Siyazi ukuthi abantu abanesifo sikashukela basengozini yezinye izinkinga zempilo
eziningana , okuhlanganisa nezinkinga zezinso nezenhliziyo. Nakuba kunemithi eyahlukahlukene yokunciphisa le ngozi, abantu abaningi abanesifo sikashukela bangaba nesifo sezinso esingamahlalakhona (CKD) ngokuhamba kwesikhathi. Uma unesifo sikashukela kanye ne-CKD, kungenzeka kakhulu ukuthi ube nezinkinga zempilo ezinkulu. Kodwa-ke, umuthi obizwa ngokuthi i-Kerendia, owavunywa ngo-2021, ungasiza ekunciphiseni lezi zingozi kwabanye abantu.
I-Kerendia ibasiza kanjani abantu abanesifo sikashukela kanye nesifo sezinso?
Uma unesifo sikashukela sohlobo lwesibili, amazinga aphezulu kashukela egazini ngokuhamba kwesikhathi angalimaza izitho ezahlukene zomzimba. Ikakhulukazi, lokhu kuthinta izinso kubantu abaningi. Izinso ezonakele ngale ndlela azikwazi ukusebenza kahle. Lesi simo sibizwa ngokuthi
i-Chronic Kidney Disease (CKD) . Ngokuhamba kwesikhathi, lesi simo siba sibi kancane kancane futhi singaholela ekuhlulekeni kwezinso. Amazinga aphezulu kashukela egazini nawo alimaza inhliziyo nemithambo yegazi (uhlelo lwenhliziyo). Lokhu kwandisa ingozi yezimo ezibucayi ezifana nesifo sohlangothi, ukuhlaselwa yinhliziyo, kanye nokwehluleka kwenhliziyo. Ngenxa yokuthi izinso azisebenzi kahle, abantu abane-CKD nabo banamathuba amaningi okuthola isifo senhliziyo. Ngakho-ke, umuntu onesifo sikashukela, i-CKD, kanye nesifo senhliziyo ndawonye usengozini enkulu yokufa.
Ngokulawula ushukela wegazi lakho kanye nomfutho wegazi, unganciphisa umonakalo enhliziyweni yakho, emithanjeni yegazi kanye nasezinso. Kodwa ngenkathi usenza lokho, kunemithi engasiza ekuvikeleni izinso zakho ekulimaleni okwengeziwe. I-Kerendia ingenye yemithi ekhethekile. I-Kerendia isebenza ngendlela ehluke kancane ukuvimbela umonakalo enhliziyweni yakho nasezinso. Isithako esisebenzayo kuleli philisi yi
-finerenone . Isebenza ngokuvimba i-receptor ebizwa ngokuthi
i-mineralocorticoid receptor (MR) ezinso zakho, enhliziyweni, nasemithanjeni yegazi. Le receptor ye-MR ingaba namandla kakhulu kubantu abanesifo sikashukela. Ngokuvimba le receptor, i-Kerendia isiza izinso zakho ukuthi zisuse i-sodium (usawoti) egazini lakho. Iphinde isize ekunciphiseni ukuvuvukala kanye nezibazi (fibrosis) enhliziyweni yakho nasemithanjeni yegazi. Uma uyithatha isikhathi eside, unganciphisa ingozi yakho yezinkinga ezinkulu zempilo.
Ngingawusebenzisa kanjani lo muthi?
I-Kerendia iyiphilisi elingathathwa kanye ngosuku ngokudla noma ngaphandle kokudla. Uma unenkinga yokugwinya iphilisi lonke, ungayichoboza bese ulixuba namanzi amancane noma ukudla okuthambile njenge-applesauce. Kodwa-ke,
kufanele ulithathe ngokushesha ngemva kokulixuba. Ngemva kokuqala ukuthatha i-Kerendia, udokotela wakho uzohlola
amazinga akho e-potassium egazini njalo. Ngakho-ke, kufanele uqiniseke ukuthi uya kohlolwa igazi nsuku zonke udokotela wakho akutshela zona. Kuye ngamazinga akho e-potassium egazini, udokotela wakho angakweluleka ukuthi wandise noma wehlise umthamo womuthi, noma uyeke ukuthatha umuthi izinsuku ezimbalwa. Uma uphuthelwa umthamo, thatha ngokushesha nje lapho ukhumbula. Kodwa kuphela uma kungaphakathi kosuku lophuthelwa umthamo. Uma ukhumbula ngosuku olulandelayo, ungathathi umthamo ophuthelwe.
Ukuthatha umthamo ophindwe kabili kungandisa ingozi yemiphumela emibi. Yiziphi izivivinyo ezenziwe kulo muthi?
Manje ungase uzibuze ukuthi lo muthi uthembeke kangakanani nokuthi ubani owusebenzisile. Ake sibheke izifundo ezenziwe ngawo. Kuye kwenziwa izivivinyo ezimbili ezinkulu ukuze kubonwe ukuthi iKerendia iphephile futhi isebenza kangakanani kubantu abadala abanesifo sikashukela kanye ne-CKD. Isilinganiso seminyaka yabahlanganyeli kulezi zivivinyo sasiyiminyaka engaba ngu-64.
Ulwazi olubalulekile ngalabo abahlanganyele esivivinyweni:
- Bonke babenesifo sikashukela sohlobo lwesibili kanye ne -CKD .
- Nakuba abanye babeke batholakala benesifo senhliziyo ngaphambilini, akekho owayenezimpawu ngesikhathi sokuhlolwa.
- Wonke umuntu wayesebenzisa umuthi okwakufanele uvikele izinso .
- Ama-97% asebenzisa imithi yokulawula ushukela egazini .
- Umuthi iKerendia waqhathaniswa ne -placebo , iphilisi elingelona iqiniso elalingenamphumela. Akekho owayazi ukuthi babethola umuthi wangempela noma iphilisi elingelona iqiniso.
Olunye lwalezi zivivinyo lulinganise ukuthi zingaki izinkinga ezinkulu zezinso ezenzeka ngesikhathi kuthathwa umuthi. Okungukuthi:
- Abantu abanesifo sezinso esibi kakhulu.
- Abantu abanenkinga yezinso.
- Abantu abashona ngenxa yezinkinga zezinso.
Okunye ukuhlolwa kwalinganisa ukuthi zingaki izehlakalo ezinkulu zenhliziyo nezemithambo yegazi ezenzekile. Okungukuthi:
Iyini imiphumela yokuhlolwa?
Izinkinga zezinso: Ocwaningweni, olwathatha iminyaka engaba ngu-2.5, abantu abathatha iKerendia babenezinkinga ezincane zezinso ezingathi sína kunalabo abathatha i-placebo. Lokhu kusho ukuthi abanye abantu babenamathuba amancane okuthola izinkinga ezinkulu zezinso, njengokwehluleka kwezinso, ukwehluleka kwezinso, noma ukufa ngenxa yesifo sezinso.
Izinkinga zenhliziyo: Ocwaningweni, olwathatha iminyaka engaba ngu-3.5, abantu abathatha iKerendia babenezinkinga ezimbalwa ezinkulu zenhliziyo kunalabo abathatha i-placebo. Lokhu kusho ukuthi abanye abantu babenamathuba amancane okuthola izinkinga ezinkulu zenhliziyo, njengohlangothi, ukuhlaselwa yinhliziyo, ukulaliswa esibhedlela ngenxa yesifo senhliziyo, noma ukufa.
Imiphumela emibi nokuthi ungayiphatha kanjani?
Njenganoma yimuphi umuthi, i-Kerendia ingabangela imiphumela emibi. Eyinhloko ukwanda kwamazinga e-potassium egazini. Yingakho udokotela wakho ezohlola igazi lakho njalo.
| Imiphumela/izingozi ezingaba khona | Okufanele ukwenze/okufanele ukugweme |
|---|
| Amazinga e-potassium akhuphukile egazini. | Ungathathi noma yiziphi izithasiselo ze-potassium ngaphandle kokukhuluma nodokotela wakho. Hamba uyohlolwa igazi lakho ngezinsuku udokotela wakho akutshela zona. |
| Ukusetshenziswa kwezinto ezithatha indawo kasawoti. | Ezinye izinto ezithatha indawo kasawoti emakethe zinothe nge-potassium. Gwema ukuzisebenzisa. Xhumana nodokotela wakho mayelana nokudla kwakho. |
| Ukusebenzisana nezinye izidakamizwa. | Tshela udokotela wakho ngayo yonke imithi oyithathayo (kufaka phakathi amavithamini nemikhiqizo yamakhambi). |
| Ukusabela nge-grapefruit. | Gwema ngokuphelele.Ukudla i-jumbo shrimp noma ukuphuza ijusi ye-jumbo shrimp ngenkathi uthatha i-Kerendia kungakhuphula izinga lomuthi emzimbeni futhi kwandise imiphumela emibi. |
Into ebaluleke kakhulu ukukhuluma nodokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi izimpawu ezingavamile ezikukhathazayo.
Ungase ungezwa umehluko omkhulu uma usebenzisa lo muthi. Lokhu kungenxa yokuthi umsebenzi wawo oyinhloko ukunciphisa izinga lomonakalo wangaphakathi. Ngakho-ke,
noma ngabe uzizwa ungcono, ungayeki ukuthatha umuthi ngaphandle kweseluleko sikadokotela wakho. Umlayezo Wokuya Nawe Ekhaya
- I-Kerendia umuthi okhethekile onikezwa abantu abanesifo sikashukela sohlobo lwesibili kanye nesifo sezinso esingamahlalakhona (CKD) ukunciphisa umonakalo enhliziyweni nasezinso.
- Uma uthatha lo muthi, kufanele uqaphele kakhulu amazinga akho e-potassium egazini. Ngakho-ke qiniseka ukuthi uyahamba uyohlolwa igazi ngezinsuku udokotela wakho akutshele zona.
- Ungalokothi uyeke ukuthatha iKerendia noma eminye imithi yesifo sikashukela kanye nomfutho wegazi ophezulu ngaphandle kweseluleko sikadokotela wakho.
- Gwema ukudla i-grapefruit noma ukuphuza ijusi ye-grapefruit ngokuphelele ngenkathi usebenzisa i-Kerendia.
- Kubaluleke kakhulu ukwazisa udokotela wakho ngayo yonke eminye imithi, amavithamini, kanye nezithasiselo ozithathayo.
I-Kerendia, i-finerenone, isifo sikashukela, isifo sezinso, isifo sezinso esingamahlalakhona, i-CKD, isifo senhliziyo, iSri Lanka
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