Covid-19 hripui hian engtiang chiahin nge kan nun a tihdanglam tih sawi chian a ngai lo. Vaccine kan la vek a, eng emaw chen chu venhim ni mah ila, he virus hi a awm reng dawn lo . A variant thar a lo lang fo thin. Alpha, Beta, leh tun hnaia kan sawi tawh Omicron variant te kha i hre reng mai thei. Hetianga virus hi a inthlak danglam zel avangin tuna vaccine hman mekte hi a chang chuan heng hri kai thar darh zel tur tihtawp nan hian a hlawhtling lo zawk thei a ni. Chuvangin hei bakah hian khawvel hmun hrang hrangah hmanraw him dang chungchangah zirchianna neih mek a ni. A bik takin, mipui tamna hmuna hri kai darh lohna tur kawng hrang hrang, infiamna lian tak tak leh music concert-ah te. Chu chu chutiang zirchianna pakhat chu vawiinah hian kan sawi dawn a ni. Chu chu Covid tana hnar spray siam mek chungchang a ni.
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He experimental Covid nasal spray hi eng nge ni?
Hei hi zirchianna stage-ah la awm mah se, United States-a National Institute of Allergy and Infectious Diseases (NIAID) chuan he zirchianna hi an kalpui mek a ni. A awlsam zawngin sawi ila, hei hi hnar chhunga kah theih damdawi a ni. Tun thleng hian mice-a test-naah result hlawhtling tak a awm tawh a ni . Chuvângin, zirchiangtute chuan mihringte tân pawh chutiang bawka vênhimna pe thei tûrin theihna a nei niin an ngai a ni.
Hei hi thil thar a la nih avangin a thatna leh a side effect chungchang hi hriat tur a tam lo hle. Mahse zirchiangtute chuan mi pakhatin hri kai a kai hnua hnar chhunga spray hman chuan hri kai venna kawngah a pui thei niin an ngai. Tin, spray hi exposure hnu lawkah (darkar 12 chhungin) hman a nih chuan enkawlna hmasa atan hman theih niin an ngai bawk.
Experiment-ah hian mice-te chu human cell receptor inject-in Covid virus, SARS-CoV-2 virus an kai a ni. Tichuan, he molecule bik N-0385 an tih hi spray an pe a. He molecule hian mice te chu natna hrik lakah a veng thei tih finfiah a ni. Chu mai ni lovin, Covid virus original chauh ni lovin, a chi hrang hrang lakah pawh a tangkai hle tih hmuhchhuah a ni .
Treatment awmsa leh he nasal spray hi eng nge an danglamna?
COVID-19 virus chi thar a lo chhuah rual hian antibody enkawlna awmsa thenkhatte thatna a tlahniam chho zel a. Dik tak chuan antibody treatment awm tawh thenkhat chuan Omicron variant pawh hi an control thei lo. Tin, heng antibody enkawlna te hi a man a to hle bawk. Siam, phurh leh dahkhawm harsa tak an ni. Tin, doctor chauhvin a pe thei bawk. Heng avang hian sum leh pai lama harsatna nei ram tan chuan heng enkawlna te hi hmuh a harsa hle.
Mahse, he hnar spray thar hi a danglam bik hle. A hnuaia table hi en la, tehkhin rawh.
| Nihphung | Hnar Spray hmanga tihfai a ni | Antibody Enkawlna a ni |
|---|---|---|
| A man leh a siam chhuah | A man tlawm a, E. coli ang chi microorganism pangngai hmanga siam theih a ni. | A man a to hle mai. Thil siam chhuah, phurh chhuah leh dahkhawm harsa tak. |
| Dahthatna | Temperature sang takah pawh a nghet thei hle. | Refrigeration condition bik hnuaiah dah tur a ni. |
| Hman dan tur | I hnar chhungah nangmah ngeiin i spray thei bawk. A awlsam khawp mai. | Doctor-in thisenah (IV) chauh pek tur a ni. |
| A chi hrang hrang lakah | Test-ah chuan chi thar tam tak lakah a tangkai hle tih hmuhchhuah a ni. | Variant thar (e.g. Omicron) lakah hlawhtlinna a hniam hle. |
Researcher te chuan he hnar spray hi damdawi dawr pangngaiah pawh hman theih tura siam thuai an beisei.
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Check Availability →He hnar spray hian engtin nge hna a thawh?
Hei hi hrethiam tur chuan kan taksaah Covid virus a luh dan hi kan hriatthiam hmasak a ngai a ni. Covid virus hi ball te tak te, spike tam tak nei ang mai hi han ngaihtuah teh. Heng spike te hi spike protein kan ti a . Kan taksa cell-te hian heng spike-te nena inmil chiah receptor an nei a, chu chu key-in lock-a a fit ang maiin a ni. Virus chhunga heng spike protein te hi kan cell chhunga heng receptor te nen hian an inzawm chuan virus chu cell chhungah a lut a, min ti na thin.
Tuna antibody enkawlna hian heng spike protein te hi a block thin. Mahse virus hi a inthlak danglam a, strain thar a lo chhuah chhoh zel chuan heng spike proteins te pianzia pawh hi a danglam deuh deuh a ni. Tichuan treatment hlui te chuan a pianzia thar chu an hre chiang thei lo.
Mahse, he hnar spray thar hian kawng dangin hna a thawk thung. Virus spike protein chu a target lo va, kan cell-a receptor chu a target zawk a ni . Phên dangin sawi ila, he spray hian a tih chu chu ‘lock’ chu hun eng emaw chen atan a khar a ni. Tichuan, virus ‘key’ chu eng ang pawhin danglam mah se, a fit tur lock a awm lo. Hei vang hian he method hi strain thar tan pawh a hlawhtling thei niin kan ring.
Hei hi a hlawhtling tak tak em?
Tun thlenga test-ah chuan hei hi mice-ah a hlawhtling hle. Covid vei mice te hi he N-0385 spray an pek hian 70% an damchhuak , an lung pawh a chhe lo niin a lang. Test dang pakhatah chuan mice 10 te chu ni 4 chhung he enkawlna hi pek an nih chuan mi 10 te chu an dam vek a ni. Mahse, he enkawlna aiah saline solution pangngai pek mice 20 zinga pakhat chauh a damchhuak.
Heng test te hian hei hi enkawlna beisei awm tak a ni tih a tilang chiang hle. A dawt leh tur chu mihring fiahna bul tan hi a ni. A tul anga sum pek a nih veleh mihringah hian hei hi eng ang taka him leh hlawk nge a nih tih chiang takin kan hre thei tawh ang. Chuvangin hei hi research stage-ah a la awm tih kan hriat reng a ngai a ni. Mahse nakin lawkah Covid ang virus dona kawngah ralthuam chak tak ni thei tur khawpin theihna a nei a ni.
Take-Home Thuchah a ni
- Tunah hian COVID-19 hri laka invenna atana hnar (nasal spray) chungchangah zirchianna kalpui mek a ni. Hei hi enchhin mek a ni.Research stage-ah a la awm a, mipui hman atan tihchhuah a la ni lo.
- Mice hmanga test-naah result hlawhtling tak a awm a, natna kai venna atan leh natna kai tirh lamah pawh enkawlna atan pawh a thawk a ni.
- He spray hi tuna antibody enkawlna man to leh hman harsa zawk ai chuan a man tlawm zawk, hman awlsam zawk leh dahkhawm awlsam zawk a nih beisei a ni.
- Hei hian virus hmun thenkhat target ai chuan kan cell-a virus luh theihna tur receptor te chu hun eng emaw chen a block avangin hna a thawk a ni. Hei hian virus chi thar lakah a thawk tha zawk a ni.
- Mihring fiahna hnuah chauh he thil hi hlawhtlinna leh himna dik tak chu finfiah theih a ni. Chuvangin, hmalam hun atana beiseina a awm lai hian tuna vaccine hman mek hi lak a, hriselna lama thurawn zawm a pawimawh hle.
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