Nilengin i chau a, engmah tih theihna chakna i nei lo em ni? Kan hnathawh tam lutuk vang te, kan ei that loh vang te, kan mut that loh vang te a ni tih kan ngaihtuah fo thin. Mahse, kan taksa chhungah hian heng zawng zawng hi a chhan thuk zawk a awm thei tih i hria em? Kan taksaa energy factory te te te hi i hre tawh em? Hengte hi mitochondria kan tihte chu an ni. Hengte hi a thawk tha lo a nih chuan kan ngaihtuah ngai loh harsatna lian tak tak a lo chhuak thei a ni. Chuvangin vawiin hian he thu hi chipchiar tak leh awlsam takin sawi ila.
Heng mitochondria te hi engte nge ni?
A awlsam zawngin,
mitochondria hi kan taksa cell zawng zawng deuhthaw-a engine te emaw, power plant emaw ang mai a ni. Ngaihtuah teh, kan taksa hi khawpui lian tak ni ta se, heng mitochondria te hi chu khawpui tana electric petu power plant te an ni. Kan ei leh in leh kan thawk oxygen hmang hian heng mitochondria te te hian kan taksa tlan chakna, zuang, ngaihtuah, hnathawh
leh a tawi zawngin nunna atana a mamawh chakna 90% an siam chhuak thin. A bik takin taksa peng hrang hrang, thawk reng leh chakna tam zawk mamawh, kan
thinlung, thluak leh taksa peng hrang hrangah te hian heng mitochondria hi sang tam tak a awm a ni. A chhan chu chu taksa peng hrang hrangte chuan midang aiin ‘current’ an mamawh zawk a ni.
Chuti a nih chuan heng mitochondrial natna te hi engte nge ni?
Ngaihtuah teh, chu power plant ka sawi tawhte chu rang takin hna an thawk tha tawh lo va, energy tling tawk an siam chhuak tawh lo a nih chuan eng nge thleng ang? Khawpui pum pui chu a thim ang a, kan taksa hnathawh pawh a tichhe vek ang. Chutah chuan
‘Mitochondrial Diseases’ an tih condition a lo awm ta a ni. Hengte hi
chronic an ni tlangpui a, dam chhung zawng an daih thei tihna a ni. A tam zawkah chuan genetic an ni a, chu chu
nu leh pa atanga fate rochun an ni tihna a ni. A châng chuan heng chhinchhiahnate hi nau piangah a awm thei a, a châng erawh chuan nakin lawkah a lang thei bawk.
Heng natnate hi engte nge ni?
A tam zawkah chuan hei hi a chhan ber chu genetic a ni. Chu chu kan nu leh pate hnen atanga kan rochun genes-a chhiatna thenkhat a awm tihna a ni. Hei hi kawng pawimawh engemaw zatah a thleng thei a ni.
| Rochan chi hrang hrang | A awlsam zawngin... |
|---|
| Autosomal Recessive atanga lo piang chhuak | Chutiang a nih chuan naupang chuan nu leh pa hnen atangin gene chhia (mutated gene) a rochun a ni. Tichuan, chhungkuaa naupang tin hian he natna vei theihna chance 25% an nei a. |
| Autosomal Dominant Rochun a ni | Heta thil thleng chu naupang hian nu leh pa pakhat chauh, nu emaw pa emaw aṭangin gene ṭha lo a rochun a ni. Tichuan, chhungkuaa naupang tin hian natna vei theihna chance 50% an nei a. |
| Mitochondrial atanga lo piang chhuak | Hemi hi chu a danglam deuh deuh. Mitochondria hian DNA an nei ve ve a. He inheritance-ah hian mitochondria chhia nei nu chuan a fate zawng zawngin he natna hi an rochun theihna chance 100% a nei a ni. |
| Random Mutations a awm thin | A tlem hle a, naupang genes siam thar a nih chuan mutation a awm thei a, chu chu nu leh pate dik lohna engmah a awm lo. |
Tin, mitochondrial dysfunction hi damdawi lam thil thenkhat, Alzheimer natna, muscular dystrophy, zunthlum, leh cancer chi thenkhat nen a inzawm thei bawk.
Heng natna lanchhuahna te hi eng nge ni?
Hei hi mi tam tak buaina hmun a ni. Heng natna lan chhuah dan hi mi hrang hrangah a inang lo thei hle. A chhan chu taksa peng hrang hrang a nghawng dan azirin a natna lan chhuah dan a inang lo vang. Mi thenkhatin symptoms na lo
tak tak an neih laiin thenkhat erawh chuan na tak tak an nei thei thung.
Heng symptoms te hi kum eng pawhah a lang thei. Tin, heng symptoms te hi natna tlanglawn dangte nen a inang em avangin a chang chuan natna hriat chian a harsa thei bawk.
A hnuaia table-ah hian a lan chhuah theih dan thenkhat tarlan a ni.
| System/organ a nghawng dan | Symptoms awm thei te |
|---|
| Hmasawn leh thau | Exercise neih laiin a than chak lohna, taksa ruh chak lohna leh hah lutuk. |
| Thluak leh nerve te | Zirna lama harsatna, hmasawnna tlai, autism spectrum disorder, migraine, seizures, stroke, leh dementia te. |
| Sensory organs te hi a awm a | Mit leh hriatna lama harsatna nei. |
| Chhungril taksa peng hrang hrang | Lung, kal emaw thin natna, zunthlum, thyroid lama harsatna nei te. |
| Chaw ei dan (digestive system) a ni | Chaw ei harsa, pum na, ril\am emaw, ril\am emaw, luak chhuak. |
Engtin nge natna hi kan hriat theih ang?
A hmaa ka sawi tawh ang khan heng natna lan chhuah dan hi a danglam thei hle a, chuvangin natna chu eng nge ni tih chiang taka hriat chian a harsa deuh thei a ni.
Test pakhat chauh hmanga hriat theih a ni lo. Chuvangin doctor chuan damlo pakhat a enfiah a, test hrang hrang nei turin a tir thin.
Test tih tlangpui
- Chhungkaw damdawi lam chanchin uluk taka thlirletna .
- Taksa leh thluak enfiahna kimchang tak neih .
- Thisen leh zun test hmanga taksaa chemical inthlak danglamna hriatchhuah (Metabolic exam).
- MRI scan (a bik takin thluak lama harsatna nei tan).
- ECG (Electrocardiogram) emaw Echocardiogram test hmanga thinlung hnathawh dan enfiah a ni.
- Genetic defects hriat theihna turin DNA test bik neih a ni .
- A then phei chuan test (biopsy) atan taksa ruh emaw vun emaw tlemte lak a ngai thei bawk .
Hei hi eng enkawlna nge ni?
Mi tam takin zawhna an zawh thin chu hei hi damdawi famkim a awm em tih hi a ni. Dik tak chuan
mitochondrial natna damdawi chiang tak a la awm lo. Mahse, chu chu hlau suh. Natna lan chhuah dan thunun tur leh natna zual zel tur tikhawtlai thei tur damdawi chi hrang hrang a awm a. Enkawlna chu damlo natna, a taksa peng hrang hrang leh natna nasat danah a innghat a ni. Natna inang vei mi pahnihin enkawlna inang an nei a nih pawhin a thawk dan inang lo mai thei.
Enkawl dan tlangpui thenkhat:
- Vitamin leh supplement: Vitamin thenkhat hian mitochondrial function a pui thin.
- Exercise: A bik takin taksa ruh tichaktu exercise. Hengte hi i doctor emaw physical therapist emaw kaihhruaina hnuaiah tih tur a ni.
- Physical therapy , occupational therapy, leh speech therapy : Hengte hian damlo chu nitin hnathawh awlsam zawkin a ti thei a ni.
Tin, damlote chu thil engemaw laka inthiarfihlim turin an chah bawk. Entirnan, khaw lum emaw, lum lutuk emaw, riltam, mut tlem, lungkhamna,
zu in, leh zu in te ang chi thilte pumpelh a pawimawh hle
Take-Home Thuchah a ni
- Mitochondria hi power plant te tak te ang mai a ni a, kan taksa chhunga cell te tan chakna pe thin a ni.
- Hengte hnathawh that lohna avanga natna lo awm hi a tlangpuiin hun rei tak chhung a ni a, genetically atanga rochun a ni fo bawk.
- Symptoms hi a chi hrang hrang hle a, taksa chak lohna , than chak lohna, mit leh hriatna lama harsatna, leh thinlung natna te pawh a tel thei.
- Heng natnate hi damdawi bik awm lo mah se, a natna lan chhuah dan thunun a, i nunphung siamremna hmangin nun tha tak i hmang thei a ni.
- Nangmah emaw, i chhungte zinga tu emaw hian he natna hi i neih chuan fa i neih hmain i doctor nen genetic counseling chungchang sawipui a pawimawh hle. Thil tha ber chu hlauthawng lo, damdawi lam thurawn dik tak lak hi a ni.
Mitochondria, Mitochondria, Mitochondrial Disease, Genetic Disease, Energy, Cells, Symptoms, Enkawl dan
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