Koj puas feem ntau mob pob qij txha , mob nraub qaum , lossis mob hnyav uas los thaum muaj hli? Tom qab ntawd peb sai sai noj tshuaj loog mob . Tab sis koj puas paub tias muaj ntau hom tshuaj loog mob no? Hnub no peb yuav tham txog ib hom tshuaj loog mob uas muaj qhov chaw tshwj xeeb ntawm lawv, thiab ua haujlwm txawv me ntsis. Ntawd yog COX-2 inhibitors .
Hauv lus yooj yim, cov tshuaj COX-2 inhibitors no yog dab tsi?
Cov tshuaj COX-2 inhibitors yog ib pawg tshuaj uas pab txo qhov mob thiab txo qhov o (anti-inflammatory). Lub npe kho mob rau pawg no yog NSAIDs, uas sawv cev rau Nonsteroidal Anti-inflammatory Drugs. Cov tshuaj xws li Ibuprofen , Naproxen , thiab Diclofenac uas koj feem ntau hnov txog kuj koom nrog pawg no hu ua NSAIDs .
Txawm li cas los xij, hom tshuaj no, hu ua COX-2 inhibitors, ua haujlwm hauv lub cev txawv me ntsis ntawm cov NSAIDs ib txwm uas peb txhua tus paub. Cia peb saib seb qhov txawv ntawd yog dab tsi.
Cov tshuaj no ua haujlwm li cas hauv lub cev? Nws yog ib qho txheej txheem zoo kawg nkaus!
Yuav kom nkag siab qhov no, peb yuav tsum xub nkag siab ob hom enzymes hauv peb lub cev. Cov no yog cov enzymes COX-1 thiab COX-2 . Ob qho tib si ntawm cov enzymes no tsim cov tshuaj lom neeg hauv peb lub cev hu ua prostaglandins . Cov prostaglandins no yog qhov laj thawj tseem ceeb uas ua rau peb mob, o (o), thiab kub taub hau.
Xav txog qhov no: Muaj ob tug neeg ua haujlwm hauv lub hoobkas hu ua peb lub cev.
- COX-1 (tus neeg ua haujlwm thawj zaug): Qhov no yog tus neeg ua haujlwm zoo. Nws ua cov prostaglandins uas ua rau mob thiab o. Tab sis ntxiv rau qhov ntawd, nws ua ob yam tseem ceeb heev . Ib qho yog los tiv thaiv cov ntaub ntawm peb lub plab thiab cov hnyuv los ntawm cov kua qaub hauv plab. Qhov thib ob yog los pab nrog cov txheej txheem ntshav txhaws.
- COX-2 (Tus Neeg Ua Haujlwm 2): Qhov no yog qhov teeb meem tiag tiag. Nws txoj haujlwm tseem ceeb yog ua cov prostaglandins uas ua rau mob thiab o.
Tam sim no saib, thaum peb noj cov tshuaj tua kab mob (Non-selective NSAIDs) xws li Ibuprofen thiab Diclofenac, cov tshuaj yuav nres ob qho tib si ntawm cov neeg ua haujlwm ntawd. Tom qab ntawd, vim tias COX-2 raug nres, qhov mob thiab o yuav txo qis. Tab sis vim tias tus neeg ua haujlwm zoo, uas yog, COX-1, raug nres, lub plab tiv thaiv yuav ploj mus , thiab qhov muaj feem yuav mob plab hnyuv, mob plab, thiab tej zaum yuav mob qog nqaij hlav ntau ntxiv.
Tiam sis, cov tshuaj no hu ua COX-2 inhibitors yog cov tshuaj ntse heev. Lawv mus ncaj qha rau tus neeg ua haujlwm teeb meem, uas yog, COX-2 enzyme . Lawv cia tus neeg ua haujlwm zoo (COX-1) ua nws txoj haujlwm. Yog li ntawd, kev puas tsuaj rau lub plab yog qhov tsawg heev. Qhov no yog qhov zoo tshaj plaws ntawm cov tshuaj no.
Cov tshuaj COX-2 inhibitors siv rau cov mob twg?
Cov kws kho mob pom zoo kom siv hom tshuaj no los tswj qhov mob me me mus rau qhov mob nruab nrab thiab o uas tshwm sim los ntawm ntau yam mob.
| Mob nkeeg | Ib qho lus piav qhia yooj yim |
|---|---|
| Mob pob qij txha | Qhov mob thiab mob nqaij vim yog kev sib koom ua ke thiab kev tsim kua muag thaum peb laus zuj zus. |
| Mob Pob Qij Txha Rheumatoid | Ib yam kab mob uas ua rau pob qij txha o thiab mob vim yog lub cev tiv thaiv kab mob ua haujlwm. |
| Mob Pob Qij Txha Rau Cov Hluas | Mob pob qij txha rau cov menyuam yaus. |
| Ankylosing Spondylitis | Ib yam kab mob uas cov pob qij txha, feem ntau yog nyob rau hauv tus txha nraub qaum, o thiab tuaj yeem sib koom ua ke raws sijhawm. |
| Mob thaum lub sijhawm muaj hli (Dysmenorrhea) | Mob plab hnyav thaum muaj hli. |
| Kev raug mob luv luv, xws li kev raug mob kis las | Hauv cov xwm txheej ntawm cov pob txha tawg, cov leeg nqaij ntshiv, thiab lwm yam. |
Tsis tas li ntawd xwb, koj tus kws kho mob kuj tseem yuav sau cov tshuaj no rau cov mob xws li mob gout thiab mob migraine.
Cov kev pheej hmoo thiab cov kev mob tshwm sim ntawm kev siv COX-2 Inhibitors yog dab tsi?
Txawm hais tias lawv txo cov kev mob tshwm sim ntawm txoj hnyuv plab, COX-2 inhibitors tsis yog cov tshuaj uas tsis muaj kev pheej hmoo kiag li. Tej zaum yuav muaj qee qhov kev pheej hmoo , tshwj xeeb tshaj yog thaum siv ntau npaum li cas thiab siv sijhawm ntev .
Cov kev pheej hmoo tseem ceeb
- Mob plawv thiab mob hlwb: Cov tshuaj COX-2 inhibitors tau pom tias muaj feem cuam tshuam nrog kev pheej hmoo ntawm kev mob plawv thiab mob hlwb me ntsis. Qhov kev pheej hmoo no tseem ntau dua rau cov neeg uas twb muaj mob plawv lossis muaj cov yam ua rau mob plawv. Vim li no, qee cov tshuaj COX-2 inhibitors, xws li 'Rofecoxib (Vioxx®)' thiab 'Valdecoxib (Bextra®)', tau raug tshem tawm ntawm kev ua lag luam.
- Teeb meem ntawm lub plab thiab txoj hnyuv: Txawm hais tias qhov kev puas tsuaj rau lub plab raug txo qis, nws tsis ploj mus tag nrho. Ib txhia neeg yuav muaj kev los ntshav thiab mob qog .
Cov kev mob tshwm sim feem ntau
| Hom kev phiv tshuaj | Cov tsos mob uas yuav tshwm sim |
|---|---|
| Kev zom zaub mov | Mob o, raws plab, cem quav, xeev siab, mob plab, mob hauv siab. |
| Lub plawv thiab cov hlab ntsha | Ntshav siab, mob hauv siab, mob plawv nres, mob hlwb. |
| Cov raum | Kev ua haujlwm ntawm lub raum tsis zoo, kev sib sau ua ke ntawm cov dej hauv lub cev thiab o (edema). |
| Lub paj hlwb | Mob taub hau, kiv taub hau. |
Leej twg yuav tsum tsis txhob noj cov tshuaj COX-2 inhibitors?
Koj tus kws kho mob yuav tshuaj xyuas koj cov keeb kwm kev noj qab haus huv kom paub seb cov tshuaj no puas yog rau koj. Koj yuav tsum tsis txhob noj cov tshuaj no yog tias koj muaj ib qho ntawm cov mob hauv qab no:
- Yog koj tau muaj mob stroke ua ntej lawm.
- Yog tias koj nyuam qhuav muaj lossis tab tom yuav muaj kev phais mob plawv coronary bypass .
- Yog koj muaj kab mob raum lossis kab mob siab hnyav.
- Yog tias koj tau muaj mob hawb pob lossis ua xua hnyav rau lwm yam NSAID, aspirin, lossis tshuaj tua kab mob sulfa yav dhau los.
- Yog tias koj nyob rau hauv peb lub hlis kawg ntawm cev xeeb tub .
- Yog koj yog niam uas pub niam mis rau menyuam (tham nrog koj tus kws kho mob txog qhov no).
Thaum twg koj yuav tsum mus ntsib kws kho mob tam sim ntawd?
Yog tias koj muaj ib qho ntawm cov tsos mob hauv qab no thaum noj cov tshuaj no, tsis txhob ncua sijhawm thiab mus ntsib koj tus kws kho mob tam sim ntawd lossis mus rau chav kho mob ceev (ETU) ze tshaj plaws.
- Cov cim qhia txog teeb meem ntawm daim siab: zis tsaus, qaug zog heev, tawv nqaij lossis qhov muag daj, quav xim dawb, mob plab.
- Cov cim qhia txog kev los ntshav: ntuav ntshav lossis ntuav zoo li cov hmoov kas fes, tso ntshav rau hauv cov quav (cov quav dub lossis liab tsaus), tso ntshav rau hauv cov zis, cov pos hniav los ntshav, cov tawv nqaij raug mob txawv txawv.
- Cov tsos mob ntawm teeb meem raum: tsis muaj peev xwm tso zis, hloov pauv ntawm cov zis tsim tawm, hnyav nce sai.
- Cov cim qhia txog kev ua xua hnyav: tawv nqaij tawm pob lossis ua pob khaus, khaus, ua pa nyuaj, o ntawm lub ntsej muag, daim di ncauj, lossis tus nplaig.
- Cov tsos mob ntawm tus kab mob plawv nres: mob hauv siab, ua tsis taus pa, mob uas kis mus rau lub puab tsaig lossis xub pwg nyom.
- Cov tsos mob ntawm tus mob stroke: loog ntawm ib sab ntawm lub cev, hais lus tsis tau, lub ntsej muag poob qis.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj COX-2 inhibitors yog ib pawg tshuaj tshwj xeeb uas tsis muaj teeb meem rau lub plab npaum li cov tshuaj tua kab mob (NSAIDs). Cov tshuaj uas siv ntau tshaj plaws hauv Sri Lanka yog Celecoxib thiab Etoricoxib.
- Cov no tsis yog muaj kev pheej hmoo kiag li, tshwj xeeb tshaj yog vim lawv tuaj yeem ua rau muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb.
- Tsis txhob siv cov tshuaj no los ntawm lub tsev muag tshuaj yam tsis tau daim ntawv qhia los ntawm kws kho mob.
- Siv cov tshuaj tsawg tshaj plaws uas koj tus kws kho mob pom zoo, rau lub sijhawm luv tshaj plaws .
- Yog tias koj muaj tej yam mob xws li kab mob plawv, kab mob raum, kab mob siab, lossis gastritis, nws yog ib qho tseem ceeb uas yuav tsum qhia rau koj tus kws kho mob ua ntej noj cov tshuaj no.
- Nco ntsoov ceev faj txog cov cim ceeb toom uas tau hais los saum toj no. Yog tias muaj teeb meem tshwm sim, nrhiav kev pab kho mob tam sim ntawd.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus