Mina míasrɔ̃ nu tso DMARDs, si nye atike siwo wozãna tsɔ daa Ankylosing Spondylitis ŋu ko.

Ðe nèfɔna le ŋdi me ɣeaɖewoɣi eye nèsena le ɖokuiwò me be yeƒe lãme sẽ eye yeƒe lãme sẽa? Ðe wòsesẽna be woabɔbɔ ɣeyiɣi aɖea? Esia ate ŋu atso Ankylosing Spondylitis , si nye dɔléle aɖe si gblẽa nu le akɔta ƒe ƒunukpeƒewo ŋu. Ne ète vevesesenutsitike siwo womeƒlena o ( NSAIDs ) zazã kpɔ eye vevesesea kple vuvua nu meɖe kpɔtɔ o la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàzã DMARD. Eyata mina míaɖo nya sia ƒe gɔmedzedze.

Nukae nye DMARDwo eye aleke wowɔa dɔe?

Le Ankylosing Spondylitis me la, míaƒe ŋutilã ƒe ametakpɔnu, si nye dɔlélenutsiŋutete , wɔa dɔ akpa eye wòdzea mía ŋutɔwo ƒe aklã ƒe ƒunukpeƒewo dzi dzedze gɔme. Esia hea abi , vevesese, kple sesẽ si wɔnɛ be wòsesẽna be woaʋuʋu akɔta nyuie.

DMARD nye ‘Atike si Trɔa Dɔléle’ ƒe kpukpui aɖe . Kpuie ko la, efia be ‘ƒunukpeƒetetedɔ ƒe atike si trɔa dɔléle’. Atike siawo wɔa dɔ to dɔlélenutsiŋutete si wɔa dɔ akpa la dzi ɖeɖe kpɔtɔ me. To vovo na vevesesenutsitike siwo wozãna edziedzi (NSAID) la, menye ɖeko esiawo ɖea vevesese dzi kpɔtɔna ko o, ke wokpena ɖe ame ŋu hã be woaɖu dɔlélea ƒe ŋgɔyiyi dzi eye womegagblẽa nu le ƒunukpeƒewo ŋu o. Esia tae woyɔa wo be "dɔléle-trɔtrɔ" atikewo.

DMARD ƒomevi kawoe wonana na Ankylosing Spondylitis?

Woate ŋu ama DMARD siwo wonana na dɔléle sia ɖe hatsotso vevi geɖe me. Woyɔa wo be biologics kple DMARD siwo wozãna tsã. Mina míalé ŋku ɖe ƒomevi siawo dometɔ ɖesiaɖe ŋu.

Biologics: Atike siwo wɔa dɔ ɖe taɖodzinu ɖeka dzi

Biologics le abe tudalawo ene. Protein siwo hea kuxia vɛ tẽ koe woɖoa taɖodzinu na hedzea wo dzi.

• TNF mɔxenuwo: Esiawoe nye dɔlékuiwutike gbãtɔ siwo dzi woda asi ɖo na ankylosing spondylitis. Wowɔa dɔ to mɔxexe ɖe protein aɖe si woyɔna be Tumor Necrosis Factor (TNF), si naa dɔdzẽ vɛ la nu. Woate ŋu akpe ɖe akɔta kple ƒunukpeƒe bubuwo ƒe ƒunukpeƒetetedɔ ŋu, kpakple nɔnɔme siwo ate ŋu ado mo ɖa kple dɔlélea, abe uveitis , ŋku ƒe dɔdzẽ, kple Inflammatory Bowel Disease (IBD) ( Crohn ƒe dɔléle kple ulcerative colitis). Zi geɖe la, wò ɖɔkta aŋlɔ nusiawo na wò ne ète vevesesenutsitike ƒomevi eve ya teti (NSAID) kpɔ eye womekpɔ ŋusẽ aɖeke ɖe dziwò o.
• Adalimumab (Humira) ƒe atike .
• Certolizumab (Cimzia) ƒe atike .
• Etanercept (Enbrel) ƒe lãmesẽnyawo gbɔ kpɔkpɔ .
• Infliximab (Atike si wozãna tsɔ ɖɔa amee) .
• Golimumab (Simponi) ƒe atike .

• IL-17 mɔxenuwo: Esiawo wɔa dɔ to mɔxexe ɖe dɔdzẽ ƒe protein bubu si woyɔna be Interleukin-17 (IL-17) nu. Wonye tiatia nyui aɖe na amesiwo mewɔ nu ɖe ​​TNF mɔxenuwo ŋu o alo amesiwo mate ŋu ano TNF mɔxenuwo o le nɔnɔmewo abe dzidɔ alo lãmekawo ƒe ʋuʋu (MS) ene ta.
• Ixekizumab (Taltz) ƒe atike .
• Secukinumab (Cosentyx) ƒe dɔlékuiwutike .

JAK inhibitors: Atike yeye siwo woate ŋu ano abe atikekuiwo ene

Esiawo to vovo na nugbagbeŋutinunyalawo. Wonye egbɔkpɔnu nyui aɖe na amesi melɔ̃a atikekuiwo dodo o, elabena wova le atikekui ƒe nɔnɔme me. Wowɔa dɔ to enzyme ƒe ɖoɖo aɖe si woyɔna be Janus Kinase (JAK), si naa dɔdzẽ vɛ la ŋudɔwɔwɔ me.

• Tofacitinib (Xeljanz) ƒe atike .
• Upadacitinib (Rinvoq) ƒe atike .

DMARD siwo wozãna tsã: Atike siwo wozãna wu na ƒunukpeƒe siwo le gota

Wotsɔa esiawo naa vevesese kple ƒunukpeƒetetedɔ abe asi, afɔ, akɔta, kple klo ene koŋ, tsɔ wu be woana vevesese le akɔta.

• Methotrexate: Esia va abe atikekui alo atikekui ene. Ekpena ɖe ame ŋu be ƒunukpeƒewo nagagblẽ o.
• Sulfasalazine (Azulfidine): Esia hã nye atike na ƒunukpeƒe siwo le gota kple IBD. Wononɛ abe atikekui ene.

Aleke ɖɔkta awɔ atia DMARD si sɔ na wò?

Wò ɖɔkta bua nu geɖe ŋu ne ele atike aɖe tiam.

• Aleke gbegbe wò dzesiawo nu sẽe.
• Atike siwo nèzã va yi kple emetsonu siwo nèkpɔ tso wo me.
• Atike si ŋu nya ku ɖo ƒe nugbegblẽ le ame ŋu kple alesi wokpɔa ŋusẽ ɖe wò lãmesẽ dzii.

Nukawoe nye atike sia ƒe nugbegblẽ le ame ŋu?

Abe atikewo katã ene la, DMARD-tikewo ate ŋu agblẽ nu le ame ŋu. Wo dometɔ aɖewo nye nu suewo, evɔ bubuwo ya ate ŋu anye nu veviwo. Eyata ƒo nu tso esiawo ŋu na wò ɖɔkta hafi nàdze atikeawo zazã gɔme.

• Biologics kple JAK inhibitors: Esiawo nana dɔlélenutsiŋutete nɔa blewu, si wɔnɛ be mete ŋu wɔa avu kple dɔlékuiwo o. Eyata ele vevie be nàkpɔ egbɔ be yenya nu tso yeƒe atikewɔmɔnuwo katã ŋu hafi adze atike siawo zazã gɔme.
• Yɔmekpe (TB) Dodokpɔ: Ele vevie be woado yɔmekpe (TB) kpɔ hafi adze TNF mɔxenuwo gɔme, elabena atike siawo ate ŋu ana yɔmekpe dɔlékui siwo le alɔ̃ dɔm le wò ŋutilã me la nagawɔ dɔ ake.
• Nu bubu siwo wògblẽna le ame ŋu: Ate ŋu abiã le afisi wodoe ɖo, ta naɖui, eye ŋutigbalẽa navuvu. IL-17 mɔxenuwo ate ŋu agblẽ nu le IBD ŋu ɣeaɖewoɣi.

DMARD siwo wozãna tsã ƒe nugbegblẽ le ame ŋu

• Methotrexate: Dɔgbo ƒe dɔmawɔmawɔ nyuie, nu me ƒoƒo, kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ si mede o ate ŋu ahe dɔlékuiwo, dzoxɔxɔ, kple ƒoƒoe vɛ. Be nàɖe nusiawo dzi akpɔtɔ la, wò ɖɔkta ana folic acid ƒe atikekuiwo wò. While taking this medication , ahiã be woado ʋu kpɔ ɣleti 1-3 ɖesiaɖe be woakpɔ wò ayiku kple aklã ƒe dɔwɔwɔ ɖa. Womekafu atike sia le fufɔɣi o.
• Sulfasalazine: Aɖuɖɔtoe, ʋuʋudedi, ɣe ƒe keklẽ ƒe seselelãme, ŋutigbalẽ ƒe ʋuʋu, kple taɖuame ate ŋu adzɔ. Atike sia ate ŋu atrɔ wò aɖuɖɔ, fifia, kple aɖatsiwo wòazu amadede ɣi kple aŋutiɖiɖi. Menye afɔku mele eme o, gake ate ŋu aƒo ɖi awuwo.

Nukae nàkpɔ mɔ na ne èle atikewɔwɔ gɔme dzem?

Atike siawo mewɔa dɔ ɖekae na amesiame o. Na emetsonuwo nasu asiwòAte ŋu axɔ kwasiɖa ʋɛ aɖewo alo ɣleti ɖeka alo eve. Eyata ele vevie be nàgbɔ dzi ɖi. Mègadzudzɔ atikeawo nono zi ɖeka le esi nèsusu be manyo o ta o.

Azɔ hã, ne wò dzesiawo nu fa keŋkeŋ hã la, ele vevie ŋutɔ be nàyi wò atikeawo nono dzi ɣeyiɣi didi si wò ɖɔkta gblɔ na wò. Ne èdzudzɔ la, dɔlélea ate ŋu agadze egɔme ake.