Koj puas muaj qhov ntswg txhaws thiab? Koj puas tsis hnov tsw thiab saj tsis tau zoo? Koj puas muaj qhov ntswg ntws tas li? Cov no tsis yog tsuas yog mob khaub thuas xwb, tab sis yog ib yam mob hu ua Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) . Txawm hais tias ntau tus neeg feem ntau tau txais kev pab los ntawm kev siv tshuaj tsuag qhov ntswg lossis tshuaj noj, qee tus neeg pom tias nws nyuaj heev rau kev tswj lawv cov tsos mob nrog cov kev kho mob no. Tab sis tsis txhob txhawj, nrog kev nce qib ntawm kev tshawb fawb kho mob, tam sim no muaj cov txoj hauv kev tshiab thiab zoo los kho cov mob no. Hnub no peb yuav tham txog ib qho kev kho mob tshwj xeeb, Dupixent.
Cov tshuaj Dupixent ua haujlwm li cas rau CRSwNP?
Hais yooj yim xwb, cov pob ntswg hauv qhov ntswg yog cov pob me me uas tsim rau ntawm cov ntaub so ntswg ntawm cov hnab cua (sinuses) hauv lossis nyob ib puag ncig peb lub qhov ntswg. Qhov ua rau muaj qhov no yog mob sinusitis ntev . Qhov no yog thaum lub qhov ntswg thiab cov qhov ntswg o thiab o rau ntau tshaj 3 lub hlis. Qhov o no yog qhov ua rau cov pob ntswg tsim.
Feem ntau, cov polyps no tsis ua rau muaj tsos mob. Tab sis thaum lawv loj hlob tuaj, lawv tuaj yeem pib thaiv kev ua haujlwm ntawm lub qhov ntswg thiab cov qhov ntswg. Xav txog nws zoo li cov yeeb nkab dej uas tsis ntws thaum muaj qee yam daig hauv nws.
Qhov no tuaj yeem ua rau muaj cov tsos mob xws li lub qhov ntswg txhaws, ntswg ntws ntau zaus, txham, thiab tshwj xeeb tshaj yog tsis hnov tsw thiab saj . Tsis tas li ntawd, thaum cov hnoos qeev (phlegm) tsis tuaj yeem ntws tawm ntawm cov qhov ntswg, nws tuaj yeem sib sau ua ke, ua rau mob thiab kis kab mob.
Lub hom phiaj tseem ceeb ntawm kev kho mob ntawm no yog kom txo qhov o ntawm lub qhov ntswg thiab cov qhov ntswg, uas yuav ua rau cov hnoos qeev me me thiab pab txo cov tsos mob.
Cov khoom xyaw nquag hauv Dupixent yog dupilumab . Nws ua haujlwm los ntawm kev thaiv ob hom protein (`interleukin-4` thiab `interleukin-13`) uas xa cov cim uas ua rau peb lub cev tiv thaiv kab mob ua haujlwm ntau dhau thiab ua rau o. Thaum cov protein no raug thaiv, o thiab tsis xis nyob hauv lub qhov ntswg thiab sinuses raug txo qis heev.
Puas muaj leej twg uas muaj tus mob no siv tau Dupixent?
Feem ntau cov neeg uas muaj CRSwNP yuav tau kho nrog cov tshuaj tsuag rau qhov ntswg. Cov no yog ib hom tshuaj hu ua corticosteroid. Yog tias koj tau siv cov tshuaj tsuag no tau ob peb lub hlis thiab koj cov tsos mob tsis tau tswj hwm, tej zaum yuav yog lub sijhawm los xav txog koj tus kws kho mob.Tus kws kho mob yuav sau ntawv kom noj tshuaj corticosteroid luv luv. Ib txhia neeg kuj yuav tsum tau phais kom tshem tau lub qog.
Dupixent yog ib qho kev xaiv zoo rau cov neeg uas tau sim tag nrho cov no, suav nrog cov tshuaj tsuag ntswg, tshuaj ntsiav, thiab tej zaum phais, tab sis tseem muaj cov tsos mob hnyav. Qhov no txhais tau tias nws feem ntau yog siv ua kev kho mob thib ob lossis thib peb.
Kev tshawb fawb txog kev ua haujlwm ntawm Dupixent (LIBERTY Studies)
Ob qhov kev sim tshuaj loj, hu ua LIBERTY, tau ua los txiav txim siab seb cov tshuaj no muaj kev nyab xeeb thiab ua tau zoo npaum li cas. Txhua tus neeg koom nrog hauv cov kev sim no tau siv tshuaj tsuag qhov ntswg txhua hnub tab sis tseem muaj cov tsos mob. Tsis tas li ntawd, 76% ntawm lawv tau poob lawv qhov kev hnov ntxhiab tsw tag lossis ib nrab.
Hauv cov kev tshawb fawb no, Dupixent raug piv rau cov placebo, ib yam tshuaj uas zoo li tshuaj tab sis tsis muaj cov khoom xyaw nquag. Cov txiaj ntsig tau ntsuas tom qab 6 lub hlis.
| Cov txiaj ntsig tau los ntawm kev tshawb fawb | Kev piav qhia |
|---|---|
| Qhov loj ntawm lub qhov ntswg septum | Cov neeg uas tau noj Dupixent rau 6 lub hlis muaj cov moles tsawg dua thiab cov moles tsawg dua li cov neeg uas tau noj placebo. Cov txiaj ntsig zoo ib yam li ib xyoos tom qab. |
| Cov tsos mob ntawm qhov ntswg txhaws | Cov neeg uas tau noj Dupixent muaj cov tsos mob ntawm qhov ntswg txhaws thiab ntswg ntws tsawg dua li cov neeg uas tau noj placebo. Qhov no kuj kav ntev li ib xyoos. |
| Kev hnov tsw ntxhiab | Ntawm cov neeg uas muaj kev hnov tsw tsis zoo, cov neeg uas tau noj Dupixent tau zoo dua qub dua li cov neeg uas tau noj placebo. |
Dupixent siv li cas?
Dupixent yog ib qho kua txhaj uas raug txhaj rau hauv qab daim tawv nqaij txhua ob lub lis piam , feem ntau yog nyob rau hauv lub duav, lub plab, lossis sab caj npab.
Qhov no los nrog ib lub cuab yeej zoo li tus cwj mem uas tau ntim ua ntej lawm uas koj tuaj yeem txhaj tshuaj rau koj tus kheej hauv tsev. Yog li ntawd, tsis tas yuav txhawj txog koob lossis koob txhaj tshuaj. Tab sis nco ntsoov, koj tus kws kho mob lossis tus nais maum yuav qhia koj paub yuav txhaj tshuaj li cas ua ntej. Nws yog ib qho tseem ceeb heev uas yuav tsum ua raws li cov lus qhia ntawd.
Yuav siv sijhawm ntev npaum li cas los pom cov txiaj ntsig los ntawm Dupixent?
Yog tias cov tshuaj no ua haujlwm rau koj, koj yuav pom tias koj qhov kev hnov ntxhiab tsw zoo dua me ntsis hauv thawj lub lim tiam. Nws yuav siv sijhawm ob peb lub lis piam lossis ib hlis lossis ob hlis rau lwm cov tsos mob, xws li qhov ntswg txhaws, kom ploj mus.
Tseem ceeb heev: Tsis txhob tsum noj Dupixent lossis lwm yam tshuaj rau qhov mob no yam tsis tau nrog koj tus kws kho mob tham, txawm tias koj cov tsos mob tau zoo dua lawm los xij. Ua li ntawd yuav ua rau koj cov tsos mob rov qab los.
Cov kev mob tshwm sim thiab teeb meem nrog lwm cov tshuaj
Qhov tshwm sim feem ntau ntawm Dupixent yog qhov ua xua ntawm daim tawv nqaij ntawm qhov chaw txhaj tshuaj . Qhov no tuaj yeem suav nrog liab, mob, o, lossis mob qhov chaw txhaj tshuaj. Txoj hauv kev zoo tshaj plaws kom tsis txhob muaj qhov no yog hloov qhov chaw txhaj tshuaj. Tsis tas li ntawd, tsis txhob txhaj tshuaj rau hauv daim tawv nqaij tawg, mob, lossis raug mob.
Cov no tsis yog txhua yam kev mob tshwm sim uas yuav tshwm sim tau. Yog tias koj muaj tej yam tsos mob uas ua rau koj ntxhov siab, nco ntsoov nrog koj tus kws kho mob tham txog lawv.
Lwm yam tshuaj thiab tshuaj tiv thaiv kab mob
- Lwm cov tshuaj: Ua ntej koj pib Dupixent, nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj noj (tshwj xeeb tshaj yog cov tshuaj kho mob hawb pob), cov vitamins, thiab txawm tias cov tshuaj ntsuab.
- Tshuaj Tiv Thaiv Kab Mob: Yuav tsum tsis txhob muab qee cov tshuaj tiv thaiv kab mob "muaj sia" thaum noj Dupixent. Yog li ntawd, yog tias koj yuav tsum tau txhaj tshuaj tiv thaiv kab mob sai sai no, qhia rau koj tus kws kho mob ua ntej pib kho mob.
Puas muaj tej yam tshwj xeeb xav txog thaum noj Dupixent?
Dupixent tsis yog tshuaj uas koj tuaj yeem tau yooj yim ntawm cov tsev muag tshuaj ib txwm muaj. Nws raug cais ua "tshuaj tshwj xeeb." Qhov no txhais tau tias nws tsuas yog tuaj yeem tau los ntawm qee lub tsev kho mob loj lossis cov tsev muag tshuaj tshwj xeeb.
Kev kho mob no yuav kim heev. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum nrog koj tus kws kho mob tham txog qhov no ua ntej pib kho mob thiab kom paub meej txog tus nqi thiab cov hau kev tau txais nws hauv peb lub tebchaws.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Dupixent yog ib txoj kev kho mob tshiab rau mob rhinosinusitis thiab sinusitis (CRSwNP). Feem ntau nws yog sau rau cov neeg uas muaj cov tsos mob hnyav uas tsis tau tswj hwm los ntawm lwm yam kev kho mob (tshuaj tsuag qhov ntswg, tshuaj ntsiav, phais).
- Qhov no ua haujlwm los ntawm kev thaiv cov teeb liab ntawm lub cev tiv thaiv kab mob uas ua rau mob, txo qhov o ntawm lub qhov ntswg thiab cov sinuses.
- Qhov no yog ib qho tshuaj txhaj uas raug txhaj rau hauv qab daim tawv nqaij txhua ob lub lis piam. Nws yog ib qho tseem ceeb uas yuav tsum kawm paub txhaj tshuaj kom raug los ntawm kws kho mob lossis kws saib mob.
- Tsis txhob tsum kev kho mob rau txhua yam laj thawj yam tsis tau koj tus kws kho mob qhia. Ua li ntawd yuav ua rau cov tsos mob rov qab los.
- Nws yog ib qho tseem ceeb heev uas yuav tsum qhia rau koj tus kws kho mob txog txhua yam tshuaj, cov vitamins, thiab cov tshuaj tiv thaiv kab mob uas koj tab tom noj.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus