Ngaba kukho umntu kusapho lwakho, mhlawumbi umama wakho, utata wakho, okanye umakhulu wakho, olibalayo izinto ezincinci? Xa ungakhumbuli kwanezona zinto zincinci, nathi siziva sibuhlungu kakhulu kwaye soyika. Isizathu esiphambili soku sisenokuba sisifo sika-Alzheimer. Enyanisweni, akukho nyango lwaso okwangoku. Nangona kunjalo, kukho unyango olutsha olunokunceda ukulawula ukusasazeka ngokukhawuleza kwesi sifo kunye nokucothisa ukuqhubela phambili kwaso. I-Kisunla yenye yeziyobisi ezinjalo ezizise ithemba elitsha. Masithethe ngale nto ngokulula nangokucacileyo namhlanje.
Isifo sika-Alzheimer kunye nendlela esebenza ngayo iKisunla
Ngamafutshane, isifo se-Alzheimer sisifo sengqondo esikhula kancinci kancinci ngokuhamba kwexesha. Usenokuba ukhe weva ngaso njengesifo sokulahlekelwa yinkumbulo esixhaphakileyo kubantu abadala. Xa esi sifo sikhula, iindawo zengqondo zethu ezilawula izinto ezibalulekileyo ezifana nenkumbulo, ukuqonda, ulwimi, ingqalelo, kunye nokuqiqa ziyamoshakala. Isizathu esiphambili soku kukuqokelelana kweproteni enobuthi ebizwa ngokuba yi -amyloid phakathi kweeseli zobuchopho.
Njengokuba umbhobho wamanzi endlwini yethu uvaleka luthuli uze uyeke ukuhamba kwamanzi, xa le protein ye-amyloid iqokelelana phakathi kweeseli zobuchopho, iiseli zobuchopho azikwazi ukunxibelelana kwaye zisebenze kakuhle.
Usenokuba ukhe weva ukuba isifo sika-Alzheimer luhlobo lwe-dementia. I-Dementia ligama eliqhelekileyo leemeko ezibangela ubunzima bokucinga ngokucacileyo kangangokuba awukwazi ukwenza imisebenzi yemihla ngemihla.
Oogqirha badla ngokuhlulahlula esi sifo sibe ngamanqanaba aliqela. Kwinqanaba lokuqala, ukulahleka kwenkumbulo yexesha elifutshane luphawu oluphambili. Njengoko isifo siqhubeka, nemisebenzi yemihla ngemihla efana nokulungiselela ukutya, ukufumana indlela yakho, kunye nokulawula imali iba nzima. Kwinqanaba lokugqibela, unokubonisa iimpawu zengqondo ezifana nokurhoxa eluntwini, ukuphelelwa ngumdla kuyo nayiphi na into, kunye nokuphazamiseka.
Ngoko ke, lenza ntoni eli yeza litsha elibizwa ngokuba yiKisunla? Liqulathe i-antibody ekhethekileyo ebizwa ngokuba yi -donanemab-azbt . Into eliyenzayo kukuba lijolise kwiiproteni ze-amyloid endizikhankanyileyo ngaphambili eziqokelelana engqondweni zize zizisuse engqondweni. Ngale ndlela, iKisunla inceda ekunciphiseni umonakalo wobuchopho kwaye inciphise isantya esiba sibi ngaso isifo.
Ungayisebenzisa njani iyeza leKisunla?
IKisunla ayilopilisi. Inikwa njenge -intravenous (IV) . Njengokuba besinokufumana i-saline, kuya kufuneka ufumane olu nyango esibhedlele okanye ekliniki, oluthatha malunga nemizuzu engama-30.
Xa uqala unyango, uza kunikwa iidosi ezintathu ze-700 milligrams (700 mg) rhoqo emva kweeveki ezine. Emva koko, ugqirha wakho uza kunyusa idosi iye kwi-1400 milligrams (1400 mg) qho emva kweeveki ezine.
Ngaphambi kokuba uqalise olu nyango, ugqirha wakho uza kuyalela i-brain scan ekhethekileyo ebizwa ngokuba yi-tau positron emission tomography (PET) . Oku kujonga ukuba ingakanani i-amyloid efakwe kwingqondo yakho. Ukuba i-scan ibonisa ukuba inqanaba le-amyloid kwingqondo yakho lehlile kakhulu, ugqirha wakho unokugqiba ekubeni ayeke unyango.
Amanqaku akhethekileyo omawuwalumkele kunye nemiphumo emibi
Kukho isiphumo esibi kakhulu ekufuneka silumke ngakumbi xa sinyanga iKisunla. Sibizwa ngokuba yi -ARIA (i-amyloid-related imaging abnormalities) . Ngamafutshane, eli yeza libangela utshintsho olungaqhelekanga ukuba lubonwe kwi-MRI scan yobuchopho. Oku akusoloko kubangela iimpawu.
Nangona kunjalo, kunqabile, abanye abantu banokufumana iimpawu ezifana nezi:
- Intloko ebuhlungu
- Ukudideka
- Ukuhlanza
- Utshintsho lombono
- Ukulahlekelwa yibhalansi xa uhamba
Ngamanye amaxesha iimpawu ze-ARIA zinokufana kakhulu nezo zestroke. Ngoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo ukuze akwazi ukufumanisa ukuba kungenxa ye-ARIA okanye enye into.
Ngubani osengozini enkulu ye-ARIA?
Abanye abantu banomngcipheko ophezulu wokufumana i-ARIA ngokuxhomekeke kwimilo yabo yemfuza. Abantu abaneekopi ezimbini ze-gene ebizwa ngokuba yi -apolipoprotein E e4 (ApoE e4) basengozini enkulu yokufumana iziphumo ebezingalindelekanga ezinzulu ezifana nokudumba kobuchopho okanye ukopha ebuchotsheni. Ke ngoko, ugqirha wakho uya kuyalela uvavanyo lwemfuza ukujonga umngcipheko wakho we-ARIA ngaphambi kokuba uqale unyango ngeKisunla. Kuya kufuneka wenze ii-MRI scans rhoqo ukuze ujonge le meko ngexesha lonyango.
Impumelelo yeziyobisi zaseKisunla yafundwa njani?
Kuye kwenziwa uphando olukhulu lwezonyango ukuze kubonwe ukuba eli yeza lisebenza kangakanani na. Inani elikhulu lezigulana ezinesifo se-Alzheimer esikwinqanaba lokuqala ziye zathatha inxaxheba koku.
Abaphandi bahlukanise aba bantu baba ngamaqela amabini.
1. Iqela elinye lanikwa: amayeza aseKisunla.
2. Elinye iqela: lanikwa into efana neyeza, kodwa ingenaso isithako esisebenzayo (siyibiza ngokuba yi-placebo ).
Iziphumo ziyakhuthaza ngokwenene. Masiqonde ezo ziphumo kwitheyibhile engasezantsi.
| Inzuzo | Oko kufunyenwe luphando |
|---|---|
| Ukucothisa ukusasazeka kwesifo | Izinga lokuqhubela phambili kwesifo kwabo bafumene iKisunla laliphantsi malunga nama-20% kunabo bafumene i-placebo. |
| Iimpawu azibi zimbi | Amashumi amane anesixhenxe ekhulwini abo bafumene iKisunla abazange babe naso isifo sabo esibi kunyaka nje omnye, xa kuthelekiswa nama-29% kuphela abo bakwiqela le-placebo. |
| Ukuncipha kwe-amyloid engqondweni | Ekupheleni kolu phando, ama-76% abo bafumene iKisunla babenezinga eliphantsi kakhulu lee-amyloid deposits ebuchotsheni babo. |
Ezi ziphumo zibonisa ukuba iKisunla inokucothisa kakhulu ukuqhubela phambili kwesifo se-Alzheimer.
Kuthatha ixesha elingakanani ukuba iyeza lisebenze kwaye ngaba kukho naluphi na unxibelelwano olukhoyo namanye amayeza?
Kwangoko nje ukuba ufumane idosi yakho yokuqala yeKisunla, iqala ukusebenza ngokujolisa kwi-amyloid engqondweni. Nangona kunjalo, kungathatha iinyanga ezininzi ukuba wena, abanakekeli bakho, kunye nogqirha wakho niqaphele ukuba iimpawu zenu ziyancipha kwaye indlela esi sifo sihamba ngayo iyehla.
Ukusebenzisana nezinye iziyobisi
Ngenxa yomngcipheko wokopha ebuchotsheni nge-ARIA, kufuneka kuthathwe unonophelo olukhethekileyo xa usebenzisa iKisunla enezithinteli zegazi . Nangona kungekho bungqina bucacileyo okwangoku, ukuba uthatha izithinteli zegazi, ngokuqinisekileyo kufuneka uxoxe ngale nto nogqirha wakho ngaphambi kokuba uqalise unyango lweKisunla.
Eyona nto ibalulekileyo kukwazisa ugqirha wakho ngazo zonke iziyobisi ozisebenzisayo - nokuba uzinikwe ngugqirha wakho, amayeza athengiswa ngaphandle kwemvume kagqirha, iivithamini, amayeza e-Ayurvedic okanye e-Sinhala.
Ukuba ufumana naziphi na iimpawu ezifana nentloko ebuhlungu ngexesha lonyango, musa ukuzityeshela. Isenokuba luphawu lwe-ARIA, ngoko yazisa ugqirha wakho ngoko nangoko .
Umyalezo Wokuya Ekhaya
- IKisunla liyeza elitsha elisetyenziselwa ukunyanga amanqanaba okuqala esifo sika-Alzheimer.
- Oku kusebenza ngokususa iproteni enobuthi ebizwa ngokuba yi-amyloid eqokelelana engqondweni kwaye inciphise isantya esiba sibi ngaso isifo.
- Olu lunyango lokufakwa ngemithambo yegazi (i-IV) kwaye kufuneka lufunyanwe esibhedlele okanye eklinikhi.
- Kubaluleke kakhulu ukuqaphela isiphumo esibi esibizwa ngokuba yi-ARIA. Oku kufuna ukuba kwenziwe i-MRI scan rhoqo ngaphambi nangexesha lonyango.
- Kubalulekile ukuthetha ngokukhululekileyo nogqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka amayeza okunciphisa igazi) kunye nazo naziphi na iimpawu ezintsha ozifumanayo.
- Nangona oku kungeyonyango, kuyayicothisa kakhulu indlela esi sifo siqhubeka ngayo kwaye kunika ithemba elitsha kwizigulana nakwiintsapho zazo.
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