Ake sifunde nge-GABA (gamma-aminobutyric acid), imfihlo yobuchopho ethobisa ingqondo yakho.

Ingabe ngezinye izikhathi uzizwa ukhungathekile, ukhathazekile, noma umane wesaba nje? Noma ingabe uhlushwa ukuqwasha ebusuku? Ngemuva kwalezi zinto kungase kube nesithunywa esincane samakhemikhali ebuchosheni bethu. Yilokho esizokhuluma ngakho namuhla. Yi-GABA. Isebenza njengenkinobho 'epholile' ebuchosheni bethu.

Iyini i-GABA (i-gamma-aminobutyric acid)?

Kalula nje, i-GABA iyikhemikhali edlulisa imiyalezo phakathi kwamangqamuzana ezinzwa (ama-neurons) ebuchosheni bethu. Ifana neposi elihlakaniphile emzimbeni wethu. Kodwa okukhethekile ngayo ukuthi "ithobisa" umsebenzi wobuchopho ongadingekile. Okusho ukuthi, ivimba amangqamuzana ezinzwa zobuchopho ukuthi angashukunyiswa futhi angaphazamiseki ngokweqile. Ososayensi babiza lezi zinhlobo zamakhemikhali ngokuthi ama-neurotransmitters. Cabanga nge-GABA "njengebhuleki" elilawula isivinini sesimiso sethu sezinzwa esiyinhloko, okuhlanganisa ubuchopho bethu kanye nomgogodla. Yilokho okusisiza ukuthi singajabuli kakhulu noma sesabe.

Isebenza kanjani i-GABA? Kwenzekani ngaphakathi kobuchopho bethu?

Manje bheka ukuthi le GABA isebenza kanjani ngaphakathi kobuchopho bethu. Kuyindlela emangalisayo kakhulu. Sinezigidigidi zamaseli ezinzwa ebuchosheni bethu. Sidinga ukuthumela umlayezo kusuka kwelinye iseli lezinzwa kuya kwelinye. Empeleni kukhona igebe elincane phakathi kwala maseli amabili ezinzwa. Lokho kubizwa ngokuthi `(i-Synapse)` noma i-nerve junction.

I-`(Neurotransmitter)` efana ne-GABA yenza lokhu ngokuthatha umlayezo udlule kule ndawo yokuhlangana bese inamathela ku-`(Receptors)` ethile kuseli lemizwa elilandelayo. Kufana nokhiye ofakwa kukhiye. Njengoba nje kungewona wonke ukhiye ongavula yonke ikhiye, akuwona wonke u-`(Neurotransmitter)` onganamathela ku-`(Receptor)` ngayinye. I-GABA futhi inama-`(Receptors)` amabili athile ayiqondayo – `(GABA-A)` kanye no-`(GABA-B)`.

Ngakho-ke, uma i-GABA ihamba futhi ibopha kula ma-receptor, kunciphisa ikhono leseli elandelayo yemizwa lokuphendula. Okusho ukuthi, kunciphisa amathuba alelo seli lokwenza umlayezo ongadingekile noma ukuwuthumela komunye umuntu. Yingakho i-GABA ibizwa ngokuthi "inhibitory" noma i-neurotransmitter ezolisayo.

Yiziphi izinzuzo zezempilo ezinikezwa yi-GABA?

Ngakho-ke, yiziphi izinzuzo zezempilo esizithola ku-GABA, ezolisa ubuchopho ngale ndlela? Empeleni ziningi. Cabanga, "ucindezelekile" kakhulu, okungukuthi, uma ucindezelekile kakhulu, ingqondo yakho ayikho endaweni eyodwa, ukhathazekile kakhulu, futhi isifuba sakho sizizwa sengathi siyashaya. Ngesikhathi esinjengaleso, uma izinga le-GABA emzimbeni wakho lilungile, lizothulisa ingqondo yakho futhi likusize unciphise lokhu kucindezeleka .

I-GABA inekhono elimangalisayo lokulawula ukukhathazeka . Iyasiza ekunciphiseni ukwesaba okungadingekile nokukhathazeka ngakho konke.

Enye into ukuthi, abanye abantu abakwazi ukulala ebusuku. Bamane bajikijele futhi baphenduke lapho beyolala, kodwa kubonakala sengathi abalali nhlobo. Ucwaningo lwamanje lubonisa ukuthi i-GABA iyasiza nasekulaleleni okuhle nokuphumuzayo .

I-GABA ne-Glutamate: Ukushintsha 'kokucinywa' kobuchopho

Kanye ne-GABA, kukhona enye i-`(Neurotransmitter)` ebaluleke kakhulu ebuchosheni bethu. Yi-`(Glutamate)`. Lezi ezimbili zisebenza njengezinhlangothi ezimbili zohlamvu lwemali, noma njengezinkinobho ezimbili 'ezivuliwe' kanye 'nezivaliwe'. Okusho ukuthi, ngezindlela eziphikisanayo.

• I-GABA: 'Ivala' ukusebenza kobuchopho bese ibuthulisa (ivimbela).
• I-Glutamate: 'Ivula' futhi ivuselele umsebenzi wobuchopho (isikhuthazi).

Ngakho-ke, ukuze ubuchopho bethu busebenze kahle futhi ngendlela efanele, kudingeka kube nokulinganisela okubucayi phakathi kwamandla okuzola e-GABA kanye namandla okuvuselela e-`(Glutamate) . Njenge-accelerator kanye ne-brake yemoto. Kuphela uma kokubili kusebenza kahle nangesikhathi lapho singahamba khona kahle nangokuphepha. Uma lokhu kulinganisela kulahleka, kuvela izinkinga ezahlukahlukene. Ngokumangazayo, le agent yokuzola ebizwa ngokuthi i-GABA nayo ikhiqizwa ngesikhuthazi `(Glutamate). I-`(enzyme)` ekhethekile ihilelekile kuyo, okungukuthi, i-enzyme (`glutamic acid decarboxylase`).

I-GABA isebenza futhi nenye i-neurotransmitter, i-serotonin. Eqinisweni, ama-neurotransmitter amaningi asebenza ndawonye, ​​​​ngezinye izikhathi aphikisana, ukugcina imizimba yethu nobuchopho bethu kusebenza kahle.

Izifo ezingabangelwa amazinga aphansi e-GABA

Cabanga ukuthi bekuzokwenzekani ukube lokhu kushintshana kwemiyalezo ye-GABA bekungasebenzi kahle, okusho ukuthi amazinga e-GABA ebuchosheni aphansi? Lokhu kungaholela ezinkingeni ezahlukahlukene zezinzwa zempilo yengqondo. Ucwaningo luthole ukuthi ukwehla komsebenzi we-GABA kungabangela izimo ezifana nalezi:

• Ukukhathazeka kanye nokuphazamiseka kwemizwelo: Ukuzizwa usaba njalo, ukhathazekile, ulahlekelwa yinjabulo, futhi ungakwazi ukugxila.
I-Schizophrenia : Isifo sengqondo esiyinkimbinkimbi esibonakala ngokulahlekelwa ukuxhumana neqiniso nokubona, ukuzwa, nokucabanga izinto ezingezona ezangempela.
• Isifo se-Autism spectrum: Isifo sokuthuthukiswa esibonakala ngokukhubazeka ekuxhumaneni nabantu nasekuxhumaneni.
• Ukucindezeleka: Umuzwa wokudabuka wesikhathi eside, ukulahlekelwa isithakazelo kunoma yini, kanye nomuzwa wokukhathala ngempilo.
• Isithuthwane kanye nokuxhuzula: Izimo ezinjengokuxhuzula kanye nokuxhuzula okwenzeka emzimbeni ngenxa yokusebenza ngokweqile okungazelelwe, okungalawuleki kwamaseli ezinzwa ebuchosheni.

Ngaphezu kwalezi zimo ezinkulu, kunezinye izifo eziningana okucatshangwa ukuthi zihlotshaniswa nokungalingani kwe-GABA:

• Ukuntuleka kwe-pyridoxine:Lesi yisifo esingavamile. Sibangelwa ukuntuleka kwe-vitamin B6 (pyridoxine), ebalulekile ekukhiqizweni kwe-GABA. Lokhu kuvame ukubangela ukuxhuzula okuvamile ezinganeni ezincane. Lokhu kuxhuzula kunzima ukukulawula ngemithi ejwayelekile yokulwa nesifo sokuxhuzula, kodwa kungelapheka ngezithasiselo zamavithamini.
• I-Hepatic encephalopathy: Isifo sesibindi esibi esithinta ukusebenza kobuchopho.
• Isifo sikaHuntington: Isifo esizuzwe njengefa esibhubhisa kancane kancane amangqamuzana obuchopho.
• I-Dystonia kanye ne-spasticity: Izimo ezibonakala ngokuqina kwemisipha okungavamile kanye nokudikiza.
• I-Hypersomnia: Ukuzizwa ulele kakhulu noma ulele kakhulu emini.

Ingabe ukwandisa amazinga e-GABA kunikeza izinzuzo zezempilo?

Abacwaningi basafunda ngemiphumela yokwenyuka kwamazinga e-GABA. Nakuba ubufakazi bungakacaci ngokuphelele, kuyaphenywa ukuthi i-GABA ingasiza yini ekwelapheni noma ekuvimbeleni izimo ezithile zempilo. Isibonelo:

• Umfutho wegazi ophakeme
• Ukungalali
• Isifo sikashukela

Kudingeka ucwaningo olwengeziwe ngalezi zinto.

Izinhlobo zemithi ehlasela i-GABA

Ngenxa yalokhu kubaluleka kwe-GABA, abakhiqizi bemithi bathuthukise imithi eminingi ehlose "ama-receptor" e-GABA. Lawa asebenza ngokusiza noma ukuthuthukisa imiphumela yemvelo yokuzola ye-GABA. Kungenzeka ukuthi uke wezwa ngalezi:

• Ama-Benzodiazepine: Lolu hlobo lwemithi luhlanganisa i-diazepam (eyaziwa nangokuthi i-Valium) kanye ne-alprazolam (eyaziwa nangokuthi i-Xanax) futhi isetshenziselwa ukwelapha ukukhathazeka, ukuqwasha, ukuquleka, kanye nokuhoxa kotshwala. Zisetshenziswa futhi njenge-anesthesia ngesikhathi sokuhlinzwa.
• Ama-Barbiturates: Lawa futhi uhlobo lwesidakamizwa esidambisayo esibangela ukozela. Kodwa-ke, ukusetshenziswa kwawo manje akusavamile.
• I-Vigabatrin (Sabril®): Umuthi osetshenziselwa ukwelapha ukuxhuzula kanye nokuqina kwemisipha ezinganeni ezincane.
• I-Flumazenil (Romazicon®): Isetshenziselwa ukwelapha ukweqisa i-benzodiazepine. Iphinde isetshenziswe ukuthuthukisa isimo sengqondo ku-hepatic encephalopathy, isimo esibangelwa yisifo sesibindi.
• I-Valproic acid: Lona umuthi oqinisa imizwa olawula ukuxhuzula kwesithuthwane.
• I-Zolpidem (eyaziwa nangokuthi i-Ambien® noma i-Edluar®): Lona umuthi omkhulu wokungalali.
• I-Propofol (eyaziwa nangokuthi i-Diprivan®): Umuthi osetshenziselwa ukudambisa ubuhlungu nokulalisa isiguli ngesikhathi sokubulala izinzwa okuvamile.
• I-Baclofen (`Baclofen (Lioresal®, Gablofen®)`): Isiphumuza imisipha.

Khumbula: Le mithi kanye neminye efanayo kufanele isetshenziswe kuphela ngaphansi kokuqashwa ngudokotela. Ukuyisebenzisa wedwa, noma ngoba nje othile oseduze nawe ekutshelile, kungabangela umonakalo omkhulu. Ngakho-ke qaphela.

Ingabe izithasiselo ze-GABA ziwusizo?

Manje abanye bangase babuze, 'Pho kungani singenakuyithenga i-GABA njengesengezo?' Yebo, i-GABA iyatholakala njengesengezo sokudla. Kodwa kunenkinga encane lapha. Akukacaci kahle ukuthi ingakanani i-GABA esiyithatha ngomlomo engena ebuchosheni bethu.

Ngoba, ubuchopho bethu buzungezwe ulwelwesi olukhethekile kakhulu oluvikelayo olubizwa ngokuthi "umgoqo wegazi nobuchopho". Lokhu kufana nesango, elingavumeli wonke amakhemikhali ukuthi angene kalula ebuchosheni, kuvumela kuphela akhethiwe. Ngakho-ke, abukho ubufakazi obuqinile besayensi bokuthi lezi zithako ze-GABA zinomthelela ngempela ebuchosheni noma cha. Ngakho-ke, kudingeka kwenziwe ucwaningo olwengeziwe ngalokhu kusetshenziswa iqembu elikhulu labantu. Ngenxa yesimo samanje, akuhlakaniphile ukusebenzisa izithako ze-GABA ngaphandle kokukhuluma nodokotela.

Ingabe kukhona ukudla okuqukethe i-GABA?

I-GABA ikhona ngokwemvelo nakwezinye ukudla. Isibonelo:

• Ukudla okubilisiwe: izinto ezifana ne-kimchi (i-pickle yaseKorea), i-miso (i-soy paste yaseJapan), kanye ne-tempeh (umkhiqizo we-soy wase-Indonesia).
• Izinhlobo zetiye: Itiye eliluhlaza, itiye elimnyama, kanye netiye le-oolong nazo ziqukethe i-GABA.
• Okunye ukudla: Ukudla okufana nelayisi elinsundu, ubhontshisi, uphizi, ama-chestnut (uhlobo lwamantongomane), amakhowe, utamatisi, isipinashi, i-broccoli, iklabishi, i-cauliflower, ama-Brussels sprouts (uhlobo lweklabishi elincane), okusanhlamvu okuhlumile (isib., ubhontshisi oluhlaza uma uhlumile), kanye namazambane amnandi nakho kuqukethe i-GABA noma kusiza umzimba ukuthi ukhiqize i-GABA.

Kodwa njengoba kushiwo ngezithasiselo, akukacaci ukuthi ingakanani i-GABA evela kulokhu kudla efinyelela ebuchosheni. Kuhle ukuyifaka njengengxenye yokudla okunempilo, kodwa akukhuthazwa ukuthembela kuphela kulokhu kudla njengokwelashwa okukhethekile kwesimo esithile. Futhi, funa iseluleko sezokwelapha ngalokhu.

Okokugcina, izinto okufanele uzikhumbule (Umyalezo Wokuya Ekhaya)

Ngakho-ke, cishe usuyaqonda manje ukuthi i-GABA (i-gamma-aminobutyric acid) esikhulume ngayo namuhla iyi-neurotransmitter ethulisa ubuchopho bethu futhi ibaluleke kakhulu empilweni yethu yengqondo, ebuthongweni, kanye nokusebenza kwemizimba yethu jikelele.

Kuyasiza ukulawula ukukhathazeka, ukucindezeleka, kanye nokungalali. Amazinga aphansi e-GABA angabangela izifo ezahlukahlukene zezinzwa nezengqondo. Eminye imithi isebenza ngokugxila ohlelweni lwe-GABA.

Kudingeka ucwaningo olwengeziwe lwesayensi ngezinzuzo zezithako ze-GABA nokudla okuqukethe i-GABA. Ngakho-ke, uma unemibuzo, ukungabaza, noma unemibuzo mayelana ne-GABA, into engcono kakhulu nephephile ongayenza ukubona udokotela womndeni wakho, uxoxe ngesimo sakho, bese uthola iseluleko esifanele.Ungayi emsebenzini ngenxa yokuqagela noma inzwabethi. Impilo yakho ibalulekile kuwe.

` I-GABA, i-gamma-aminobutyric acid, i-neurotransmitter, ubuchopho, impilo yengqondo, ukukhathazeka, ukulala