Yu kin it yu bɔdi ɔltɛm? Yu tink se i kin tɔn rɛd? Lɛ wi lan bɔt dis sik we nɔ kin bɔku (Systemic Mastocytosis) .

Yu kin it bak ɔlsay na yu bɔdi wan wan tɛm? Yu fes ɛn nɛk kin tɔn rɛd wantɛm wantɛm ɛn fil lɛk se yu de gɛt ɔt flush? Yu gɛt bɛlɛ we de at, yu ed de tɔn, ɛn yu at de rɔn? Ivin if yu tink se dɛn tin ya na jɔs alɛji, sɔm tɛm dɛn kin gɛt difrɛn kɔndishɔn biɛn dis, wan we wi nɔ yɛri bɔku bɔt. Tide wi de tɔk bɔt wan pan dɛn kayn sik ya we nɔ kin bɔku, we na Systemic Mastocytosis. Nɔ wɔri, lɛ wi ɔndastand dis simpul wan.

Wetin na sistɛm mastosaytɔsis?

Fɔ tɔk am simpul wan, dis na sik we kin kam bikɔs wan kayn sɛl we dɛn kɔl ‘mast sɛl’ na wi bɔdi nɔ kin bɔku. Mast sɛl na wan kayn wayt blɔd sɛl. Tink bɔt dɛn mast sɛl ya as sojaman dɛn na wi imyun sistɛm. Dɛn men wok na fɔ protɛkt wi frɔm sik dɛn ɛn ɛp wi fɔ wɛl we wi wund . Bɔt pan dis sik, dɛn mast sɛl ya kin gɛda pasmak ɛn nɔ kin gɛda na difrɛn pat dɛn lɛk wi skin, bon mɛro , bon, ɛn intestinal. Wetin kin apin da tɛm de? fכ sכm trigεr, dεn εksyכs mast sεl dεm ya kin bi aktif wan wan εn de rilis bכku kεmikכl dεm lεk ‘histamine’ insay di bכdi. Na da tɛm de di sayn dɛn we a bin dɔn tɔk bɔt, lɛk fɔ flash, it, ɛn ɛkzema , kin apin.

Wetin kin mek pɔsin gɛt dis sik?

Bɔku pipul dɛn kin wɔnda if dis na sik we pɔsin kin gɛt frɔm in mama ɛn papa. Bɔt dis nɔ kin bi sik we pɔsin kin gɛt frɔm in mama ɛn papa. Bɔku tɛm, i kin apin na wan jin we dɛn kɔl KIT, we de na wi mast sɛl dɛn.I kin kɔmɔt frɔm wan chenj we kin apin we nɔ apin (mutation). dis jin de εp fכ mek wan protin we de kכntro di sεl dεm we de gro. So we dis chenj, di mast sɛl dɛn kin bigin fɔ gro we dɛn nɔ ebul fɔ kɔntrol. Pan ɔl we dɛn sik ya kin apin ɛni ej, dɛn kin apin mɔ pan pipul dɛn we dɔn ol, mɔ we dɛn ol bitwin 40 ɛn 50 ia .

Trigεr dεm wae de mek dεn simptom dεm bכku

Nɔto ɔlman wae gɛt dis sik kin gɛt di sem sayn. Dɔn bak, de tin wae kin mek pɔrsin gɛt de sik kin difrɛn frɔm pɔrsin to ɔda pɔrsin. Bɔt sɔm pan di tin dɛn we kin mek pɔsin sik, de na di tebul we de dɔŋ ya. I impɔtant fɔ no bɔt dɛn tin ya. I impɔtant bak fɔ mɛmba se sɔmtɛm, di sayn dɛm kin apia wae nɔr gɛt ɛni patikyula rizin.

Wetin na di men kayn ɛn sayn dɛm fɔ dis sik?

fayv men tכp dεm de fכ Sεstεmik Mastosaytosis. Yu dɔktɔ go tɛst yu ɛn tɛl yu us kayn yu gɛt.

• Indolent Systemic Mastocytosis (ISM): dis na di kayn we we kכmכn pas כl εn we nכ kin siriכs. Di sik kin go bifo smɔl smɔl ɛn i nɔ kin mek di ɔgan dɛn pwɛl bad bad wan.
• Smoldering Systemic Mastocytosis (SSM): I kin rili bad smɔl pas ISM. Di sayn dɛm kin tranga pasmak ɛn kin afɛkt di ɔgan dɛm as tɛm de go.
• Sεstεmik Mastosaytosis wit wan Asosiet εmatכlכjik Nioplasm (SM-AHN): insay dis kes, mastosaytosis de kכmכn wit כda sik we de kכmכt wit bכdi (e.g. lukimiya ).
• Aggressive Systemic Mastocytosis (ASM): Dis kayn de go bifo kwik kwik wan ɛn i kin pwɛl di ɔgan dɛn lɛk di liva, di splin, ɛn di bon dɛn.
• Mast Cell Leukemia (MCL): Dis na di kayn we we nɔ kin bɔku ɛn we kin rili bad. bכku nכmba dεm fכ mast sεl dεm de na di bon mכro εn bכdi.

Di sayn dɛm wae yu kin gɛt kin dip pan di kayn sik wae yu gɛt ɛn usay na yu bɔdi di abnɔmal mast sɛl dɛm kin bɔku. Na sɔm kɔmɔn sayn dɛn ya:

• I de it, rash , we yu de flush
• Bɛlɛ de pen, blo, dayarɛa
• Nɔs ɔ vɔmit
• Ed we de at ɛn taya
• At bit kwik kwik wan
• Lɔw blɔd prɛshɔn, diziz, nɔr kin no natin
• Di liva, di splin, ɛn di limf no dɛm kin swel
• Anemia ɛn blɔd kɔndishɔn
• We di bon dɛn wik (Osteoporosis) .
• Na yu maynd, tin dɛm lɛk wae yu nɔr kin ebul fɔ pe atɛnshɔn, wae yu de wɔri ɔltɛm, ɔr yu gɛt pwɛl hat.

Aw fɔ no di sik? (Diagnosis) .

Yu dɔktɔ go aks yu fɔs bɔt yu sik dɛn ɛn du yu bɔdi ɛgzam. Dɔn, dɛn kin se dɛn fɔ du sɔm tɛst fɔ no if pɔsin gɛt di sik:

• Skin biopsy: Dɛn kin tek smɔl pat pan di skin frɔm wan say we di sik afɛkt ɛn chɛk am ɔnda maykroskɔp fɔ si if bɔku mast sɛl dɛn de.
• Bone Marrow Biopsy: Wan dɔktɔ we de mɛn blɔd kin yuz wan tint nidul fɔ tek smɔl sampul pan yu bon mɛro ɛn chɛk am.
• Blɔd ɛn urine tɛst:Dɛn kin yuz kɔmplit blɔd kɔnt (CBC) bak fɔ chɛk fɔ ɔda tin dɛn lɛk we pɔsin nɔ gɛt bɛtɛ blɔd.
• Jɛnɛtik Tɛst: Dɛn kin tɛst blɔd ɔ tisu sɛmpul fɔ si if ɛni chenj de na di KIT jin we wi bin dɔn tɔk bɔt.
• Imej tɛst: X-ray, ɔltra saund, ɛn CT skan kin ɛp fɔ no if di bon wik ɛn di ɔgan dɛn lɛk di liva ɛn di splin de swel.
• Ɛndoskopi ɔ Kolonoskopi: Dɛn kin yuz tin tiub we gɛt kamɛra we dɛn tay pan am fɔ chɛk di insay pat pan di bɛlɛ ɔ di intestinal fɔ chɛk fɔ ɛnitin we nɔ fayn, lɛk ɔlsa.

Wetin na di tritmɛnt dɛn?

Di dɔktɔ go disayd aw fɔ trit yu bay di sayn dɛn we yu gɛt, di ɔgan dɛn we yu gɛt, ɛn di kayn sik we yu gɛt.

• Antihistamines: Dɛn mɛrɛsin ya kin ɛp fɔ kɔntrol tin dɛn lɛk skin it, rɛd, ɛn bɛlɛ we de at.
• Epinephrine: Na ɔmon we dɛn kin yuz if pɔsin gɛt siriɔs alɛji (anaphylaxis).
• Proton Pump Inhibitors: Kכntro di bεlε asid εn rεdכks tin dεm lεk bεlε inflameshn.
• Mast Cell Stabilizers: Na mεdikeshכn dεm we de stכp di rilis fכ histamin frכm di mast sεl dεm.
• Stɛroyd: I kin ɛp wit di sik dɛn we de apin na di skin ɛn di we aw pɔsin de blo.
• Targeted Therapy: Na drɔgs we de target wan patikyula jin ɔ protin we de insay di sik. Dɛn kin nid dɛn tin ya fɔ pipul dɛn we gɛt siriɔs sik.
• Kimotɛrapi: Dis tritmɛnt kin nid fɔ bi if di sik de skata kwik kwik wan ɛn de mek di ɔgan dɛn pwɛl bad bad wan.
• Stem Cell Transplant: Na tritmɛnt opshɔn we dɛn kin tink bɔt insay kes dɛm we nɔ kin apin so ɔltɛm.

Sistεmik Mastosaytosis, mast sεl dεm, skin rεsh, anafylaksis, anafylaksis, KIT jin, histamin