Umdlavuza webele uyinto eyethusa abesifazane abaningi. Ikakhulukazi ngemva kokunqamuka kokuya esikhathini, okungukuthi, ngemva kokunqamuka kokuya esikhathini kwanyanga zonke, abantu abaningi bacabanga ngale ngozi. Ngakho-ke, namuhla sikhuluma ngomuthi osiza abesifazane abasengozini yalolu hlobo lomdlavuza ukunciphisa leyo ngozi. Lo muthi ubizwa ngokuthi i-Evista. Isithako esisebenzayo kuwo yi-raloxifene. Usetshenziselwa ukunciphisa ingozi yomdlavuza webele , kanye nokunciphisa ingozi yokuphuka okubangelwa yi-osteoporosis, isifo esincipha amathambo esenzeka ngemva kokunqamuka kokuya esikhathini.
Uyini ngempela umdlavuza webele ohlaselayo?
Ake siqale sikuqonde kalula lokhu. Kunezinhlobo ezimbili eziyinhloko zomdlavuza webele. Omunye umdlavuza ongangenisi. Kulokhu, amangqamuzana omdlavuza angaphakathi kwemigudu yobisi noma izindlala ezikhiqiza ubisi (ama-lobule) zebele, futhi awadluli kuleyo mingcele.
Kodwa-ke, umdlavuza webele ohlaselayo uyisimo esibi kakhulu. Okwenzekayo lapha ukuthi amangqamuzana omdlavuza aphuma emigudwini yobisi nasema-gland asakazekele ezicutshini zebele eziphilile ezizungezile. Ukusuka lapho, angasakazekela nakwezinye izingxenye zomzimba, njengesibindi, amaphaphu, nobuchopho. Lesi yisimo esiyingozi kakhulu. Yingakho kubaluleke kakhulu ukuthola nokwelapha umdlavuza onjalo kusenesikhathi.
I-Evista iyinciphisa kanjani ingozi yalo mdlavuza?
Umuthi i-Evista ungowesigaba semithi ebizwa ngokuthi "i-SERM (Selective Estrogen Receptor Modulator)". Kalula nje, le mithi isebenza njenge-hormone i-estrogen kwezinye izingxenye zomzimba futhi isebenza ngokumelene ne-hormone i-estrogen kwezinye.
Njengoba kungenzeka wazi, i-estrogen isiza ezinye izinhlobo zomdlavuza webele ukuthi zikhule. Njengoba nje isitshalo sidinga amanzi ukuze sikhule. I-Evista isebenza ngokunamathela kuma-receptor e-estrogen ezicutshini zebele, ivimba isikhala sokuba i-hormone yangempela ye-estrogen inamathele lapho. Lokhu kusho ukuthi ivimba amangqamuzana omdlavuza ekutholeni umlayezo we-estrogen awudingayo ukuze akhule.
Kodwa kubalulekile ukukhumbula lokhu: I-Evista ayilona ikhambi lomuntu osevele enomdlavuza webele. Ayinikezwa futhi ukuvimbela umdlavuza ukuthi ungabuyi kumuntu osevele enomdlavuza. Isetshenziswa kuphela ukunciphisa ingozi yomdlavuza kwabesifazane abatholakale benawo ngemva kokunqamuka kokuya esikhathini.
Ingabe ikhona imiphumela emibi ye-Evista?
Yebo. Njenganoma yimuphi umuthi, i-Evista ingaba nemiphumela emibi. Eminye mincane, kodwa futhi kunemiphumela emibi emibi okufanele uyiqaphele. Ngakho-ke, kufanele uxoxe kokubili okuhle nokubi nodokotela wakho ngaphambi kokunquma ukuthatha lo muthi.
| Uhlobo lomphumela ongemuhle | Incazelo |
|---|---|
| Imiphumela emibi kakhulu edinga ukunakekelwa okusheshayo | |
| Amahlule egazi | Ingozi yokuqhekeka kwegazi emithanjeni yemilenze (i-Deep Vein Thrombosis) nasemaphashini (i-Pulmonary Embolism) inganda. |
| Isifo sohlangothi | Abesifazane, ikakhulukazi labo abasengozini yesifo senhliziyo, bangase babe nengozi eyengeziwe kancane yokushaywa yisifo sohlangothi. |
| Imiphumela emibi evamile, engemibi kangako | |
| Ukungakhululeki ngokomzimba | Ukuqaqamba kwemilenze, ubuhlungu bamalunga, ukuvuvukala kwamalungu. |
| Ezinye izinkinga | Izimpawu ezifana nomkhuhlane, ukushisa okukhulu, ukujuluka, ukuqwasha, kanye nokoma kwesitho sangasese sowesifazane. |
Ngakho-ke ubani ofanele ukuthatha lo muthi?
Lona umbuzo obaluleke kakhulu. I-Evista akuyona imithi efanela wonke umuntu. Udokotela wakho uzoxoxa nawe ngomlando wakho wezempilo .Futhi izici eziyingozi zinquma ukuthi lokhu kufanelekile noma cha. Ngokuvamile, abantu abangazuza kakhulu kulo muthi yilaba:
- Abesifazane abangaphezu kweminyaka engama-60 ubudala: Ngoba ingozi yokuba nomdlavuza webele iyanda njengoba iminyaka ikhula.
- Abantu abake baba nomdlavuza webele emndenini wabo: ikakhulukazi isihlobo esiseduze njengomama noma udadewabo.
- Abantu abanokuthambekela kwezakhi zofuzo: Uma ukuhlolwa kuqinisekisile ukuthi banezinguquko zezakhi zofuzo ezifana ne-BRCA1 kanye ne-BRCA2.
- Labo abake bahlolwa ibele ngaphambilini futhi batholakale benesifo esingaba yisandulela somdlavuza, njenge-‘lobular carcinoma in situ (LCIS).`
- Abantu abanezinye izici eziyingozi: Isibonelo, ukuguga ekuzalweni kokuqala, ukunqamuka kokuya esikhathini sekwephuzile, njll.
Ngemva kokucabangela konke lokhu, udokotela wakho uzohlola ngokunembile ingozi yakho.
Ubani okungafanele athathe i-Evista?
I-Evista ingabangela umonakalo omkhulu kunokuhle kwabesifazane abanezinkinga ezithile zempilo. Ngakho-ke, akuvunyelwe ngokuphelele ukusebenzisa lo muthi uma ungowamaqembu alandelayo:
- Abesifazane abakhulelwe noma abanethemba lokukhulelwa.
- Abesifazane abanesifo sokuwa kwegazi emilenzeni, emaphashini, noma emehlweni okwamanje noma ngaphambilini.
- Abesifazane abangakafiki esikhathini sokuya esikhathini, okusho ukuthi basaya esikhathini nyanga zonke.
- Abantu abasebenzisa umuthi wokwehlisa i-cholesterol njenge-Cholestyramine.
- Labo abathatha ezinye izindlela zokwelapha ngama-hormone e-estrogen (i-estrogen eyengeziwe).
Uyini umehluko phakathi kwe-Evista ne-Tamoxifen?
Kungenzeka ukuthi uke wezwa nangomuthi obizwa ngokuthi i-Tamoxifen. Futhi uwumuthi osekilasini le-SERM. Izifundo zithole ukuthi zombili lezi zidakamizwa zisebenza kahle ngokulinganayo ekunciphiseni ingozi yomdlavuza webele.
Kodwa-ke, kuneminye imehluko ebalulekile. Kubikwe ukuthi i-Tamoxifen ihlotshaniswa nengozi ephezulu yomdlavuza wesibeletho kune-Evista. Kuye kwaboniswa nokuthi i-Evista ayivimbeli umdlavuza ongangenisi njenge-ductal carcinoma in situ (DCIS), kuyilapho i-Tamoxifen ikwenza.
Izingozi zokuqhekeka kwegazi kanye nesifo sohlangothi zivamile kuzo zombili izidakamizwa. Ezinye izifundo zithi ingozi iphansi kancane nge-Evista kune-Tamoxifen, kanti ezinye izifundo zithi akukho mehluko obalulekile.
Ngakho-ke ekugcineni, isinqumo sokuthi yimuphi kule mithi emibili ongcono kuwe, noma ukuthi kuyadingeka ngempela yini ukuthatha umuthi onjalo, yisinqumo okufanele sicatshangelwe ngokucophelela ngemva kokuxoxa ngazo zonke izinzuzo nezingozi nodokotela wakho.
Umlayezo Wokuya Nawe Ekhaya
- I-Evista (i-raloxifene) umuthi onikezwa abesifazane abasengozini enkulu yokuba nomdlavuza webele ngemva kokunqamuka kokuya esikhathini ukuze banciphise leyo ngozi . Akuyona ikhambi lomdlavuza.
- Kukhona ingozi yemiphumela emibi kakhulu njengokuqhekeka kwegazi kanye nokukhubazeka lapho usebenzisa lo muthi.
- Isinqumo sokuthatha lo muthi noma cha singesomuntu siqu okufanele senziwe ngemuva kokuxoxa ngokucophelela nodokotela wakho ngezinto eziyingozi kanye nesimo sakho sempilo.
- Ngisho nangemva kokuthatha i-Evista, abanye besifazane basengaba nomdlavuza webele, ngakho-ke kubalulekile ukuqhubeka nokuzihlola njalo amabele kanye nokuhlolwa kwe-mammogram.
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