Kana kuma fama da cutar cholesterol ? Wataƙila kana shan maganin da likitanka ya rubuta maka, kana sarrafa abincinka , kana motsa jiki. Amma har yanzu yana da wuya a rage yawan cholesterol ɗinka, ko ba haka ba? Wani lokaci, komai ƙoƙarinka, mummunan matakin cholesterol a jikinka na iya ci gaba da ƙaruwa. A cikin wannan labarin, muna magana ne game da wani sabon nau'in magunguna da zai iya taimaka wa irin waɗannan mutane.
A taƙaice dai, menene waɗannan masu hana PCSK9?
Wannan yana iya yin kama da suna mai rikitarwa, amma yana aiki cikin sauƙi. Masu hana PCSK9 nau'in magunguna ne da ke rage cholesterol. Musamman ma, suna kai hari ga LDL (Low-Density Lipoprotein) cholesterol , wanda shine "mummunan cholesterol" wanda ke da illa ga jikinmu. Wasu mutane suna da yawan cholesterol a tsawon rayuwarsu. Ga waɗannan mutanen, wannan nau'in magani na iya zama da amfani sosai.
To, yanzu bari mu ga ma'anar sunan 'PCSK9'. 'PCSK9' wani nau'in furotin ne na musamman da hantarmu ke samarwa. Sunan wannan furotin shine 'proprotein convertase subtilisin/kexin type 9'. Abin da yake yi shine sarrafa abubuwan da ake kira 'LDL receptors' a jikinmu. Nazarin likitanci ya gano cewa idan jikin mutum ya samar da ƙarin furotin 'PCSK9' ta halitta, wannan mutumin zai fi samun yawan cholesterol .
Wa ke buƙatar wannan maganin?
Wannan tambaya ce mai matuƙar muhimmanci. Domin ba a ba wa duk wanda ke da yawan cholesterol wannan maganin ba. Akwai manyan yanayi guda biyu da likitanka zai iya rubuta maka wannan maganin 'PCSK9 inhibitor':
1. Idan wasu magunguna ba sa rage cholesterol: Idan kana amfani da wasu magunguna masu rage cholesterol, kamar `(statins),` amma matakan cholesterol dinka har yanzu suna da yawa, za ka iya ɗaukar wannan maganin a matsayin mataki na gaba.
2. A wasu yanayi na kwayoyin halitta: Wasu mutane suna da yanayin gado na yawan cholesterol a cikin mahaifa. Ana kiran wannan "familial hypercholesterolemia" a fannin likitanci.Wannan maganin yana da matuƙar amfani ga mutanen da ke da wannan matsalar.
Ka tuna, babban burin wannan maganin shine rage yawan sinadarin cholesterol, ta haka rage haɗarin matsalolin zuciya da jijiyoyin jini kamar bugun zuciya da bugun jini .
Ta yaya wannan maganin yake aiki a cikin jiki?
Domin fahimtar wannan, bari mu ɗauki ƙaramin misali.
Ka yi tunanin jikinka yana da "hannaye masu kama cholesterol." Muna kiran waɗannan "masu karɓar LDL." Waɗannan "masu karɓar LDL" galibi ana samun su ne a saman ƙwayoyin hanta. Waɗannan "hannaye" suna ɗaukar mummunan cholesterol da ke iyo a cikin jini (LDL cholesterol) su kai shi hanta. Sannan hanta tana wargaza wannan cholesterol ɗin ta cire shi daga jiki. Wannan tsari ne na yau da kullun.
Amma akwai ɗan mugun mutum a nan. Wannan shine furotin '(PCSK9)' da muka yi magana a kai a baya. Wannan furotin 'PCSK9' yana aiki kamar 'almakashi'. Abin da yake yi shi ne lalata waɗannan hannayen da ke kama cholesterol, wato, 'masu karɓar LDL', da kuma rage ayyukansu. Lokacin da furotin 'PCSK9' ya ƙaru a jiki, adadin 'hannaye' da ke kama cholesterol yana raguwa. Sannan hanta ba za ta iya cire mummunan cholesterol a cikin jini ba kuma ta taru a cikin jini.
Yanzu wataƙila ka fahimci abin da maganin 'PCSK9 inhibitor' ke yi. A taƙaice dai, wannan maganin yana hana furotin 'PCSK9' wanda ke aiki kamar almakashi. Wannan yana nufin, idan aka sha wannan maganin, furotin 'PCSK9' ba zai iya lalata waɗannan hannayen da ke ɗauke da cholesterol ba (masu karɓar LDL).
Me zai faru to?
- Akwai ƙarin masu karɓar LDL masu aiki.
- Waɗannan 'hannaye' masu aiki suna kama yawancin mummunan cholesterol a cikin jini kuma suna kai shi hanta.
- Hanta tana cire wannan cholesterol daga jiki.
Sakamakon ƙarshe shine raguwa sosai a cikin matakin mummunan cholesterol a cikin jinin ku.
Yaya wannan maganin yake da tasiri? Kuma menene nau'ikansa?
Masu hana PCSK9 nau'in magunguna ne da aka nuna suna da tasiri sosai ga wasu mutane. Wasu bincike sun gano cewa waɗannan magungunan na iya rage matakan cholesterol mara kyau (LDL cholesterol) har zuwa kashi 70% kuma suna iya rage haɗarin kamuwa da bugun zuciya da kusan kashi ɗaya bisa uku.
Akwai nau'ikan "PCSK9 inhibitors" guda biyu waɗanda aka fi amfani da su a yanzu a Sri Lanka da kuma duniya:
- `Alirocumab` (sunan alama: Praluent®)
- `Evolocumab` (sunan alama: Repatha®)
Yaya ake shan maganin?
Wannan ba kwaya ba ce da za a sha kowace rana. Ana ba da 'PCSK9 inhibitors' a matsayin allura.Yawanci za ku buƙaci yin wannan allurar bayan 'yan makonni ko bayan 'yan watanni, kamar yadda likitan ku ya ƙaddara.
Yayin shan wannan maganin, likitanka zai yi gwajin jini akai-akai don duba yadda maganin yake aiki. Wani lokaci ana iya ba da wannan maganin shi kaɗai, wani lokacin kuma ana iya ba da shi tare da maganin da kake sha, kamar statin.
Menene fa'idodi da kuma illolin da ka iya biyo baya?
Kamar kowace magani, wannan maganin yana da fa'idodi da ƙananan illa. Duk da haka, yawancin mutane ba sa fuskantar mummunan sakamako.
| Bayani | Misalai |
|---|---|
| Babban fa'idodi |
|
| Illolin da aka saba samu | |
| Illolin da ba kasafai ake samu ba |
Shin maganin shi kaɗai ya isa? A'a, wannan wani ɓangare ne na babban shiri.
Wannan yana da matuƙar muhimmanci. Ko da kuna shan maganin hana PCSK9 ko wani magani mai rage cholesterol, ɓangare ɗaya ne kawai na tsarin maganin ku gaba ɗaya. Akwai wasu abubuwa da yawa da za ku iya yi don kare lafiyar zuciyar ku, ba tare da dogaro da magani kawai ba.
- Abinci mai kyau: Ku rage cin mai, sukari, da gishiri, sannan ku ƙara yawan kayan lambu, 'ya'yan itatuwa, ganye, da abinci mai yawan fiber.
- Motsa Jiki: Shiga cikin motsa jiki mai kyau ga zuciya, kamar tafiya mai sauri, gudu, ko hawa keke, aƙalla 'yan kwanaki a mako.
- Gudanar da damuwa: Shakatar da hankalinka ta hanyar abubuwa kamar tunani da yoga.
- Barci mai kyau: Ka samu akalla awanni 7-8 na barci kowace dare.
- A guji shan taba: Idan kana shan taba, ka daina shan taba gaba daya.
Za ku sami sakamako mafi kyau idan kun haɗa waɗannan canje-canjen salon rayuwa da magani.
Likitan ku ne kawai zai iya yanke shawara ta ƙarshe kan tsawon lokacin da ya kamata ku sha wannan maganin, da kuma ko za ku daina ko kuma ku ci gaba da shansa. Saboda haka, yana da mahimmanci ku bi umarnin likitan ku daidai.
Saƙon Ɗauka Gida
- 'Masu hana PCSK9' nau'in magani ne mai matuƙar tasiri, wanda aka bayar a matsayin allura, don matsalolin cholesterol masu yawa waɗanda ke da wahalar shawo kansu ta hanyar amfani da magunguna na gargajiya.
- Waɗannan suna taimaka wa hanta wajen cire "mummunan cholesterol" (LDL) daga jini.
- Ba a saba bayar da wannan magani a matsayin magani na farko ba. Likitanka zai yi la'akari da shi ne kawai idan wasu jiyya suka gaza.
- Yayin shan wannan maganin, yana da matukar muhimmanci a kula da rayuwa mai kyau wacce ta kunshi abinci mai kyau da motsa jiki.
- Yi magana a fili da likitanka game da ko wannan maganin ya dace da kai ko a'a da kuma duk wani bayani da ya shafi hakan.
Masu hana PCSK9, cholesterol, cholesterol, LDL cholesterol, bugun zuciya, bugun jini, hypercholesterolemia na iyali, statin, Alirocumab, Evolocumab
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