Isano iri hagati y'indwara ya Alzheimer n'uturemangingo (Alzheimer's na APOE4 Gene) - Ese nawe uri mu kaga?

Twese tugira ubwoba bwo gutakaza kwibuka uko tugenda dusaza, si byo se? Cyane cyane niba hari umuntu wo mu muryango wawe warwaye indwara nka Alzheimer , ikibazo 'Ese nanjye nzayirwara?' gishobora kuba kiri mu mutwe wawe. Ni gute imiterere yacu y'uturemangingo igira ingaruka kuri ibi? Ubushakashatsi buherutse gukorwa bwerekana ko hari isano ikomeye hagati ya gene runaka yitwa APOE4 n'indwara ya Alzheimer kuruta uko byatekerezwaga mbere. None rero uyu munsi, reka tuvuge kuri ibi, niba bikugiraho ingaruka, n'icyo twakora kuri byo.

Iyi gene yitwa APOE4 ni iki mu by'ukuri?

Mu magambo make, APOE ni gene iri mu mubiri wacu. Akazi kayo k'ingenzi ni ugutwara ibinure , nka cholesterol, hagati y'uturemangingo twacu (transport lipide). Tekereza ku turemangingo two mu mubiri wacu nk'amazu mato. Ayo mazu akeneye ibinure kugira ngo akore, ayubake, kandi atange ingufu. gene ya APOE ni nk''serivisi yo gutanga ibinure' izana ibinure mu turemangingo no kubisohora. Iyo aka kazi kadakoze neza, ibibazo bishobora kuvuka, cyane cyane mu turemangingo tw'ubwonko.

Ese buri wese afite iyi gene ya APOE?

Yego, twese dufite iyi gene ya APOE mu mibiri yacu. Ariko si kimwe. Ni nk'uko, ndetse no muri 'service' imwe, abakozi bamwe ni abanyabwenge cyane, abandi ni abantu basanzwe, abandi ni abanebwe gato. Hari ubwoko butatu bw'ingenzi. Reka turebe itandukaniro riri hagati y'ibyo.

Ubushakashatsi bushya buvuga iki?

Twatekerezaga ko APOE4 ari "ikintu gishobora gutera Alzheimer" gusa. Ni ukuvuga ko kuyigira bitavuze ko uzarwara iyi ndwara, ahubwo bivuze ko amahirwe ari menshi.

Ariko ubu bushakashatsi bushya bwerekana ko kugira kopi ebyiri za gene ya APOE4 atari ikintu gishobora gutera ibyago gusa, ahubwo ko bishobora kuba ari ubwoko bw’indwara ya Alzheimer ubwayo. Ibyo bivuze ko abantu bafite gene zombi baba bafite ibyago byinshi byo kurwara iyi ndwara. Kandi ibimenyetso bishobora gutangira bakiri bato.

Ubusanzwe tuzi ko utunyangingo dutera indwara ya Alzheimer ari `(APP)`, `(PSEN1)` na `(PSEN2)`. Ni gake cyane. Ariko ubu bushakashatsi bwabegereye cyane. Basanze 95% by'abantu bafite kopi ebyiri za APOE4 bafite urugero rudasanzwe rwa `(beta amyloid)`, poroteyine mbi ifitanye isano n'indwara ya Alzheimer, mu bwonko bafite imyaka 65.

Ese kugira gene ya APOE4 bivuze ko uzarwara indwara ya Alzheimer's?

Oya. Ntabwo byemejwe 100%. Ariko ibyago ni byinshi cyane. Ni nko gutwara imodoka wihuta cyane kandi gukora impanuka byongera amahirwe yo gukora impanuka. Ntabwo bizabaho, ariko byongera amahirwe yawe. Hafi 2% by'abaturage bafite kopi zombi za gene ya APOE4. Hagati ya 15% na 25% bafite kopi imwe.

Ese nshobora gupima kugira ngo ndebe niba mfite iyi gene?

Yego, hari ibizamini bya genetiki kuri ibi. Ariko iki si ikizamini gisanzwe cyanditswe na muganga wawe kandi gishobora gukorwa byoroshye mu bitaro. Ibi ntibikunze kubaho cyane muri Sri Lanka. Ndetse no mu bihugu by'amahanga, ni gake cyane bitwikirwa n'ubwishingizi.

Ibi bizamini bishobora kwishyurwa binyuze mu bigo byigenga. Kuba wahisemo gukora ibi cyangwa utabihisemo ni icyemezo cyawe bwite. Niba hari abantu benshi bo mu muryango wawe barwaye indwara ya Alzheimer, ushobora kuvugana na muganga bakagufatira umwanzuro kuri ibi.

Nubwo hari ibyago, ni iki twakora kugira ngo twirinde iyi ndwara?

Dore igice cy'ingenzi. Ntidushobora guhindura utunyangingo twacu. Ariko dushobora kurwanya ibyago bizana natwo. Nubwo tudashobora gusubiza inyuma indwara imaze gukura neza, imibereho yacu ishobora kuyitinza cyangwa kuyibuza .

1. Reka dutangire n'imirire.

Ubushakashatsi bwagaragaje kenshi ko indyo yiganjemo ibimera ishobora kugabanya ibyago byo kurwara indwara ya Alzheimer ku kigero cya 50%. Ibyo bivuze ko indyo irimo imboga nyinshi, imbuto, ibinyamisogwe, imbuto z’ibinyampeke n’ibinyampeke byuzuye . Indyo yo mu karere ka Mediterane nayo ni ingirakamaro.

2. Imyitozo ngororamubiri si ugukora urugendo n'amaguru gusa.

Imyitozo ngororamubiri ni ikindi gikoresho gikomeye cyo kugabanya ibyago. Ariko kugenda mu busitani gusa ntibihagije. Ni ubwoko bw'imyitozo ngororamubiri butuma ubira ibyuya kandi ukumva unaniwe cyane mu bwonko bwawe. Imyitozo ngororamubiri , nko guterura ibiremereye , ni ingenzi cyane. Ubushakashatsi bumwe bwagaragaje ko abantu bafite ikibazo cyo kudatekereza neza bakoze imyitozo yo gukomeza amaguru bagabanya ibyago byo kurwara iyi ndwara ku kigero cya 40%.

3. Imyitozo ngororamubiri n'ubwonko bwawe

Imyitozo ngororamubiri yo mu mutwe ni ingenzi kimwe n'imyitozo ngororamubiri. Ibi bikomeza isano iri hagati y'uturemangingo twitwa neuron mu bwonko.

• Wige ikintu gishya (ururimi, igikoresho cy'umuziki).
• Kosora amapuzzle, Sudoku, nibindi.
• Jya mu buryo bwimbitse mu byo ukunda.
• Guhura n'ibibazo bishya.

Icyo buri wese agomba kumenya ku byerekeye imiterere y'uturemangingo, nubwo yaba atabizi

Ibyo bivuze ko twese turi mu kigero cy'imyaka 30, 40, na 50 tugomba gutekereza ku buzima bw'ubwonko bwacu ubu.

Vugana na muganga wawe umenye urugero rwa cholesterol yawe, umuvuduko w'amaraso, n'ibipimo bya HbA1c, bigaragaza uko diyabete yawe ihagaze. Kugenzura ibi ni kimwe mu bikorwa bikomeye ushobora gushora mu kurinda ubwonko bwawe.