Xa ugqirha ekuxelela ukuba umhlaza webele usasazeke kwamanye amalungu omzimba, oko kukuthi, 'usuguqukile', kuyinto eqhelekileyo ukuziva uloyiko olukhulu kunye nexhala. Nangona kunjalo, ngokuhambela phambili kwezonyango zanamhlanje, kukho unyango olusebenzayo kakhulu kwiimeko ezinjalo namhlanje. I-Verzenio yenye yeziyobisi ezinjalo ezizisa ithemba. Ngoko ke namhlanje, masithethe ngokufutshane ngeli yeza libizwa ngokuba yi-Verzenio, indlela elisebenza ngayo, kunye nezinto ekufuneka uzilumkele xa ulisebenzisa.
Isebenza njani iVerzenio emzimbeni?
Ngamafutshane, iVerzenio liyeza elikwiqela lamayeza abizwa ngokuba yi-"kinase inhibitors." Cinga ngayo ngokungathi kukho ii-enzymes emzimbeni wethu ezisebenza njenge-"messengers" ezithwala ulwazi phakathi kweeseli. Ezi zizinto esizibiza ngokuba yi-"kinases." Iiseli zomhlaza zenziwe ngala ma-messengers akhethekileyo azixelela ukuba zahlukane kwaye zikhule ngokukhawuleza.
I-Verzenio isebenza ngokuthintela isenzo sezithunywa ezibizwa ngokuba yi-'cyclin-dependent kinases 4 kunye ne-6 (CDK4 kunye ne-CDK6)', ezithumela imiqondiso kwiiseli zomhlaza ukuba zikhule. Ngokuchanekileyo, ithintela loo miyalezo phakathi kohambo. Ngale ndlela, xa ii-enzymes ze-CDK4 kunye ne-CDK6 ziyeka ukusebenza, iiseli zomhlaza zilahlekelwa yisignali yokwahlukana nokukhula. Ngenxa yoko , ukukhula kweeseli zomhlaza kuyayeka okanye kuyeke . Oku kunceda ekunciphiseni iithumba.
Zeziphi iintlobo zomhlaza webele ezisetyenziselwa iVerzenio?
Eli yeza alinikwa zonke iintlobo zomhlaza webele. Lisetyenziselwa ngokukodwa:
- i-hormone receptor (HR)-positive kunye
- I-receptor ye-Human epidermal growth factor 2 (HER2)-negative
Isetyenziselwa uhlobo lomhlaza webele olubizwa ngokuba yi-metastatic breast cancer. Ikwanikwa xa umhlaza usasazeke ngaphandle kwebele uye kwamanye amalungu omzimba, njengesibindi, imiphunga, okanye amathambo.
Ngamanye amaxesha eli yeza linikwa kunye nezinye iindlela zonyango lweehomoni. Nangona kunjalo, kwiimeko apho umhlaza usasazeke kwaye isifo asizange siphendule kuzo zombini iindlela zonyango lwe-chemotherapy kunye nolwe-hormone, iVerzenio inokunikwa yodwa . Konke oku kugqitywa ngugqirha okunyangayo.
Ungayithatha njani iVerzenio? Yintoni omele uyiqaphele?
I-Verzenio yipilisi. Kufuneka uziqaphele ezi zinto xa uyisebenzisa.
- Kufuneka uthathe le pilisi kabini ngemini .
- Ungayithatha ngaphambi okanye emva kokutya, kodwa zama ukuyithatha ngexesha elifanayo yonke imihla .
- Ithebhulethi mayiginywe yonke . Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna.
- Musa ukuthatha naziphi na iipilisi eziphukileyo, eziqhekeziweyo, okanye ezonakeleyo.Ngelo xesha, fowunela ugqirha wakho umxelele ngako.
- Ukuba uyahlanza emva kokusela iyeza, yiyeke loo dosi. Musa ukuthatha ipilisi eyongezelelweyo . Thatha ipilisi elandelayo ngexesha elicwangcisiweyo.
Ugqirha wakho uza kukucebisa ukuba uqhubeke nokusela eli yeza ude umhlaza wakho ulawuleke okanye ude ufumane iziphumo ebezingalindelekanga ezibi kakhulu. Ukuba ufumana ezinye iziphumo ebezingalindelekanga, ugqirha wakho angagqiba ekubeni anciphise umthamo wakho, ayeke ukuwuthatha okwethutyana, okanye awuyeke ngokupheleleyo.
Isebenza kangakanani iVerzenio ngokwenene? (Iziphumo zoVavanyo lweKlinikhi)
Eli yeza livunyiwe ngokusekelwe kwiziphumo zezilingo ezininzi zeklinikhi eziphumelele kakhulu. Makhe sijonge ngokukhawuleza iziphumo zezo zilingo.
| Uvavanyo lweklinikhi | Iqela elinyangiweyo | Isiphumo esiphambili |
|---|---|---|
| UKumkani 3 | Izigulana ezingazange zifumane unyango lwangaphambili lomhlaza ophucukileyo. (Verzenio + unyango lwehomoni) | I-Progression-Free Survival (PFS) yayiziinyanga ezingama-28.2 kwabo bathatha iVerzenio, xa kuthelekiswa neenyanga ezili-14.8 kwabo bathatha amanye amayeza. |
| UKumkanikazi 2 | Izigulane ezazifumene unyango lwehomoni ngaphambili (Verzenio + Fulvestrant). | Abo basebenzise iVerzenio babenexesha eliphakathi lokusinda leenyanga ezili-16.4 ngaphandle kokusasazeka komhlaza (kwezinye iinyanga ezili-9.3), kunye nexesha lilonke lokusinda leenyanga ezingama-46.7 (kwezinye iinyanga ezingama-37.3). |
| UKumkani 1 | Izigulana ezinesifo esingakhange silawulwe nge-chemotherapy kunye nonyango lwe-hormone ngaphambili. (I-Verzenio kuphela) | I-17.4% yezigulana ibonakalise ukuncipha okukhulu okanye ukunyamalala ngokupheleleyo kweeseli zethumba. |
Ezi zibalo zibonisa ukuba iVerzenio liyeza elinegalelo elikhulu ekulawuleni ukusasazeka komhlaza nokwandisa ubomi bezigulana.
Ugqirha uyijonga njani inkqubela yonyango?
Emva kokuba uqalile ukusebenzisa amayeza, ugqirha uza kukujonga rhoqo.
- Iiskeni: Iskeni idla ngokwenziwa malunga neeveki ezi-6 emva kokuqala amayeza ukuze kubonwe ukuba umhlaza usabela njani kwiyeza.
- Uvavanyo lweGazi: Oku kubaluleke kakhulu. Amanqanaba eeseli egazini lakho, njengeeseli ezimhlophe zegazi, ii-neutrophils, kunye neeplatelets, ajongwa rhoqo ukuqinisekisa ukuba iyeza lisebenza ngokukhuselekileyo emzimbeni wakho.
Ungazilawula njani iziphumo ebezingalindelekanga xa zisenzeka?
Iziphumo ebezingalindelekanga ziqhelekile kumayeza omhlaza. Eyona nto ibalulekileyo kukuxelela ugqirha wakho ngalo naluphi na utshintsho okanye ukungakhululeki okuzivayo, nokuba azincinci.
- Uvavanyo lwegazi oluqhelekileyo: I-Verzenio ngamanye amaxesha inokubangela ukwehla kweeseli ezimhlophe zegazi. Oku kubizwa ngokuba yi-"neutropenia." Oku kunokukhokelela kwiintsholongwane ezinzulu. Yiyo loo nto kubalulekile ukufumana zonke iimvavanyo zegazi eziyalelwe ngugqirha wakho.
- Ukuphazamiseka kwesisu: Ukucaphuka, ukuhlanza, kunye norhudo zizinto eziqhelekileyo. Ezi zinto zinokulawulwa ngokutya ukutya okungeyondlwantyala, okunamafutha aphantsi, kunye nokutya ukutya okuncinci endaweni yokutya ukutya okukhulu. Nangona kunjalo, ukuba urhudo lwakho lubi kakhulu, kufuneka uxelele ugqirha wakho ngoko nangoko . Uza kukunika iingcebiso ezifunekayo.
- Ezinye iziphumo ebezingalindelekanga ezinzulu: Ukuba ufumana naziphi na iimpawu zegazi eliqhekekileyo (ukudumba okanye ukukrweleka emlenzeni) ezichaphazela imiphunga yakho, njengokukhwehlela, ubunzima bokuphefumla, okanye ukuphefumla kancinci, kufuneka wazise ugqirha wakho ngoko nangoko.
Ngaba kukho ezinye izinto ezikhethekileyo ekufuneka uzazi?
Ewe, kukho ezinye izinto ezimbalwa.
- Yitya igrapefruit, hayi ijusi: Igrapefruit iyayithintela umzimba ekuqhekezeni iVerzenio. Oku kunokubangela ukuba amanqanaba esiyobisi emzimbeni anyuke ngokungeyomfuneko, nto leyo eyandisa iziphumo ebezingalindelekanga.
- Amayeza athile: Ukusela amayeza okubola njenge ketoconazole kunye nala mayeza kunokubangela iziphumo ebezingalindelekanga eziyingozi. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka iivithamini kunye nezongezo) .
- Ezinye izifo:Ukuba unezinye iingxaki zempilo, ezifana nesifo sesibindi, idosi yakho yeVerzenio inokufuneka ilungiswe. Thetha nogqirha wakho malunga nembali yakho epheleleyo yempilo.
Umyalezo Wokuya Ekhaya
- I-Verzenio lunyango olujoliswe ekuthinteleni iintlobo ezithile zomhlaza webele (i-HR-positive, i-HER2-negative).
- Landela imiyalelo kagqirha wakho ngokuchanekileyo. Sela amayeza ngexesha elifanelekileyo nangedosi efanelekileyo.
- Xela ugqirha wakho ngoko nangoko naziphi na iziphumo ebezingalindelekanga ozifumanayo, nokuba zincinci kangakanani na.
- Kubaluleke kakhulu ukuba kwenziwe uvavanyo lwegazi kunye neeskeni ngexesha.
- Yiphephe ngokupheleleyo i-grapefruit. Xelela ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo.
- Olu asilohambo oluhamba wedwa. Iqela lakho lezonyango lihlala likhona ukukunceda. Ngoko ke ungoyiki ukubuza imibuzo nokucacisa amathandabuzo akho.
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