Ngaba uziva nje ungenazimvakalelo okanye urhawuzelelwa zizandla zakho neenyawo? Okanye ubuthathaka bemisipha kwaye kunzima ukuhamba? Ngamanye amaxesha, ezi mpawu zinokubangelwa yimeko engaqhelekanga esingazange sive ngayo okwangoku. Namhlanje, siza kuthetha ngenye yemeko enjalo kunye nonyango olutsha lwayo.
Yintoni i-haTTR? Isebenza njani i-Amvuttra?
Ngamafutshane, i-hATTR (i-Heroditary Transthyretin-Mediated Amyloidosis) sisifo esidluliselwa ngelifa. Sikwiqela lezifo ezibizwa ngokuba yi-amyloidosis. Kwezi zifo, iiproteni ezithile emzimbeni wethu zitshintsha imilo yazo, ziqokelelane ngeendlela ezingaqhelekanga, kwaye zihlale kwizitho ezahlukeneyo zomzimba.
Kwisifo se-haTTR, iproteni ebizwa ngokuba yiTransthyretin (TTR) ifakwa ngale ndlela. I-TTR yiproteni elungileyo eveliswa esibindini sethu kwaye inceda ukuthutha iihomoni ze-thyroid kunye ne-vitamin A emzimbeni wonke. Nangona kunjalo, umntu onesifo se-haTTR unotshintsho oluncinci kwi-gene ye-TTR, oko kukuthi, utshintsho. Ngenxa yoko, iproteni ye-TTR eveliswayo ikwimo engalunganga. Le protein yemilo engalunganga iyaqokelelana kwaye ifakwa kwiindawo ezifana nemithambo-luvo, intliziyo, kunye nenkqubo yokugaya ukutya njengeediphozithi ezibizwa ngokuba yi-amyloid .
Xa ezi zidipozithi ziqokelelana zijikeleze imithambo-luvo, ziyabola. Oku sikubiza ngokuba yi -polyneuropathy . Kulapho ke iimpawu ezikhankanyiweyo ngaphambili, ezinje ngokudumba, ukuba ndindisholo, intlungu, kunye nobunzima bokuhamba, ziqala khona.
Into ebalulekileyo kukuba nokuba ufumana uhlobo lwe-gene oluhambelana nesi sifo kwilungu losapho, akuthethi ukuba ngokuqinisekileyo uza kuba nesifo se-hATTR.
Eli yeza i- Amvuttra lisebenza ngokunciphisa ubungakanani bale protein ye-TTR engaqhelekanga eveliswa sisibindi. Oku kunciphisa ukuqokelelwa kwee-amyloid deposits emzimbeni, kunceda ukulawula iimpawu kunye nokuthintela okanye ukulibazisa ukuba isifo singabi sibi.
| Iimpawu eziqhelekileyo ezibonwa kwisifo se -hATTR | |
|---|---|
| Iimpawu ezinxulumene nemithambo-luvo | |
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| Iimpawu zokugaya ukutya | |
| |
| Ezinye Iimpawu Eziqhelekileyo | |
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Ugqirha wakho uza kucebisa utshintsho kwindlela otya ngayo kunye nendlela owuzilolonga ngayo umzimba, kunye nokunyanga iimpawu zakho. Kude kube kutshanje, iindlela zonyango kuphela zesi sifo yayikukulawula iimpawu kwaye, ukuba kuyimfuneko, ukufakelwa isibindi okanye intliziyo. Kodwa amayeza anamhlanje afana ne-Amvuttra ngoku akuvumela ukuba ulawule esi sifo ngokunciphisa iproteni ye-TTR, eyimbangela eyintloko yesifo.
Ulisebenzisa njani eli yeza?
I-Amvuttra yinaliti enikwa phantsi kwesikhumba . Inikwa yingcali yezempilo, njengogqirha okanye umongikazi oqeqeshiweyo. Idla ngokunikezelwa kane ngonyaka (rhoqo kwiinyanga ezintathu) . Ungalungiselela ukufumana inaliti eofisini kagqirha wakho, ekliniki, okanye nasekhaya.
Luphandwe njani olu yeza?
Njengalo naliphi na iyeza elitsha, i-Amvuttra iye yavavanywa kwiimvavanyo zeklinikhi ukuze kufunyaniswe ukusebenza kwayo kunye nokhuseleko lwayo. Kolu vavanyo, iqela lezigulana ezafumana i-Amvuttra lithelekiswa neqela lezigulana ezafumana i-placebo , unyango olungelulo olungenazo izithako ezisebenzayo. Le yindlela esinokubona ngayo ukuba iyeza liyasebenza ngokwenene.
Olu phononongo luquke izigulane ezinesifo se-hATTR kunye ne-polyneuropathy ebangelwe yiyo. Ubuthathaka bazo bemithambo-luvo, amandla emisipha, kunye nokukwazi kwazo ukwenza imisebenzi yemihla ngemihla zilinganiswe kusetyenziswa iinkqubo ezikhethekileyo zokuvavanya amanqaku.
Ngokweziphumo zophando, izigulane ezifumene i-Amvuttra ziphucule ukusebenza kwazo kwemithambo-luvo kunye nomgangatho wobomi. Ngelixa amanqaku azo emithambo-luvo ehla kwaye iimpawu ziphucukile, abo bafumene i-placebo bafumana ukwanda kweempawu.
Kodwa khumbula, iziphumo zezi zifundo zisenokungafani kuye wonke umntu. Kufuneka uxoxe nogqirha wakho malunga nokuba eli yeza likulungele na kwaye ingaba iingenelo zingaphezulu kweengozi.
Ndiza kuqala nini ukuva imiphumo yeyeza?
Olu ayilonyango lukhawulezileyo. Njengoko amayeza eqala ukusebenza kancinci kancinci emzimbeni wakho, unokubona ukuncipha okanye ukuphucuka kweempawu zakho kwiinyanga ezimbalwa . Injongo yexesha elide yolu nyango kukulawula ukuqhubela phambili kwesi sifo. Ke ngoko, kubaluleke kakhulu ukuhlala ujonge iimpawu zakho.
Xelela ugqirha wakho ukuba aqaphele ezi zinto:
- Ukukwazi ukuhamba ngaphandle koncedo
- Ukungaziva mnandi kunye nokurhawuzelela kwamalungu omzimba
- Ukusabela komzimba
- Ukulawula uxinzelelo lwegazi ngelixa umile
Nokuba awuboni tshintsho ngoko nangoko, ungaphoswa kukufumana imigonyo yakho ngexesha. Ugqirha wakho unokwenza uvavanyo lwegazi olwahlukeneyo, iiskeni, okanye uvavanyo lomzimba ukujonga inkqubela yakho.
Iziphumo ebezingalindelekanga kunye nendlela yokuzilawula?
Iziphumo ebezingalindelekanga ezixhaphakileyo ezibonwa nge-Amvuttra zezi:
- Intlungu ezingalweni okanye emilenzeni
- Intlungu yamalungu
- Ubunzima bokuphefumla
Ukongeza, i-Amvuttra inokunciphisa amanqanaba akho e-vitamin A. Ke ngoko, ugqirha wakho uya kwenza uvavanyo lwegazi ukujonga amanqanaba akho e-vitamin A ngaphambi nangexesha lonyango. Ukuba ubona naluphi na utshintsho embonweni wakho, ingakumbi iingxaki zokubona ebusuku , yazisa ugqirha wakho ngoko nangoko.
Ezi azizo zodwa iziphumo ebezingalindelekanga. Ukuba uneempawu ezintsha ezikwenza uzive ungakhululekanga, xelela ugqirha wakho ngoko nangoko.
Ngaba kukho iingxaki ngamanye amayeza?
I-Amvuttra ayaziwa ukuba ibangela naluphi na unxibelelwano olubalulekileyo nokunye ukutya, iziselo, okanye amayeza. Nangona kunjalo, kungcono ukuxelela ugqirha wakho malunga nawo onke amayeza, iivithamini, iimveliso zezityalo, kunye nezongezo ozithathayo.
Umyalezo Wokuya Ekhaya
- I-hATTR yimeko engaqhelekanga, ezuzwe njengelifa eyonakalisa imithambo-luvo.
- I-Amvuttra lunyango lwanamhlanje olunceda ukulawula ukuqhubela phambili kwesi sifo.
- Olu lugonyo olunikwa yingcali yezempilo rhoqo emva kweenyanga ezintathu.
- Ngaphambi kokuba uqale unyango, xoxa ngoncedo kunye nokungalungi nogqirha wakho.
- Kubaluleke kakhulu ukujonga amanqanaba evithamini A ngexesha lonyango kunye nokwazisa ugqirha ngokukhawuleza ukuba kukho naluphi na utshintsho ekuboneni.
- Xelela ugqirha wakho ngoko nangoko malunga naziphi na iziphumo ebezingalindelekanga okanye ukungonwabi.
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