Ngaba ukhe weva ngale protein ingaqhelekanga egazini lakho? (Cryoglobulinemia) Masithethe ngayo!

Ngamanye amaxesha izinto ziyenzeka emizimbeni yethu esingazilindelanga, akunjalo? Namhlanje siza kuthetha ngemeko engaqhelekanga, kodwa kubalulekile ukwazi ngayo. Oku kubizwa ngokuba yi-cryoglobulinemia. Igama lisenokuvakala liyinkimbinkimbi kancinci, kodwa ungakhathazeki, masilichaze ngokulula.

Yintoni i-cryoglobulinemia? Ngamafutshane...

Ngamafutshane, i-cryoglobulinemia yimeko apho iiproteni ezithile ezingaqhelekanga egazini lakho, ezibizwa ngokuba yi-cryoglobulin, ziqina, zihlangane, kwaye zenze amahlwili xa zibekwe kumaqondo obushushu abandayo. Cinga ngayo njengokuqandisa ioyile yekhokhonathi xa uyibeka emanzini abandayo. Kodwa oku kwenzeka ngaphakathi egazini lethu. Le meko ngokwenene luhlobo lwe-vasculitis. Kukudumba, njengokudumba, kwemithambo yegazi yakho, iityhubhu ezincinci ezithwala igazi emzimbeni wakho wonke. Xa le mithambo yegazi ivuvukala, ukuhamba kwegazi kunokuphazamiseka. Kwenzeka ntoni emva koko? Ulusu lwakho, imithambo-luvo, amalungu, izihlunu, kwaye okona kubaluleke kakhulu, amalungu angaphakathi njengezintso zakho, anokonakala. Oku ngamanye amaxesha kubizwa ngokuba yi-cryoglobulinemic vasculitis.

Ngaba kukho iintlobo ze-cryoglobulinemia?

Ewe, ezi proteni zibizwa ngokuba yi-cryoglobulin nazo luhlobo lwe-antibody. Ngokuxhomekeke kuhlobo lwe-antibody eveliswa ngumzimba wethu, i-cryoglobulinemia inokwahlulwa ibe ziintlobo ezintathu eziphambili:

• Uhlobo I lweCryoglobulinemia: Oku kudla ngokubangelwa yimidlaza enxulumene negazi lakho okanye imidlaza enxulumene nenkqubo yakho yokuzikhusela komzimba.
• Uhlobo lweCryoglobulinemia yohlobo lwesibini kunye nohlobo lwesithathu lweCryoglobulinemia: Ezi ntlobo zimbini zihlala zibonakala zineemeko zokudumba ezingapheliyo (oko kukuthi, ixesha elide). Umzekelo, zinokubonakala kubantu abanezifo zokuzikhusela komzimba . Ngokukodwa, uhlobo lweCryoglobulinemia yohlobo lwesibini luxhaphake kakhulu kubantu abosulelwe yintsholongwane yeHepatitis C (HCV). Ezi ntlobo zimbini zidityanisiwe kwaye zibizwa ngokuba yiMixed Cryoglobulinemia.

Ixhaphake kangakanani le meko?

I-Cryoglobulinemia yimeko engaqhelekanga.Kodwa abaphandi abakwazi ukusho ngokuthe ngqo ukuba bangaphi abantu abanale meko. Ngenxa yokuba abanye abantu banokuba namanqanaba aphantsi ezi cryoglobulins egazini labo kodwa bangabonakalisi zimpawu, abaphandi baqikelela ukuba le meko ichaphazela malunga nomntu omnye kwisigidi kwihlabathi liphela.

Zithini iimpawu? Ngaba wonke umntu ufumana iimpawu?

Hayi, ayinguye wonke umntu one-cryoglobulinemia oza kuba neempawu. Abanye abantu basenokungaqapheli nto. Kodwa xa iimpawu zibonakala, uphawu oluqhelekileyo kukuqhambuka kwesikhumba okubizwa ngokuba yi-purpura. Oku kubonakala njengamabala abomvu okanye imivumbo emfusa emilenzeni esezantsi. Usenokuziva udiniwe kwaye unentlungu yamalungu. Ezinye iimpawu zinokuvela. Ezi ziquka:

• Xa ibekwe kumaqondo obushushu abandayo, imithambo yegazi ezandleni okanye ezinyaweni iyaxina, nto leyo ebangela ukuba ijike ibe luhlaza okwesibhakabhaka. Oku kubizwa ngokuba yimeko kaRaynaud .
• Ukuhla ukusinda .
• Uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi oluphezulu).
• Ukudumba, ingakumbi emaqatheni nasemilenzeni (i-Edema).
• Izilonda zesikhumba kwaye ngamanye amaxesha ukufa kwezicubu (gangrene).
• Isibindi esikhulu (iHepatomegaly) okanye ipleen ekhulisiweyo (iSplenomegaly).
• Ukuba ndindisholo , ukurhawuzelela, okanye ubuthathaka kwimilenze.
• Ukonakala kwezintso.

Cinga ngayo, oku akupheleli nje ekubeni amalungu akho omzimba ajika abe luhlaza ngenxa yokubanda. Oku kungaba luphawu lwengxaki enkulu emzimbeni wakho. Yiyo loo nto kubalulekile ukuba uqaphele izinto ezinje.

Zithini izizathu ze-cryoglobulinemia?

Abaphandi abakayazi kakuhle into ebangela i-cryoglobulinemia. Kodwa njengoko besitshilo ngaphambili, luhlobo lwesifo sokuzikhusela komzimba esibizwa ngokuba yi-vasculitis, esikukudumba kwemithambo yegazi. Isifo sokuzikhusela komzimba sibangelwa kukuba inkqubo yomzimba wakho yokuzikhusela, inkqubo yokuzikhusela yomzimba ekukhusela kwizifo, ihlasela ngempazamo izicubu zakho ezisempilweni. Kukho izinto ezininzi ezinokubangela oku:

• I-genetics: Ukuba kukho umntu kusapho onaso, sinokuchaphazeleka.
• Ezinye iintlobo zamayeza: Ayizizo zonke amayeza, kodwa ezinye.
• Iintsholongwane kunye neentsholongwane: Ingakumbi iintsholongwane.
• Izinto ezisingqongileyo: Ezinye zezinto ezikwindawo esingqongileyo.

I-Cryoglobulinemia ngamanye amaxesha inokwenzeka yodwa ngaphandle kwesizathu esicacileyo (oku kubizwa ngokuba yi-idiopathic), kodwa rhoqo iyenzeka xa idibene nezinye izifo. Ezinye zezi zifo ziquka:

• Usulelo lweHepatitis C: Le yeyona nto iphambili neyona ixhaphakileyo.
• Ukungaqheleki kweeseli zegazi: Umzekelo, iimeko zomhlaza ezifana ne-lymphoma kunye ne-multiple myeloma.
• Izifo zezicubu ezidityanisiweyo: Umzekelo yi-lupus.

Ngubani osengozini enkulu yoku?

Kubonakala ngathi i-cryoglobulinemia ichaphazela abafazi ngaphezu kwamadoda, kwaye ixhaphake kakhulu kubantu abangaphezu kweminyaka engama-50 ubudala.

Ngaba iingxaki zingavela ukuba azinyangwanga kakuhle?

Ewe, ngokuqinisekileyo. Ukuba i-cryoglobulinemia ayinyangwanga kakuhle, inokubangela umonakalo ongunaphakade kulusu lwakho, izicwili, kunye nezitho zangaphakathi. Ezinye zeengxaki ezinkulu ezinokubakho ziquka:

• Usulelo lolusu okanye amanxeba angapholiyo.
• Ukufa kolusu (i-necrosis).
• Ukungasebenzi kakuhle kwezintso.
• Ukungasebenzi kakuhle kwesibindi.

Ezi ziimeko ezinzulu ngokwenene, yiyo loo nto kubalulekile ukuxilonga nokunyanga esi sifo ngokukhawuleza.

Oogqirha bayixilonga njani le meko?

Xa ubona ugqirha, uya kuqala akubuze ngembali yakho yezonyango aze enze uvavanyo lomzimba. Emva koko, baya kuyalela uvavanyo lwegazi olukhethekileyo ukujonga ii-cryoglobulin egazini lakho. Olu vavanyo lwegazi lunokukuxelela nokuba loluphi uhlobo lwe-cryoglobulin onayo. Oku ngamanye amaxesha kunokunceda ekufumaneni unobangela wemeko yakho kunye nendlela yokuyinyanga. Ukongeza kolu vavanyo lwegazi, ugqirha wakho unokuyalela ezinye iimvavanyo ezininzi ukuqinisekisa ukuxilongwa nokuqonda imeko:

• Uvavanyo lomchamo (Uhlalutyo lomchamo).
• I-X-ray yesifuba.
• I-CT scan (i-computed tomography (CT scan).
• I-angiogram (ijonga imeko yemithambo yegazi).
• Uvavanyo lwe-MRA (magnetic resonance angiogram) okanye uvavanyo lwe-CT angiogram (CT angiogram).
• Uvavanyo lokuqhuba imithambo-luvo.
• Uvavanyo lwe-electromyography (EMG) (jonga umsebenzi wezihlunu).
• I-biopsy (ukuthatha iqhekeza elincinci lesicwili, mhlawumbi eluswini okanye kwizintso, ukuze lihlolwe).

Iphathwa njani le nto?

Unyango lwe-cryoglobulinemia luxhomekeke ekubeni ngawaphi amalungu omzimba achaphazelekileyo, ubungakanani bomonakalo, nokuba unezinye izifo na.Kubalulekile ukunyanga ezinye iimeko ezinokunxulunyaniswa ne-cryoglobulinemia, njenge-hepatitis C, kunye nezinye iimeko ezinokunxulunyaniswa nayo. Oku kungenxa yokuba ukunyanga ezo meko ngamanye amaxesha kunokunceda ukunciphisa iimpawu ze-cryoglobulinemia. Ukuba iimpawu zakho azikho qatha, ugqirha wakho unokucebisa amayeza okunciphisa iintlungu athengiswa ngaphandle kwemvume kagqirha (afana ne-NSAIDs) kwaye akucebise ukuba uphephe ukuvezwa kubushushu obubandayo . Banokucebisa nokuba uhlolwe rhoqo ukuze ujonge imeko yakho. Kwiimeko eziphantsi, okanye eziphakathi ukuya kwezinzima, unyango lunokwahluka kancinci:

• Amayeza okuthintela amajoni omzimba: Olu lolona nyango luphambili. Ii-corticosteroids, ezifana ne-prednisone, ngamanye amaxesha zinikwa kunye nezinye iziyobisi. Oku kuxhomekeke kwisitho esichaphazelekileyo kunye nobungakanani bomonakalo.
• Amayeza okulwa neentsholongwane: Ukuba ugqirha wakho ufumanisa ukuba unesinye isifo, esifana nehepatitis C, unokucebisa unyango lokulwa neentsholongwane. Banokukuthumela kwingcali yesibindi (i-hepatologist).
• I-Biologics: I-Rituximab lunyango oluqhelekileyo lwe-cryoglobulinemia. I-Biologics ziiproteni ezintsonkothileyo ezenziwe ngezinto eziphilayo ezijolise kwiindawo ezithile zenkqubo yomzimba yokuzikhusela ukulawula ukudumba.
• I-Plasmapheresis: Olu lolunye unyango. Lusebenza ngokunciphisa inani le-cryoglobulins egazini lakho. Kule nkqubo, ii-cryoglobulins zisuswa kwi-plasma yakho (inxalenye engamanzi egazini lakho). Oku kunceda ukuthintela ii-cryoglobulins ukuba zingavali imithambo yakho yegazi, zithintele ukuhamba kwegazi kwaye zinciphise umonakalo kwizitho zomzimba.

Masiqaphele nemiphumo emibi kunye neengxaki zonyango.

Amayeza anikwa ngoogqirha ukunyanga i-cryoglobulinemia anokuba nemiphumo emibi kakhulu. Eyona iphambili yi-osteoporosis kunye nokuncipha kwamandla omzimba okulwa nosulelo. Ke ngoko, kubaluleke kakhulu ukubona ugqirha wakho rhoqo ukuze ahlolwe. Emva koko, ugqirha wakho unokukunika amanye amayeza okulawula ezi miphumo emibi. Kubalulekile nokuzikhusela kwiintsholongwane. Ke ngoko, thetha nogqirha wakho malunga nokugonywa okunokunciphisa umngcipheko wosulelo.

Ngaba ikho indlela yokuthintela le meko?

Ngenxa yokuba unobangela ochanekileyo we-cryoglobulinemia ayaziwa, akukho ndlela ithile yokuyithintela. Nangona kunjalo, ukuphepha ukuvezwa kumkhuhlane kunokunceda .Inokunceda ekulawuleni ezinye iimpawu, ezifana nesiganeko sikaRaynaud. Kubaluleke kakhulu ukuba uvavanyelwe usulelo lweHepatitis C kwaye ufumane unyango ukuba unalo.

Ithini ingqikelelo yomntu ophila nesi sifo?

Imbono yakho, oko kukuthi, ukuba esi sifo siza kujongeka njani, ixhomekeke kwizinto ezininzi:

• Ezinye iimeko zempilo ezifihlakeleyo onazo.
• Ubungakanani bomonakalo kwizitho zakho zomzimba.
• Indlela osabela kakuhle ngayo kunyango.

Kwakhona, ubukhali besifo buyahluka kumntu nomntu. Abanye abantu basenokungabi nazimpawu konke konke, okanye imeko yabo inokuba buthathaka kangangokuba abadingi nyango. Kubantu abaneengxaki eziphakathi okanye ezinzima, ukuxilongwa kwangoko kunye nonyango kunokunceda ekunciphiseni iimpawu kunye nokuthintela iingxaki ezihlala ixesha elide. Ukuba amalungu akho omzimba awonakalanga ngonaphakade, imeko intle kakhulu.

Ndingazinyamekela njani? Ngubani oza kundinceda?

Eyona nto ingcono onokuyenza kukusebenzisana ngokusondeleyo neqela lakho lezonyango. Ngokuxhomekeke ekubeni zeziphi izitho ezichaphazelekileyo yi-cryoglobulinemia yakho, kunokufuneka usebenze neqela loogqirha abanolwazi oluninzi. Oku kungabandakanya:

• Oogqirha abaziingcali kwizifo zezicubu ezidityanisiweyo kunye nezidibeneyo (iiRheumatologists).
• Iingcali zesikhumba.
• Iingcali zegazi.
• Oogqirha abaziingcali kwizifo zezintso (iiNefrologists).
• Iingcali zentliziyo.
• Iingcali ze-neurological.
• Iingcali zeHepatologists.

Yazi kakuhle iqela lakho lezonyango. Thetha ngokwakho. Buza imibuzo. Ukuba uneengxaki malunga nesicwangciso sakho sonyango, thetha ngaso. Oogqirha bakho bakhona ukuze bakuphulaphule kwaye baqinisekise ukuba uyiqonda ngokupheleleyo yonke into echaphazela impilo yakho kunye nokhathalelo lwakho.

Ndifanele ndimbone nini ugqirha?

Ukuba uneempawu ze-cryoglobulinemia, kufuneka ufune uncedo lwezonyango ngokukhawuleza. Kwakhona, ukuba une-hepatitis C kwaye naziphi na ezi mpawu zibonakala, bona ugqirha. Nokuba unyango lusebenza kakuhle, isifo sinokuphinda sibuye (siphinde sibuye). Ukuba ubonakalisa iimpawu ezintsha, ukuba iimpawu ezikhoyo ziya zisiba mandundu, okanye ukuba iimpawu ziyabuya, bona ugqirha. Ukuhlolwa rhoqo kwezonyango kunye nokulandelela rhoqo kubalulekile ukuze kufunyanwe naluphi na ukuphinda kwenzeke kwangethuba kwaye kuthintelwe iingxaki.

Ndingayibuza yiphi imibuzo ugqirha?

Xa ubona ugqirha wakho, kungcono ukubuza imibuzo efana nale:

• Yintoni eyabangela ukuba ndibe nesi sifo?
• Loluphi unyango olucebisayo?
• Zeziphi iziphumo zonyango ekufuneka ndizixhalabele?
• Ziziphi iingxaki ezinokwenzeka ngenxa yale meko?
• Ndingenza ntoni ukuthintela ukuba esi sifo singaphindi sibuye?

Izinto ezibalulekileyo ekufuneka sizikhumbule (Umyalezo Wokuya Ekhaya)

Ukuphila ne-cryoglobulinemia kunokuba nzima ngamanye amaxesha. Iimpawu kunye nemiphumo emibi yamayeza inokuba nefuthe elikhulu kwimpilo-ntle yakho yengqondo. Ingachaphazela nezinye iinkalo ezininzi zobomi bakho.

Kodwa khumbula, awuwedwa. Cela uncedo kugqirha wakho, kwaye ufumane amaqela enkxaso apho abanye abajongene neemeko ezifanayo banokudibana khona. Ukwabelana ngamava akho kunye noko ukwaziyo kunokukunceda uphile ne-cryoglobulinemia. Ukuzikhusela kumkhuhlane, ukufuna iingcebiso zonyango, ukungatshayi, kunye nokutya ukutya okunesondlo konke kubalulekile.

Ndiyathemba ukuba olu lwazi luluncedo kuwe. Hlala usempilweni!