Wake wezwa ngegama elithi 'Methylene Blue'? Mhlawumbe akunjalo. Liyisidakamizwa esingavamile, kodwa esibaluleke kakhulu. Empeleni liwuketshezi oluhlaza okwesibhakabhaka. Libukeka njengodayi owufaka endwangu, kodwa lingalapha ezinye izifo ezinkulu. Kulungile, ake sibone ukuthi indaba ithini ngalo muthi oluhlaza okwesibhakabhaka ongavamile?

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Iyini ngempela iMethylene Blue?

Kalula nje, i-methylene blue umuthi osetshenziswa odokotela ukwelapha isifo segazi esingavamile esibizwa ngokuthi i-methemoglobinemia . Nakuba empeleni iyinto eqinile, uma isetshenziswa njengomuthi, iyancibilika emanzini bese inikezwa njengomjovo njengoketshezi oluhlaza okwesibhakabhaka. Umlando walo muthi nawo uyathakazelisa kakhulu. Waqala ukutholwa yisazi semithi saseJalimane ngekhulu le-19. Ekuqaleni wawusetshenziswa njengodayi embonini yezindwangu. Kamuva, wasetshenziswa futhi njengombala ezivivinyweni zelebhu. Cishe eminyakeni eyi-125 eyedlule, udokotela waseJalimane waqala ukuwusebenzisa njengomuthi wokwelapha umalaleveva. Kusukela ngaleso sikhathi, izinzuzo zawo zithuthuke kakhulu. Njengamanje, uvunyelwe yi-US FDA kuphela njengomuthi wokwelapha i-methemoglobinemia. Kodwa-ke, odokotela ngezinye izikhathi bawusebenzisela nezinye izimo zezokwelapha.

Lolu hlobo lwesifo olusetshenziswa kulo muthi?

Njengoba sishilo ngaphambili, ukusetshenziswa okuyinhloko kwalomuthi ukwelapha isifo esibizwa ngokuthi i-methemoglobinemia.

Ngakho-ke iyini i-methemoglobinemia?

Lesi yisifo esihlobene negazi lethu. Kalula nje, uma lesi sifo sivela, amangqamuzana abomvu egazini lethu awakwazi ukuthwala umoya-mpilo kahle aye ezicutshini zomzimba.

Uma umzimba ungatholi umoya-mpilo owanele, izingxenye zomzimba ezifana nezindebe, isikhumba, ulimi, nezinzipho ziqala ukuphenduka zibe luhlaza okwesibhakabhaka. Lokhu kubizwa nangokuthi i-cyanosis . Uma lokhu kwenzeka ezinganeni ezincane, ngezinye izikhathi kubizwa ngokuthi 'i-blue baby syndrome'.

Abanye abantu bathola lesi sifo njengefa ngokusebenzisa izakhi zofuzo, okungukuthi, kubazali babo. Kodwa kwabaningi, sivela ngenxa yokusetshenziswa kwemithi ethile, izidakamizwa, noma ukungenisa amakhemikhali athile. I-Methemoglobinemia yisimo esibi esingaba yingozi ngisho nokuphila . I-Methylene blue ingenye yezindlela zokwelapha ezingcono kakhulu zalokhu.

Lomuthi usebenza kanjani?

I-Methylene blue isebenza ngokuguqula ama-molecule e-methemoglobin ngamakhemikhali, angakwazi ukuthwala umoya-mpilo, abe ama-molecule e-hemoglobin angathwala umoya-mpilo. Kufana nokushaja ibhethri. Lo muthi unikezwa njenge-IV esibhedlela noma emtholampilo ngudokotela noma umhlengikazi. Kuthatha cishe imizuzu emi-5 kuya kwengama-30. Ngokuvamile, umthamo owodwa uzonciphisa izimpawu. Kodwa-ke, uma izimpawu zisabonakala ngemva kwehora, udokotela anganquma ukunikeza omunye umthamo.

Imiphumela emibi kanye nokusebenzisana neminye imithi

Ngaphambi kokukunikeza lo muthi, udokotela wakho uzobuyekeza umlando wakho wezokwelapha ophelele, njengoba lo muthi ungaba yingozi kubantu abanezimo ezithile zezokwelapha.

Izinto okufanele uzitshele udokotela wakho nakanjani

Ukuntuleka kwe-G6PD	Lesi yisifo esithinta izakhi zofuzo esithinta amangqamuzana abomvu egazi. Uma umuntu onalesi sifo enikwa i-methylene blue, amangqamuzana abomvu egazi angaqhekeka ngokushesha (i-hemolysis) futhi agule kakhulu. Lena yinto ebaluleke kakhulu.
Ukukhulelwa noma ukuncelisa	Qiniseka ukuthi utshela udokotela wakho uma ukhulelwe, uzama ukukhulelwa, noma uncelisa.
Ezinye izimo zezokwelapha	Sicela usazise uma unesifo sezinso noma sesibindi.
Ukungezwani komzimba	Sitshele uma une-allergies ku-methylene blue noma eminye imithi, ukudla, noma udayi.
Ubuthi be-Cyanide	Uma usola ukuthi i-cyanide inobuthi, kufanele utshele udokotela wakho .

Yiziphi imiphumela emibi?

Njengayo yonke imithi, lokhu kungaba nemiphumela emibi.

Imiphumela emibi emincane (akukho okufanele ukhathazeke ngakho):
Umchamo oluhlaza okwesibhakabhaka kanye nendle (lokhu kuvamile, okubangelwa umbala womuthi)
Isicanucanu nokuhlanza
Ushintsho oluncane kumbala wesikhumba
Ubuhlungu esandleni lapho kwanikezwa khona i-IV

Imiphumela emibi kakhulu okufanele ibikwe kudokotela ngokushesha:
Ubuhlungu besifuba
Isiyezi
Ikhanda elibuhlungu (ikhanda elibuhlungu)
Ukudideka
Ukujuluka okukhulu
Isisu esibuhlungu

Ukusebenzisana kwezidakamizwa

Lokhu futhi kuyingxenye ebaluleke kakhulu. Eminye imithi ingaba nemiphumela eyingozi kakhulu uma ithathwa nge-methylene blue.

Ikakhulukazi, imithi ethile yokucindezeleka noma ukukhathazeka (isib. ama-SSRI) ingabangela isimo esingaba yingozi esibizwa ngokuthi 'i-Serotonin Syndrome' uma ithathwa kanye ne-methylene blue.

Lokhu kusho ukuthi i-serotonin yamakhemikhali ebuchosheni bethu iyanda kakhulu, okubangela izimpawu ezinzima njengokuthuthumela, umkhuhlane omkhulu, ukulahlekelwa ukwazi, ngisho nokufa. Ngakho-ke, kubalulekile ukutshela udokotela wakho ngayo yonke imithi, amavithamini, kanye nezithasiselo ozithathayo.

Ezinye izinzuzo nezici ezisekelwe ocwaningweni

Nakuba ivunyiwe yi-FDA kuphela nge-methemoglobinemia, odokotela bayisebenzisela ezinye izimo ezimweni ezikhethekile. Lokhu kubizwa ngokuthi ukusetshenziswa 'okungekho ku-label'.

Njengekhambi: Njengekhambi lokudambisa ubuthi ngamakhemikhali anjenge-nitrite, asetshenziswa kwezinye izimboni. Uma usola into efana nale, iya e-Emergency Treatment Unit (ETU) yesibhedlela ngokushesha. Uma kudingeka, bazoshayela i-National Poison Information Centre e-Colombo National Hospital ukuze bathole iseluleko.
Ukushaqeka: Yelapha ukushaqeka kwezinye iziguli ezigula kakhulu egunjini lokunakekelwa okujulile (ICU).
Ukutholwa komdlavuza: Ngesikhathi sokuhlinzwa komdlavuza, kusetshenziswa njengodayi wokubonisa amangqamuzana omdlavuza nama-lymph node ngombala oluhlaza okwesibhakabhaka.
Ukuthuthukisa inkumbulo: Ucwaningo luyaqhubeka ukuze kubonakale ukuthi lokhu kungaba usizo yini ezifweni ezifana ne-Alzheimer's ezenzeka ngokukhula.
Njengomuthi wokubulala amagciwane:Ucwaningo oluthile lukhombisile ukuthi ukuhlanganisa i-methylene blue nokukhanya kungabulala amagciwane afana ne-coronavirus.

Okubalulekile: Eziningi zalezi zisesesigabeni sokucwaninga. Ngakho-ke ungazizami ngoba nje uzibona ku-inthanethi. Landela njalo imiyalelo kadokotela wakho.

Umlayezo Wokuya Nawe Ekhaya

I-Methylene Blue umuthi okhethekile onikezwa ukwelapha isifo segazi esingavamile kodwa esibi esibizwa ngokuthi i-methemoglobinemia.
Lomuthi akufanele usetshenziswe wodwa . Uhlala unikezwa ngemithambo esibhedlela ngaphansi kokuqondisa kukadokotela noma umhlengikazi.
Uma unesifo sofuzo esibizwa ngokuthi ukuntuleka kwe-G6PD , kufanele utshele udokotela wakho nakanjani. Kubaluleke kakhulu ekuphepheni impilo.
Yazisa udokotela wakho ngayo yonke eminye imithi oyithathayo (ikakhulukazi leyo yezifo zengqondo) ukuvimbela i-serotonin syndrome eyingozi.
Kujwayelekile ukuthi umchamo wakho uphenduke ube luhlaza okwesibhakabhaka ngemva kokuthatha umuthi. Ungakhathazeki ngakho. Kodwa uma uzwa izimpawu ezifana nobuhlungu besifuba noma ukudideka, bheka udokotela ngokushesha.
Ezinye izinzuzo zalo muthi zisesesigabeni socwaningo, ngakho-ke landela njalo iseluleko sikadokotela wakho.