I-Brentuximab Vedotin Vaccine: Oko Ufanele Ukwazi

Ngaba oogqirha bakho bagqibe ekubeni bakunike okanye umntu omaziyo inaliti ebizwa ngokuba yiBrentuximab Vedotin ukuze banyange imeko yomhlaza efana ne-lymphoma? Ukuba kunjalo, namhlanje siza kuthetha ngale chiza, indlela elisebenza ngayo, iziphumo zalo ezingalindelekanga, kunye nezinto ekufuneka uzazi. Ekubeni eli liyeza elinzima kancinci, kubalulekile ukuba ucacelwe zezi zinto.

Luhlobo luni lonyango iBrentuximab Vedotin?

Ngamafutshane, iBrentuximab Vedotin sisitofu esikhethekileyo esisetyenziselwa ukunyanga uhlobo lomhlaza olubizwa ngokuba yiLymphoma. Oku kungenxa yokuba kukho iproteni ekhethekileyo enceda iiseli zomhlaza zikhule, zahlule, kwaye zande. Ngokuyivala loo proteni, eli yeza linceda ekumiseni ukusasazeka kweeseli zomhlaza, okanye ubuncinane linciphise isantya salo. Ukuchaneka, eli liyeza elinikwa iiseli zomhlaza (unyango olujoliswe kulo). Igama layo elidumileyo yi -ADCETRIS . Ngamanye amaxesha, ugqirha wakho angalisebenzisa eli yeza kwezinye iimeko. Ke ukuba unemibuzo, kungcono ukubuza ugqirha wakho okanye ikhemisti.

Zeziphi izinto ekufuneka uzixelele iqela lakho lezonyango ngaphambi kokuba usebenzise eli yeza?

Ngaphambi kokuba uqale eli yeza, kufuneka uxelele iqela lakho lokhathalelo izinto ezithile ngokucacileyo. Kuba olo lwazi luya kubanceda bagqibe ukuba eli yeza likulungele na kwaye bangalinika njani. Musa ukufihla nantoni na, nokuba yeyiphi na into encinci. Ukuba unayo nayiphi na kwezi meko, qiniseka ukuba ubaxelela:

• Isifo seswekile : Ukuba unesifo seswekile.
• Isifo sezintso : Ukuba kukho ingxaki okanye isifo kwizintso .
• Isifo sesibindi : Ukuba kukho ingxaki okanye isifo esibindini.
• Inani leeseli ezimhlophe zegazi eliphantsi: Ukuba sele ufunyenwe uneeseli ezimhlophe zegazi eziphantsi egazini lakho, ezi ziiseli ezilwa nezifo emzimbeni wethu.
• Isifo semiphunga : Ukuba unesifo semiphunga , umzekelo , ubunzima bokuphefumla .
• Iingxaki zemithambo-luvo : Ukuba une-hayidreyi kwimilenze yakho, imvakalelo yokurhawuzelela, okanye ezinye iingxaki zemithambo-luvo (ezifana ne-peripheral neuropathy).
• Ii-Allergies: Ukuba ukhe waba ne-allergy kule yeza, iBrentuximab Vedotin, naluphi na olunye unyango owakha walusebenzisa ngaphambili, naluphi na ukutya, nayiphi na idayi, okanye naziphi na izithinteli.
• Ukukhulelwa okanye ukuzama ukukhulelwa: Ukuba ukhulelwe ngoku okanye uceba ukuba nomntwana kungekudala.
• Ukuncancisa: Ukuba uncancisa umntwana wakho.

Xa ezi zinto zithethwe ngokuchanekileyo, iqela lezonyango linokunyanga ngokukhuselekileyo.

Ndingakunika njani eli yeza?

Eli yeza ulinikwa njengenaliti emthanjeni (ngokufakwa ngaphakathi kwemithambo yegazi okanye nge-IV). Eli yeza lidla ngokunikwa ngabasebenzi bezonyango abaqeqeshiweyo esibhedlele okanye kwikliniki yomhlaza. Oku kuthetha ukuba awunakulithatha uliyise ekhaya ulisebenzise.

Ngaba eli yeza linokunikwa abantwana abancinci?

Ewe, kwezinye iimeko ezikhethekileyo, eli yeza linokunikwa abantwana abaneminyaka emi-2 ubudala . Nangona kunjalo, kufuneka kulandelwe amanyathelo akhethekileyo okhuseleko. Ukuba umntwana wakho unikwe eli yeza, thetha nogqirha wakho ngalo ngononophelo uze ufumane iinkcukacha.

Kuza kwenzeka ntoni ukuba uthatha amayeza amaninzi kakhulu?

Ukuba ucinga ukuba usele eli yeza kakhulu ngempazamo, fowunela iziko lolawulo lwetyhefu okanye igumbi longxamiseko ngokukhawuleza.

Kubalulekile: Eli yeza limiselwe wena kuphela. Musa ukwabelana ngalo nabanye abantu nangasiphi na isizathu.

Kuthekani ukuba ndiphoswa lidosi leyeza?

Uza kunikwa umhla nexesha elithile lokufumana olu gonyo. Kubaluleke kakhulu ukuya kufumana ugonyo ngaloo mihla. Ukuba ngesizathu esithile awukwazi ukuya ngomhla ocwangcisiweyo, fowunela iqela lakho lezempilo ngokukhawuleza uze ubazise.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

Kukho amayeza athile anokubangela iingxaki xa esetyenziswa ngeBrentuximab Vedotin. Ngoko ke, kufuneka uxelele ugqirha wakho ngawo onke amayeza owasebenzisayo, kuquka iivithamini, amayeza emifuno, kunye nezongezo zokutya. Amanye amayeza angafanele asetyenziswe kunye nala mayeza aquka:

• I-Bleomycin

Kwakhona, kukho ezinye izinto ezinokusebenzisana nale mithi:

• I-Ketoconazole
• I-Rifampin
• I-St. John's Wort - Le yimifuno yesintu esetyenziswa ngabanye abantu.

Olu luhlu aluphelelanga. Ngoko ke, xelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo, nokuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi. Ezinye izinto zinokuchaphazela indlela eli yeza elisebenza ngayo.

Yintoni omele uyilumkele xa usebenzisa eli yeza?

Imeko yakho iya kuhlolwa ngoogqirha bakho ngelixa usebenzisa eli yeza. Kwakhona, kufuneka uqaphele ezinye izinto.

• Uvavanyo lwegazi: Kuya kufuneka uhlolwe igazi rhoqo (uvavanyo lwegazi) ngelixa usebenzisa eli yeza. Oku kukujonga indlela eli yeza elichaphazela ngayo umzimba wakho kunye nokuba kukho naziphi na iziphumo ebezingalindelekanga.
• Umngcipheko wokosuleleka: Usenokuba sengozini enkulu kancinci yokufumana izifo, ingakumbi izifo, ngelixa usebenzisa eli yeza. Ke ngoko, ukuba ufumana naziphi na iimpawu zomkhuhlane, ezinje ngomkhuhlane, ukugodola, umphimbo obuhlungu, okanye ezinye iimpawu ezifana nomkhuhlane , musa ukuzinyanga kwaye ufune iingcebiso zonyango ngoko nangoko. Zama ukuphepha iindawo apho abantu bagula khona kangangoko unako.
• I-Progressive Multifocal Leukoencephalopathy (PML): Oku kunokuvakala kusoyikisa, kodwa kubalulekile ukwazi. Kwabanye abantu, eli yeza linokubangela usulelo olukhulu lobuchopho (Progressive Multifocal Leukoencephalopathy - PML). Oku kunqabile kakhulu, kodwa kunokubulala. Ngoko ke ukuba uneempawu, ezinje ngokutshintsha kombono, ingxaki yokucinga, ingxaki yokuthetha, okanye ingxaki yokuhamba okanye yokuma , xelela iqela lakho lezonyango ngoko nangoko. Ukuba awukwazi ukufikelela kubo, fumana olunye uncedo lwezonyango ngoko nangoko.
• Iswekile ephezulu egazini: Eli yeza linokubangela ukuba iswekile yakho yegazi inyuke. Lo mngcipheko uphezulu kubantu abasele benesifo seswekile. Ngoko ke, buza iqela lakho lezonyango ngeendlela zokulawula amanqanaba eswekile egazini lakho.
• Ukukhulelwa nokuncancisa:
• Musa ukukhulelwa ngelixa usela eli yeza kwaye emva kweenyanga ezi-6 emva kokuyeka iyeza. Oku kubaluleke kakhulu, kuba eli yeza linokulimaza kakhulu umntwana osesiswini.
• Kungoko ke, kubalulekile ukusebenzisa uthintelo lokukhulelwa olufanelekileyo ngeli xesha. Thetha nogqirha wakho malunga neendlela zokuthintela ukukhulelwa ezifanelekileyo kuwe nakwiqabane lakho.
• Ukuba ucinga ukuba wena okanye iqabane lakho nikhulelwe, xelela ugqirha wakho ngoko nangoko.
• Musa ukuncancisa umntwana xa usebenzisa eli yeza.
• Ukuzala: Eli yeza linokuchaphazela ukuzala, oko kuthetha ukungabi nabantwana. Ukuba uneenkxalabo malunga noku, thetha neqela lakho lezonyango.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengayo nayiphi na iyeza, iBrentuximab Vedotin inokubangela ezinye iziphumo ebezingalindelekanga. Ezinye zinzima, ezinye azinzima kangako. Eyona nto ibalulekileyo kukuxelela ugqirha wakho ngoko nangoko ukuba ubona into engaqhelekanga.

Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha ngoko nangoko:

Ukuba ufumana naziphi na kwezi mpawu, fowunela iqela lakho lezonyango ngokukhawuleza:

• Iimpendulo ze-allergy: Ukurhawuzelela kwesikhumba, ukurhawuzelela, amaqhuqhuva, ukudumba kobuso, imilebe, ulwimi, nomqala.
• Iingxaki zesiyezi kunye nokulungelelanisa:Ukuba nesiyezi, ukulahlekelwa kukulinganisela okanye ukulungelelanisa izinto, ukudideka, kunye nobunzima bokuthetha.
• Amanqanaba aphezulu eswekile egazini (iHyperglycemia): Ukuziva unxaniwe kakhulu, ufuna ukuchama rhoqo, uzive udiniwe ngendlela engaqhelekanga, umbono ofipheleyo.
• Iimpawu zosulelo: umkhuhlane, ukugodola, ukukhohlela, umphimbo obuhlungu, amanxeba angapholiyo, iintlungu okanye ubunzima bokuchama, kunye nokungonwabi ngokubanzi.
• Iimpawu zokulimala kwesibindi: Intlungu kwicala eliphezulu lasekunene lesisu, ukuphelelwa ngumdla wokutya, isicaphucaphu, indle ekhanyayo, umchamo otyheli okanye omdaka, ukutyheli kolusu namehlo (i-jaundice), kunye nokudinwa okungaqhelekanga.
• Iimpawu zeeseli ezibomvu zegazi ezisezantsi: ukuziva udiniwe ngendlela engaqhelekanga, isiyezi, intloko ebuhlungu, ubunzima bokuphefumla.
• Iimpawu zokwenzakala emiphungeni: ubunzima bokuphefumla, ukukhohlela, igazi kwi-sputum, iintlungu zesifuba, umkhuhlane.
• Intlungu, ukurhawuzelela, okanye ukuba ndindisholo ezandleni okanye ezinyaweni: Oku kungaba luphawu lwe-peripheral neuropathy.
• I-Pancreatitis: Intlungu ebuhlungu esiswini (oku kunokuphumela emqolo, kwaye intlungu inokuba mandundu emva kokutya okanye xa ushukuma), umkhuhlane, isicaphucaphu, kunye nokuhlanza.
• Iimpendulo zesikhumba: Ububomvu, ukudumba, ukuxobuka kwesikhumba, nezinye izinto ezifanayo zinokwenzeka ngaphakathi emlonyeni.
• Iimpawu zokopha esiswini: indle enegazi okanye ehlala ixesha elide, okanye ukuhlanza igazi elifana nekofu egayiweyo.
• Intlungu yesisu eqatha ngequbuliso: Intlungu yesisu eqatha ngequbuliso, urhudo olunegazi, umkhuhlane, isicaphucaphu, kunye nokuhlanza.
• I-Tumor Lysis Syndrome (TLS): Oku kwenzeka xa iiseli zomhlaza ziwohloka ngokukhawuleza. Iimpawu ziquka: isicaphucaphu, ukuhlanza, urhudo, ukuncipha komchamo, umchamo omnyama, ukudinwa okungaqhelekanga, ukudideka, ukuxhuzula kwemisipha okanye iintlungu, ukubetha kwentliziyo okukhawulezayo okanye okungahambelaniyo, kunye nentlungu yamalungu.
• Ukugruzuka okanye ukopha okungaqhelekanga: Ukugruzuka lula, ubunzima bokuyeka ukopha.

Iziphumo ebezingalindelekanga ezihlala zingadingi nyango (kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza):

Ezi ziphumo bezingalindelekanga azisoloko zimbi. Nangona kunjalo, ukuba ziyaqhubeka okanye zikukhathaza kakhulu, xelela iqela lakho lezonyango.

• Ukukhwehlela
• Urhudo
• Ukudinwa
• Intlungu yamalungu
• Isicaphucaphu
• Intlungu yesisu
• Ukuhlanza

Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona into engaqhelekanga, buza ugqirha wakho ngayo. Ungaxela iziphumo ebezingalindelekanga kwi-FDA (Food and Drug Administration) ngokufowunela ku-1-800-FDA-1088.

Ndingaligcina njani eli yeza?

Ekubeni eli yeza linikwa wena esibhedlele okanye ekliniki, akufuneki ulithathe uliyise ekhaya uligcine. Ngoko ke akufuneki ukhathazeke ngalo.

Okokugqibela, ezona zinto zibalulekileyo ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngoko ke sithethe kakhulu ngeBrentuximab Vedotin. Ukuqukumbela, nazi izinto ezibalulekileyo ekufuneka uzikhumbule:

• Eli liyeza elikhethekileyo elilawula ukukhula kweeseli zomhlaza.
• Qiniseka ukuba uxelela ugqirha wakho ngezinye izifo zakho kunye namayeza owasebenzisayo.
• Zikhusele kwiintsholongwane ngelixa usebenzisa amayeza kwaye uqaphele naziphi na iimpawu ezingaqhelekanga.
• Landela imiyalelo malunga nokukhulelwa nokuncancisa ngononophelo.
• Ukuba unemibuzo okanye amathandabuzo, ungoyiki ukubuza iqela lezonyango. Bakhona ukukunceda.

Olu nyango lunokuba nzima, kodwa awuwedwa. Sikunqwenelela amandla! I-Brentuximab Vedotin, iLymphoma, Unyango lomhlaza, Amayeza omhlaza, Iziphumo ebezingalindelekanga, i-ADCETRIS