Hnute cancer i vei tih i hriat chuan hlauhna, mangang leh zawhna tam tak lo chhuak thin chu kan hrethiam a ni. Mahse tun dinhmuna pawimawh ber chu uluk taka hriattir hi a ni. A chhan chu, hnute cancer zawng zawng hi a inang vek lo. Cancer chi thenkhat tan bik enkawlna tur bik a awm. Awle, mi tam tak tâna hlawhtling taka hman tawh enkawlna pakhat chu hormone therapy . Vawiin hian awlsam takin sawi ila.
Hormone therapy chu eng nge ni? Mi zawng zawng tan a dik em?
A awlsam zawngin, kan taksaa hormone ṭhenkhat chuan hnute cancer cell ṭhenkhat chu a tipung thei a ni. A bik takin hormone pahnih estrogen leh progesterone tih te hi a ni.
Cancer cell te hi in te tak te angin ngaihtuah rawh. Cancer cell thenkhat chuan ‘doors’ (receptors) bik an nei a, chu chuan heng hormone te hi a luh tir thei a ni. Heng kawngkhar nei cancer te hi hormone receptor-positive kan ti thin . Doctor-te u, hei hi in report-ah ER-positive (estrogen-doors) emaw PR-positive (progesterone-doors) emaw tiin in lo chhinchhiah tawh mai thei.
Hormone therapy hian heng hormone gate nei cancer te tan hna a thawk a ni. Heng enkawlnate hian chu kawngkharte chu a khar emaw, taksaa chu hormone siam chhuah chu a ti tlem emaw a ni. Hei hian cancer cell-te mamawh "nutrition" a hloh a, an lo thang lian tawh lo emaw, an thi emaw a ni.
A pawimawh ber chu, i cancer cell-te hian heng hormone receptor te hi an nei lo a nih chuan, chu chu hormone receptor-negative an nih chuan heng hormone enkawlna te hian hna a thawk dawn lo tihna a ni. Chutiang mite tan chuan doctor-te chuan enkawlna dang an rawt a ni.
Hormone therapy chi hrang hrangte chu engte nge ni?
Breast cancer tan hian hormone therapy hman chi hrang hrang a awm a. I doctor chuan thil tam tak a zirin i tan damdawi tha ber a thlang ang a, chung zingah chuan i kum, cancer chi hrang hrang, leh menopause i paltlang tawh leh tawh loh te pawh a tel. A chi lian ber pahnih han thlir ila.
| Enkawlna chi hrang hrang | Tu hnenah nge pek a nih ber? | Side effects hriat tur a awm |
|---|---|---|
| Tamoxifen a ni | Hmeichhia kum eng pawh (pre leh post menopause) tan. Kum sawm tam tak chhunga hlawhtling taka hman tawh damdawi. | Uterine cancer, ke leh lungah thisen zam, stroke, mitdel, leh hot flashes te a awm theihna a sang deuh. |
| Aromatase tihkhawtlai (AI) te hi a awm a. Ex: Anastrozole, Letrozole tih te hi a ni | A bik takin hmeichhia menopause hnua tan. | Ruh chak lo (Osteoporosis) leh ruh tliak, ruh leh ruh na, hriatrengna lama harsatna, leh thinlung natna vei theihna a sang deuh. |
Tamoxifen chungchang tlem tal
Hei hi nitin i ei thin pill a ni. Research atanga a lan dan chuan kum engemaw zat, a tlangpuiin kum 5 vel ei hian cancer lo kir leh theihna leh cancer thar vei theihna a ti tlem hle .
Mahse, chu table-a kan sawi tawh side effects te pawh i hriat a ngai a ni. A bik takin uterine cancer vei theihna a ni. Chuvangin he damdawi hi ei lai hian regular pelvic exam neih a ngai a ni. Tin, vaginal bleeding danglam tak i neih chuan doctor hnenah i hrilh nghal tur a ni.
Aromatase Inhibitors (AIs) chungchang tlem tal chu
Hetiang damdawi chi hian hmeichhiaah menopause hnua hormone estrogen siam chhuah a tihtawp avangin hna a thawk a ni. Hei hian cancer cell te chu an thanlenna atana an mamawh hormone a hloh tir a ni.
He damdawi ei hian a hlauhawm ber chu osteoporosis , ruh chak lo leh awlsam taka tihchhiat theihna a ni. Hemi avang hian i doctor chuan he damdawi hi i ei tan hma leh i ei lai hian bone density test a ti ngei ang. Calcium leh vitamin D supplement ei turin a rawt thei bawk.
Enkawlna dang leh hmasawn tak takte
A chunga kan sawi tak damdawi chi hrang hrang bakah hian damdawi chi dang hman a awm a, a bik takin cancer hian taksa peng dang (advanced emaw metastatic emaw) a lo darh tawh chuan.
Entirnan, damdawi chi hrang hrang `Fulvestrant (Faslodex)` leh `Toremifene (Fareston)` te a awm a. Hei bakah hian tunlai hian damdawi changkang tak tak `Targeted Therapy` tih hi a awm nual a. `Palbociclib (Ibrance)`, `Abemaciclib (Verzenio)`, `Alpelisib (Piqray)` te hi chutiang damdawi entir nan hman a ni. Hengte hian cancer cells te tihpunna tura puitu protein bikte target-in hna an thawk a ni. Hengte hi a chunga kan sawi tak hormone therapy nen hian damlote hnenah pek a ni fo thin.
Heng enkawlna chungchanga thutlukna siam zawng zawng hi i dinhmun, cancer chi hrang hrang, i kum leh i hriselna zawng zawng a zirin siam a ni. Chuvangin zawhna i neih apiang chu i doctor nen sawiho hlau suh .
Menopause paltlang lote tan enkawlna bik (Ovarian Ablation) .
Menopausal i la ni lo a, chu chu period mumal i nei tihna a ni a nih chuan i taksaa estrogen hormone ber chu i ovary atanga siam a ni. Chuvangin, ER-positive cancer vei tan chuan i doctor chuan heng ovary te hian estrogen an siam chhuah loh nan a titawp mai thei. Hei hi ovarian ablation/suppression an ti a.
Chutianga tih theih dan kawng hrang hrang a awm a:
- Ovaries surgery hmanga lakchhuah : Hei hi a awm reng tur a ni.
- Radiation therapy to the ovaries: Hei hian ovaries hnathawh chu a titawp reng thei bawk.
- Ovary hnathawh tihtawp theihna damdawi: Hemi atan hian damdawi `(LHRH) agonists` (a tam zawkah chuan injection) an hmang thin. Heng damdawi te hi i ei chhung chuan i ovary te hian hormone a siam chhuak dawn lo.
Research atanga a lan dan chuan heng ovary te hi tihtawp bakah hian tamoxifen ang chi hormone therapy hian result tha tak a nei thei a ni.
Take-Home Thuchah a ni
- Hormone therapy hi hnute cancer zawng zawng enkawlna a ni lo. Hormone receptor-positive (ER/PR-positive) cancer tan chauh pek a ni.
- I tana tha ber enkawlna (e.g. Tamoxifen emaw Aromatase Inhibitor) chu i doctor-in a ruat ang a, i kum leh hriselna dinhmun a zirin a ni ang.
- Heng damdawi zawng zawng hian side effect a nei thei vek a ni. Hlau suh, an nihna hre reng mai rawh. Symptom danglam tak tak i neih chuan doctor hnenah hrilh nghal rawh.
- Inenkawl lai hian a hun taka Doctor-in a pek test neih a pawimawh hle.
- I hlauhthawnna te, rinhlelhna te, leh zawhna te chu i medical team te nen zalen takin sawipui thin ang che. Hei hi i damna zinkawngah chakna nasa tak a ni ang.
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