Ngati mutatsegula kabati yanu ya mankhwala kunyumba, mwina mungapeze imodzi mwa mitundu iyi ya mankhwala. Tikulankhula za mankhwala ena omwe amagwiritsidwa ntchito pa ziwengo, kuvutika maganizo, kupweteka kosatha, nseru, kapena kusowa tulo. Awa ndi mankhwala omwe takhala tikugwiritsa ntchito kwa zaka zambiri. Koma kafukufuku watsopano akuwonetsa kuti kugwiritsa ntchito mankhwalawa kwa nthawi yayitali sikungakhale kwabwino kwambiri pa thanzi la ubongo wathu. Kungawonjezere chiopsezo cha matenda a dementia , matenda okumbukira. Chifukwa chake tiyeni tiwone zomwe mankhwala awa a anticholinergic ndi, momwe amakhudzira ubongo, komanso momwe angawagwiritsire ntchito mosamala.

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Kodi mankhwala oletsa cholinergic awa ndi otani kwenikweni?

Mwachidule, mankhwala awa akhoza kugawidwa m'magulu awiri akuluakulu. Gulu loyamba ndi lomwe timagwiritsa ntchito mwadala kuti tipeze mphamvu yotsutsana ndi cholinergic. Gulu lachiwiri ndi lomwe limaperekedwa chifukwa china chachikulu, koma limakhala ndi mphamvu yotsutsana ndi cholinergic ngati zotsatira zoyipa. Gome ili pansipa likuwonetsa zina mwazomwe zimagwiritsidwa ntchito kwambiri ndi mankhwalawa.

Matenda/kagwiritsidwe ntchito	Zitsanzo za mankhwala
Matenda ena a kugwedezeka	Benztropine, Trihexyphenidyl
Kusanza ndi kusanza	Scopolamine
Kusadziletsa kwa Mkodzo	Oxybutynin, Tolterodine
Kuvutika maganizo, kusowa tulo, ndi ululu	Mankhwala oletsa kuvutika maganizo a tricyclic monga amitriptyline
Matenda oopsa a chifuwa chachikulu, kusowa tulo, ndi nkhawa	Mankhwala oletsa antihistamine akale monga diphenhydramine (omwe amapezeka mu pyrithione ) ndi hydroxyzine

Kodi mankhwala amenewa amakhudza bwanji ubongo wathu?

Ndi zophweka kwambiri. Mankhwala oletsa cholinergic awa akalowa mu ubongo, amatseka mankhwala otchedwa acetylcholine . Acetylcholine iyi ndi neurotransmitter yomwe ndi yofunika kwambiri pakugwira ntchito kwa ma neuron ambiri mu ubongo. Ganizirani ubongo wanu ngati positi ofesi yayikulu. Acetylcholine ndi mthenga wofunikira kwambiri mmenemo. Ndiwo umathandiza kusunga zokumbukira, kusunga chidziwitso mu kukumbukira kwakanthawi kochepa, ndikuchikonza kukhala zokumbukira za nthawi yayitali. Chifukwa chake zomwe mankhwalawa amachita ndikusokoneza ntchito ya mthengayo. Ngati sasiya kwathunthu, amachepetsa kwambiri ntchito ya ma neuron amenewo.

Kodi kugwiritsa ntchito izi kungakhudze bwanji ntchito ya ubongo?

Kafukufuku akusonyeza kuti mankhwalawa si abwino kwambiri pa luso lanu lokumbukira ndi kuganiza. Makamaka, mukawagwiritsa ntchito kwa nthawi yayitali, zimakhala zovuta kwambiri kusintha zotsatira zake. Tiyeni tigawane chiopsezochi m'magawo atatu. 1. Zotsatira zake nthawi yomweyo: Ngakhale mutamwa mankhwalawa kamodzi, mutha kukumana ndi mavuto okumbukira. Sitikuganiza kuti kumwa kamodzi kungawononge moyo wanu wonse. Koma ngakhale kugwiritsa ntchito kwakanthawi kochepa kungayambitse mavuto okumbukira. 2. Zotsatira zake kwa nthawi yayitali: Tangoganizani kuti mwakhala mukumwa mankhwalawa kwa miyezi ingapo . Pankhaniyi, mutasiya kumwa mankhwalawa, zingatenge miyezi ingapo kuti zotsatira zake pa kukumbukira zithe kwathunthu. Nthawi zambiri, m'zipatala, luso la wodwala lokumbukira ndi kuganiza limawunikidwanso miyezi itatu mutasiya kumwa mankhwalawa. 3. Zotsatira zake kwa nthawi yayitali: Umboni womwe wasonkhanitsidwa kwa zaka zambiri umasonyeza kulumikizana pakati pa mankhwala oletsa cholinergic awa ndi dementia , makamaka matenda a Alzheimer's .

Matenda a Alzheimer akayamba, kuwonongeka kumeneku kumakhudza makamaka maukonde a mitsempha muubongo omwe amagwiritsa ntchito acetylcholine . Chifukwa chake mankhwalawa amatha kuipitsa njira imeneyi.

Ndani amene ali pachiwopsezo chachikulu cha zotsatirapozi?

Zinthu ziwiri zazikulu zimakhudza izi.

Ukalamba : Pamene tikukalamba, timayamba kukhudzidwa kwambiri ndi zotsatirapo za mankhwala aliwonse. Mosiyana ndi pamene tinali aang'ono, matupi athu amatenga nthawi yaitali kuti achire pamene tikukalamba. Chifukwa chake, tiyenera kusamala kwambiri ndi mankhwala athu. Izi ndi zoona makamaka pa mankhwala oletsa cholinergic.

Kutengera majini : Anthu ena amakhala ndi chibadwa chotenga matenda a Alzheimer's . Izi zimachitika chifukwa cha mtundu wina wa majini wotchedwa ApoE4 . Kafukufuku wapeza kuti anthu omwe ali ndi jini iyi ali pachiwopsezo chachikulu chotaya kukumbukira akamamwa mankhwala oletsa cholinergic.

Kafukufuku wina adapeza kuti anthu azaka zopitilira 55 omwe adagwiritsa ntchito mankhwala amphamvu oletsa cholinergic pa mlingo wocheperako wovomerezeka watsiku ndi tsiku kwa zaka zitatu pazaka 10 anali ndi chiopsezo chowonjezeka cha 50% cha matenda a dementia.

Ndiye anthu omwe amagwiritsa ntchito mankhwalawa ayenera kuchita chiyani?

Chofunika kwambiri ndichakuti musasiye kumwa mankhwala aliwonse omwe dokotala wanu wakupatsani. Kuchita zimenezi kungapangitse kuti vuto lanu likhale loipa kwambiri. Tangoganizirani kuti mwadzidzidzi mwakhala ndi vuto lalikulu la ziwengo ndipo muyenera kumwa mankhwala nthawi imeneyo. Kumwa kamodzi si nkhani yaikulu. Vuto ndikugwiritsa ntchito mobwerezabwereza komanso kwa nthawi yayitali. Chomwe muyenera kuchita ndikulankhula momasuka ndi dokotala wanu za mankhwala omwe mukumwa. "Dokotala, kodi mankhwala omwe ndikumwawa ali ndi zotsatira zotsutsana ndi cholinergic? Kodi ndipitirize kumwa? Kodi pali njira zina zomwe ndingasankhe?" Dzifunseni nokha. Ponseponse, ngati mukudera nkhawa za thanzi la ubongo wanu, ndi bwino kupewa mankhwala omwe ali ndi zotsatira zotsutsana ndi cholinergic momwe mungathere.

Ndi njira zina ziti zomwe zingagwiritsidwe ntchito m'malo mwa mankhwalawa?

Mwamwayi, lerolino tili ndi njira zina zotetezeka pa matenda ambiriwa.

Mavuto a kusowa tulo

Njira yabwino yochitira izi ndikukhala ndi zizolowezi zabwino zogona. Gonani nthawi yomweyo tsiku lililonse. Siyani kuyang'ana foni yanu kapena TV musanagone. Ngati simungathe kugona mkati mwa mphindi 15 kuchokera pamene mwagona, dzukani ndikuchita china pamalo amdima opanda foni yanu kwa mphindi 15 musanagonenso. Ngati kuli kofunikira, lankhulani ndi dokotala wanu za kugwiritsa ntchito chinthu monga melatonin .

Nkhawa ndi Kuvutika Maganizo

Pali mankhwala ena ambiri omwe alibe mphamvu zotsutsana ndi cholinergic pa matenda awa. Mwachitsanzo, mankhwala monga Duloxetine angagwiritsidwe ntchito pochiza kuvutika maganizo komanso ululu.Ndi chida champhamvu kwambiri.

Kuvuta kulamulira mkodzo

Tsopano palinso mankhwala atsopano a izi omwe alibe zoopsa zotsutsana ndi cholinergic. Mirabegron ndi imodzi mwa mankhwala otere.

Ululu wa nthawi yayitali

Kuchiza ndi thupi kuyenera kukhala chithandizo chachikulu cha matenda ambiri opweteka nthawi yayitali. Pali umboni wakuti kuchiza ndi thupi kumatha kuchepetsa ululu bwino kuposa mankhwala.

Matenda a ziwengo

Pali mitundu yambiri yatsopano ya mankhwala oletsa kutupa omwe amapezeka m'ma pharmacy. Zitsanzo zake ndi Cetirizine , Fexofenadine , ndi Levocetirizine . Komabe, samalani ngati mugula mankhwala ena a chifuwa ndi chimfine kuchokera ku pharmacy omwe ali ndi mawu oti "DM" kumapeto kwa dzinalo. Nthawi zambiri amakhala ndi diphenhydramine .

Uthenga Wopita Nawo Kunyumba

Mankhwala ena omwe timagwiritsa ntchito nthawi zambiri pa matenda monga ziwengo , ululu, ndi kusowa tulo ali ndi mphamvu zoletsa cholinergic zomwe zingakhudze ubongo.
Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kungayambitse kuiwala kukumbukira ndikuwonjezera chiopsezo cha matenda a dementia.
Musasiye kumwa mankhwala aliwonse omwe dokotala wanu wakupatsani popanda kufunsa dokotala wanu.
Nthawi zonse lankhulani ndi dokotala wanu za mankhwala omwe mukumwa, zotsatira zake, ndi zomwe mungasankhe.
Ngati n'kotheka, yesani njira zina monga kusintha moyo wanu, chithandizo chamankhwala, ndi uphungu musanayambe kugwiritsa ntchito mankhwala.