Koj puas muaj mob plab, kub hnyiab hauv plab, lossis mob plab hnyuv thaum koj noj tshuaj tua kab mob uas koj tus kws kho mob sau rau mob pob qij txha, mob nraub qaum, lossis lwm yam mob? Qhov no yog qhov teeb meem uas ntau tus neeg feem ntau ntsib. Nws yog qhov ntxhov siab heev uas muaj lwm yam teeb meem tom qab noj tshuaj kom txo qhov mob. Tab sis koj puas paub tias muaj ib pawg tshuaj tshwj xeeb uas tuaj yeem txo qhov mob plab no thiab tswj qhov mob? Pawg tshuaj ntawd hu ua COX-2 inhibitors . Hnub no peb tab tom tham txog qhov ntawd.
Cov Tshuaj COX-2 Inhibitors yog dab tsi? Cia peb nkag siab yooj yim.
Cov tshuaj COX-2 inhibitors yeej yog ib tug tswv cuab ntawm tib tsev neeg ntawm cov tshuaj tua mob hu ua NSAIDs (Nonsteroidal Anti-inflammatory Drugs) . Cov tshuaj uas koj feem ntau siv, xws li Ibuprofen , Diclofenac, thiab Naproxen , yog cov tshuaj NSAIDs no. Lub luag haujlwm tseem ceeb ntawm cov tshuaj no yog txo qhov mob, txo qhov o, thiab txo qhov kub taub hau.
Yog li ntawd, dab tsi tshwj xeeb txog cov tshuaj COX-2 inhibitors no? Yuav kom nkag siab qhov ntawd, peb yuav tsum xub saib seb cov NSAID ua haujlwm li cas hauv peb lub cev.
Ob tug "neeg ua haujlwm" hauv peb lub cev: COX-1 thiab COX-2
Xav txog tias hauv peb lub cev muaj ib hom enzyme hu ua Cyclooxygenase ( COX ). Cov no zoo li cov neeg ua haujlwm me me uas ua ntau yam haujlwm hauv peb lub cev. Muaj ob hom COX ua haujlwm no.
1. COX-1: Qhov no yog ib tug neeg ua haujlwm "zoo". Nws txoj haujlwm tseem ceeb yog los tiv thaiv lub plab thiab txoj hnyuv. Nws pab tsim ib txheej tiv thaiv los tiv thaiv lub plab los ntawm cov kua qaub hauv cov zaub mov uas peb noj thiab haus. Nws kuj koom nrog cov txheej txheem ntshav txhaws .
2. COX-2: Qhov no feem ntau yog tus "ua teeb meem." Thaum muaj kev raug mob, kev kis kab mob, lossis kev puas tsuaj rau peb lub cev, nws mus rau qhov ntawd thiab tsim cov tshuaj hu ua prostaglandins . Cov prostaglandins no yog cov ua rau mob, o, thiab kub taub hau. Txawm hais tias qhov no yog ib qho txheej txheem tiv thaiv hauv lub cev, hauv cov kab mob ntev xws li mob pob qij txha, cov txheej txheem no tseem ua rau mob.
Tam sim no saib, thaum peb noj cov NSAID zoo li Ibuprofen, cov tshuaj ntawd nkag mus rau hauv lub cev thiab thaiv ob qho tib si tus neeg zoo (COX-1) thiab tus neeg phem (COX-2), txhais tau tias lawv ob leeg tsis ua haujlwm. Vim tias COX-2 raug thaiv, qhov mob thiab o yuav txo qis. Qhov ntawd zoo. Tab sis vim tias COX-1 raug thaiv, kev tiv thaiv ntawm lub plab kuj raug nres, thiab qhov muaj feem yuav mob plab, mob plab, thiab txawm tias mob plab ntau ntxiv.
Yuav kom daws tau qhov teeb meem no, cov kws tshawb fawb tau tshawb pom cov tshuaj hu ua COX-2 inhibitors. Cov tshuaj no zoo li cov neeg tua phom. Thaum lawv nkag mus rau hauv lub cev, lawv ncaj qha tsom mus rau tus neeg ua haujlwm COX-2 uas ua rau muaj teeb meem. Tus neeg ua haujlwm zoo COX-1 tsis cuam tshuam dab tsi. Nws tsuas yog ua nws txoj haujlwm xwb.
Yog li ntawd, thaum lub plab tseem raug tiv thaiv, tsuas yog COX-2 enzyme, uas ua rau mob thiab o, raug txwv. Hais yooj yim, qhov zoo tshaj plaws ntawm COX-2 inhibitors yog tias lawv tswj qhov mob thaum txo qis cov kev phiv ntawm lub plab.
Cov tshuaj COX-2 inhibitors feem ntau siv rau cov mob twg?
Cov kws kho mob pom zoo kom siv hom tshuaj no rau ntau yam mob thiab mob o. Hauv qab no yog qee cov tshuaj tseem ceeb.
| Mob nkeeg | Ib qho lus piav qhia yooj yim |
|---|---|
| Mob pob qij txha | Mob pob qij txha thiab o uas tshwm sim thaum cov pob txha mos ntawm cov pob qij txha lwj thaum laus lossis vim lwm yam. Feem ntau nws cuam tshuam rau cov pob qij txha xws li lub hauv caug thiab lub duav. |
| Mob Pob Qij Txha Rheumatoid | Kev o ntawm cov pob qij txha thiab mob hnyav uas tshwm sim thaum muaj qhov tsis zoo ntawm lub cev tiv thaiv kab mob tawm tsam cov pob qij txha. |
| Mob Pob Qij Txha Rau Cov Hluas | Cov mob pob qij txha hauv cov menyuam yaus. |
| Ankylosing Spondylitis | Ib yam kab mob uas feem ntau ua rau cov pob qij txha ntawm tus txha nqaj qaum o thiab, dhau sijhawm, sib koom ua ke, ua rau mob. |
| Mob Thaum Muaj Hli / Mob Thaum Muaj Hli | Txhawm rau tswj qhov mob plab qis hnyav uas cuam tshuam nrog kev coj khaub ncaws rau cov poj niam. |
| Mob luv luv | Nws kuj tseem siv rau qhov mob luv luv, xws li kev raug mob kis las, qhov mob tom qab phais, thiab qhov mob tom qab rho hniav tawm. |
Ntxiv mus, cov tshuaj no kuj siv tau rau lwm yam mob xws li mob gout thiab mob taub hau migraine, raws li tus kws kho mob pom zoo.
Cov tshuaj COX-2 Inhibitors siv hauv Sri Lanka thiab thoob ntiaj teb yog dab tsi?
Cov tshuaj COX-2 inhibitor uas siv ntau tshaj plaws hauv ntiaj teb thiab hauv Sri Lanka yog Celecoxib . Tej zaum koj yuav tau hnov txog nws nyob rau hauv lub npe lag luam Celebrex® .
Ntxiv rau, lwm cov tshuaj COX-2 inhibitors xws li Etoricoxib (Arcoxia®) thiab Parecoxib (Dynastat®) kuj siv rau hauv ntau lub tebchaws thoob ntiaj teb.
Tiam sis koj yuav tsum paub qhov no thiab. Ob peb xyoos dhau los, lwm cov tshuaj COX-2 inhibitors, xws li Rofecoxib (Vioxx®) thiab Valdecoxib (Bextra®) , tau muaj nyob rau hauv kev ua lag luam. Txawm li cas los xij, kev tshawb fawb tom qab ntawd pom tias cov tshuaj no ua rau muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb thaum siv ntev. Lawv kuj ua rau qee tus neeg muaj kab mob tawv nqaij loj heev. Vim li no, cov tshuaj no tau raug tshem tawm ntawm kev ua lag luam.
Qhov tseem ceeb tshaj plaws uas peb kawm tau los ntawm cov xwm txheej no yog tias tsis muaj tshuaj tua kab mob twg yuav tsum siv mus ntev yam tsis tau kev qhia los ntawm kws kho mob . Txhua yam tshuaj muaj nws cov txiaj ntsig thiab kev pheej hmoo. Tsuas yog koj tus kws kho mob thiaj li xaiv tau cov tshuaj uas tsim nyog thiab muaj kev nyab xeeb tshaj plaws rau koj.
Kuv yuav tsum noj cov tshuaj no li cas? Kuv yuav tsum noj nws ntev npaum li cas?
Cov tshuaj COX-2 inhibitors feem ntau tuaj ua cov tshuaj ntsiav, tab sis lawv kuj tseem muaj nyob rau hauv daim ntawv ntawm cov kua dej haus.
Qhov mob pib ploj mus hauv ib teev tom qab noj cov tshuaj no.Txawm li cas los xij, nws yuav siv sijhawm ob peb hnub kom paub txog tag nrho cov txiaj ntsig tiv thaiv kev o, xws li txo qhov o.
Koj yuav tsum noj cov tshuaj no ntev npaum li cas nyob ntawm koj tus mob.
- Rau qhov mob luv luv (xws li ob peb hnub lossis ob lub lis piam): Nws ib txwm pom zoo kom noj cov tshuaj tsawg tshaj plaws uas muaj txiaj ntsig zoo rau lub sijhawm luv tshaj plaws .
- Rau ib qho mob ntev xws li mob pob qij txha: Koj tus kws kho mob yuav tshuaj xyuas koj keeb kwm kev noj qab haus huv tag nrho, lwm yam tshuaj uas koj noj, thiab txawm tias cov txiaj ntsig ntawm kev kuaj ntshav yog tias tsim nyog, los txiav txim siab seb nws puas muaj kev nyab xeeb rau koj txuas ntxiv noj cov tshuaj no.
Qhov tseem ceeb tshaj plaws yog noj cov tshuaj uas koj tus kws kho mob sau tseg, raws nraim li tau sau tseg, thiab rau lub sijhawm uas tau sau tseg. Yog tias koj muaj kev txhawj xeeb, nco ntsoov nrog koj tus kws kho mob tham ua ntej tso tseg cov tshuaj lossis hloov cov tshuaj noj.
Cov kev pheej hmoo thiab cov kev mob tshwm sim ntawm COX-2 inhibitors yog dab tsi?
Raws li peb tau tham ua ntej lawm, qhov zoo tshaj plaws ntawm cov tshuaj no yog tias lawv muaj kev cuam tshuam tsawg dua rau lub plab thiab txoj hnyuv. Tab sis qhov ntawd tsis tau txhais hais tias lawv tsis muaj kev pheej hmoo. Qee qhov kev phiv tshwm sim tuaj yeem tshwm sim, tshwj xeeb tshaj yog thaum noj ntau thiab ntev.
Ob qho kev pheej hmoo tseem ceeb:
1. Kev Pheej Hmoo ntawm Kev Mob Plawv thiab Mob Hlwb: Txhua yam NSAIDs, suav nrog COX-2 inhibitors, yuav ua rau muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb ntau ntxiv rau qee qhov. Qhov kev pheej hmoo no tseem ntau dua rau cov neeg uas twb muaj cov yam ua rau muaj kab mob plawv, xws li ntshav siab thiab roj cholesterol ntau.
2. Teeb meem plab thiab hnyuv: Txawm hais tias tsis tshua muaj ntau dua li cov tshuaj NSAIDs ib txwm muaj, COX-2 inhibitors tuaj yeem ua rau muaj ntshav hauv plab thiab mob qog rau qee tus neeg. Qhov kev pheej hmoo no yog qhov siab tshwj xeeb tshaj yog rau cov neeg laus thiab cov neeg uas noj lwm yam tshuaj uas ua rau mob plab.
Lwm yam kev mob tshwm sim uas yuav tshwm sim tau:
| Lub cev system | Tej zaum yuav muaj tej yam tshwm sim tsis zoo |
|---|---|
| Kev zom zaub mov | Mob plab, mob plab, xeev siab, ntuav, raws plab, cem quav, thiab mob siab. |
| Lub plawv thiab cov hlab ntsha | Ntshav siab (Hypertension), lub plawv dhia ceev lossis tsis xwm yeem (Palpitations), tsis tshua muaj mob plawv nres lossis mob hlwb. |
| Cov raum | Kev ua haujlwm ntawm lub raum tsis zoo, ob txhais ceg o (o) vim muaj dej thiab ntsev sib sau ua ke hauv lub cev, thiab cov potassium ntau ntxiv hauv cov ntshav. |
| Lub paj hlwb | Mob taub hau, kiv taub hau. |
Tsis yog txhua tus neeg yuav tau txais tag nrho cov kev mob tshwm sim uas teev nyob rau hauv daim ntawv teev npe no. Yog tias koj muaj ib qho ntawm cov tsos mob no lossis pom muaj dab tsi txawv txawv, qhia rau koj tus kws kho mob tam sim ntawd.
Leej twg yuav tsum tsis txhob noj cov tshuaj no?
Muaj ib txhia neeg uas muaj tej yam mob tsis haum rau cov tshuaj COX-2 inhibitors. Koj tus kws kho mob yuav xav txog tag nrho cov no ua ntej muab tshuaj rau koj.
Cov neeg uas yuav tsum tsis txhob noj cov tshuaj COX-2 inhibitors:
- Yog tias koj tau muaj mob stroke yav dhau los.
- Yog tias koj tab tom npaj rau lossis nyuam qhuav muaj kev phais mob plawv los ntawm kev hla txoj hlab ntsha.
- Yog koj muaj kab mob raum hnyav lossis daim siab tsis ua haujlwm.
- Yog tias koj tau muaj mob hawb pob lossis ua xua hnyav tom qab noj tshuaj aspirin lossis lwm yam tshuaj NSAID.
- Yog tias koj ua xua rau cov tshuaj tua kab mob sulfonamide.
Cov neeg uas yuav tsum tau ceev faj tshwj xeeb:
- Yog koj twb muaj mob plab los yog los ntshav lawm.
- Yog tias koj nyob rau hauv 3 lub hlis kawg ntawm cev xeeb tub.
- Yog koj yog niam pub niam mis.
Yog koj muaj ib qho ntawm cov mob no, koj yuav tsum qhia rau koj tus kws kho mob paub.
Cov cim ceeb toom uas yuav tsum tau kho mob tam sim ntawd!
Yog tias koj muaj ib qho ntawm cov tsos mob hauv qab no thaum noj cov tshuaj COX-2 inhibitors, tsum tsis txhob noj cov tshuaj thiab mus ntsib koj tus kws kho mob tam sim ntawd lossis mus rau chav kho mob ceev hauv tsev kho mob (ETU) ze tshaj plaws.
- Cov tsos mob ntawm teeb meem siab: zis tsaus, qaug zog heev, tawv nqaij lossis qhov muag daj, quav xim dawb, mob plab.
- Cov cim qhia txog kev los ntshav: ntuav ntshav, ntuav zoo li cov hmoov kas fes, ntshav hauv cov quav lossis cov quav dub uas muaj cov kua nplaum, ntshav hauv cov zis, cov pos hniav los ntshav, thiab yooj yim raug mob.
- Cov tsos mob ntawm cov teeb meem raum: tsis muaj peev xwm tso zis, tso zis tsawg dua, ntshav hauv cov zis, hnyav nce sai.
- Cov cim qhia txog kev ua xua hnyav: tawv nqaij tawm pob, khaus, ua pa nyuaj, ua pa nrov nrov, o ntawm lub ntsej muag, daim di ncauj, lossis tus nplaig.
- Cov tsos mob ntawm tus kab mob plawv nres: mob hauv siab, mob kis mus rau sab caj npab laug, lub puab tsaig, lossis nraub qaum, ua pa nyuaj, tawm hws.
- Cov tsos mob ntawm tus mob stroke: loog ntawm ib sab ntawm lub ntsej muag, caj npab, lossis ceg, hais lus tsis tau zoo, thiab mob taub hau loj heev tam sim ntawd.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Cov tshuaj COX-2 inhibitors yog ib hom tshuaj tua mob tshwj xeeb (NSAID) uas muaj tsawg dua cov kev mob tshwm sim hauv plab.
- Cov no yog siv rau mob pob qij txha, mob thaum muaj hli, thiab lwm yam mob.
- Tsis zoo li cov tshuaj tua kab mob ib txwm muaj, cov no tsuas yog tsom mus rau COX-2 enzyme, uas ua rau mob, thiab tsis cuam tshuam rau COX-1 enzyme, uas tiv thaiv lub plab.
- Txawm hais tias lawv muaj txiaj ntsig zoo los, cov tshuaj no kuj tseem tuaj yeem ua rau muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb mus rau qee qhov. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum siv lawv tsuas yog muaj lus qhia los ntawm kws kho mob xwb.
- Tsis txhob noj cov tshuaj no ntau dua lossis ntev dua li tau qhia yam tsis tau koj tus kws kho mob qhia.
- Yog koj muaj tej yam tsos mob txawv txawv, nrhiav kev pab kho mob tam sim ntawd.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus