Kodi mungathe kulosera za chiopsezo cha Alzheimer's? Tiyeni tikambirane za Kuyesa kwa APOE4

Tangoganizirani, ngati mutadziwa kale kuti mudzakhala ndi matenda a Alzheimer mtsogolo, mungatani? Kwenikweni, kodi tingatani titadziwa zimenezi? Ili ndi vuto lalikulu lomwe madokotala ndi ofufuza ambiri akukumana nalo masiku ano. Posachedwapa, gulu la ofufuza linapeza kuti pafupifupi 20% ya anthu omwe amadwala matenda a Alzheimer amatha kuzindikirika msanga pongoyang'ana majini awo. Ndicho chifukwa chake ndikofunikira kwambiri kukambirana za izi.

Kodi APOE4 iyi ndi chiyani? N’chifukwa chiyani imagwirizana ndi matenda a Alzheimer’s?

Mwachidule, `APOE` iyi ndi jini m'thupi lathu. Ntchito yake yayikulu ndikuthandizira kunyamula mafuta monga cholesterol m'magazi athu. Pali mitundu yosiyanasiyana ya jini iyi ya `APOE`. Timapeza jini iyi, imodzi kuchokera kwa amayi athu ndi inayo kuchokera kwa abambo athu.

Anthu ambiri ali ndi mtundu wotchedwa `APOE3`, koma ena akhoza kukhala ndi mtundu wotchedwa `APOE4`.

• Pa avareji, pafupifupi 20% ya anthu ali ndi kopi imodzi ya jini ya `APOE4`.
• Komabe, pafupifupi 2% ya anthu amalandira makope awiri a jini ya `APOE4` (kuchokera kwa amayi ndi abambo). M'mawu azachipatala, timatcha anthu awa `(APOE4 homozygotes)`.

Kwakhala kudziwika kwa nthawi yaitali kuti anthu omwe ali ndi makope onse awiri a jini ya APOE4 ali pachiwopsezo chachikulu chotenga matenda a Alzheimer's .

Kodi kafukufuku waposachedwapa akunena chiyani?

Kafukufuku waposachedwapa wofalitsidwa mu magazini yotchuka ya zamankhwala ya Nature Medicine adafufuza izi mozama. Iwo adasanthula zambiri zaumoyo wa ubongo woperekedwa ndi anthu 3,300 ndi anthu 10,000.

Kumeneko adapeza chinthu chodabwitsa: 95% ya anthu omwe ali ndi makope onse awiri a jini ya APOE4 anali ndi kusintha (zolemba zamoyo) kokhudzana ndi matenda a Alzheimer muubongo wawo kapena madzi amthupi.

Kusintha kumeneku nthawi zambiri kumayamba ali ndi zaka 55. Zizindikiro zinayamba ali ndi zaka 65. Pomaliza, matenda a dementia , omwe ndi kuchepa kwakukulu kwa kukumbukira ndi kuganiza, adapezeka ali ndi zaka 74.

Chabwino kwambiri pa izi ndichakuti mtsogolo, pakhoza kukhala mwayi wozindikira ndi kuchiza anthu omwe ali ndi matenda a ubongo zizindikiro zisanawonekere.

Kodi aliyense ayenera kulemba mayeso awa?

Funso lofunika kwambiri ndi ili. Yankho ndi lakuti, ayi! Poganizira momwe zinthu zilili panopa, mabungwe azachipatala sakulangiza aliyense kuti ayesere mayesowa, mosasamala kanthu za zizindikiro zake. Pali zifukwa zingapo zomwe zimapangitsa zimenezo.

Kumvetsetsa zofooka za kafukufukuyu

• Fuko: Kafukufukuyu adachitika makamaka pa anthu oyera ochokera ku Ulaya. Choncho sizikudziwika bwino kuti zotsatira zake zikugwira ntchito bwanji kwa anthu m'dziko lathu, kutanthauza anthu aku Asia.
• Mtundu wa chitsanzo: Deta inasonkhanitsidwa kuchokera kwa anthu omwe adachita nawo kafukufuku wa Alzheimer's, kotero akhoza kukhala ndi malingaliro osiyana pang'ono ndi matendawa kuposa anthu onse.

Si aliyense amene amalandira zizindikiro.

Ichi ndi chinthu chofunika kwambiri chotonthoza . Kafukufukuyu akunena kuti si aliyense amene ali ndi makope onse awiri a `APOE4` amene ali ndi zizindikiro . Anthu ena akhala ndi moyo mpaka zaka 80 popanda zizindikiro za matenda a dementia. Komanso, zaka zomwe zizindikiro zimayambira zimatha kusiyana kwambiri malinga ndi munthu aliyense.

Ngati mukuganiza za mayeso awa, muyenera kuchita chiyani?

Tangoganizirani kuti wina m'banja mwanu ali ndi matenda a Alzheimer's ndipo mukuda nkhawa nawo. Ngati mukuganiza za mayeso a `APOE4` awa, nazi zinthu zina zomwe muyenera kukumbukira.

1. Musangolemba mayeso: Musalembe mayeso amtunduwu chifukwa cha chidwi chokha. Samalani kwambiri ndi mayeso omwe adayitanidwa pa intaneti.

2. Lankhulani ndi dokotala wanu: Choyamba, lankhulani ndi dokotala wa banja lanu kapena katswiri wa mitsempha za izi. Khalani omasuka za mbiri ya banja lanu komanso mantha anu.

3. Uphungu wa majini ndi wofunikira : Ngati mukufuna mayeso ngati awa, sikuyenera kukhala nkhani yongotenga lipoti. Ndikofunikira kulankhula ndi mlangizi wa majini kapena dokotala yemwe ndi katswiri pa izi musanayambe komanso mutamaliza. Muyenera kufotokoza tanthauzo la zotsatira zake, momwe zidzakhudzire moyo wanu, komanso momwe mungathanirane ndi zotsatira zamaganizo zomwe zingakhudze.

4. Ganizirani zinthu zomwe mungathe kuzilamulira: Sitingathe kusintha majini athu. Koma pali zinthu zambiri zomwe tingathe kuzilamulira. Chinthu chabwino kwambiri chomwe tingachite ndikukhala ndi moyo wabwino pa thanzi la ubongo .

• Idyani zakudya zopatsa thanzi.
• Kuchita masewera olimbitsa thupi nthawi zonse .
• Gonani bwino usiku.
• Lamulirani kuthamanga kwa magazi, matenda a shuga, ndi kuchuluka kwa cholesterol.
• Chitani zinthu zomwe zimavuta ubongo (kuwerenga mabuku, kuthetsa ma puzzle, kuphunzira china chatsopano).
• Khalani ndi anthu ena.