E mōhio ana koe ki te mate ira onge e kiia nei ko te Homocystinuria (HCU)? Me kōrero tāua!

I tēnei rā ka kōrero tātou mō tētahi āhuatanga kāore anō kia rangona i mua, engari he mea tino nui kia mōhio te katoa. Ko te ingoa o tēnei ko te Homocystinuria, ko te `(HCU)` rānei. I ētahi wā, ina kore e tika te haere o ētahi tukanga matū e puta ana i roto i tō tātou tinana, ka puta pea ngā raruraru ohorere. Ko tētahi o ēnei āhuatanga ko te `(HCU)`. Kaua e mataku, me kōrero noa iho tātou mō tēnei.

He aha te Homocystinuria (HCU)?

Ki te kī ngāwari, he mate ira onge te `(HCU)`. Ko te mea ka tupu i roto i tēnei, kāore e taea e tō tātou tinana te whakahaere tika i te waikawa amino `(Homocysteine)`, arā, kāore e taea te whakamahi me te tango atu. Whakaarohia, he aha ka tupu mēnā ka kohia ngā mea koretake i roto i tō tātou tinana? Pērā tonu, ka kohia tēnei `(Homocysteine)` i roto i te toto me te mimi. Ka taea e tēnei kohi te whakararuraru nui i ngā kanohi, te pūnaha angaiwi (tō tātou angaiwi), te pūnaha io matua (te roro me te taurakira), me te pūnaha toto (ngā uaua toto). He pātai tāu , he aha ēnei waikawa amino? Ko ngā waikawa amino ngā poraka hanga taketake o ngā pūmua. Pērā i ngā pereki e hiahiatia ana hei hanga whare, e hiahiatia ana ngā waikawa amino hei hanga pūmua i roto i tō tātou tinana. Ka hangaia e tō tātou tinana tētahi wāhanga o tēnei `(Homocysteine)` mai i tētahi atu waikawa amino e kiia nei ko `(Methionine)`. Waihoki, mai i ngā kai nui te pūmua e kainga ana e tātou, hei tauira, te mīti, te ika, me ngā hua manu, ka nui ake te `(Methionine)` ka whiwhi tātou. I te nuinga o te wā, ka pakaruhia e tō tātou tinana tēnei `(Methionine)` ka hurihia hei `(Homocysteine)`. Heoi, i roto i te tinana o te tangata e pāngia ana e te `(Homocystinuria), kei te ngaro te whākōkī e hiahiatia ana hei whakahaere tika i tēnei `(Homocysteine)`, arā, hei pupuri i te taumata e hiahiatia ana me te whakarerekē i te toenga, kāore rānei e mahi tika. Ko te whākōkī he momo pūmua e tere ake ai ngā tauhohenga matū i roto i tō tātou tinana. Nō reira, ina ngaro tēnei whākōkī, ka piki ake te taumata o `(Homocysteine)`.

He aha ngā momo matua o te homocystinuria?

Kua wehea e ngā kairangahau te homocystinuria kia maha ngā momo i runga i ngā take ira. E rua ngā momo matua:

1. Te ngoikore o te Cystathionine beta-synthase (CBS) (Homocystinuria Matarohia)

Koinei te momo homocystinuria tino noa . Ko te Cystathionine beta-synthase (CBS) he whākōkī e āwhina ana ki te huri i te homocysteine ​​​​ki tētahi atu waikawa amino, ko te cysteine. Ka puta tēnei momo mate ina iti rawa, ina kore rānei e puta te whākōkī CBS e te ira CBS, ina kore rānei e mahi tika te whākōkī CBS. Me whai huaora B6, e mōhiotia ana ko te pyridoxine, te whākōkī CBS kia pai ai te mahi. Ka wehea anō tēnei momo i runga i te pai o tō urupare ki ngā tāpiringa huaora B6.

2. Te hapa o te pākia o te cobalamin (cbl)

Me huri e tō tātou tinana ētahi o te homocysteine ​​​​ki te methionine. Kei roto i tēnei tukanga te huaora B12, e mōhiotia ana ko te cobalamin. He maha ngā taahiraa e haere ana tō tātou tinana ki te huri i te homocysteine ​​​​ki te methionine. Ko te homocystinuria, e puta mai ana i te korenga o te cobalamin, ka puta ina kore e taea e te tinana te whakaoti i tēnei taahiraa, kaore e hanga i te whākōkī tika, ka whakaputa rānei i ngā whākōkī hapa.

He aha te rerekētanga i waenga i te homocystinuria me te Marfan syndrome?

He mate ira onge te Marfan syndrome e pā ana ki ngā kiko honohono puta noa i te tinana. He rite tonu ngā tohu o tēnei mate ki ngā tohu o te homocystinuria. Hei tauira, he roa ngā waewae, he roa, he kikokore ngā maihao, he ectopia lentis, me te myopia. Heoi, ko te Marfan syndrome te take o te whakarerekētanga ira i roto i te ira Fibrillin-1 (FBN1). He noa ngā taumata o te homocysteine ​​​​me te methionine o te hunga whai Marfan syndrome.

Ko wai te hunga e tino pāngia ana e tēnei mate? He pēhea te noa o tōna pānga?

Ko te homocystinuria te take o tētahi whakarerekētanga ira. Nō reira, ka taea e te tangata katoa te pāngia e tēnei mate. Heoi, kua whakaatuhia e ētahi rangahau he nui ake te pānga o tēnei mate ki te iwi i ētahi whenua i ētahi atu. Ko ēnei whenua ko:

• Airana
• Nōwei
• Tiamana
• Katā

He mate ira tino onge te homocystinuria. Ko te momo mate tino noa ka pā ki te kotahi i roto i te 200,000 me te kotahi i roto i te 335,000 tāngata puta noa i te ao. He tino onge tēnā.

He aha ngā tohu o te homocystinuria?

He rerekē ngā tohu o te `(Homocystinuria)` i runga i te momo e pāngia ana koe. Ka tīmata te puta mai i ngā tau tuatahi o te oranga. Heoi, tera pea ētahi tāngata kāore e pāngia e ngā tohu tae noa ki te pakeketanga. Ko te momo `(Homocystinuria)` tino noa ka pā ki ēnei pūnaha:

• Ngā kanohi
• Pūnaha angaanga
• Pūnaha io matua
• Pūnaha toto

Ko ngā tohu o te `(Homocystinuria)` ko:

Ngā tohu e pā ana ki ngā kanohi:

• Ka neke te karu o te kanohi i tōna tūranga noa (ectopia lentis). Ka raru pea te tirohanga i tēnei.
• Te tirohanga pōuri rawa (myopia), arā, te kore e taea te kite i tawhiti.

Ngā tohu e pā ana ki te pūnaha angaiwi:

• E whakaatu ana i te tipu nui rawa .
• Te roanga rerekē o ngā ringa, ngā waewae me ngā maihao.
• Ka piko ngā turi ki roto, ā, ka patoto ngā turi tetahi ki tetahi ina tika ngā waewae (e kiia ana hoki tēnei ko ngā "turi patoto").
• Kua totohu te uma ki roto, kua pūwero rānei ki mua.
• He piko o te tuaiwi (scoliosis).
• Ko te hunga whai homocystinuria kei te mōrearea hoki ki te pāngia e te osteoporosis .

Ngā tohu e pā ana ki te pūnaha io matua:

• Ngā whakaroa whanaketanga . Ko te tikanga tēnei kāore e whakaatu i te whanaketanga hinengaro, tinana rānei e tika ana mō te tau.
• Ngā uauatanga ako.

Ngā tohu e pā ana ki te pūnaha manawa:

• Te pikinga ake o te mōrearea o te toto totoka. Ka taea e ēnei toto totoka te whakararu i ngā āhuatanga kino pērā i te whiu , te embolism pūkahukahu rānei.

He aha ngā take o te homocystinuria?

He maha ngā momo homocystinuria e puta mai ana i ngā huringa ira, i ngā whakarerekētanga rānei, i roto i ngā momo ira.

Ngā take ira

Ko te momo `(Homocystinuria)` tino noa ka puta mai i te whakarerekētanga o te ira `(CBS)`. Mā tēnei ira `(CBS)` ka tohutohu i tō tātou tinana ki te hanga i tētahi whākōkī e kiia nei ko `(Cystathionine beta-synthase)`. Ko tēnei whākōkī te kawenga mō te ara matū e huri ai te waikawa `(Homocysteine)` ki `(Methionine)`. Ka taea hoki te `(Homocystinuria)` te puta mai i ngā whakarerekētanga o ngā ira `(MTHFR)`, `(MTR)`, `(MTRR)` me `(MMADHC)`. Ko ēnei ira katoa te kawenga mō te huri i te waikawa `(Homocysteine)` ki `(Methionine). Mena he whakarerekētanga o tētahi o ēnei ira, kāore te whākōkī e tika ana e mahi tika. Kātahi ka tīmata te `(Homocysteine)` ki te kohikohi i roto i te tinana. Heoi, kāore anō kia tino mārama ngā kairangahau he aha ngā taumata tiketike o te homocysteine ​​​​e puta ai ngā tohu o te homocystinuria. Ka riro i a koe te homocystinuria i roto i te tauira autosomal recessive. Ko te tikanga o tēnei, ka riro mai i a koe te mate mēnā ka tukuna atu e ō mātua e rua te ira e pāngia ana ki a koe, arā, kāore nei he tohumate i te nuinga o te wā.

Ka taea te whakaputa i te homocystinuria e te korenga o ngā huaora?

Āe, ka puta anō hoki te homocystinuria nā ngā take ehara i te ira. Ka puta anō hoki tēnei āhuatanga nā te korenga nui o te huaora B6, te huaora B9 (folate), te huaora B12 rānei (cobalamin).

Me pēhea te tautuhi i te Homocystinuria?

I ngā whenua pēnei i te Hononga o Amerika, ka whakamahia ngā whakamātautau tirotiro pēpi hou hei tirotiro i ētahi āhuatanga pākia o te tinana, tae atu ki te homocystinuria. Ka ine te whakamātautau homocysteine ​​i ngā taumata o te homocysteine ​​​​me te methionine i roto i te toto o tō pēpi. Mena he pai ngā hua o te whakamātautau, e tohu ana kei te kitea pea te āhuatanga, ka whakahau te tākuta o tō pēpi i ētahi atu whakamātautau hei whakaū i ngā hua. Heoi, kāore i te tika katoa ēnei whakamātautau pēpi hou. I ētahi wā, kāore pea e taea te kite i ētahi āhuatanga. Nō reira, ka tātaritatia ētahi tāngata he homocystinuria i muri i te putanga mai o ngā tohu. Ahakoa he maha ngā tohu e puta mai ana i te wā pēpi, i te wā tamarikitanga rānei, ka puta pea i ētahi wā i te wā pakeke. Mena kei a koe ngā tohu o te `(Homocystinuria)`, ka whakahau tō tākuta i tētahi `(whakamātautau Homocysteine)` hei whakaū i te āhuatanga. Mena ka whakaatu ngā hua kei a koe te `(homocystinuria matarohia)` (arā, te `(CBS)` ngoikore), ka whakahau tō tākuta i tētahi atu whakamātautau hei kimi i te momo momo kei a koe. Ka kiia tēnei he `(wero huaora B6)` . Ka kitea e tēnei whakamātautau te āhua o tō urupare ki ngā tāpiringa huaora B6. Kātahi ka taea e tō tākuta te waihanga i te mahere maimoatanga tika māu. Ka taea te whakarōpū i te `(Homocystinuria Matarohia)` penei:

• Huaora B6-aroha: Ka nui te whākōkī "(CBS)" ka hangaia e tō tinana, nō reira ka taea e te huaora B6 te āwhina i taua whākōkī kia mahi tika.
• He wāhanga o te huaora B6 e aro ana ki: Ka hangaia e tō tinana tētahi wāhanga o te whākōkī "(CBS)", nō reira ka āwhina pea te huaora B6 i tētahi wāhanga.
• Kāore e aro te huaora B6: Kāore e nui te whākōkī "(CBS)" e hangaia ana e tō tinana, nō reira, kāore pea te huaora B6 e āwhina i te whākōkī.

Ka taea e ngā whakamātautau ira te kite i ngā whakarerekētanga ira i roto i ngā ira e puta ai te homocystinuria. Heoi, kāore i te nuinga o te wā ka whakamahia ēnei e ngā tākuta nā te mea ko te whakamātautau homocysteine ​​anake ka taea te tautuhi i te mate.

He aha ngā maimoatanga mō te homocystinuria?

Ko te maimoatanga mō te homocystinuria ko te whakahaere i ngā taumata o te homocysteine ​​​​i roto i tō toto me te whakahaere i ō tohu. Ko te tikanga, ko te maimoatanga ko te tango i ngā tāpiringa huaora B6. Mena kei a koe te momo e aro ana ki te huaora B6 (homocystinuria tawhito), tera pea he nui ngā tāpiringa huaora B6 hei whakaiti me te whakahaere i ō taumata homocysteine. Heoi, ki te mea kei a koe te momo kāore e aro, e aro ana rānei ki te huaora B6 (homocystinuria tawhito), tera pea kāore e ranea ngā tāpiringa huaora B6 anake. Me hiahia pea koe ki ētahi atu kōwhiringa maimoatanga. Kei roto pea i ēnei:

• Ko te rongoā `(Betaine)` (Betaine) `(Cystadane rānei): `(Betaine)` ka āwhina i te whakaiti i te taumata o `( Homocysteine ​​)` i roto i tō toto.
• Kai motuhake mō te `(Homocystinuria)`: Me whai koe i tētahi kai e whakawhāiti ana i ngā kai kei roto ko te pūmua me te `(Methionine)`.
• Ngā tāpiringa tāpiri: Mena he momo homocystinuria anō tōu, me tango pea e koe he tāpiringa folate ( huaora B9 ) me te cobalamin ( huaora B12 ) rānei.

Ko te mea nui ko te haere tonu o tēnei maimoatanga mō te roanga o tō oranga . Mā reira anake ka taea e koe te whakahaere i ō taumata homocysteine, te whakaiti i ngā raruraru, me te noho ora.

Kia pēhea te roa ka taea e koe te ora me te homocystinuria?

Ki te kitea wawetia te mate, ā, ka rongoatia tika mō te roanga o te oranga, ka taea e te nuinga o ngā tamariki e pāngia ana e te Homocystinuria te tumanako kia ora noa, kia ora hauora . Nō reira, he mea tino nui te kitea wawetia me te haere tonu o te maimoatanga.

Ka taea te ārai i te homocystinuria?

Nā te mea he mate ira tēnei, kāore e taea te ārai i te homocystinuria. Heoi, ki te mea kei te hapu koe, kei te whakaaro rānei koe ki te whānau tamariki ā muri ake nei, he mea tika kia kōrero koe ki tētahi kaitohutohu ira. Ka taea e te tohutohu ira te āwhina i a koe ki te mārama ki tō tūponotanga ki te whānau tamariki me te homocystinuria. He mea noa te pōuri ina kitea e koe he mate ira tōu, tō pēpi rānei. Whakapaua te wā ki te ako i ngā mea katoa e taea ana e koe mō te homocystinuria. Kātahi, kimihia he tākuta e tino mārama ana ki tō mate. Mā te mahi tahi me tētahi tohunga metabolic ka taea e koe te whai mana whakahaere. Mā te whakamana i a koe anō ki ngā mōhiohio me ngā rauemi, ka taea e koe te whakatutuki i te putanga pai rawa atu.

Hei whakamutunga, ko te mea tino nui (Karere hei tango i te kāinga)

Āe, ko tāku tumanako kua mārama ake koe ki tā tātou i kōrero ai (Homocystinuria). Anei ētahi mea nui hei maumahara:

• He aha te `(Homocystinuria)`?He mate ira onge engari he mate kino pea.
• Ko te mea ka tupu i tēnei, kāore e taea e te tinana te whakahaere tika i tētahi matū e kiia nei ko te "Homocysteine," ā, ka kohia ki roto i te tinana.
• Ka pā mai pea ngā raruraru ki ngā kanohi, ki te angaanga, ki te pūnaha io, me ngā uaua toto .
• Ko te mea nui ko te mōhio wawe ki te mate, me te whiwhi maimoatanga tika mō tō oranga katoa . Ki te mahi koe i tēnā, ka taea e koe te noho i te oranga noa.
• Ko te Huaora B6, he kai motuhake, me ētahi rongoā ngā maimoatanga matua mō tēnei.
• Mena he pātai anō āu mō tēnei, mēnā rānei kei roto i tō whānau ēnei tohu, me rapu tohutohu hauora.

Kaua e wehi, ko te huarahi pai ki te whakatau i tētahi mate hauora ko te mōhio pai ki tēnei mate. Homocystinuria, ngā mate ira, homocysteine, ngā waikawa amino, huaora B6, huaora B12, methionine