Isimila esingenamsebenzi emzimbeni? Ake sixoxe ngalokhu (Undifferentiated Pleomorphic Sarcoma - UPS)!

Wake wazizwa into efana neqhubu elikhula futhi likhula endaweni ethile emzimbeni wakho? Ngezinye izikhathi, ngaphandle kwesizathu esibonakalayo, ungase uvuvuke noma ungabi namizwa engalweni noma emlenzeni. Nakuba ngokuvamile singazinaki kakhulu lezi zinto, kungase kube nokuthile okungathi sína okufihliwe ngemuva kwazo. Namuhla, sizokhuluma ngohlobo olukhethekile lomdlavuza abantu abaningi abangaluzwa njalo, kodwa kubaluleke kakhulu kithi sonke ukuba siluqaphele. Ungesabi, ake sikuqonde kalula lokhu.

Kuyini "i-Undifferentiated Pleomorphic Sarcoma - UPS"?

Kalula nje, i-"Undifferentiated Pleomorphic Sarcoma" noma i-"UPS" njengoba siyibiza ngamafuphi, uhlobo lomdlavuza olubizwa ngokuthi i-soft tissue sarcoma . Yilapho amangqamuzana omdlavuza akheka khona ezicutshini ezithambile zomzimba wethu, njengemisipha, izicubu ezinamafutha, kanye nemithambo yegazi.

Ngokuvamile, lokhu `(UPS)` kuqala ezicutshini ezithambile zezingalo noma imilenze yakho . Ngezinye izikhathi kungenzeka nasengxenyeni ejulile yangemuva kwesisu, ebizwa ngokuthi `i-retroperitoneum` . Akuvamile kakhulu, lokhu `(UPS)` kuthinta amathambo. Into edabukisayo ukuthi, lokhu kuvame ukuba uhlobo lomdlavuza olunamandla . Ngakho-ke kungenzeka kakhulu ukuthi lusakazekele kwezinye izingxenye zomzimba, ikakhulukazi amaphaphu noma ama-lymph node .

Esikhathini esidlule, le `(UPS)` yayibizwa ngokuthi `malignant fibrous histiocytoma` . Isizathu salokhu ukuthi abacwaningi babecabanga ukuthi lo mdlavuza uvela kumaseli akhethekile omzimba abizwa ngokuthi `histiocytes` . Kodwa-ke, ucwaningo lwakamuva luthole ukuthi cishe uqala kumaseli abizwa ngokuthi `amaseli e-mesenchymal`, akha izicubu ezixhumene emzimbeni wethu.

Manje ake sibheke incazelo yamagama amabili kuleli gama.

"Ukungahlukanisiwe" kusho ukuthi la maseli omdlavuza abonakala edidekile futhi engahlelekile . Njengamathoyizi asakazeke ngaphandle kokuhleleka. Aye ahluka kakhulu futhi angavuthiwe kangangokuthi akunakwenzeka ukwazi ukuthi aqale kumaphi amaseli anempilo noma ukuthi ayehloselwe ukwenza muphi umsebenzi.

Igama elithi "pleomorphic" lisho ukuthi la maseli ahlukile ngesimo, usayizi, noma i-nucleus, isikhungo sokulawula seseli . Cabanga ngakho njengefenisha engenziwanga ngesikhunta esifanayo, ngalinye lihlukile ngesimo nosayizi. Amanye amaseli mancane, amanye makhulu. Amanye ayindilinga, amanye amade. Ngisho ne-nucleus, equkethe ama-chromosome ngaphakathi kwamaseli, ihlukile kuseli ngalinye. Yingakho la maseli omdlavuza ekhula ngokungajwayelekile nangokushesha ngaphandle kokulawulwa.

I-UPS empeleni uhlobo lomdlavuza olungavamile kakhulu . Isibonelo, e-United States, lesi sifo sithinta abantu abangaphansi kuka-5,000 ngonyaka. Kodwa-ke, phakathi kwezinhlobo ze-sarcomas zezicubu ezithambile,Kanye ne-liposarcoma (umdlavuza okhula ezicutshini ezinamafutha) kanye ne-leiomyosarcoma (umdlavuza okhula emisipheni ebushelelezi), i-(UPS) uhlobo lwesithathu oluvame kakhulu lwe-sarcoma yezicubu ezithambile .

Ziyini izimpawu ze-`(UPS)`?

Izimpawu ze-`Undifferentiated Pleomorphic Sarcoma (UPS)` zingahluka kumuntu nomuntu. Abanye abantu bangase bangabi nazo izimpawu. Kodwa-ke, kunezimpawu ezithile ezivamile:

• Iqhubu noma isisindo esikhula kancane kancane: Lolu uphawu oluyinhloko. Kungazwakala njengeqhubu noma kuphi emzimbeni, ikakhulukazi engalweni, emlenzeni, noma esiswini.
• Iqhubu elingenabuhlungu elingase linyakaze noma linganyakazi uma lithintwa: Esikhathini esiningi, la maqhubu awabangeli ubuhlungu ezigabeni zokuqala. Ngakho-ke, abanye abantu bangase banganaki kakhulu.
• Ukuba ndikindiki noma umuzwa wokushisa ngenxa yesimila esicindezela inzwa: Ngezinye izikhathi, njengoba lesi simila sikhula, singacindezela inzwa eseduze. Lokhu kungabangela ukuba ndikindiki ezandleni noma ezinyaweni, umuzwa wokuthuthumela, noma umuzwa wokushisa.
• Ukuvuvukala engalweni noma emlenzeni: Uma ingalo noma umlenze uvuvukala ngaphandle kwesizathu esibonakalayo, lokho kufanele kucatshangelwe.

Okubalulekile, i-UPS ayibonisi njalo izimpawu ezisobala. Ngokuvamile azibuhlungu , futhi akukho shintsho esikhumbeni phezu kweqhubu (njengokushintsha kombala noma izilonda). Futhi, izimpawu ezivamile ezifana nomkhuhlane, ukwehla kwesisindo, kanye nokungaphatheki kahle azivamile ukubonakala.

Yiziphi izimbangela ze-`(UPS)`?

Ochwepheshe abakakazi kahle ukuthi yini ebangela i-UPS. Abakwaziyo ukuthi ibangelwa izinguquko (ukuguqulwa kwezakhi zofuzo) ku -DNA (i-molecule equkethe ulwazi lwethu lwezakhi zofuzo) zamaseli anempilo. Kodwa-ke, ukuthi yini ebangela lezo zinguquko ku-DNA akukacaci.

Izici Zengozi Ezandisa Ingozi Yokuthuthukisa I-UPS

Isici esiyingozi yinto ekhulisa amathuba okuthola isifo. Kunezici eziningana eziyingozi eziye zatholakala ngenxa ye-`(UPS)`. Kodwa khumbula, akuwona wonke umuntu onalezi zinto eziyingozi ozothuthuka nge-`(UPS)`, futhi akunakushiwo ukuthi abantu abangenazo lezi zinto eziyingozi ngeke bathuthuke nge-`(UPS)`.

Izici eziyingozi ezitholakale njengamanje yilezi:

• Ukuba yindoda: Amadoda anamathuba amaningi okuthola lesi sifo kunabesifazane, kanti ingozi iphezulu kakhulu phakathi kwabesilisa abamhlophe.
• Abantu abangaphezu kweminyaka engama-50 ubudala: Ukusabalala kwalesi sifo kuyanda njengoba iminyaka ikhula.
• Izimo ezithile zezokwelapha: Isibonelo, abantu abanezifo ezifana ne -neurofibromatosis (isimo esibangela ukwakheka kwamathumba ohlelweni lwezinzwa) noma isifo se-Paget samathambo (isifo esibangela ukukhula kwamathambo okungavamile) basengozini enkulu yokukhula (i-UPS).
• Ezinye izimo zofuzo:Abantu abanezimo zofuzo ezingavamile njenge-Li-Fraumeni syndrome basengozini enkulu yokuthola izinhlobo ezahlukene zomdlavuza, okuhlanganisa (i-UPS).
• Ukuchayeka kumakhemikhali athile: Ukuchayeka isikhathi eside kumakhemikhali athile, njenge -arsenic noma i-vinyl chloride, nakho kungaba yisici esiyingozi.
• Ukwelashwa ngemisebe ngaphambilini endaweni ethintekile: Uma uke wathola ukwelashwa ngemisebe endaweni ethile ngenxa yesifo esithile, kunengozi encane yokuthola i-sarcoma (UPS) kuleyo ndawo kamuva.
• Ukuchayeka emisebeni emsebenzini: Uma kufanele uchayeke emisebeni kweminye imisebenzi, lokho kungaba yisici esiyingozi.

Kuyamangalisa ukuthi abantu abaningi abathola i-UPS abanazo lezi zinto eziyingozi . Ngakho-ke uma ubona into ebukeka njengeqhubu elingavamile emzimbeni wakho, ungakushayi indiva ngokucabanga ukuthi, "Anginazo lezi zinto eziyingozi."

Odokotela bayibona kanjani i-`(UPS)`?

Uma ubona udokotela oneqhubu elifana naleli, uzoqala akubuze ngempilo yakho , ukuthi ngabe kukhona yini emndenini wakho oke waba nezifo ezifana nomdlavuza (umlando womndeni), njll. Bese ebuza ngezimpawu zakho. Sekuyisikhathi esingakanani lesi siqhubu sikhona? Ingabe siyakhula? Ingabe sibuhlungu? Ngaphezu kwalokho, uzokwenza izivivinyo ezilandelayo:

1. Ukuhlolwa komzimba: Udokotela uzohlola indawo yesimila, ubukhulu baso, nokuthi sizizwa kanjani uma sithintekile (siqinile noma sithambile).

2. Ukuhlolwa kwezithombe: Lokhu kuhlolwa kusiza ukubona ukuthi isimila sibukeka kanjani ngaphakathi nokuthi sisakazeke kangakanani. Ngokuvamile, ukuhlolwa okukodwa noma ngaphezulu, njenge -X-ray, i-ultrasound scans, kanye/noma i-MRI scans, kungenziwa.

3. I-Biopsy: Lesi isivivinyo esibaluleke kakhulu sokuthola lesi sifo ngokuqinisekile . Lokhu kuhilela ukuthatha ingxenye encane yezicubu ezivela esimila (mhlawumbe ngethuluzi elincane elifana nenaliti) bese sihlolwa ngaphansi kwe-microscope ngudokotela wezifo (udokotela ochwepheshe ekuxilongeni izifo). Yilapho kuphela lapho singasho khona ngokuqinisekile ukuthi yi-UPS noma esinye isimo.

Yiziphi izindlela zokwelapha `(UPS)`?

Ukwelashwa kwe-UPS kuncike ezintweni ezifana nobukhulu besimila nokuthi umdlavuza ususabalele yini. Ukwelashwa okuyinhloko kwe-UPS yesigaba sokuqala ukuhlinzwa ukuze kususwe isimila . Lokhu kuvame ukwenziwa kanye nokwelashwa ngemisebe . Kodwa-ke, ngezinye izikhathi kungadingeka ukwelashwa okwengeziwe komdlavuza.

Ukuhlinzwa

Umgomo oyinhloko wokuhlinzwa kwe-`(UPS)` ukususa ngokuphelele isimila esinomdlavuza.. Odokotela bazama ukususa hhayi umdlavuza kuphela, kodwa futhi nenani elincane lezicubu ezinempilo ezizungezile (lokhu kubizwa ngokuthi "umkhawulo") . Njengoba nje lapho sisusa ukhula engadini, asisusi isitshalo kuphela, kodwa futhi nengqimba encane yomhlabathi ezungezile. Ngemuva kwalokho akusalanga ngisho nengxenye encane yempande yokhula. Ngendlela efanayo, lapho odokotela besusa lo mdlavuza, bayawususa kanye nenani elincane lezicubu ezinempilo ezizungezile. Kulapho kuphela lapho singaqiniseka khona ukuthi wonke amangqamuzana omdlavuza asusiwe ngaphandle kwalawo asele. Uma kukhona amangqamuzana omdlavuza emaphethelweni esimila esisusiwe, kusho ukuthi kungase kube namangqamuzana omdlavuza engeziwe asele emzimbeni.

Uma isimila sisengalweni noma emlenzeni wakho, udokotela wakho ohlinzayo uzozama ukususa umdlavuza futhi alondoloze ukusebenza okuningi ngangokunokwenzeka engalweni noma emlenzeni. Kodwa-ke, kwezinye izimo ezinzima, ukunqunywa kwezicubu kungadingeka . Ngakho-ke, kubalulekile ukukhuluma nodokotela wakho womdlavuza ukuze unqume ukuthi iyiphi indlela yokwelapha engcono kakhulu esimweni sakho.

Ukwelashwa Komdlavuza Okwengeziwe

Odokotela bezifo zomdlavuza bangasebenzisa nokwelashwa okwengeziwe ngaphambi noma ngemva kokuhlinzwa. Nakuba lokhu kwelashwa kuvame ukunganciphisi isimila, kungasiza ekwenzeni kube okuphephile ukuhlinzwa ukuze kususwe isimila, noma ukubulala noma yimaphi amangqamuzana omdlavuza angase asale ngemva kokuhlinzwa.

Lezi zindlela zokwelapha ezengeziwe yilezi:

• Ukwelashwa ngamakhemikhali: Ukunikeza imithi ebulala amangqamuzana omdlavuza.
• Ukwelashwa Ngezifo Ezithathelwana Ngocansi: Ukuvuselela amasosha omzimba ukuze alwe namaseli omdlavuza.
• Ukwelashwa ngemisebe: Ukubhubhisa amangqamuzana omdlavuza kusetshenziswa imisebe enamandla aphezulu.

Uhlelo lwakho lokwelashwa luhlukile kuwe. Lungase luhluke kolunye umuntu. Ngakho-ke khuluma nodokotela wakho wezifo zomdlavuza mayelana nezinketho zakho. Uzovame ukwelashwa yithimba elihlanganisa imikhakha eminingi . Leli qembu lingafaka udokotela ohlinzayo, udokotela wezifo zomdlavuza ngemisebe, kanye nodokotela wezifo zomdlavuza wezokwelapha. Nakuba uchwepheshe ngamunye enendima ehlukile, bonke basebenzisana ukukwelapha. Bazokusiza ukuthi unqume ukuthi yini engcono kakhulu ngesimo sakho.

Kufanele ngimbone nini udokotela?

Uma ubona iqhubu noma ukukhula noma kuphi emzimbeni wakho okukhula kancane kancane , ikakhulukazi uma kuhambisana nezimpawu ezifana nobuhlungu, ukuvuvukala, noma ukungakwazi ukuhambisa isitho sakho kahle , kufanele ubonane nodokotela ngokushesha .

Uma usuvele ubonile ukuthi une-`(UPS)`, wenaUma uba nezimpawu ezintsha, noma uma izimpawu zakho ziba zimbi kakhulu, tshela udokotela wakho womdlavuza ngokushesha .

Yiziphi izinto umuntu one-`(UPS)` angalindela?

Isikhathi sokuphila siyahlukahluka kuye ngomuntu nomuntu. Kuya ngobukhulu be-sarcoma kanye nesigaba salesi sifo . Ngokuvamile, izinga lokusinda kweminyaka emihlanu yezinga eliphezulu (UPS) licishe libe ngu-60% . Lokhu kusho ukuthi cishe abantu abangu-60% abatholakale benalesi sifo basaphila ngemva kweminyaka emihlanu. Izinga lokusinda kweminyaka eyi-10 licishe libe ngu-48% .

Kodwa khumbula, lawa mazinga okusinda ayizilinganiso ezijwayelekile . Awakutsheli ukuthi uzophila isikhathi esingakanani noma ukuthi yikuphi ukwelashwa okuzosebenza kahle kuwe. Ukuze ufunde kabanzi ngamazinga okusinda nokuthi akuthinta kanjani, kungcono ukukhuluma nethimba lakho le-oncology.

Ingabe i-`(UPS)` ingelapheka ngokuphelele?

(UPS) ingelapheka ngokuphelele, ikakhulukazi uma itholakale kusenesikhathi . Ngisho nasezimweni lapho lesi sifo sesisakazeke khona, kunezindlela zokwelapha ezingasiza ekuthuthukiseni ikhwalithi yokuphila kwakho futhi zandise impilo yakho. Njenganoma yiluphi uhlobo lomdlavuza, ukutholakala nokwelashwa kusenesikhathi (UPS) kuyindlela engcono kakhulu yokuthola umphumela ophumelelayo .

Izinto okufanele uzicabangele

Uma utholakala ukuthi unomdlavuza, ungathinta zonke izici zokuphila kwakho. Uma kungumdlavuza ongavamile njenge-Undifferentiated Pleomorphic Sarcoma (UPS), ungase uzizwe unesizungu kakhulu futhi sengathi akekho okuqondayo. Ngezikhathi ezinjengalezi, kungaba usizo ukujoyina iqembu lokusekela lapho kukhona abanye abadlula khona kokuhlangenwe nakho okufanayo nawe . Ukukhuluma nabo kungakusiza uqonde imizwa yakho futhi uyilawule.

Futhi, ithimba lakho lezokwelapha lihlala likhona ukukusiza . Bangakhuluma nawe ngezinketho zakho zokwelashwa, bakusekele, futhi bakunikeze ulwazi nezinsiza ozidingayo ukuze wenze izinqumo zezempilo ezinolwazi. Ungesabi ukubabuza noma yimiphi imibuzo onayo . Khumbula njalo ukuthi awuwedwa.

I - Sarcoma ye-Pleomorphic engahlukaniseki, i-UPS, i-sarcoma, umdlavuza wezicubu ezithambile, umdlavuza, isimila, izimpawu zomdlavuza, ukwelashwa komdlavuza