Kodi thupi lanu limakhala loyabwa nthawi zonse? Kodi limasanduka lofiira? Tiyeni tiphunzire za matenda osowa awa (Systemic Mastocytosis)

Kodi mumayabwanso thupi lanu lonse nthawi zina? Kodi nkhope ndi khosi lanu zimasanduka zofiira mwadzidzidzi ndipo mukumva ngati mukuyamba kutentha? Kodi muli ndi kupweteka m'mimba, chizungulire, komanso mtima ukuthamanga? Ngakhale mutaganiza kuti zinthuzi ndi ziwengo chabe, nthawi zina pangakhale vuto lina kumbuyo kwa izi, lomwe sitinamve zambiri. Lero tikulankhula za matenda osowa kwambiri, Systemic Mastocytosis. Musadandaule, tiyeni timvetse izi mosavuta.

Kodi mastocytosis ya dongosolo ndi chiyani?

Mwachidule, uwu ndi matenda omwe amayamba chifukwa cha kuchuluka kwa maselo otchedwa 'mast cells' m'thupi lathu. Mast cells ndi mtundu wa maselo oyera amagazi. Ganizirani maselo a mast awa ngati asilikali m'thupi lathu. Ntchito yawo yayikulu ndi kutiteteza ku matenda ndikutithandiza kuchira tikavulala . Koma mu matendawa, maselo a mast awa amasonkhana mochulukirapo komanso modabwitsa m'ziwalo zosiyanasiyana monga khungu lathu, mafuta a m'mafupa , mafupa, ndi matumbo. Ndiye chimachitika ndi chiyani? Chifukwa cha zina zomwe zimayambitsa, maselo a mast ochulukirapowa amayamba kugwira ntchito mwadzidzidzi ndipo amatulutsa mankhwala ambiri monga 'histamine' m'thupi. Pamenepo ndi pomwe zizindikiro zomwe ndatchula kale, monga kutuluka m'magazi, kuyabwa, ndi eczema , zimawonekera.

N’chiyani chimayambitsa matendawa?

Anthu ambiri amadabwa ngati iyi ndi matenda obadwa nawo. Koma nthawi zambiri iyi si matenda obadwa nawo. Nthawi zambiri, imachitika mu jini yotchedwa KIT, yomwe imapezeka m'maselo athu a mast.Zimayambitsidwa ndi kusintha kwachisawawa (mutation). Jini iyi imathandiza kupanga puloteni yomwe imalamulira kukula kwa maselo. Chifukwa chake izi zikasintha, maselo a mast amayamba kukula mosalamulirika. Ngakhale zizindikirozi zimatha kuwoneka pa msinkhu uliwonse, zimapezeka kwambiri mwa okalamba, makamaka azaka zapakati pa 40 ndi 50 .

Zomwe zimayambitsa zizindikiro zimawonjezera

Si aliyense amene ali ndi matendawa amene amakumana ndi zizindikiro zofanana. Komanso, zinthu zomwe zimayambitsa zizindikirozi zimatha kusiyana malinga ndi munthu. Komabe, zina mwa zinthu zomwe zimayambitsa matendawa zalembedwa patebulo pansipa. Ndikofunikira kudziwa izi. Ndikofunikanso kukumbukira kuti nthawi zina zizindikiro zimatha kuwoneka popanda chifukwa chilichonse.

Kodi mitundu ndi zizindikiro zazikulu za matendawa ndi ziti?

Pali mitundu ikuluikulu isanu ya Systemic Mastocytosis. Dokotala wanu adzakuyezani ndikukuuzani mtundu womwe muli nawo.

• Indolent Systemic Mastocytosis (ISM): Iyi ndi mtundu wofala kwambiri komanso wosaopsa kwambiri. Matendawa amakula pang'onopang'ono ndipo samayambitsa kuwonongeka kwakukulu kwa ziwalo.
• Kutupa kwa Systemic Mastocytosis (SSM): Koopsa pang'ono kuposa ISM. Zizindikiro zake zimakhala zoopsa kwambiri ndipo zimatha kukhudza ziwalo pakapita nthawi.
• Mastocytosis Yachilengedwe Yokhala ndi Associated Hematological Neoplasm (SM-AHN): Pankhaniyi, mastocytosis imatsagana ndi matenda ena okhudzana ndi magazi (monga leukemia ).
• Aggressive Systemic Mastocytosis (ASM): Mtundu uwu umakula mofulumira ndipo ukhoza kuwononga ziwalo monga chiwindi, ndulu, ndi mafupa.
• Matenda a khansa ya m'magazi a Mast Cell (MCL): Uwu ndi mtundu wosowa kwambiri komanso woopsa kwambiri. Pali maselo ambiri a mast mu mafupa ndi m'magazi.

Zizindikiro zomwe mumakumana nazo zimadalira mtundu wa matenda omwe muli nawo komanso komwe m'thupi lanu muli maselo osazolowereka a mast omwe amakhala ambiri. Nazi zizindikiro zodziwika bwino:

• Kuyabwa, ziphuphu , kutsuka
• Kupweteka m'mimba, kudzimbidwa, kutsegula m'mimba
• Kusanza kapena kusanza
• Mutu ndi kutopa
• Kugunda kwa mtima mwachangu
• Kuthamanga kwa magazi pang'ono, chizungulire, kutaya chidziwitso
• Kutupa kwa chiwindi, ndulu, ndi ma lymph nodes
• Matenda a magazi m'thupi komanso matenda otuluka magazi
• Kufooka kwa mafupa (Osteoporosis)
• M'maganizo, zinthu monga kuvutika kuganizira, nkhawa pafupipafupi, kapena kuvutika maganizo.

Kodi mungazindikire bwanji matendawa? (Kuzindikira)

Dokotala wanu adzakufunsani kaye za zizindikiro zanu ndikukuyesani thupi. Kenako, angakulangizeni mayeso angapo kuti atsimikizire matendawa:

• Kufufuza khungu: Kachidutswa kakang'ono ka khungu kamatengedwa kuchokera pamalo omwe akhudzidwa ndikuwunika pogwiritsa ntchito maikulosikopu kuti awone ngati pali maselo ambiri a mast.
• Kufufuza Mafupa a M'mafupa: Katswiri wa zamagazi amagwiritsa ntchito singano yopyapyala kuti atenge chitsanzo cha mafupa anu ndikuchiyang'ana.
• Kuyezetsa magazi ndi mkodzo:Kuchuluka kwa magazi (CBC) kungagwiritsidwenso ntchito poyesa matenda ena, monga kuchepa kwa magazi m'thupi.
• Kuyesa Majini: Chitsanzo cha magazi kapena minofu chimayesedwa kuti chione ngati pali kusintha kulikonse mu jini ya KIT yomwe yatchulidwa kale.
• Mayeso ojambulira: X-ray, ultrasound, ndi CT scan zingathandize kuzindikira kufooka kwa mafupa ndi kutupa kwa ziwalo monga chiwindi ndi ndulu.
• Endoscopy kapena Colonoscopy: Chubu chopyapyala chokhala ndi kamera yolumikizidwa nacho chimagwiritsidwa ntchito kufufuza mkati mwa m'mimba kapena matumbo kuti chione ngati pali vuto lililonse, monga zilonda.

Kodi mankhwala ake ndi otani?

Dokotala adzasankha njira yochizira matenda anu kutengera zizindikiro zanu, ziwalo zomwe zakhudzidwa, ndi mtundu wa matenda.

• Mankhwala oletsa kuyabwa: Mankhwalawa amathandiza kuchepetsa kuyabwa pakhungu, kufiira, komanso kusokonezeka kwa m'mimba.
• Epinephrine: Homoni yomwe imagwiritsidwa ntchito ngati pali vuto lalikulu la ziwengo (anaphylaxis).
• Zoletsa Pump ya Proton: Zimaletsa asidi m'mimba ndikuchepetsa zinthu monga kutupa m'mimba.
• Mast Cell Stabilizers: Mankhwala omwe amaletsa kutulutsidwa kwa histamine kuchokera ku maselo a mast.
• Ma Steroid: Angathandize ndi matenda a pakhungu ndi kupuma.
• Chithandizo Cholunjika: Mankhwala omwe amayang'ana jini kapena mapuloteni enaake omwe ali ndi matendawa. Mankhwalawa angafunike kwa anthu omwe ali ndi zizindikiro zoopsa.
• Chemotherapy: Chithandizochi chingakhale chofunikira ngati matendawa akufalikira mofulumira komanso kuwononga ziwalo za thupi.
• Kusamutsa Maselo Oyambira: Njira yochiritsira yomwe imaganiziridwa nthawi zina.

Mastocytosis ya m'thupi, maselo a mast, ziphuphu pakhungu, anaphylaxis, anaphylaxis, jini ya KIT, histamine