Siyayiqonda ixhala, ukothuka, kunye nemibuzo emininzi ephakamayo xa ufumanisa ukuba unomhlaza webele. Kodwa eyona nto ibalulekileyo ngeli xesha kukwazi kakuhle. Kuba, ayizizo zonke iintlobo zomhlaza webele ezifanayo. Kukho unyango olujoliswe ngokukodwa kwiintlobo ezithile zomhlaza. Ewe, olunye unyango oluye lwasetyenziswa ngempumelelo kubantu abaninzi lunyango lweehomoni . Makhe sithethe ngalo namhlanje.
Yintoni unyango lweehomoni? Ingaba lufanelekile kuye wonke umntu?
Ngamafutshane, iihomoni ezithile emizimbeni yethu zinceda ukukhula kweeseli zomhlaza webele. Ngokukodwa, iihomoni ezimbini ezibizwa ngokuba yi-estrogen kunye ne-progesterone.
Cinga ngeeseli zomhlaza njengezindlu ezincinci. Ezinye iiseli zomhlaza zine 'iminyango' ekhethekileyo (ii-receptors) ezivumela ezi hormone ukuba zingene. Sibiza ii-cancer ezinee-cancer ezine -hormone receptor-positive . Oogqirha, kusenokwenzeka ukuba nikuphawulile oku kwingxelo yenu njenge -ER-positive (ii-estrogen-doors) okanye i-PR-positive (ii-progesterone-doors).
Unyango lweehomoni lusebenza kwimihlaza enala masango eehomoni. Olu nyango luvala loo masango okanye lunciphise ukuveliswa kwezo homoni emzimbeni. Oku kuncitshisa iiseli zomhlaza "isondlo" ezisidingayo, nto leyo ebangela ukuba ziyeke ukukhula okanye zife.
Into ebalulekileyo kukuba, ukuba iiseli zakho zomhlaza azinazo ezi hormone receptors, oko kukuthi, ukuba azinazo iihormone receptor , olu nyango lweehormone aluzukusebenza. Oogqirha bacebisa ezinye iindlela zonyango kubantu abanjalo.
Ziziphi iintlobo eziphambili zonyango lwehomoni?
Kukho iintlobo ezininzi eziphambili zonyango lweehomoni ezisetyenziselwa umhlaza webele. Ugqirha wakho uza kukhetha amayeza afanelekileyo kuwe ngokusekelwe kwizinto ezininzi, kuquka ubudala bakho, uhlobo lomhlaza, kunye nokuba sele udlule kwixesha lokuya exesheni. Makhe sijonge iintlobo ezimbini eziphambili.
| Uhlobo lonyango | Inikwa bani ikakhulu? | Iziphumo ebezingalindelekanga ekufuneka uzazi |
|---|---|---|
| Tamoxifen | Kwabasetyhini banoma yiphi na iminyaka (ngaphambi nasemva kokuya exesheni). Iyeza elisetyenziswe ngempumelelo amashumi eminyaka. | Umngcipheko okhulayo kancinci womhlaza wesibeleko, ukuqhekeka kwegazi emilenzeni nasemiphungeni, isifo sohlangothi, i-cataracts, kunye nobushushu obuphezulu. |
| Izithinteli zeAromatase (ii-AI) Umzekelo: iAnastrozole, iLetrozole | Ikakhulu kubafazi emva kokuya exesheni. | Ubuthathaka bamathambo (i-Osteoporosis) kunye nomngcipheko wokuqhekeka kwamathambo, iintlungu zamalungu kunye nemisipha, iingxaki zokukhumbula, kunye nomngcipheko okhulayo wesifo sentliziyo. |
Okungakumbi malunga neTamoxifen
Le yipilisi oyithatha yonke imihla. Uphando lubonise ukuba ukuyithatha iminyaka eliqela, ngesiqhelo malunga neminyaka emi-5, kunciphisa kakhulu umngcipheko wokubuya komhlaza kunye nomngcipheko wokufumana umhlaza omtsha.
Nangona kunjalo, kufuneka uqaphele nemiphumo emibi esiyixubushileyo kule theyibhile. Ingakumbi umngcipheko womhlaza wesibeleko. Yiyo loo nto kunyanzelekile ukuba uhlolwe rhoqo i-pelvic ngelixa usebenzisa la mayeza. Kwakhona, ukuba ufumana ukopha okungaqhelekanga kwilungu lobufazi, kufuneka uxelele ugqirha wakho ngoko nangoko.
Okungakumbi malunga ne-Aromatase Inhibitors (AIs)
Olu hlobo lwamayeza lusebenza ngokuthintela ukuveliswa kwehomoni i-estrogen kubasetyhini emva kokuya exesheni. Oku kuthintela iiseli zomhlaza ukuba zingafumani ihomoni ezifunekayo ukuze zikhule.
Umngcipheko ophambili wale mayeza yi -osteoporosis , eyingozi yokuba amathambo abe buthathaka aze aphuke lula. Ngenxa yesi sizathu, ugqirha wakho uya kwenza uvavanyo loxinano lwamathambo ngaphambi kokuba uqale ukuthatha eli yeza kwaye ngelixa ulisebenzisa. Usenokucebisa ukuba uthathe izongezo ze-calcium kunye ne-vitamin D.
Ezinye iindlela zonyango eziphambili
Ukongeza kwiintlobo eziphambili zamayeza akhankanyiweyo apha ngasentla, kukho ezinye iintlobo zamayeza asetyenziswayo, ingakumbi xa umhlaza usasazeke kwamanye amalungu omzimba (aphambili okanye aguqukileyo).
Umzekelo, kukho amayeza afana ne-`Fulvestrant (Faslodex)` kunye ne-`Toremifene (Fareston)`. Ukongeza, kukho amayeza amaninzi aphucukileyo abizwa ngokuba yi-`Targeted Therapy` namhlanje. I-`Palbociclib (Ibrance)`, `Abemaciclib (Verzenio)`, `Alpelisib (Piqray)` yimizekelo yala mayeza. La mayeza asebenza ngokujolisa kwiiproteni ezithile ezinceda iiseli zomhlaza zikhule. La mayeza adla ngokunikezelwa kwizigulana kunye nonyango lwehomoni olukhankanyiweyo ngaphambili.
Zonke ezi zigqibo zonyango zenziwa ngokusekelwe kwimeko yakho, uhlobo lomhlaza, ubudala bakho, kunye nempilo yakho iyonke. Ngoko ke ungoyiki ukuxoxa ngayo nayiphi na imibuzo onayo nogqirha wakho.
Unyango olukhethekileyo kwabo bangakhange bafikelele kwixesha lokuyeka ukuya exesheni (i-Ovarian Ablation)
Ukuba awukafiki kwixesha lokuyeka ukuya exesheni, oko kuthetha ukuba uya exesheni rhoqo , i-hormone ephambili ye-estrogen emzimbeni wakho iveliswa zii-ovari zakho. Ngoko ke, kumntu onomhlaza we-ER-positive, ugqirha wakho unokugqiba ekubeni ayeke la ma-ovari ekuveliseni i-estrogen. Oku kubizwa ngokuba yi -ovarian ablation/suppression .
Kukho iindlela ezahlukeneyo zokwenza oku:
- Ukususwa kwamaqanda ngotyando: Le yindlela ehlala ihleli.
- Unyango ngemitha kwii-ovari: Oku kunokuthintela ukusebenza kwee-ovari ngokusisigxina.
- Amayeza okuthintela ukusebenza kwamaqanda okwethutyana: Amayeza abizwa ngokuba yi-`(LHRH) agonists` (adla ngokujova) asetyenziselwa oku. Lo gama nje usebenzisa la mayeza, amaqanda akho awayi kuvelisa iihomoni.
Uphando lubonise ukuba kunye nokucinezela la ma-ovari, unyango lweehomoni olufana ne-tamoxifen lunokufezekisa iziphumo ezilungileyo kakhulu.
Umyalezo Wokuya Ekhaya
- Unyango lwehomoni alulonyango lwazo zonke iintlobo zomhlaza wamabele. Lunikwa kuphela abantu abanomhlaza we-hormone receptor-positive (ER/PR-positive) .
- Unyango olufanele wena (umz. iTamoxifen okanye iAromatase Inhibitor) luya kugqitywa ngugqirha wakho, ngokusekwe kwiminyaka yakho kunye nemeko yakho yempilo.
- Onke la mayeza anokuba nemiphumo emibi. Musa ukuwoyika, yazi nje ukuba yintoni na. Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, xelela ugqirha wakho ngoko nangoko.
- Kubaluleke kakhulu ukuba ugqirha anike uvavanyo ngexesha elifanelekileyo ngexesha lonyango.
- Qiniseka ukuba uxoxa ngokukhululekileyo ngoloyiko lwakho, amathandabuzo, kunye nemibuzo yakho neqela lakho lezonyango. Oku kuya kuba namandla amakhulu kuhambo lwakho lokuphiliswa.
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