Dzimwe nguva unonzwa sekuti hauna simba here, uye tsandanyama dzako dzisina simba? Kunyanya kana ziso rimwe chete kana ese ari maviri akarembera, chiso chako chikachinja, kana kuti uchinetseka kutaura kana kumedza? Izvi zvinogona kunge zviri zviratidzo zvechirwere chinonzi Myasthenia Gravis . Kunyangwe ichi chiri chirwere chinotyisa, ikozvino kune mishonga yakanaka kwazvo yekurapa. Nhasi tiri kutaura nezveimwe nzira itsva uye inobudirira yekurapa.

⚡ Interactive Clinical Tool

⚖️

BMI Calculator

Know your body mass index (BMI) and weight classification

Open Interactive Calculator →

Chii chinonzi Myasthenia Gravis?

Zvichitaurwa zviri nyore, ichi chirwere apo masoja emuviri wako anorwisa tsandanyama dzako. Tinoti ichi chirwere che autoimmune.

Tsandanyama inogamuchira chiratidzo kubva kuuropi hwedu panzvimbo panosangana tsinga nesero retsandanyama. Nzvimbo iyi yekubatana inonzi neuromuscular junction. Pano, neurotransmitter inonzi acetylcholine inotumira chiratidzo kune tsandanyama, ichiti, "Zvakanaka, ita izvozvi."

Zvisinei, vanhu vazhinji vane myasthenia gravis vanogadzira ma antibodies anorwisa ma receptors anogamuchira chiratidzo ichi che acetylcholine. Ma antibodies aya anonzi anti- acetylcholine receptor (AChR) antibodies . Nekuda kwema antibodies aya, tsandanyama hadzigamuchire chiratidzo kubva kuuropi zvakanaka. Mugumisiro wacho unobva pakushaikwa kwetsandanyama.

Zviratidzo zvakajairika zve myasthenia gravis
Maziso akarembera	Kurembera kwemaziso erimwe kana ese ari maviri kusingadzoreki.
Kuchinja kwechiso	Kuchinja kwechitarisiko kana uchinyemwerera kana kutaura nekuda kwekushaya simba kwetsandanyama dzechiso, muromo, kana shaya.
Kushaya simba mumakumbo nemakumbo	Kushaya simba mumaoko, makumbo, neminwe. Kuomerwa nekusimudza zvinorema nekufamba.
Kuoma kumedza	Kuoma kumedza chikafu kana chinwiwa, kudzipwa nguva nenguva.
Kuoma kutaura	Kuchinja kwezwi uye kusanzwisisana kwemashoko pakutaura.

Chinhu chakakosha ndechekuti havasi varwere vese vanozosangana nezviratidzo izvi zvese. Zviratidzo zvinogona kusiyana zvichienderana nekuoma kwechirwere.

Ultomiris (Ravulizumab) inoshanda sei?

Hakuchina mushonga wekurapa myasthenia gravis parizvino. Asi kune nzira dzakawanda dzekurapa dzinoshanda dzinogona kubatsira kudzora zviratidzo uye kurarama hupenyu hwakajairika. Ultomiris ndeimwe yenzira itsva dzekurapa.

Ultomiris iantibody yakakosha inovhara puroteni muimmune system yedu inonzi C5 . Iyi protein yeC5 ndiyo inobatsira kukuvadza tsandanyama. Saka kana Ultomiris ikaimisa, immune system yako inomira kuparadza masero etsandanyama. Izvi zvinoreva kuti mushonga uyu unoshanda nekuenda zvakananga kumudzi wechirwere.

Kurapwa uku kunopiwa sei?

Mushonga uyu unopihwa kwauri semushonga wemutsinga (IV infusion) semushonga wesaline. Uyu unopihwa kwauri nachiremba kana mushandi wehutano akadzidziswa muchipatara kana kiriniki.

Kazhinji, uchapihwa mushonga wekutanga, wozoteverwa nemumwe mushonga mavhiki maviri gare gare. Mushure meizvozvo, uchafanirwa kuramba uchitora mushonga uyu mavhiki masere ega ega . Zvisinei, chiremba wako ndiye achasarudza kuti uchatora mushonga uyu kwenguva yakareba sei uye kuti uchatora mushonga upi (zvichienderana nehuremu hwemuviri wako) .

Zvakakosha kutora mushonga wako nenguva. Kana ukarasikirwa nemushonga, fonera chiremba wako pachine nguva .

Unoziva sei kana mushonga wacho uchishanda?

Uchatanga kunzwa tsandanyama dzako dzichisimba zvishoma nezvishoma. Uchakwanisa kuita mabasa ako ezuva nezuva zviri nyore. Muzvidzidzo zvekiriniki, zviratidzo zvechirwere zvakavandudzika zvishoma nezvishoma mukati mevhiki imwe chete.

Zvisinei, kana usinganzwe mutsauko, kana zviratidzo zvako zvichiratidza kunge zviri kuwedzera kuipa, iva nechokwadi chekutaura nachiremba wako . Iye anogonaChinjai mushonga, ipai mumwe mushonga, kana kuti chinjai mumwe mushonga.

Ndezvipi zvingakonzera migumisiro yakaipa?

Kufanana nemushonga upi zvawo, inogona kukonzera migumisiro midiki. Migumisiro yakajairika ndeiyi:

Kuzvimba (manyoka)
Utachiona hwemhino kana pahuro
Huro inorwadza
Zviratidzo zvechikosoro chinowanzoitika

Kuti udzore dambudziko remudumbu, idya zvekudya zvakapfava zvakaita semupunga, mabhanana, nechingwa. Inwa mvura yakawanda. Deredza kudya kwako zvinwiwa zvine caffeine zvakaita sekofi. Kana matanho aya asingabatsire, kana zviratidzo zvakaita sekurwadziwa pahuro kana mhino inoramba ichiyerera, taura nachiremba wako . Iye ndiye achasarudza mushonga wakanakira iwe.

Ndezvipi zvinhu zvakakosha zvekuziva? (Chirongwa cheREMS)

Izvi zvakakosha zvikuru!

Ultomiris mushonga unopihwa pasi pechirongwa chekuchengetedza njodzi (Risk Evaluation and Mitigation Strategy - REMS). Izvi zvinodaro nekuti pane njodzi diki asi yakakura yekubatwa nehutachiona hwebhakitiriya hunonzi meningococcal, kunyanya meningitis, iyo inokanganisa uropi nemusana.

Nekuda kweizvi, chiremba wako achakupa kadhi rekuchengetedza murwere rakakosha .

Inotsanangura zvakajeka zviratidzo zvehutachiona uhwu (semuenzaniso fivha inongoerekana yaitika, musoro unotemwa nemusoro, mutsipa wakaoma, kuda kurutsa, kurutsa, uye kunzwa chiedza).
Zvinonziwo kana zviratidzo zvakadaro zvikaitika, munhu anofanira kuenda kuEmergency Treatment Unit (ETU) nekukasika.
Zvakakosha kuchengeta kadhi iri newe nguva dzese — panguva yekurapwa uye kusvika kumwedzi misere mushure mekunge kurapwa kwamira.

Pamusoro pezvo, usati watanga kurapwa, chiremba wako achakubvunza kana wakambobaiwa nhomba yekudzivirira chirwere chemeningococcal. Kana zvisina kudaro, vachakukurudzira kuti uwane nhomba iyi kwemavhiki maviri usati watanga kurapwa.

Matambudziko nemimwe mishonga

Zvakakosha kuudza chiremba wako kana uri kutora mimwe mishonga, kunyanya:

Kurapa kunobvisa plasma muropa (plasma exchange kana plasmapheresis)
Kurapa kweIntravenous immunoglobulin (IVIg)
Mishonga inovhara myasthenia gravis kubva muvana vanoberekwa (neonatal Fc receptor (FcRn)

Zvinhu zvakaita seizvi zvinogona kuderedza kushanda kweUltomiris. Saka udza chiremba wako nezvemishonga yese yaunotora, kunyangwe mavhitamini.

Mharidzo Yekuenda Nayo Kumba

Ultomiris (Ravulizumab) mushonga wemazuva ano uye unobudirira kune varwere vane myasthenia gravis (ine ma antibodies eAChR).
Izvi zvinodzivirira masoja emuviri kurwisa tsandanyama dzawo.
Uku kurapwa kunopihwa netsinga mavhiki masere ega ega (mushure mekupiwa mishonga yekutanga).
Nekuti pane njodzi yehutachiona hwemeningococcal kana uchitora mushonga uyu, zvinosungirwa kuti ubayiwe majekiseni uye ugare uine kadhi rako rekuchengetedza murwere.
Taura pachena nachiremba wako nezve chero migumisiro yakaipa, zviratidzo zvinowedzera kuipa, kana kushandisa mimwe mishonga. Kutaurirana kwakanaka pakati pako nachiremba wako kwakakosha kuti kurapwa kwako kubudirire.