Kungenzeka ukuthi uke wezwa igama elithi MTHFR ngesikhathi uphequlula i-inthanethi, noma kumngane. Uma uzwa likhulunywa kanye "nokuguqulwa kwezakhi zofuzo", ungase wesabe kancane futhi ube nelukuluku. "O, angazi ukuthi nami nginalokhu, ingabe lokhu kuzobangela ukugula okukhulu?" Ungase ucabange. Ingabe lokhu kungokungathi sína ngempela futhi kuyinto okufanele uyesabe njengoba abantu abaningi becabanga? Ngakho-ke namuhla, ake sixoxe kalula futhi ngobungane ngokuthi iyini i-MTHFR nokuthi kufanele siyesabe ngempela yini.
Okokuqala, iyini le gene ye-MTHFR?
Cabanga ngemizimba yethu njengefektri eyinkimbinkimbi kakhulu nemangalisayo. Le fektri inesethi yemiyalelo yokwenza konke. Le ncwadi yemiyalelo iyizakhi zofuzo zethu. I-MTHFR nayo iyizakhi zofuzo ezibaluleke kakhulu emizimbeni yethu. Umsebenzi oyinhloko walesi sakhi sofuzo ukufundisa imizimba yethu ukwenza 'iphrotheni ye-MTHFR'. Le phrotheni ibalulekile kithi. Ngoba, i-vithamini
B ebizwa ngokuthi
i-folate , etholakala ekudleni esikudlayo, iguqulwa ibe
uhlobo olusebenzayo umzimba wethu ongalusebenzisa. Le folate esebenzayo ibalulekile ekwenzeni izinto eziyisisekelo emizimbeni yethu, njenge
-DNA .
Ngakho-ke kuyini lokhu "kuguquka"?
Ukuguquka kwezakhi zofuzo kuwushintsho oluncane emiyalweni ekulesi sakhi sofuzo. Kufana noshintsho oluncane ezincwadini ezisencwadini. Lolu shintsho lungenza iphrotheni ye-MTHFR ingasebenzi kahle. Lokho kusho ukuthi ayicubunguli ne-vitamin folate. Uma le folate ingacubungulwanga kahle, izinga le-amino acid ebizwa ngokuthi
i-homocysteine egazini lethu lingakhuphuka. Esikhathini esidlule, odokotela babecabanga ukuthi amazinga aphezulu e-homocysteine ayimbangela yezifo eziningi, njengesifo senhliziyo kanye nokuqhekeka kwegazi.
Kodwa-ke, ucwaningo olusha selukhombisa ukuthi ukuguqulwa kwe-MTHFR kanye namazinga aphezulu e-homocysteine akubangeli ingozi enkulu empilweni njengoba abantu abaningi becabanga.
Yiziphi izimpawu ezibangelwa ukuguqulwa kwe-MTHFR?
Nansi into ebaluleke kakhulu neduduzayo.
Iningi labantu abane-MTHFR gene mutation abanazo izimpawu. Baphila impilo enempilo ngokuphelele, evamile. Abantu abaningi abazi nokuthi banayo le gene mutation. Ezimweni ezingavamile kakhulu, ezinye izimpawu zingase zivele. Kodwa akuvamile. Kodwa-ke, ucwaningo luphakamise ukuthi abantu abanale gene mutation bangase babe "nokuthambekela okuthile" kokuthuthukisa izimo ezithile zempilo. Kodwa lokhu akusho ukuthi wonke umuntu onale gene mutation uzoqala lesi sifo.
| Isimo sobudlelwano esingenzeka | Izinto ezilula okufanele uzazi |
|---|
| Umkhuba wokujiya kwegazi (i-Thrombophilia) | Nakuba kukhona inkolelo yokuthi abanye abantu bangase babe nengozi eyengeziwe kancane yokuqhekeka kwegazi, ukuguqulwa kwe-MTHFR kuphela okwamanje akubhekwe njengembangela enkulu yalokhu. |
| Izinkinga ngesikhathi sokukhulelwa | Nakuba kuthiwa kuhlotshaniswa nezinto ezifana nokuphuphuma kwesisu kanye nomfutho wegazi ophakeme, lo mbono uye wenqatshwa kakhulu namuhla. |
| Izingane Ezinezinkinga Ze-Neural Tube | Lokhu kuyinto abantu abaningi abayesabayo. Kodwa le ngozi ingagwenywa cishe ngokuphelele ngokuthatha i-folic acid ngendlela efanele ngesikhathi sokukhulelwa. Sizoxoxa ngalokho kabanzi. |
| I-neuropathy ehlobene nesifo sikashukela | Kukhona inkolelo yokuthi abantu abanesifo sikashukela abanokuguqulwa kwe-MTHFR bangase babe nengozi eyengeziwe kancane yokuba nezinkinga zezinzwa. |
Ingabe ngidinga ukwenza isivivinyo ukuze ngithole?
Kukhona ukuhlolwa kwegazi ukuthola lokhu kuguqulwa kwezakhi zofuzo. Kodwa-ke,
izinhlangano ezinkulu zezokwelapha njenge-American College of Medical Genetics azincomi lokhu kuhlolwa emphakathini jikelele. Kunezizathu eziningana zalokhu:
- Ukungabi namsebenzi: Njengoba sishilo ekuqaleni, abantu abaningi abanalolu guquko ababi nezinkinga zempilo. Ngakho-ke noma ngabe uhlolwe futhi uthola ukuthi unalo, ngeke kushintshe impilo yakho. Kungase kukwenze wesabe.
- Inketho engcono: Uma kukhona into eyodwa ofuna ukuyihlola ngempela, izinga le-homocysteine egazini lakho. Kuwukuhlolwa kwegazi okulula nokungabizi. Uma izinga lakho liphakeme, ungakhuluma nodokotela wakho ngalokho okufanele ukwenze ngakho. Khona-ke akudingeki uchithe imali ekuhlolweni kofuzo .
Ingabe omama abakhulelwe kufanele bakwesabe ngempela lokhu?
Lona umbuzo obaluleke kakhulu. Omama abaningi abakhulelwe bayesaba lapho bezwa ngale MTHFR, bethi, "O, ingabe ingane yami izoba nesici se-neural tube njenge-Spine Bifida?"
Umyalezo omuhle kakhulu ongawunikeza uthi, "Ungesabi nhlobo." Izinhlangano ezihamba phambili zezifo zabesifazane kanye nodokotela bokubeletha eSri Lanka nasemhlabeni jikelele (njenge-ACOG) azincomi ukuhlola omama abakhulelwe ngalolu shintsho lwezakhi zofuzo. Ngoba, akudingekile. Into ebaluleke kakhulu
ukuthatha iphilisi le-folic acid elinconywa udokotela nsuku zonke ngaphandle kokwehluleka ngaphambi nangesikhathi sokukhulelwa. Inani lama-milligram anikezwayo, ngisho nakumama onalolu shintsho lwezakhi zofuzo lwe-MTHFR, liye lafakazelwa emhlabeni wonke ukuthi lanele ngokuphelele ekuthuthukisweni okunempilo kwesimiso sezinzwa sengane. Ngakho-ke, kunokuba ukhathazeke ngokuhlolwa kwe-MTHFR, kubaluleke kakhulu ukulandela imiyalelo kadokotela wakho futhi uthole inani elifanele le-folic acid.
Yiziphi izindlela zokwelapha ukuguquka kwe-MTHFR?
Asikho isidingo "sokwelapha" ukuguqulwa kwezakhi zofuzo ze-MTHFR. Akusona isifo. Kodwa-ke, uma ukuhlolwa kuqinisekisa ukuthi amazinga akho e-homocysteine aphakeme, udokotela wakho uzokweluleka ukuthi uwalawule. Lokhu kuvame ukuhilela ukwenza okulandelayo:
- Izithasiselo ze -Folic Acid : Udokotela wakho uzoncoma isithasiselo se-folic acid esifanele wena. Bangase batuse futhi izithasiselo ze -vitamin B6 kanye ne-B12.
- Ukudla okune-folate eningi: Faka ukudla okune -folate eningi ekudleni kwakho.
- Imifino eluhlaza okotshani njengespinashi, i-kale, kanye nemifino ye-collard
- Imifino efana ne-lentile, ubhontshisi kanye nobhontshisi
- Izithelo ezifana namawolintshi nama-avokhado
- Ubhontshisi
Kungcono futhi kuphephile ukukhuluma nodokotela womndeni wakho ngaphambi kokuqala noma yiziphi zalezi zinto bese ulandela iseluleko sakhe. Umlayezo Wokuya Nawe Ekhaya
- I-MTHFR ayisona isifo. Kumane kuyinguquko encane kakhulu engenzeka ezizakhini zethu zofuzo.
- Iningi labantu abanalolu guquko alibi nazo izimpawu noma izinkinga zempilo kukho konke ukuphila kwabo.
- Odokotela abancomi ukuhlolwa kwalokhu ngqo. Ungesabi ngokungadingekile.
- Omama abakhulelwe akudingeki bakhathazeke ngalokhu. Into ebaluleke kakhulu ukuphuza iphilisi le-folic acid udokotela wakho akunika lona nsuku zonke.
- Uma usenakho ukukhathazeka noma ukwesaba ngalokhu, ungadideki ngokufunda izinto ku-inthanethi, kodwa buza udokotela womndeni wakho omethembayo ngakho.
Ukuguqulwa kwezakhi zofuzo ze-MTHFR, ukuguqulwa kwezakhi zofuzo ze-MTHFR, i-folate, i-homocysteine, ukukhulelwa, i-folic acid, ukuhlolwa kwezakhi zofuzo
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