Ii-antibiotics azisebenzi? Ngaba wakha weva ngeentsholongwane ezibulala iintsholongwane? (Phage Therapy)

Kwezinye izifo, ugqirha wakho uza kukunika amayeza okubulala iintsholongwane, akunjalo? Adla ngokuba ngawona mayeza siwasebenzisayo xa sisosulela iintsholongwane. Kodwa ngamanye amaxesha, nokuba sinikela ngawuphi na amayeza okubulala iintsholongwane, sinokungamelani nawo, kwaye iintsholongwane eziyingozi (esizibiza ngokuba 'zii-superbugs') zinokungena emizimbeni yethu. Ngoko ke senza ntoni ngamaxesha anje? Namhlanje siza kuthetha ngonyango olungaqhelekanga kodwa olunamandla kakhulu olunokunceda ngamaxesha anje. Yiyo loo nto iPhage Therapy.

Ngamafutshane, yintoni iPhage Therapy?

I-Phage okanye i-bacteriophage luhlobo lwentsholongwane. Musa ukoyika ukubuza, "Ngaba yintsholongwane?" Le ayisiyontsholongwane efana neCorona okanye iDengue esisigulisayo. Eyona nto ijoliswe kuyo kwaye kukutya kuphela kwezi ntsholongwane ze-phage ziintsholongwane. Azilimazi iiseli zabantu. Cinga ngayo njenge-commando ekhethekileyo eqeqeshelwe ukuzingela iintsholongwane.

I-Phage ayiyontsholongwane eyenziwe ngumntu. Ifumaneka ngokwemvelo kuyo yonke indawo kwihlabathi liphela - emhlabeni, emanzini, kwaye, ngokumangalisayo, emzimbeni wakho. Ngoko ke, unyango lwe-phage lubandakanya ukusebenzisa le ntsholongwane ye-phage, 'elutshaba' olukhethekileyo lwaloo ntsholongwane, ukulwa nentsholongwane engenakubulawa nazii-antibiotics.

Ngoko ke olu nyango lusebenza njani?

Le yinkqubo yendalo enomdla kakhulu. Intsholongwane ye-phage ayinakuzalela ngokwayo, oko kukuthi, yande. Ngokuqinisekileyo ifuna intsholongwane ukuze yenze njalo.

1. Ukuqaphela iithagethi: Okokuqala, intsholongwane ye-phage ifumana intsholongwane ethile enokuyitshabalalisa ize izincamathele kumphezulu wayo.

2. Ukufaka i-DNA: Okulandelayo, i-phage virus ifaka ulwazi lwayo lwemfuza, oko kukuthi, i-DNA, kwiseli yebhaktiriya.

3. Ukulawula: Iseli yebhaktiriya ngoku ilawulwa ngokupheleleyo yintsholongwane ye-phage. Isebenzisa onke amandla ebhaktiriya, iqala ukwenza amakhulu eentsholongwane ezintsha ze-phage isebenzisa i-DNA engene kuyo.

4. Ukutshatyalaliswa nokusasazeka: Xa kungekho ndawo ngaphakathi kwiseli yebhaktiriya yokuba iintsholongwane ezintsha ze-phage zenzeke, iseli yebhaktiriya iyaqhuma. Emva koko, amakhulu amawaka ezo ntsholongwane ze-phage zisandula ukwenziwa ayaphuma, afumane ezinye iintsholongwane, aze aqalise umjikelo wokuzitshabalalisa nazo.

Oogqirha basebenzisa le ndlela ngale ndlela ilandelayo: Bachonga iintsholongwane ezibangela usulelo emzimbeni wakho. Emva koko, 'kwithala leencwadi leentsholongwane' ezingamawakawaka eentsholongwane ezahlukeneyo, bakhetha intsholongwane ehlasela ezo ntsholongwane baze bayisebenzisele unyango.

Kukho iimeko ezininzi apho olu nyango lunokunceda khona:

• Usulelo lwemiphunga oluhambelana ne-cystic fibrosis
• Usulelo lwendlebe olubangelwa yintsholongwane i-P. aeruginosa
• Ezinye izifo ezibangelwa yi-E. coli okanye i-P. aeruginosa bacteria
• Usulelo lwezilonda zemilenze ezingapholiyo
• Usulelo lwamehlo olubangelwa yibhaktiriya
• I-Sepsis (usulelo lwegazi) kwiintsana ezisandul’ ukuzalwa
• Usulelo lwendlela yomchamo
• Usulelo lwenxeba emva kotyando

Ziziphi iingenelo kunye neengxaki zonyango lwe-phage?

Njengalo naluphi na unyango, olu luneengenelo kunye neengozi ezithile. Masijonge zombini. Masiqale sithethe ngeengenelo.

Ngaba oku kungabangela ingozi? Zithini iingozi?

Kukho izinto ezininzi ezixhalabisa oogqirha xa bethetha ngolu nyango.

• Ukunqongophala kolwazi olwaneleyo: Nangona unyango lwe-phage lusetyenziswe ixesha elithile kumazwe afana neRashiya nePoland, izilingo ezinkulu zeklinikhi zanamhlanje kwihlabathi liphela zisekwinqanaba lazo lokuqala. Ke ngoko, akukho datha yaneleyo yokutsho ngokuqinisekileyo nge-100% ukuba zeziphi iziphumo ebezingalindelekanga zexesha elifutshane nezexesha elide zolu nyango.

• Umngcipheko Wokothuka Okubangelwa YiSeptic: Le yeyona ngozi iphambili. Xa iintsholongwane ze-phage ziqhekeza iiseli zebhaktiriya ngokukhawuleza, izinto ezinobuthi ezibizwa ngokuba zii-endotoxins ezingaphakathi kwezo seli zinokukhutshwa emzimbeni. Ezi zinto zinokuchaphazela inkqubo yomzimba yokuzikhusela, zibangele uxinzelelo lwegazi ukuba lwehle ngequbuliso, kwaye zibangele ukungasebenzi kakuhle kwamalungu omzimba. Kodwa khumbula, le ngozi iyafana xa usebenzisa amayeza okubulala iintsholongwane anamandla.

• Umngcipheko wokudluliselwa kwe-DNA: Iintsholongwane ze-Phage zinokudlulisela i-DNA ngokwemvelo ukusuka kwenye intsholongwane ukuya kwenye. Ngoko ke abanye abantu bakholelwa ukuba olu kudluliselwa kwe-DNA lunokukhokelela ekudalweni kweentlobo ezintsha neziyingozi zebhaktheriya. Kodwa akukho mfuneko yokukhathazeka, kuba izazinzulu zihlola ngononophelo ii-phages ezisetyenziswa kolu nyango kwaye zikhetha kuphela ezo zingenazo iityhefu okanye iijini eziyingozi.

Ingaba olu nyango lufumaneka eSri Lanka?

Okwangoku, unyango lwe-phage alukabi lolona nyango luqhelekileyo kumazwe amaninzi kwihlabathi liphela, kuquka neSri Lanka. Lusekwinqanaba lophando, okanye luphantsi kodidi "lokusetyenziswa ngobubele." Oku kuthetha ukuba oogqirha banokulusebenzisa olu nyango kuphela kwiimeko ezingxamisekileyo, xa zonke ezinye iindlela zonyango ezivunyiweyo zingaphumelelanga kwaye kungekho ndlela yimbi yokusindisa ubomi , ngemvume ekhethekileyo.

Le ndlela yonyango ineminyaka engaphezu kwe-100 ubudala. Nangona yayisetyenziswa kakhulu naseMelika ngeminyaka yoo-1940, yaphela kancinci kancinci xa kwafunyanwa amayeza okubulala iintsholongwane. Kodwa ngoku ekubeni ingxaki yeentsholongwane ezinganyangekiyo kumayeza okubulala iintsholongwane iye yaba sisisongelo esikhulu kwihlabathi liphela, kuye kwakho umdla omtsha kunyango lwe-phage. Ke ngoko, uphando ngale nto lwenzeka ngokukhawuleza kwihlabathi liphela.