Yu kin gɛt bɛlɛ pen bak, yu bɛlɛ kin bɔn, ɔ yu gɛt gastritis we yu de tek mɛrɛsin we yu dɔktɔ dɔn tɛl yu fɔ mek yu jɔyn pen, yu bak pen, ɔ ɔda pen? Dis na rili prɔblɛm we bɔku pipul dɛn kin gɛt. I kin rili anɔynt fɔ gɛt ɔda prɔblɛm afta yu dɔn tek mɛrɛsin fɔ ridyus pen. Bɔt yu no se wan spɛshal klas de fɔ drɔgs we kin ridyus dis bɛlɛ pen ɛn kɔntrol pen? Dɛn kɔl da klas de fɔ drɔgs COX-2 inhibitors . Tide wi de tɔk bɔt dat.
Wetin na COX-2 Inhibitors? Lɛ wi ɔndastand am simpul wan.
COX-2 inhibito dεm na rili wan mεmba fכ di sem famili fכ pen kil dεm we dεn kכl NSAIDs (Nonsteroidal Anti-inflammatory Drugs) . Di mɛrɛsin dɛn we yu kin yuz bɔku tɛm, lɛk Ibuprofen , Diclofenac, ɛn Naproxen , de pan dis grup fɔ NSAID. Di men wok we dɛn mɛrɛsin ya de du na fɔ mek pɔsin nɔ fil pen, fɔ mek i nɔ swel, ɛn fɔ mek i nɔ gɛt fiva.
So wetin so spɛshal bɔt dɛn COX-2 inhibito ya? Fɔ ɔndastand dat, wi fɔs nid fɔ luk aw wan tipik NSAID de wok insay wi bɔdi.
di tu "wokman" dεm na wi bכdi: COX-1 εn COX-2
Imajin se insay wi bɔdi wan kayn ɛnzaym de we dɛn kɔl Cyclooxygenase ( COX ). Dɛn tin ya tan lɛk smɔl wokman dɛn we de du difrɛn wok dɛn na wi bɔdi. Na tu kayn dɛn COX wokman ya mɔ.
1. COX-1: Dis na "gud" woka. Di men wok we i de du na fɔ protɛkt di layn we de na wi bɛlɛ ɛn insay wi bɔdi. I de ɛp fɔ mek wan layt we de protɛkt di bɛlɛ frɔm di dijestiv asid dɛn we de insay di it we wi de it ɛn drink. I de involv bak fɔ mek di blɔd klɔt .
2. COX-2: Dis kin bi di "troublemaker." We pɔsin wund, infɛkshɔn, ɔ damej na wi bɔdi, i kin go de ɛn mek kemikal dɛn we dɛn kɔl prostaglandins . Na dɛn prostaglandin ya kin mek pɔsin fil pen, swel, ɛn fiva. Pan ɔl we dis na rili tin we de protɛkt pɔsin na di bɔdi, pan sik dɛn we nɔ de mɛn lɛk at at sik, dis prɔses kin kɔntinyu fɔ mek pɔsin fil pen.
Naw luk, we wi tek wan kɔmɔn NSAID lɛk Ibuprofen, da drɔg de go insay di bɔdi ɛn blok ɔl tu di gud man (COX-1) ɛn di bad man (COX-2), we min se dɛn ɔl tu kin stɔp fɔ wok. Bikɔs COX-2 dɔn blok, di pen ɛn swel de ridyus. Dat na gud. Bɔt bikɔs COX-1 dɔn blok, di bɛlɛ in protɛkshɔn bak kin stɔp, ɛn di chans fɔ mek di bɛlɛ inflamɛns, gastritis, ɛn ivin ɔlsa na di bɛlɛ kin bɔku.
Fɔ sɔlv dis prɔblɛm, sayɛnsman dɛn dɔn fɛn mɛrɛsin dɛn we dɛn kɔl COX-2 inhibitors. Dɛn drɔgs ya tan lɛk snaypa. We dɛn go insay di bɔdi, dɛn kin tɔch di COX-2 wokman we gɛt prɔblɛm dairekt wan. Di gud wokman COX-1 nɔ de ambɔg ɛnitin. I jɔs de du in wok.
fכ dat, we di bכdi de kכntinyu fכ protεkt, na di COX-2 εnzym nכmכ we de mek yu fil pen εn inflameshn, de inhεbit. Fɔ tɔk am simpul wan, di big bɛnifit we di COX-2 inhibito dɛn gɛt na dat dɛn de kɔntrol di pen we dɛn de mek di bɛlɛ nɔ bɔku.
Us kɔndishɔn dɛn dɛn kin yuz mɔ fɔ di COX-2 inhibito dɛn?
Dis kayn mɛrɛsin na in dɔktɔ dɛn kin advays fɔ difrɛn kayn tin dɛn we kin mek pɔsin fil pen ɛn we kin mek pɔsin fil bad. Dis dɔŋ ya na sɔm pan di men wan dɛn.
| Mɛdikal kɔndishɔn | Wan simpul ɛksplen |
|---|---|
| Ɔstiɔ-arayt sik | di joyn pen εn swεla we de apin we di katilej bitwin di joyn dεm de west wit di ej כ fכ כda rizin. Bɔku tɛm i kin afɛkt di jɔyn dɛn lɛk di ni ɛn di hip. |
| Rimatɔyd Atraytis | Wan inflamɛns we nɔ de dɔn ɛn bad bad pen we kin apin we wan prɔblɛm na di bɔdi in imyun sistɛm atak di jɔyn dɛn. |
| Juvenile Arthritis we dɛn kin gɛt | Atrit sik na yɔŋ pikin dɛm. |
| Ankylosing Spɔndylitis we de mek pɔsin gɛt sik | Na sik we kin mek di joyn dɛn na di spayna swel mɔ ɛn as tɛm de go, dɛn kin jɔyn togɛda, we kin mek i stif. |
| Menstrual Pen / Dismɛnɔria | Fכ kכntrכl di siriכs lכw bכdi pen we kכnεkt wit mεnstruation pan uman dεm. |
| Pen fɔ shɔt tɛm | Dɛn kin yuz am bak fɔ pen fɔ shɔt tɛm, lɛk fɔ wund pan spɔt, pen afta dɛn dɔn ɔpreshɔn am, ɛn pen afta dɛn pul yu tut. |
Apat frɔm dat, dɛn kin yuz dɛn mɛrɛsin ya bak fɔ ɔda tin dɛn lɛk gaut ɛn maygren, we di dɔktɔ want.
Wetin na di COX-2 Inhibitors we dɛn de yuz na Sri Lanka ɛn di wɔl?
Di COX-2 inhibito we dɛn kin yuz mɔ na di wɔl ɛn na Sri Lanka na Celecoxib . Yu go dɔn yɛri bɔt am ɔnda di brand nem Celebrex® .
Apat frɔm dat, dɛn kin yuz ɔda COX-2 inhibito dɛn lɛk Etoricoxib (Arcoxia®) ɛn Parecoxib (Dynastat®) bak na difrɛn kɔntri dɛn ɔlsay na di wɔl.
Bɔt yu fɔ no dis bak. Bɔku ia bifo dis tɛm, ɔda COX-2 inhibito dɛn, lɛk Rofecoxib (Vioxx®) ɛn Valdecoxib (Bextra®) , bin de na di makit. Bɔt leta stɔdi dɛn sho se dɛn mɛrɛsin ya kin rili mek pɔsin gɛt at atak ɛn strok we dɛn yuz am fɔ lɔng tɛm. Dɛn bin mek bak sɔm pipul dɛn gɛt siriɔs sik dɛn na dɛn skin. Fɔ dɛn rizin ya, dɛn bin pul dɛn drɔgs ya na di makit.
Di impɔtant lɛsin we wi kin lan frɔm dɛn tin ya we kin apin na dat dɛn nɔ fɔ yuz ɛni mɛrɛsin fɔ mɛn pen fɔ lɔng tɛm if dɛn nɔ gɛt dɔktɔ advays . Ɛvri mɛrɛsin gɛt in bɛnifit ɛn risk dɛn. Na yu dɔktɔ nɔmɔ go ebul fɔ pik di mɛrɛsin we fit yu ɛn we nɔ bad fɔ yu.
Aw a go tek dis mɛrɛsin? Aw lɔng a fɔ tek am?
di COX-2 inhibito dεm kin kam insay di fכm fכ pils, bכt dεn kin de bak as כral sכlushכn.
Di pen kin bigin fɔ stɔp insay wan awa afta yu tek dis mɛrɛsin.Bɔt i kin tek sɔm dez fɔ gɛt di ful anti-inflammatory bɛnifit dɛm, lɛk fɔ ridyus di swɛlin.
Aw lɔng yu nid fɔ tek dis mɛrɛsin de dipen pan yu mɛrɛsin kɔndishɔn.
- Fɔ shɔt tɛm pen (lɛk fɔ sɔm dez ɔ tu wik): I fayn ɔltɛm fɔ tek di doz we smɔl pas ɔl fɔ di shɔt tɛm we pɔsin kin tek .
- Fɔ wan sik wae de kam fɔ lɔng tɛm lɛk at at sik: Yu dɔktɔ go rivyu yu kɔmplit wɛl bɔdi istri, ɔda mɛrɛsin dɛm wae yu de tek, ɛn ivin blɔd tɛst rizɔlt if nid de, fɔ no if i sef fɔ yu fɔ kɔntinyu fɔ tek dis mɛrɛsin.
Di tin we impɔtant pas ɔl na fɔ tek di doz we yu dɔktɔ tɛl yu ɔltɛm, jɔs lɛk aw dɛn tɛl yu fɔ tek, ɛn fɔ di tɛm we dɛn tɛl yu fɔ tek. If yu gɛt ɛnitin we de mɔna yu, mek shɔ se yu tɔk to yu dɔktɔ bifo yu stɔp di mɛrɛsin ɔ chenj di doz.
Wetin na di risk ɛn sayd ifɛkt dɛm fɔ COX-2 inhibitors?
As wi bin dɔn tɔk, di men bɛnifit we dɛn mɛrɛsin ya gɛt na dat dɛn nɔ kin gɛt bɛtɛ impak pan di bɛlɛ ɛn di insay. Bɔt dat nɔ min se dɛn nɔ gɛt ɛni risk. Sɔm sayd ɛfɛkt kin apin, mɔ we dɛn tek am bɔku bɔku wan ɛn fɔ lɔng tɛm.
Di tu men prɔblɛm dɛn we kin apin:
1. Risk fɔ gɛt at atak ɛn strok: Ɔl di NSAID dɛn, inklud di COX-2 inhibitors, kin mek di risk fɔ gɛt at atak ɛn strok to sɔm mak. Dis risk kin pasmak pan pipul dɛm wae dɔn ɔlrɛdi gɛt tin dɛm wae kin mek pɔrsin gɛt hat sik, lɛk ay blɔd prɛshɔn ɛn ay kɔlɔstrel.
2. Bɛlɛ ɛn intestinal prɔblɛm: Pan ɔl we i nɔ kin bɔku lɛk di rɛgyula NSAID, di COX-2 inhibitors kin mek sɔm pipul dɛn bɛlɛ blɔd ɛn ɔlsa. Dis risk kin bɔku mɔ pan di wan dɛn we dɔn ol ɛn di wan dɛn we de tek ɔda mɛrɛsin dɛn we kin mek dɛn bɛlɛ inflamɛns.
Ɔda bad bad tin dɛn we kin apin:
| Di bɔdi sistɛm | Sɔm sayd ɛfɛkt dɛn we pɔsin kin gɛt |
|---|---|
| Dijestiv sistɛm | Blɔt, bɛlɛ pen, nɔs, vɔmit, dayarɛa, kɔnstipɛshɔn, ɛn at bɔn. |
| At ɛn blɔd vesel dɛn | Ay blɔd prɛshɔn (Hypertension), at bit kwik ɔ we nɔ de bit ɔltɛm (Palpitations), nɔ kin gɛt at atak ɔ strok. |
| Kidni dɛn | di kidni dεm we de wok dכn, di leg dεm de swεla (εdima) bikoz fכ wata εn sכlt dεm we de kכmכt na di bכdi, εn di potashכm lεvεl dεm na di bכdi de inkrεs. |
| Nɛvɔ sistɛm | Ɛd we de at, we yu de tɔn diziz. |
Nɔto ɔlman kin gɛt ɔl di sayd ɛfɛkt dɛm wae de na dis list. If yu gɛt ɛni wan pan dɛn sik ya ɔ yu notis ɛnitin we nɔ kɔmɔn, tɛl yu dɔktɔ wantɛm wantɛm.
Udat nɔ fɔ tek dis mɛrɛsin?
Sɔm pipul dɛm wae gɛt sɔm mɛdikal kɔndishɔn nɔr fayn fɔ COX-2 inhibitors. Yu dɔktɔ go tink bɔt ɔl dɛn tin ya bifo i gi yu di mɛrɛsin.
Pipul dɛn we nɔ fɔ tek COX-2 inhibitors:
- If yu dɔn gɛt strok bifo.
- If yu de pripia fɔ ɔ yu jɔs dɔn gɛt korona at baypas ɔpreshɔn.
- If yu gɛt siriɔs kidni sik ɔ yu liva nɔ de wok fayn.
- If yu dɔn gɛt asma atak ɔ siriɔs alɛji afta yu dɔn tek aspirin ɔ ɔda NSAID.
- If yu gɛt alɛji to sɔlfonamid antibayɔtiks.
Di wan dɛn we fɔ tek tɛm mɔ:
- If yu dɔn gɛt ɔlsa na yu bɛlɛ ɔ yu de blɔd.
- If yu de insay di las 3 mɔnt we yu gɛt bɛlɛ.
- If yu na mama we de gi pikin in bɛlɛ.
If yu gɛt ɛni wan pan dɛn sik ya, yu fɔ rili tɛl yu dɔktɔ.
Sayn dɛn we de wɔn pipul dɛn we nid fɔ go to dɔktɔ wantɛm wantɛm!
If yu gɛt ɛni wan pan dɛn sik ya we yu de tek COX-2 inhibitors, stɔp fɔ tek di mɛrɛsin ɛn go to yu dɔktɔ wantɛm wantɛm ɔ go na di ɔspitul imejensi dipatmɛnt (ETU) we de nia yu.
- Di sayn dɛm fɔ di liva prɔblɛm: di urine dak, taya pasmak, yu skin ɔ yu yay de yɔlɔ, yu stɔl gɛt layt kɔlɔ, yu bɛlɛ de pen.
- Sayn dɛm fɔ blɔd: yu de vɔmit blɔd, yu vɔmit we tan lɛk kɔfi grɔn, blɔd na yu stɔl ɔ blak tari stɔl, blɔd na yu urine, yu gɔm de blɔd, ɛn i izi fɔ brus.
- Di sayn dɛm we de sho se yu gɛt prɔblɛm wit yu kidni: yu nɔ ebul fɔ pis, yu nɔ de pul yu urine, blɔd de na yu urine, yu gɛt bɔku bɔku wet wantɛm wantɛm.
- Sayn dɛm fɔ se yu gɛt siriɔs alɛji: yu skin de rɔsh, yu de it, yu nɔ go ebul fɔ blo, yu de swɛt, yu fes, yu lip, ɔ yu tɔng de swel.
- Di sayn dɛm fɔ at atak: swɛt pen na yu chɛst, pen we de spre to yu lɛft an, jaw, ɔ bak, i nɔ izi fɔ blo, yu de swet.
- Di sayn dɛm fɔ strok: wan say na in fes, an, ɔ leg kin swɛ, i nɔ kin izi fɔ tɔk, ɛn ed kin at bad bad wan wantɛm wantɛm.
Mɛsej we dɛn kin kɛr go na os
- COX-2 inhibito dεm na wan spεshal kayn pen kil (NSAID) we gεt bכku bכdi sayd ifekt dεm.
- Dɛn kin yuse dɛn tin ya fɔ at at sik, pen we pɔsin kin gɛt we i de gɛt mɔnt, ɛn ɔda tin dɛn we kin mek i fil pen.
- difrεnt lεk di rεgulεr pen kil dεm, dεn ya de כnli tכk to di COX-2 εnzym we de mek yu fil pen, εn dεn nכ de intafεr di COX-1 εnzym we de protεkt di bεlε.
- Pan ɔl we dɛn mɛrɛsin ya kin bɛnifit, dɛn kin mek bak di risk fɔ gɛt at atak ɛn strok te to sɔm mak. So, i rili impɔtant fɔ yuz dɛn ɔnda dɔktɔ advays nɔmɔ.
- Nɔ ɛva tek dis mɛrɛsin fɔ lɔng tɛm ɔ fɔ lɔng tɛm pas aw dɛn tɛl yu if yu dɔktɔ nɔ advays yu.
- If yu gɛt ɛni sayn we nɔ kɔmɔn, go to dɔktɔ wantɛm wantɛm.
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