Sonke sinoloyiko lokulahlekelwa yinkumbulo njengoko sikhula, akunjalo? Ingakumbi ukuba umntu kusapho lwakho ukhe waba nesifo esifana ne -Alzheimer 's, umbuzo othi 'Ngaba nam ndiza kusifumana?' usenokuba usengqondweni yakho. Iijini zethu ziyichaphazela njani le nto? Uphando lwakutshanje lubonisa ukuba kukho unxibelelwano oluqinileyo phakathi kwejini ethile ebizwa ngokuba yi-APOE4 kunye nesifo se-Alzheimer's kunokuba bekucingelwa ngaphambili. Ngoko ke namhlanje, masithethe ngale nto, nokuba iyakuchaphazela na, kunye nento esinokuyenza ngayo.
Yintoni kanye kanye le gene ebizwa ngokuba yi-APOE4?
Ngamafutshane, i-APOE yijini emizimbeni yethu. Umsebenzi wayo ophambili kukuthutha amafutha , anjenge-cholesterol, phakathi kweeseli zethu (ukuthutha amafutha). Cinga ngeeseli emizimbeni yethu njengezindlu ezincinci. Ezi zindlu zifuna amafutha ukuze zisebenze, zizakhe, kwaye zivelise amandla. Ijini ye-APOE ifana 'nenkonzo yokuhambisa' engenisa la mafutha kwiiseli. Ukuba lo msebenzi awusebenzi kakuhle, iingxaki zinokuvela, ngakumbi kwiiseli zobuchopho.
Ngaba wonke umntu unalo olu jini lwe-APOE?
Ewe, sonke sinalo olu jini lwe-APOE emizimbeni yethu. Kodwa alufani. Kufana nendlela, nokuba 'kwinkonzo yokuhambisa' efanayo, abanye abasebenzi bakrelekrele kakhulu, abanye baqhelekile, kwaye abanye bayanqena kancinci. Kukho iintlobo ezintathu eziphambili. Makhe sibone ukuba yintoni umahluko.
| Uhlobo lweJini | Kwenzeka ntoni (Isiphumo) |
|---|---|
| I-APOE2 | Olu lolona hlobo lubalaseleyo . Ukuba unalo olu hlobo, akuyi kuba neengxaki ezininzi nge-metabolism yamafutha. Kuthiwa lukwabonelela ngokhuseleko oluthile kwisifo se-Alzheimer. |
| I-APOE3 | Olu luhlobo oluqhelekileyo . Abantu abaninzi banalo olu hlobo. Akukho nto ilungileyo okanye embi. Akongezi mngcipheko kwaye akuniki khuseleko. |
| I-APOE4 | Le yingxaki . Ayiwenzi umsebenzi wayo wokuthutha amafutha ngokufanelekileyo. Ukuba nekopi enye okanye ezimbini zale gene kuyandisa kakhulu umngcipheko wokufumana isifo se-Alzheimer. |
Luthini olu phononongo lutsha?
Besisoloko sicinga ukuba i-APOE4 'yinto nje ebangela umngcipheko' we-Alzheimer's. Oko kukuthi, ukuba nayo akuthethi ukuba uza kuba nesi sifo, kodwa kuthetha ukuba amathuba aphezulu.
Kodwa olu phononongo lutsha lubonisa ukuba ukuba neekopi ezimbini ze-APOE4 gene akuyonto nje ebangela umngcipheko, kodwa inokuba luhlobo lwemfuza lwesifo sika-Alzheimer ngokwaso. Oko kuthetha ukuba abantu abanezi jini zombini basengozini enkulu yokuhlaselwa sesi sifo. Kwaye iimpawu zinokuqala besebancinci.
Siqhele ukwazi ukuba iijini ezibangela isifo sika-Alzheimer yi-`(APP)`, `(PSEN1)` kunye ne-`(PSEN2)`. Zinqabile kakhulu. Kodwa olu phononongo lusondeze ijini ye-APOE4 kubo. Bafumanise ukuba ama-95% abantu abaneekopi ezimbini ze-APOE4 banamanqanaba aphezulu kakhulu e-`(beta amyloid)`, iproteni eyingozi enxulunyaniswa nesifo sika-Alzheimer, engqondweni xa beneminyaka engama-65 ubudala.
Ngaba ukuba ne-APOE4 gene kuthetha ukuba ngokuqinisekileyo uza kuba ne-Alzheimer's?
Hayi. Akuqinisekisiwe ngokupheleleyo. Kodwa umngcipheko uphezulu kakhulu. Kufana nokuqhuba imoto ngesantya esiphezulu kwaye ukuba nengozi kwandisa amathuba akho okuba nengozi. Ayizukwenzeka, kodwa kwandisa amathuba akho. Malunga ne-2% yabemi banazo zombini iikopi ze-APOE4 gene. Phakathi kwe-15% kunye ne-25% banekopi enye.
Ndingavavanya na ukuze ndibone ukuba ndinalo na olu jini?
Ewe, kukho uvavanyo lwemfuza lwale nto. Kodwa olu ayilovavanyo oluqhele ukumiselwa ngugqirha wakho kwaye lunokwenziwa lula esibhedlele. Oku akuqhelekanga kakhulu eSri Lanka. Kwanakwamanye amazwe, alusoloko lugutyungelwe yi-inshorensi.
Olu vavanyo lunokuhlawulwa ngamaziko abucala. Ukuba ukhetha ukwenza oku okanye akunjalo sisigqibo sakho sobuqu. Ukuba amalungu amaninzi entsapho yakho anesifo se-Alzheimer, ungafuna ukuthetha nogqirha uze wenze isigqibo malunga noku.
Nangona kukho umngcipheko, yintoni esinokuyenza ukuthintela esi sifo?
Nantsi inxalenye ebalulekileyo. Asinakuyitshintsha i-genes yethu. Kodwa singalwa nomngcipheko oza nazo. Nangona singenakukwazi ukuyibuyisela umva le sifo xa sele siphuhlile ngokupheleleyo, indlela esiphila ngayo inokusilibazisa okanye isithintele ukuba singabikho.
Eyona nto ibalulekileyo kukwakha ukuqina kwengqondo. Cinga ngengqondo yakho njengesakhiwo esikhulu esakhelwe phezu kweentsika. Emva kweminyaka engama-20, izinto esizenzayo ziyazidiliza ezi ntsika, okanye sakha iintsika ezintsha size sizenze zomelele nangakumbi.
1. Masiqale ngesondlo.
Izifundo zibonise ngokuphindaphindiweyo ukuba ukutya okuphambili kwizityalo kunokunciphisa umngcipheko we-Alzheimer's malunga nama-50%. Oko kuthetha ukutya okunemifuno emininzi, iziqhamo, iimbotyi, amandongomane kunye neenkozo ezipheleleyo . Ukutya kwaseMeditera nako kuluncedo.
2. Ukuzilolonga akupheleli nje ekuhambeni.
Ukuzilolonga sesinye isixhobo esinamandla sokunciphisa umngcipheko. Kodwa ukuhamba nje egadini akwanelanga. Luhlobo lokuzilolonga olukwenza ubile kwaye uzive udiniwe olusebenza ngokwenene engqondweni yakho. Uqeqesho lokuqinisa umzimba , njengokuphakamisa iintsimbi , lubaluleke kakhulu. Olunye uphando lubonise ukuba abantu abanesifo sengqondo esingaphambi kokuba bahlaselwe yingqondo abenza umthambo wokuqinisa imilenze banciphisa umngcipheko wabo wokufumana esi sifo ngama-40%.
3. Zilolonge nengqondo yakho
Ukuzilolonga ngengqondo kubaluleke njengokwenza umthambo. Oku kuqinisa unxibelelwano phakathi kweeseli ezibizwa ngokuba zii-neurons engqondweni.
- Funda into entsha (ulwimi, isixhobo somculo).
- Sombulula iiphazili, iSudoku, njl.
- Ngena nzulu kwinto oyithandayo.
- Jongana nemingeni emitsha.
Oko wonke umntu afanele akwazi malunga ne-genes, nokuba akakwazi
Isifo sika-Alzheimer asiqali ngophawu lokuqala lokulahlekelwa yinkumbulo. Utshintsho lwe-pathological engqondweni olubangelwa sesi sifo luqala kwiminyaka engama-20-30 ngaphambi kokuba iimpawu zokuqala zibonakale .
Oko kuthetha ukuba sonke esikwiminyaka yethu engama-30, engama-40, nengama-50 kufuneka sicinge ngempilo yengqondo yethu ngoku.
Thetha nogqirha wakho uze ufunde ngamanqanaba akho e-cholesterol, uxinzelelo lwegazi, kunye namaxabiso ovavanyo lwe-HbA1c, abonisa imeko yakho yeswekile. Ukulawula oku lolunye lolona tyalo-mali lukhulu onokulwenza ekukhuseleni ingqondo yakho.
Umyalezo Wokuya Ekhaya
- I-gene ye-APOE4 yeyona nto ibangela umngcipheko omkhulu wesifo se-Alzheimer. Ukuba neekopi ezimbini zayo, ngakumbi, kwandisa kakhulu amathuba okufumana esi sifo.
- Nangona kunjalo, ayisosiqinisekiso se-100%. Nokuba kukho umngcipheko wemfuza, esi sifo sinokulawulwa kwaye sicothiswe ngokwenza utshintsho kwindlela yokuphila.
- Ukutya okunempilo, umthambo onzima, kunye nemisebenzi yengqondo efaka umngeni engqondweni zezona zixhobo zakho zinamandla.
- Musa ukulinda ude ube mdala ukuze ucinge ngempilo yengqondo. Qala usemncinci.
- Thetha nogqirha wakho malunga noxinzelelo lwakho lwegazi, i-cholesterol, kunye namanqanaba eswekile kwaye ugcine loo manqanaba esempilweni.
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