Bɔku tɛm yu kin gɛt pen na yu jɔyn dɛn , yu kin gɛt bak pen , ɔ yu kin gɛt bad bad pen we kin kam wit yu mɔnt? Dɔn wi kin tek wan mɛrɛsin we de mek wi fil pen kwik kwik wan . Bɔt yu no se difrɛn kayn mɛrɛsin dɛn de we de mek pɔsin fil pen? Tide wi go tɔk bɔt wan kayn pen kil we de tek spɛshal ples bitwin dɛn, ɛn wok na difrɛn we smɔl. Dat na di wan dɛn we de stɔp COX-2 .
Fɔ tɔk am simpul wan, wetin na dɛn COX-2 Inhibitors ya?
COX-2 inhibito dεm na rili wan grup כf drog dεm we de rεliv pen εn rεdכks inflameshn (anti-inflammatory). Di mɛrɛsin nem fɔ dis grup na NSAID, we tinap fɔ Nonsteroidal Anti-inflammatory Drugs. Drug dɛm lɛk Ibuprofen , Naproxen , ɛn Diclofenac we yu kin yɛri bɔt bɔku tɛm de bak pan dis grup we dɛn kɔl NSAID .
Bɔt dis patikyula kayn we dɛn kɔl COX-2 inhibitors, de wok na di bɔdi difrɛn we smɔl pas di tradishɔnal NSAID dɛn we wi ɔl sabi. Lɛ wi tek tɛm luk wetin na da difrɛns de.
Aw dis mɛrɛsin de wok insay di bɔdi? Na wan we we rili wɔndaful!
Fɔ ɔndastand dis, wi fɔs nid fɔ ɔndastand tu kayn ɛnzaym dɛn na wi bɔdi. dis na di COX-1 εn COX-2 εnzym dεm . Dɛn tu ɛnzaym ya de mek kemikal dɛn na wi bɔdi we dɛn kɔl prostaglandin . Dɛn prostaglandin ya na di men rizin we mek wi kin gɛt pen, swel (inflammation), ɛn fiva.
Imajin dis: Tu wokman dɛn de insay di faktri we dɛn kɔl wi bɔdi.
- COX-1 (fɔs wokman): Dis wan na gud wokman. I de mek prostaglandin we de mek pɔsin fil pen ɛn swel. Bɔt apat frɔm dat, i de du tu tin dɛn we rili impɔtant . Wan pan dɛn na fɔ protɛkt di layn we de na wi bɛlɛ ɛn wi intestinal frɔm di asid we de na di bɛlɛ. Di ɔda wan na fɔ ɛp fɔ mek di blɔd klɔt.
- COX-2 (Worker 2): Dis na di rial prɔblɛm. di men wok we i de du na fכ mek prostaglandin dεm we de mek yu fil pen εn inflameshn.
Naw luk, we wi tek pen kil (Non-selective NSAIDs) lɛk Ibuprofen ɛn Diclofenac, di mɛrɛsin de stɔp dɛn tu wokman dɛn de. Dɔn, bikɔs dɛn dɔn stɔp COX-2, di pen ɛn swel de ridyus. Bɔt bikɔs di gud wokman, dat na, COX-1, dɔn stɔp, di bɛlɛ in difens dɛn kin lɔs , ɛn di chans fɔ gɛt gastritis, bɛlɛ inflamɛns, ɛn sɔntɛm ɔlsa kin bɔku.
Bɔt, dis klas ɔf drɔgs we dɛn kɔl COX-2 inhibitors rili smat. Dɛn kin go stret to di pɔsin we de wok fɔ di prɔblɛm, dat na di COX-2 ɛnzaym . Dɛn kin mek di gud wokman (COX-1) du in wok. So di damej we di bɛlɛ kin pwɛl nɔ kin bɔku. Dis na di big big bɛnifit fɔ dis klas fɔ drɔgs.
Us kɔndishɔn dɛn de yuz COX-2 inhibito fɔ?
Dɔktɔ dɛn kin se dɛn fɔ tek dis kayn mɛrɛsin fɔ kɔntrol di pen ɛn swɛlin we nɔ kin gɛt bɔku prɔblɛm ɛn we kin kam wit difrɛn mɛrɛsin dɛn.
| Mɛdikal kɔndishɔn | Wan simpul ɛksplen |
|---|---|
| Ɔstiɔ-arayt sik | Pen ɛn stiffness bikɔs ɔf di joyn we de west ɛn te as wi de ol. |
| Rimatɔyd Atraytis | sik we de mek di joyn dεm swel εn pen bikoz fכ di bכdi in כwn imyun sistεm we de wok. |
| Juvenile Arthritis we dɛn kin gɛt | Atraytis na yɔŋ pikin dɛn. |
| Ankylosing Spɔndylitis we de mek pɔsin gɛt sik | Na sik we di jɔyn dɛn, mɔ na di spayna, kin swel ɛn kin jɔyn togɛda as tɛm de go. |
| Pen we yu de fil we yu de gɛt mɔnt (Dysmenorrhea) . | Siriɔs bɛlɛ pen we yu de gɛt mɔnt. |
| Injury fɔ shɔt tɛm, lɛk injury we pɔsin kin gɛt we i de spɔt | If yu gɛt sprain, mɔsul dɛn strɛs, ɛn ɔda tin dɛn. |
Apat frɔm dat, yu dɔktɔ kin gi yu dis mɛrɛsin bak fɔ sik dɛn lɛk gaut ɛn maygren.
Wetin na di risk ɛn sayd ɛfɛkt dɛm we pɔsin kin gɛt we i yuz COX-2 Inhibitors?
Pan ɔl we dɛn dɔn ridyus di sayd ifɛkt dɛn we de na di bɛlɛ, di COX-2 inhibito dɛn nɔto drɔgs we nɔ gɛt risk ɔltogɛda. Sɔm prɔblɛm dɛn kin de , mɔ we dɛn yuz am bɔku bɔku wan ɛn fɔ lɔng tɛm .
Men risk dɛn
- Hat atak ɛn strok: Dɛn dɔn si se di COX-2 inhibitors gɛt fɔ du wit di risk fɔ gɛt at atak ɛn strok smɔl. Dis risk kin ivin pasmak pan pipul dɛm wae dɔn ɔlrɛdi gɛt hat sik ɔr risk factor dɛm fɔ am. fכ dis rizin, dεn dכn pul sכm COX-2 inhibito dεm, lεk `Rofecoxib (Vioxx®)` εn `Valdecoxib (Bextra®)`, na di makit.
- Prɔblɛm dɛn na di bɛlɛ ɛn di intestinal: Pan ɔl we di damej we de na di bɛlɛ kin ridyus, i nɔ kin kɔmɔt kpatakpata. Sɔm pipul dɛn kin gɛt blɔd ɛn ɔlsa .
Kɔmɔn sayd ɛfɛkt dɛn
| Tayp fɔ di sayd ɛfɛkt | Sɔm sayn dɛn we kin apin |
|---|---|
| Dijestiv sistɛm | Blɔt, dayarɛa, kɔnstipɛshɔn, nɔs, bɛlɛ at, chɛst pen. |
| At ɛn blɔd vesel dɛn | Ay blɔd prɛshɔn, chɛst pen, at atak, strok. |
| Kidni dɛn | di kidni dεm we de wok dכn, wata we de kכmכt na di bכdi εn swεla (εdima). |
| Nɛvɔ sistɛm | Ɛd we de at, we yu de tɔn diziz. |
Udat nɔ fɔ tek COX-2 Inhibitors?
Yu dɔktɔ go rivyu yu kɔmplit wɛlbɔdi istri fɔ no if dis mɛrɛsin fayn fɔ yu. Yu fɔ avɔyd fɔ tek dis mɛrɛsin if yu gɛt ɛni wan pan dɛn tin ya:
- If yu dɔn gɛt strok bifo.
- If yu jɔs dɔn du ɔ yu de kam fɔ gɛt korona at baypas ɔpreshɔn .
- If yu gɛt siriɔs kidni sik ɔ liva sik .
- If yu bin dɔn gɛt asma atak ɔ bad bad alɛji fɔ ɔda NSAID, aspirin, ɔ wan sɔlfa antibayɔtik.
- If yu de insay di las tri mɔnt we yu gɛt bɛlɛ .
- If yu na mama we de gi pikin in bɛlɛ (tɔk to yu dɔktɔ bɔt dis).
Ustɛm yu fɔ go to dɔktɔ wantɛm wantɛm?
If yu gɛt ɛni wan pan dɛn tin ya we yu de tek dis mɛrɛsin, nɔ de te ɛn go to yu dɔktɔ wantɛm wantɛm ɔ go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu .
- Sayn dɛm fɔ se yu gɛt prɔblɛm wit yu liva: yu urine dak, yu taya pasmak, yu skin ɔ yu yay de yɔlɔ, yu stɔl gɛt layt kɔlɔ, yu bɛlɛ de pwɛl.
- Sayn dɛm fɔ blɔd: yu de vɔmit blɔd ɔ yu de vɔmit we tan lɛk kɔfi grɔn, yu de pas blɔd na di stɔl (blak ɔ dak rɛd stɔl), yu de pas blɔd na yu urine, yu gɔm de blɔd, yu de brus na yu skin we nɔ kɔmɔn.
- Di sayn dɛm we de sho se yu gɛt prɔblɛm wit yu kidni: yu nɔ ebul fɔ pis, chenj di we aw yu de pis, we yu gɛt wet wantɛm wantɛm.
- Sayn dɛm fɔ se yu gɛt siriɔs alɛji: yu skin de rɔsh ɔ yu de ayv, yu de it, yu nɔ go ebul fɔ blo, yu fes, yu lip, ɔ yu tɔng de swel.
- Di sayn dɛm fɔ hat atak: chɛst de pen, yu nɔ de blo shɔt, pen we de rayt to yu jaw ɔr sholda.
- Di sayn dɛm fɔ strok: wan say na di bɔdi kin swɛ, i nɔ kin izi fɔ tɔk, in fes kin drɔp.
Mɛsej we dɛn kin kɛr go na os
- COX-2 inhibito na spɛshal klas ɔf drɔgs we nɔ de ambɔg di bɛlɛ pas kɔmɔn pen kil (NSAID). Di kayn dɛn we dɛn kin yuz mɔ na Sri Lanka na Celecoxib ɛn Etoricoxib.
- Dɛn tin ya nɔr kin gɛt ɛni risk fɔ ɔltin, mɔr lɛk dat kin mek pɔrsin gɛt at atak ɛn strok.
- Nɔ ɛva yuz dis mɛrɛsin frɔm famasi we yu nɔ gɛt dɔktɔ in prɛskrishɔn.
- Yuz di doz we smɔl pas ɔl we yu dɔktɔ tɛl yu ɔltɛm, fɔ di shɔt tɛm we yu go ebul fɔ yuz .
- If yu gɛt tin dɛn lɛk at sik, kidni sik, liva sik, ɔ gastritis, i impɔtant fɔ tɛl yu dɔktɔ bifo yu tek dis mɛrɛsin.
- Yu fɔ no ɔltɛm bɔt di sayn dɛn we de wɔn pɔsin we wi dɔn tɔk bɔt. If ɛni prɔblɛm kam, go to dɔktɔ wantɛm wantɛm.
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