wetin dɛn mɛzhɔ?: Afta 36 wiks we dɛn dɔn trit am, dɛn mɛzhɔ di urine protein-creatinine ratio fɔ si aw i go dɔŋ. di hכy dis rεshכn, na di mכr kidni dεm de damej.
Di risal sho se di urine protein-to-creatinine ratio bin ridyus bay 38% pan di pasɛnt dɛn we gɛt Vanrafia, kɔmpia wit 3% nɔmɔ pan di wan dɛn we gɛt plasɛbo. dis sho se Vanrafia de ridyus di protin we de kכmכt frכm di kidni dεm bכku bכku wan.
Wetin wi no bɔt di tin dɛn we dis mɛrɛsin kin du fɔ lɔng tɛm?
Vanrafia na wan drɔg we dɛn dɔn gri fɔ ɔnda wan prɔses we dɛn kɔl "accelerated approval." Dat min se, na drɔg we dɛn kin mek am fɔ di sik pipul dɛn kwik kwik wan bay di fɔs risach rizɔlt fɔ siriɔs kɔndishɔn dɛn we nɔ gɛt bɔku ɔda tritmɛnt opshɔn dɛn.
Bɔt afta dis aprɔval, di famasi kɔmni nid fɔ kɔntinyu fɔ du risach fɔ pruv if dis mɛrɛsin rili de ridyus di kidni damej fɔ lɔng tɛm. Di ALIGN trial stil de go bifo. Di rizɔlt dɛn we i go gɛt fɔ lɔng tɛm go sho if dis mɛrɛsin go kɔntinyu fɔ de na di makit ɔ nɔ go de.
Prɔblɛm kin de wit ɔda mɛrɛsin dɛn? (Drug Intarakshɔn) .
Yes, Vanrafia kin intarakt wit sɔm ɔda mɛrɛsin dɛn. Dis kin mek Vanrafia nɔ wok fayn ɔ i kin mek di sayd ɛfɛkt dɛn bɔku.
- Drug dεm we de inkrεs di risk fכ sayd ifekt: Di sayd ifekt dεm fכ Vanrafia kin inkrεs we dεn tek am wit drog dεm na di grup we dεn kכl `(OATP)1B1/1B3 inhibitors`.
- Drug dɛm we de ridyus di efficacy: Di effektiv we Vanrafia de du kin ridyus we dɛn tek am wit drɔgs we de insay di kategori fɔ CYP3A inducers.
So , i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn ɛn tradishɔnal mɛrɛsin dɛn). Dɔn i kin pik di tritmɛnt we go fayn fɔ yu.
Wetin yu nid fɔ no bɔt aw fɔ yuz Vanrafia we yu gɛt bɛlɛ
Dis na pɔynt we rili impɔtant. If dɛn tek Vanrafia we di pikin gɛt bɛlɛ, i kin mek di pikin gɛt siriɔs prɔblɛm wit di pikin.
- If yu na uman we ebul fɔ bɔn pikin, yu fɔ tek bɛlɛ tɛst fɔ kɔnfirm se yu nɔ gɛt bɛlɛ bifo yu bigin Vanrafia.
- If yu gɛt bɛlɛ ɔ yu de plan fɔ gɛt bɛlɛ, yu nɔ fɔ tek dis mɛrɛsin atɔl.
- Wan we we rili fayn fɔ kɔntrol bɔn pikin we dɛn de trit am ɛn fɔ tu wiks afta dɛn dɔn stɔp di tritmɛntNa mandatory fɔ yuz am. Tɔk to yu dɔktɔ ɔ dɔktɔ we de mɛn uman dɛn bɔt di we aw dɛn de kɔntrol di pikin we fayn fɔ yu.
- If yu prɛgnɛshɔn let we yu de trit yu ɔ yu tink se yu gɛt bɛlɛ, tɛl yu dɔktɔ wantɛm wantɛm.
Tin dɛn fɔ no we yu de tek dis mɛrɛsin
Vanrafia na wan spɛshal mɛrɛsin. Dis min se dɛn mɛrɛsin ya na dia dia, kɔmpleks mɛrɛsin dɛn we nɔ de na ɔl famasi.
Di prɔses fɔ gɛt dis mɛrɛsin kin difrɛn frɔm fɔ gɛt prɛskrishɔn ɔltɛm. Yu dɔktɔ go tɛl yu bɔt sɔm patikyula say dɛn (lɛk spɛshal ɔspitul famasi dɛm) usay yu go gɛt dis mɛrɛsin ɛn di we aw yu fɔ fala. Yu kin nid bak fɔ gɛt ɔtorizeshɔn bifo tɛm frɔm inshɔrans kɔmni dɛn. Yu dɔktɔ go gayd yu fɔ du ɔl dɛn tin ya.
Mɛsej we dɛn kin kɛr go na os
- IgA nεfropati (IgAN) na wan kכndyushכn we di kidni dεm de pwεl bay di akshכn we wi כwn imyun sistεm de du.
- Vanrafia na nyu mɛrɛsin we de ɛp fɔ ridyus di prɔtin we de kɔmɔt na di urine fɔ di wan dɛn we gɛt ay risk fɔ gɛt siriɔs sik.
- I rili impɔtant fɔ kɔntrol blɔd prɛshɔn, kɔntinyu fɔ liv fayn layf, ɛn tek ɔda mɛrɛsin dɛn we yu dɔktɔ tɛl yu jɔs lɛk aw dɛn tɛl yu.
- If yu de tek Vanrafia, i impɔtant fɔ mek yu tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek.
- Dis mɛrɛsin kin rili bad fɔ uman we gɛt bɛlɛ. Dɛn fɔ yuz fayn fayn kɔntrol fɔ bɔn pikin we dɛn de trit am ɛn fɔ tu wiks afta dɛn dɔn stɔp am.
- Ɔltɛm tɔk to yu dɔktɔ bɔt yu sik ɛn tritmɛnt, ɛn fala in advays.
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