Kodi pali vuto ndi maselo anu oyera a magazi? Tiyeni tiphunzire za Histiocytosis mwachidule!

Kodi mukudziwa kuti nthawi zina mitundu ina ya maselo m'thupi lathu imayamba kuchita zinthu mosiyana pang'ono? Chimodzi mwa zinthu zachilendo chotere ndi Histiocytosis. Izi zingamveke zoopsa pang'ono kwa inu, koma musadandaule. Tiyeni tikambirane mwachidule komanso m'njira yomveka bwino.

Kodi Histiocytosis ndi chiyani? Mwachidule...

Thupi lanu lili ndi mtundu wa maselo oyera a m'magazi otchedwa histiocytes. Pakati pa maselo oyera amenewo, pali mtundu wapadera wa maselo otchedwa histiocytes . Awa ali ngati alonda a chitetezo cha thupi lathu. Ndi omwe amalimbana ndi majeremusi oyambitsa matenda otchedwa mavairasi , mabakiteriya , ndi bowa - ndipo amathandiza kuti chitetezo chathu cha mthupi chikhale chathanzi.

Komabe, nthawi zina maselo a histiocyte amenewa amayamba kukula modabwitsa, kutanthauza kuti, amakhala " mutant " . Kenako, maselo a histiocyte osazolowerekawa amakula mochulukira ndipo amasonkhana m'malo osiyanasiyana a thupi lathu. Akamasonkhana mochulukira, chitetezo chathu cha mthupi chingakhale ndi mavuto. Chofunika kwambiri ndichakuti kutupa , ndiko kuti, vuto lofanana ndi kutupa, kumachitika m'thupi la munthu. Kutupa kumeneku nthawi zina kumatha kuwononga ziwalo zathu.

Maselo osazolowereka a histiocyte awa amatha kusonkhana m'ma lymph nodes anu (omwe amatchedwanso ma lymph nodes), pakhungu, mafupa, mapapo, chiwindi, ndulu, kapena kwina kulikonse m'thupi lanu. Nthawi zina zimakhudza gawo limodzi la thupi lanu. Timatcha izi kuti 'single system' condition. Nthawi zina zimatha kukhudza ziwalo zambiri za thupi lanu. Timatcha izi kuti 'multisystem' condition.

Chofunika kwambiri ndichakuti histiocytosis si khansa . Komabe, nthawi zina imatha kukhala ngati khansa ndikuwonetsa zizindikiro zofanana ndi khansa. Ichi ndichifukwa chake ndi vuto lomwe limafuna chisamaliro chapadera pang'ono. Chifukwa zizindikiro za izi zimasiyana malinga ndi munthu ndipo kuopsa kwa vutoli kumasiyana, nthawi zina zimakhala zovuta kuzindikira histiocytosis mwachangu.

Kodi mitundu ikuluikulu ya histiocytosis ndi iti?

Tsopano mwina mukumvetsa tanthauzo la histiocytosis. Pali mitundu yoposa 100 ya histiocytosis. Koma pali mitundu itatu ikuluikulu yomwe timaiona ndi kuikamba nthawi zambiri. Tiyeni tiione.

1. Langerhans cell histiocytosis (LCH):

• Uwu ndiye mtundu wofala kwambiri wa histiocytosis.
• Matendawa nthawi zambiri amakhudza ana aang'ono . Amakhudza ana pakati pa 5 ndi 9 pa ana miliyoni iliyonse.
• Nthawi zambiri, izi sizili zovuta kwenikweni, ndipo zimatha kukhala zosavuta ngati "zosawonetsa zizindikiro" . Komabe, ndikofunikira kukumbukira kuti nthawi zina, izi zitha kukhala zoopsa komanso zoika moyo pachiswe.

2. Matenda a Erdheim-Chester (ECD):

• Mtundu uwu umakhudza kwambiri akuluakulu .
• Izi ndi zochitika zachilendo kwambiri .
• Monga LCH, ECD imatha kukhala yofatsa mpaka yoopsa komanso yoika moyo pachiswe.

3. Matenda a Rosai-Dorfman (RDD):

• Monga LCH, RDD nthawi zambiri imapezeka mwa ana , koma imapezekanso kwa akuluakulu.
• Izinso sizichitika kawirikawiri. Pafupifupi munthu m'modzi pa anthu 200,000 amapezeka ndi matendawa.
• Mtundu waukulu wa izi ndi 'classical RDD' . Apa ndi pamene ma lymph nodes (tizilombo) anu amatupa.
• Mtundu wina ndi 'extranodal RDD' . Pachifukwa ichi, ziwalo zina kupatula ma lymph nodes zimakhudzidwa. Izi zikutanthauza kuti maselo ochulukirapo a histiocyte amatha kudziunjikira pakhungu, mafupa, kapena malo ena.

Kodi matenda amenewa otchedwa Histiocytosis ndi osowa bwanji?

Inde, monga ndanenera kale, histiocytosis ndi matenda osowa kwambiri . Ndipotu, mitundu yoopsa kwambiri ya khansa imakhala yosakwana 1% ya khansa zonse zomwe zimapezeka m'minofu yofewa ndi m'maselo a lymph. Kotero mutha kuganiza momwe izi zilili zachilendo.

Kodi zizindikiro za Histiocytosis ndi ziti?

Tsopano tiyeni tiwone zizindikiro zomwe zikuwonetsedwa mu vuto la histiocytosis. Zizindikirozi zimatha kusiyana kuchokera kwa munthu mmodzi kupita kwa wina . Chifukwa cha izi ndikuti ziwalo ndi minofu momwe maselo ochulukirapo a histiocyte amasonkhana, monga ndanenera, komanso kuchuluka kwa kuwonongeka kwa minofuyo, zimakhudza izi.

Nazi zina mwa zizindikiro zomwe mungaone (ndipo mwina zingakhalepo zina):

• Ziphuphu pakhungu : Izi zitha kuwoneka makamaka m'malo okhala ndi ubweya pamutu pa makanda aang'ono (timawatcha 'chipewa cha cradle' ) kapena m'malo okhala ndi matewera.
• Malungo .
• Kutopa, kutopa .
• Mutu.
• Chifuwa kapena kupuma movutikira .
• Kuchepetsa thupi kosamveka bwino .
• Kupweteka kwa mafupa .
• Kutupa kwa ma lymph nodes (izi ndi zomwe kutupa kumatanthauza).
• Kusintha kwa masomphenya kapena kutupa kwa maso .
• Kukodza pafupipafupi komanso ludzu lochuluka .
• Matumbo a pakhungu (akhoza kuwoneka ngakhale m'zikope).
• Kuvuta kuganizira kapena kukumbukira zinthu .
• Mavuto okhudzana ndi kulinganiza bwino zinthu komanso kugwirizana .

Kodi zizindikirozi zimachitika bwanji? Kutengera ndi komwe ma histiocyte amasonkhana!

Zizindikiro zimenezi zimadalira komwe maselo a histiocyte amasonkhana m'thupi. Malo akuluakulu osonkhanitsa amasiyana malinga ndi mtundu wa histiocytosis.

Malo omwe angakhudzidwe ndi Langerhans cell histiocytosis (LCH):

• Fupa
• Khungu
• Kutupa kwa ma lymph nodes (kutupa)
• Chiwindi
• Nkhumba
• Pakamwa
• Mapapu
• Dongosolo la mitsempha yapakati (ndiko kuti, ubongo ndi msana)

Madera omwe angakhudzidwe ndi matenda a Erdheim-Chester (ECD):

• Mafupa aatali (makamaka m'miyendo)
• Maso
• Dongosolo lapakati la mitsempha
• Mapapu
• Mtima
• Mitsempha ya magazi
• Impso
• Ziwalo zomwe zili kumbuyo kwa mimba (timazitcha kuti 'retroperitoneum' )

Malo omwe angakhudzidwe ndi matenda a Rosai-Dorfman (RDD):

• Ma lymph nodes (makamaka m'khosi, koma amathanso kuchitika kwina)
• Khungu
• Minofu yofewa
• Njira yopumira yapamwamba
• Fupa
• Retroperitoneum (ziwalo zomwe zili kumbuyo kwa mimba)
• Maso

Kodi n’chiyani chimayambitsa Histiocytosis?

Asayansi sakudziwabe chomwe chimayambitsa histiocytosis, koma apeza kuti ikhoza kulumikizidwa ndi kusintha kwa majini .

Mwachidule, selo lililonse m'thupi lathu lili ndi zinthu za majini, kapena malangizo. Malangizo awa amatsimikiza momwe maselo amenewo ayenera kukhalira. Chifukwa chake, kusintha kwa malangizo awa, kotchedwa kusintha kwa majini, kumachitika, maselo amayamba kuchita zinthu molakwika. Mwachitsanzo, kusintha kwa majini kungayambitse selo ngati histiocyte kudzitsanzira ndikuyamba kufalikira mosalamulirika.

Kuzindikira kusintha kwa majini kumeneku kwathandiza ofufuza kupanga njira zatsopano zochizira histiocytosis. Mankhwalawa amagwira ntchito poletsa kusintha kwa maselo koopsa komwe kumalola maselo a histiocyte kukula mosalamulirika.

Kodi mumazindikira bwanji histiocytosis?

Ngati mukuganiza kuti muli ndi histiocytosis, dokotala wanu ayamba kaye wakuyezani thupi ndikufunsani za mbiri yanu yachipatala. Kenako, adzasankha mayeso oti achite kutengera zizindikiro zanu ndi ziwalo zomwe zikuganiziridwa kuti zakhudzidwa ndi histiocytes yochulukirapo.

Nazi mayeso ena omwe mungachite:

• Njira zojambulira zithunzi :
• Dokotala wanu angakupatseni scan yapadera yotchedwa FDG PET/CT scan . Izi zitha kuzindikira zinthu monga zotupa m'thupi lonse.
• Kuphatikiza apo , mayeso monga CT scan, MRI scan, bone scan, ultrasound scan, X-ray, kapena echocardiogram (kujambula mtima) angafunike.

• Mayeso a Laboratory :
• Dokotala wanu adzayesa zitsanzo zamadzimadzi, monga magazi kapena mkodzo wanu, kuti aone ngati pali zizindikiro za histiocytosis.
• Kuchuluka kwa maselo a m'magazi anu kumayesedwa. Amafufuzanso mahomoni kapena mapuloteni enaake omwe amasonyeza momwe ziwalo zanu zikugwirira ntchito. Ngati chiwalo sichikugwira ntchito bwino, zitha kusonyeza kuti pali ma histiocyte ambiri m'chiwalo chimenecho.

• Mayeso a Biopsy `(Biopsy)` :
• Chomwe chimachitika ndi chakuti dokotala amatenga chitsanzo cha minofu ndikuchiyang'ana pansi pa maikulosikopu kuti aone ngati muli ndi histiocytosis.
• Imayang'ananso kusintha kwa majini komwe kumakhudzana ndi histiocytosis.
• Nthawi zina, ngati biopsy sizingatheke, zinthu za majini m'magazi anu zimatha kuyesedwa. Izi zimatchedwa 'liquid biopsy' .

Kodi mankhwala a Histiocytosis ndi ati?

Chithandizo cha histiocytosis chimadalira zinthu zambiri . Makamaka:

• Zizindikiro zanu ndi zoopsa bwanji .
• Kaya muli ndi chotupa chimodzi kapena zambiri (izi ndi malo omwe minofu yanu ili yosazolowereka).
• Kodi `mabala` awa ali kuti pa thupi ?
• Kaya zotupa izi ndi za khansa kapena ayi .

Madokotala amasankha chithandizo kutengera mfundo izi. Nazi njira zina zochizira:

• Yang'anirani ndipo dikirani : Ngati histiocytosis yanu si yoopsa kwambiri ndipo mulibe zizindikiro zazikulu, dokotala wanu angakuuzeni kuti muyang'anire vuto lanu.
• OpaleshoniNgati maselo a histiocyte asonkhana m'mbali imodzi yokha ya thupi, opaleshoni ikhoza kuchitidwa kuti achotse gawolo.
• Chithandizo cha radiation : Izi zimaphatikizapo kugwiritsa ntchito makina kuti atsogolere kuwala kwamphamvu kwambiri ku zilonda. Kuwala kumeneku kumapha maselo osazolowereka ndikuchepetsa kukula kwa zotupa. Nthawi zina chithandizo cha radiation chingathandizenso kuchepetsa zizindikiro.
• Chemotherapy (yomwe imatchedwanso 'chemo') : Izi zimaphatikizapo kutumiza mankhwala m'magazi mwanu kuti awononge maselo ochulukirapo a histiocyte omwe afalikira m'thupi lanu lonse. Madokotala amalangiza 'chemo' pokhapokha ngati maselo a histiocyte afalikira m'thupi lanu lonse.
• Corticosteroids : Mankhwala monga prednisone ali m'gulu ili. Izi zitha kuchepetsa kutupa komwe kumachitika chifukwa cha histiocytosis. Mankhwalawa angaperekedwe okha kapena pamodzi ndi mankhwala ena, monga chemotherapy.
• Chithandizo cha Immunotherapy : Izi zimagwira ntchito polimbitsa chitetezo cha mthupi lanu, kuwathandiza kuzindikira ndikuwononga maselo owopsa, monga ma histiocyte osazolowereka.
• Chithandizo cholunjika : Ichi ndi chithandizo chapadera. Chithandizochi chimagwiritsidwa ntchito pa matenda a histiocytosis okhudzana ndi kusintha kwa majini.

Kodi Histiocytosis ingachiritsidwe kwathunthu?

N'zovuta kunena 'inde' kapena 'ayi' pa izi, chifukwa zimatengera momwe zinthu zilili. Anthu ambiri omwe ali ndi histiocytosis amalowa mu zomwe zimatchedwa 'durable remission'. Izi zikutanthauza kuti, amatha popanda zizindikiro kapena zizindikiro za matendawa.

Mitundu ina ya histiocytosis, makamaka pamene ma histiocytes ali pamalo amodzi m'thupi, imatha kuchiritsidwa kwathunthu ndi opaleshoni . Dokotala wanu adzakupatsani maulendo obwerezabwereza kuti akaone ngati abwereranso.

Komabe, ngati mtundu wa histiocytosis womwe muli nawo sungathe kuchiritsidwa kwathunthu, dokotala wanu adzakulangizani njira yothandizira yomwe ingakuthandizeni kuthana ndi vutoli.

Kodi chiyembekezo cha matendawa ndi chiyani?

Kuyezetsa matenda anu kumadalira zinthu zambiri. Kwa anthu ena, histiocytosis imadzichiritsira yokha popanda chithandizo chilichonse . Mwachitsanzo, pafupifupi 40% ya anthu omwe ali ndi RDD amachira popanda chithandizo. Komanso, LCH ikakhudza gawo limodzi lokha la thupi (timalitcha kuti 'localized LCH') , nthawi zambiri imadzichiritsira yokha.

Koma, nthawi zina, histiocytosis imafuna chithandizo champhamvu komanso kuyang'aniridwa mosamala, mwa ana ndi akuluakulu.Pa milandu yoopsa kwambiri, histiocytosis ingayambitse kuwonongeka kwa ziwalo komanso kupha anthu .

Choncho, ndi bwino kufunsa dokotala wanu za matenda omwe angakuchitikireni.

Kodi Histiocytosis ingapewedwe? Kodi chiopsezo chingachepe bwanji?

Kunena zoona, palibe njira yopewera histiocytosis, koma chithandizo chingakuthandizeni kuthana ndi zizindikiro zanu.

Koma pali chinthu chimodzi. Kusiya kusuta kungachepetse chiopsezo chanu chokhala ndi khansa ya m'mapapo yotchedwa LCH (Langerhans cell histiocytosis). Kusiya kusuta kapena kusasuta kungathandizenso kuti muyankhe bwino chithandizo. Ngati mukufuna thandizo kuti musiye kusuta, funsani dokotala wanu za mapulogalamu oti musiye kusuta.

Ndi mafunso ati omwe ndiyenera kufunsa dokotala wanga?

Ngati mwapezeka ndi histiocytosis, ndi zachilendo kukhala ndi mafunso ambiri m'maganizo mwanu. Ndikofunikira kulankhula ndi dokotala wanu za zonsezi ndikumvetsetsa bwino za matenda anu. Nazi mafunso ena omwe mungafunse:

• Kodi ndili ndi mtundu wanji wa histiocytosis?
• Kodi ndikufunika chithandizo?
• Kodi ndi njira ziti zochiritsira zomwe mumalimbikitsa?
• Ndi zotsatirapo ziti zomwe zingayembekezeredwe panthawi ya chithandizo?
• Kodi zotsatira za chithandizo ndi ziti?
• Kodi vuto langa lingachiritsidwe kwathunthu?

Uthenga Womaliza Wopita Nawo Kunyumba

Mwachidule, histiocytosis ndi dzina lomwe limaperekedwa ku gulu la matenda osowa magazi omwe amayamba chifukwa cha kuchuluka kwa ma histiocytes, mtundu wa maselo oyera amagazi, m'minofu. Zina mwa izi zimatha kukhala zosavuta, zosayambitsa zizindikiro, pomwe zina zimatha kukhala zoopsa kwambiri moti zimatha kupha munthu .

Aliyense amene ali ndi histiocytosis ali ndi ma histiocytes ochulukirapo m'thupi mwake, zomwe zimayambitsa kutupa (kutupa). Komabe, zizindikiro, mankhwala, ndi zotsatira za matendawa zimatha kusiyana kwambiri, ngakhale pakati pa anthu omwe ali ndi histiocytosis yofanana .

Dokotala wanu ndiye munthu wabwino kwambiri womvetsetsa matenda anu ndi zochitika zapadera zomwe zikuchitika. Choncho, kuti mumvetse bwino matenda anu ndi dongosolo lanu la chithandizo, musaope kufunsa mafunso. Lankhulani ndi dokotala wanu za chilichonse chomwe chili m'maganizo mwanu.

Histiocytosis , Maselo oyera a magazi, Histiocytes, Chitetezo cha mthupi, LCH, ECD, RDD, Zizindikiro, Chithandizo